缅北禁地

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Staff Profile

Dr Glyn Nelson

Specialist Experimental Scientific Officer

Background

Introduction

I manage the , which provides access, training to a wide range of light microscopes across the University campuses, as well as help and support for image analysis.

Background

My research background has covered areas as diverse as filamentous fungi through to mammalian tissues. The overarching interest which bridges these different models is attempting to understand intracellular signalling networks, especially utilising live cell microscopy techniques.

My current research work is focused on Quality Control and Quality Assurance for Light Microscopy, developing robust, community-accepted methods for measuring and reporting microscope system performance, with the aim that such metrics will be reported in publications utilising light microscopes to improve experimental reproducibility and data reuse.

Qualifications

BSc and PhD from Edinburgh University

Previous Positions

Postdoc with Astrazeneca and Liverpool University, followed by a postdoc at Liverpool University and then postdocs with Prof. Thomas von Zglinicki at 缅北禁地.

Memberships

RMS () Fellow

Co-founder and member of Quality Assessment and Reproducibility for Instruments & Images in Light Microscopy ()


Research

Research Interests

My current work is aimed at developing standardised Quality Control methodologies for light microscopy, currently published on with QUAREP-LiMi.

My biological research background has focussed on the signalling networks involved in induction and maintenance of eukaryotic cellular senescence.

Other Expertise

I have predominantly used fluorescence microscopy, specifically live cell, timelapse imaging. For this I developed and created fluorescent fusion proteins which can report activation of signalling pathways and /or intracellular phenotoypic changes. My last research work focussed on changes in DNA damage induction and repair in senescence.


Teaching

I teach both undergraduate and postgraduates the principles of light microscopy, as well as providing training in microscopy and image analysis. I also organise an annual Bioimaging Facilities Microscopy Workshop.

Publications

  • Articles

    • Collins AL, Kirkness K, Ramon-Gil E, Tzortzopoulou E, Geh D, Dishington J, Graham E, Muir R, Cameron R, Luli S, Khurram E, Storey D, Paish HL, Nelson G, Mcdonald D, Filby A, Borthwick LA, Oakley F, Mann DA, Leslie J. . Hepatology Communications 2025, 9(6), e0706.
    • Borrello MT, Ruzic D, Paish H, Graham E, Collins AL, Scott R, Higginbotham S, Radovic B, Nelson G, Bulmer D, Borthwick LA, Robinson SM, French J, Moir J, White SA, Wilson C, Pandanaboyana S, Hammond J, Thakkar R, Alrawashdeh W, Figueiredo R, Petkovic M, Nikolic K, Oakley F, Mann DA, Mann J. . FEBS Journal 2025, 292(13), 3397-3411.
    • Kelly G, Kataura T, Panek J, Gailing M, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI. . Developmental Cell 2024, 59(15), 1924-1939.e7.
    • Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M, Singer MT, Buttner V, Keysberg LS, Kusgens L, Kohlhepp M, Gorg B, Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond A-L, Albrecht W, Loosen SH, Lohr C, Jordens MS, Babler A, Hayat S, Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jors S, Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G, Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C, Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M, Luedde T. . Immunity 2023, 56(7), 1578-1595.e8.
    • Delpiano L, Rodenburg LW, Burke M, Nelson G, Amatngalim GD, Beekman JM, Gray MA. . Proceedings of the National Academy of Sciences of the United States of America 2023, 120(47), e2307551120.
    • Nelson G, Boehm U, Bagley S, Bajcsy P, Bischof J, Brown CM, Dauphin A, Dobbie IM, Eriksson JE, Faklaris O, Fernandez-Rodriguez J, Ferrand A, Gelman L, Gheisari A, Hartmann H, Kukat C, Laude A, Mitkovski M, Munck S, North AJ, Rasse TM, Resch-Genger U, Schuetz LC, Seitz A, Strambio-De-Castillia C, Swedlow JR, Alexopoulos I, Aumayr K, Avilov S, Bakker G-J, Bammann RR, Bassi A, Beckert H, Beer S, Belyaev Y, Bierwagen J, Birngruber KA, Bosch M, Breitlow J, Cameron LA, Chalfoun J, Chambers JJ, Chen C-L, Conde-Sousa E, Corbett AD, Cordelieres FP, Nery ED, Dietzel R, Eismann F, Fazeli E, Felscher A, Fried H, Gaudreault N, Goh WI, Guilbert T, Hadleigh R, Hemmerich P, Holst GA, Itano MS, Jaffe CB, Jambor HK, Jarvis SC, Keppler A, Kirchenbuechler D, Kirchner M, Kobayashi N, Krens G, Kunis S, Lacoste J, Marcello M, Martins GG, Metcalf DJ, Mitchell CA, Moore J, Mueller T, Nelson MS, Ogg S, Onami S, Palmer AL, Paul-Gilloteaux P, Pimentel JA, Plantard L, Podder S, Rexhepaj E, Royon A, Saari MA, Schapman D, Schoonderwoert V, Schroth-Diez B, Schwartz S, Shaw M, Spitaler M, Stoeckl MT, Sudar D, Teillon J, Terjung S, Thuenauer R, Wilms CD, Wright GD, Nitschke R. . Journal of Microscopy 2021, 284(1), 56-73.
    • Rabanal-Ruiz Y, Byron A, Wirth A, Madsen R, Sedlackova L, Hewitt G, Nelson G, Stingele J, Wills JC, Zhang T, Zeug A, Fassler R, Vanhaesebroeck B, Maddocks ODK, Ponimaskin E, Carroll B, Korolchuk VI. . Journal of Cell Biology 2021, 220(5), e202004010.
    • Rigano A, Ehmsen S, Ozturk SU, Ryan J, Balashov A, Hammer M, Kirli K, Boehm U, Brown CM, Bellve K, Chambers JJ, Cosolo A, Coleman RA, Faklaris O, Fogarty KE, Guilbert T, Hamacher AB, Itano MS, Keeley DP, Kunis S, Lacoste J, Laude A, Ma WY, Marcello M, Montero-Llopis P, Nelson G, Nitschke R, Pimentel JA, Weidtkamp-Peters S, Park PJ, Alver BH, Grunwald D, Strambio-De-Castillia C. . Nature Methods 2021, 18(12), 1489-1495.
    • Oblong JE, Bowman A, Rovito HA, Jarrold BB, Sherrill JD, Black MR, Nelson G, Kimball AB, Birch-Machin M. . Aging Cell 2020, 19(10), e13248.
    • Kucheryavenko O, Nelson G, von Zglinicki T, Korolchuk VI, Carroll B. . Biogerontology 2019, 20, 331–335.
    • da Silva PFL, Ogrodnik M, Kucheryavenko O, Glibert J, Miwa S, Cameron K, Ishaq A, Saretzki G, Nagaraja-Grellscheid S, Nelson G, von Zglinicki T. . Aging Cell 2019, 18(1), e12848.
    • Roger M, Fullard N, Costello L, Bradbury S, Markiewicz E, O'Reilly S, Darling N, Ritchie P, Maatta A, Karakesisoglou I, Nelson G, von Zglinicki T, Dicolandrea T, Isfort R, Bascom C, Przyborski S. . Journal of Anatomy 2019, 234(4), 438-455.
    • Nelson G, Kucheryavenko O, Wordsworth J, von Zglinicki T. . Mechanisms of Ageing and Development 2018, 170, 30-36.
    • Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI. . Journal of Cell Biology 2017, 216(7), 1949.
    • Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI. . Autophagy 2016, 12(10), 1917-1930.
    • Scialo F, Sriram A, Fernández-Ayala D, Gubina N, Lõhmus M, Nelson G, Logan A, Cooper HM, Navas P, Enríquez JA, Murphy MP, Sanz A. . Cell Metabolism 2016, 23(4), 725-734.
    • Correia-Melo C, Marques FDM, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SWG, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF. . EMBO Journal 2016, 35(7), 724-742.
    • Miwa S, Treumann A, Bell A, Vistoli G, Nelson G, Hay S, von Zglinicki T. . Free Radical Biology and Medicine 2016, 90, 173-183.
    • Dolan DWP, Zupanic A, Nelson G, Hall P, Miwa S, Kirkwood TBL, Shanley DP. . PLoS Computational Biology 2015, 11(5), e1004246.
    • Dalle Pezze P, Nelson G, Otten EG, Korolchuk VI, Kirkwood TBL, von Zglinicki T, Shanley DP. . PLoS Computational Biology 2014, 10(8), e1003728.
    • Jurk D, Wilson C, Passos J, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SLF, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T. . Nature Communications 2014, 5, 4172.
    • Dolan D, Nelson G, Zupanic A, Smith G, Shanley D. . PLoS One 2013, 8(2), e55190.
    • Singhapol C, Pal D, Czapiewski R, Porika M, Nelson G, Saretzki GC. . PLoS One 2013, 8(1), e52989.
    • Pienaar I-S, Elson JL, Racca C, Nelson G, Turnbull DM, Morris CM. . American Journal of Pathology 2013, 183(6), 1826-1840.
    • Tsolou A, Nelson G, Trachana V, Chondrogianni N, Saretzki G, von Zglinicki T, Gonos ES. . IUBMB Life 2012, 64(5), 432-442.
    • Nelson G, Wordsworth J, Wang CF, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T. . Aging Cell 2012, 11(2), 345-349.
    • Passos JF, Nelson G, Wang CF, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TBL, von Zglinicki T. . Molecular Systems Biology 2010, 6(1), 347.
    • Wang CF, Jurk D, Maddick M, Nelson G, Martin-Ruiz C, von Zglinicki T. . Aging Cell 2009, 8(3), 311-323.
    • Nelson G, Buhmann M, von Zglinicki T. . Cell Cycle 2009, 8(20), 3379-3383.
    • Tsolou A, Passos JF, Nelson G, Arai Y, von Zglinicki T. . Experimental Gerontology 2008, 43(10), 892-899.
    • Sapountzi V, Logan IR, Nelson G, Cook S, Robson CN. . International Journal of Biochemistry & Cell Biology 2008, 40(2), 236-244.
    • Richter T, Saretzki G, Nelson G, Melcher M, Olijslagers S, von Zglinicki T. . Mechanisms of Ageing and Development 2007, 128(4), 340-345.
    • Passos J, Richter T, Wang CF, Nelson G, Saretzki G, Rudolph L, von Zglinicki T. . Age 2007, 29(2-3), 113.
    • Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, Wappler I, Birket MJ, Harold G, Schaeuble K, Birch-Machin MA, Kirkwood TBL, von Zglinicki T. . PLoS Biology 2007, 5(5), 1138-1151.
    • Friedrichsen S, Harper CV, Semprini S, Wilding M, Adamson AD, Spiller DG, Nelson G, Mullins JJ, White MRH, Davis JRE. . Endocrinology 2006, 147(2), 773-781.
    • Shen HL, Nelson G, Kennedy S, Nelson D, Johnson J, Spiller D, White MRH, Kell DB. . Chemometrics and Intelligent Laboratory Systems 2006, 82(1-2), 276-282.
    • Shen H, Nelson G, Nelson DE, Kennedy S, Spiller DG, Griffiths T, Paton N, Oliver SG, White MRH, Kell DB. . Journal of the Royal Society Interface 2006, 3(11), 787-794.
    • White MRH, Nelson DE, Johnson JR, See V, Elliott M, Horton CA, Gibney CA, Foreman BE, Nelson G, Spiller DG. . Toxicology 2005, 213(3), 205-206.
    • Nelson DE, See V, Nelson G, White MRH. . Biochemical Society Transactions 2004, 32(6), 1090-1092.
    • Nelson DE, Ihekwaba AEC, Elliott M, Johnson JR, Gibney CA, Foreman BE, Nelson G, See V, Horton CA, Spiller DG, Edwards SW, McDowell HP, Unitt JF, Sullivan E, Grimley R, Benson N, Broomhead D, Kell DB, White MRH. . Science 2004, 306(5296), 704-708.
    • Nelson G, Kozlova-Zwinderman O, Collis AJ, Knight MR, Fincham JRS, Stanger CP, Renwick A, Hessing JGM, Punt PJ, van den Hondel CAMJJ, Read ND. . Molecular Microbiology 2004, 52(5), 1437-1450.
    • Nelson G, Wilde GJC, Spiller DG, Kennedy SM, Ray DW, Sullivan E, Unitt JF, White MRH. . Journal of Cell Science 2003, 116(12), 2495-2503.
    • Nelson G, Paraoan L, Spiller DG, Wilde GJC, Browne MA, Djali PK, Unitt JF, Sullivan E, Floettmann E, White MRH. . Journal of Cell Science 2002, 115(6), 1137-1148.
    • Nelson G, Wilde GJC, Spiller DG, Sullivan E, Unitt JF, White MRH. . FEBS Letters 2002, 532(1-2), 188-192.

  • Book Chapters

    • Wordsworth J, Nelson G, vonZglinicki T. The Ageing Cell. In: Abdulla, A; Gurcharan, SR, ed. The Biology of Ageing and its clinical implication- a practical handbook. London: Radcliffe Publishing, 2013, pp.20-31.
    • Nelson G, von Zglinicki T. . In: Galluzzi, L., Vitale, I., Kepp, O., Kroemer, G, ed. Cell Senescence: Methods and Protocols. London: Springer ; Humana Press, 2013, pp.197-213.
    • Passos JF, Nelson G, von Zglinicki T. . In: Rudolph, KL, ed. Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing. Berlin: Springer, 2008, pp.43-56.

  • Conference Proceedings (inc. Abstract)

    • Krishnan KJ, Nelson G, Romero NB, Ratnaike T, Blakely EL, Ziyadeh-Isleem A, Miller J, Murphy JL, Horvath R, Lochmuller H, Flanigan K, Turnbull DM, Guicheney P, Bitoun M, Taylor RW. . In: 17th International Congress of the World Muscle Society (WMS). 2012, Perth, Australia: Elsevier Ltd.

  • Letter

    • Ratnayaka A, Paraoan L, Spiller DG, Hiscott P, Nelson G, White MRH, Grierson I. . Experimental Eye Research 2007, 84(6), 1135-1139.

  • Notes

    • Hammer M, Huisman M, Rigano A, Boehm U, Chambers JJ, Gaudreault N, North AJ, Pimentel JA, Sudar D, Bajcsy P, Brown CM, Corbett AD, Faklaris O, Lacoste J, Laude A, Nelson G, Nitschke R, Farzam F, Smith CS, Grunwald D, Strambio-De-Castillia C. . Nature Methods 2022, 19, 255.
    • Boehm U, Nelson G, Brown CM, Bagley S, Bajcsy P, Bischof J, Dauphin A, Dobbie IM, Eriksson JE, Faklaris O, Fernandez-Rodriguez J, Ferrand A, Gelman L, Gheisari A, Hartmann H, Kukat C, Laude A, Mitkovski M, Munck S, North AJ, Rasse TM, Resch-Genger U, Schuetz LC, Seitz A, Strambio-De-Castillia C, Swedlow JR, Nitschke R. . Nature Methods 2022, 19, 256.
    • Hammer M, Huisman M, Rigano A, Boehm U, Chambers JJ, Gaudreault N, North AJ, Pimentel JA, Sudar D, Bajcsy P, Brown CM, Corbett AD, Faklaris O, Lacoste J, Laude A, Nelson G, Nitschke R, Farzam F, Smith CS, Grunwald D, Strambio-De-Castillia C. . Nature Methods 2021, 18(12), 1427-1440.
    • Boehm U, Nelson G, Brown CM, Bagley S, Bajcsy P, Bischof J, Dauphin A, Dobbie IM, Eriksson JE, Faklaris O, Fernandez-Rodriguez J, Ferrand A, Gelman L, Gheisari A, Hartmann H, Kukat C, Laude A, Mitkovski M, Munck S, North AJ, Rasse TM, Resch-Genger U, Schuetz LC, Seitz A, Strambio-De-Castillia C, Swedlow JR, Nitschke R. . Nature Methods 2021, 18, 1423-1426.
    • Ratnayaka A, Paraoan L, Nelson G, Spiller DG, White MRH, Hiscott P. . International Journal of Biochemistry & Cell Biology 2007, 39(1), 85-92.
    • Nelson DE, Horton CA, See V, Johnson JR, Nelson G, Spiller DG, Kell DB, White MRH. . Science 2005, 308(5718), 52.

  • Review

    • Guimera AM, Welsh C, Pezze PD, Fullard N, Nelson G, Roger MF, Przyborski SA, Shanley DP. . Essays in Biochemistry 2017, 61(3), 369-377.