缅北禁地

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Staff Profile

Dr Veronika Boczonadi

Experimental Scientific Officer/Support for FLAME facility/Lead for CfL imaging

  • Telephone: +44 (0) 1912083551
  • Address: BIOMEDICINE WEST WING
    INTERNATIONAL CENTRE FOR LIFE
    NEWCASTLE UNIVERSITY
    CENTRAL PARKWAY
    NEWCASTLE UPON TYNE
    UNITED KINGDOM
    NE1 3BZ
Background

I completed my undergraduate studies at the University of Debrecen, Hungary in Medical Biology (2004) and subsequently I received a PhD in Cell Biology at Durham University UK (2009). 


I started my post-doctoral carrier by first investigating embryonic heart development via genetically engineered mice lines. Later, in 2011, I joined the mitochondrial research group and primarily studied the molecular basis of reversibility in infantile reversible cytochrome c oxidase deficiency myopathy and many more rare diseases linked to mitochondrial dysfunction.


In 2018, I was appointed as an Experimental Scientific Officer to establish the Applied Neuromuscular Junction Facility to support and develop the services provided by the Bio-Imaging unit. I have gained specialist knowledge in functional nerve and muscle dissection (mouse, human) followed by electrophysiology and immunohistochemistry; this role also involves providing scientific and technical support; training and advice on electrophysiological recordings; microscopy; image analysis and associated technologies.

Research


Within the Neuromuscular Junction (NMJ) Facility I'm primarily interested in impaired neuromuscular transmission resulting from defects of NMJ which plays an important role in the pathogenesis of many human diseases. Recent advances have identified numerous mutations in more than 30 genes that underlie these diseases. However, the impact of these disruptions on NMJ function have often not been directly investigated, and the molecular and structural events that underlie pathogenesis thus remain obscure. The predominant aim of the NMJ research facility is to carry out correlated studies of the function and structure of individual NMJs, using intracellular electrophysiology coupled with high-resolution fluorescence microscopy.

Teaching

I was involved in regular lecture series both at Durham and 缅北禁地 these included:

  1. Cell Biology Biomedical Sciences (缅北禁地) CMB1004
  2. Genomics of Common and Rare Diseases Lecture Series (缅北禁地 UNiversity) GNM8003
  3. Neuromuscular Diseases Bench to Bedside: Zebrafish models for neuromuscular diseases (缅北禁地 UNiversity) MMB8036
  4. Mitochondrial Biology & Medicine (缅北禁地) MMB8034
  5. Cell Biology (Durham University) BIOL2481
Publications

  • Articles

    • Kurzawa-Akanbi M, Whitfield P, Burte F, Bertelli PM, Pathak V, Doherty M, Hilgen B, Gliaudelyte L, Platt M, Queen R, Coxhead J, Porter A, Oberg M, Fabrikova D, Davey T, Beh CS, Georgiou M, Collin J, Boczonadi V, Hartlova A, Taggart M, Al-Aama J, Korolchuk VI, Morris CM, Guduric-Fuchs J, Steel DH, Medina RJ, Armstrong L, Lako M. . Journal of Extracellular Vesicles 2022, 11(12), 12295.
    • Roesl C, Evans ER, Dissanayake KN, Boczonadi V, Jones RA, Jordan GR, Ledahawsky L, Allen GCC, Scott M, Thomson A, Wishart TM, Hughes DI, Mead RJ, Shone CC, Slater CR, Gillingwater TH, Skehel PA, Ribchester RR. . Biomolecules 2021, 11(10), 1499.
    • Hathazi D, Griffin H, Jennings MJ, Giunta M, Powell C, Pearce SF, Munro B, Wei W, Boczonadi V, Poulton J, Pyle A, Calabrese C, Gomez-Duran A, Schara U, Pitceathly RDS, Hanna MG, Joost K, Cotta A, Paim JF, Navarro MM, Duff J, Mattmann A, Chapman K, Servidei S, Della Marina A, Uusimaa J, Roos A, Mootha V, Hirano M, Tulinius M, Giri M, Hoffmann EP, Lochmuller H, DiMauro S, Minczuk M, Chinnery PF, Muller JS, Horvath R. . EMBO Journal 2020, 39(23), e10536.
    • McMacken GM, Spendiff S, Whittaker RG, O'Connor E, Howarth RM, Boczonadi V, Horvath R, Slater CR, Lochmuller H. . Human Molecular Genetics 2019, 28(14), 2339-2351.
    • Boczonadi V, Jennings MJ, Horvath R. . FEBS letters 2018, 592(5), 703-717.
    • Boczonadi V, Meyer K, Gonczarowska-Jorge H, Griffin H, Roos A, Bartsakoulia M, Bansagi B, Ricci G, Palinkas F, Zahedi RP, Bruni F, Kaspar B, Lochmuller H, Boycott KM, Muller JS, Horvath R. . Human Molecular Genetics 2018, 27(12), 2187-2204.
    • Boczonadi V, King MS, Smith AC, Olahova M, Bansagi B, Roos A, Eyassu F, Borchers C, Ramesh V, Lochmuller H, Polvikoski T, Whittaker RG, Pyle A, Griffin H, Taylor RW, Chinnery PF, Robinson AJ, Kunji ERS, Horvath R. . Genetics in Medicine 2018, 20(10), 1224-1235.
    • Boczonadi V, Ricci G, Horvath R. . Essays in Biochemistry 2018, 62(3), 321-340.
    • Bartsakoulia M, Pyle A, Troncoso-Chandia D, Vial-Brizzi J, Paz-Fiblas MV, Duff J, Griffin H, Boczonadi V, Lochmuller H, Kleinle S, Chinnery PF, Grunert S, Kirschner J, Eisner V, Horvath R. . Human Molecular Genetics 2018, 27(7), 1186-1195.
    • Bansagi B, Griffin H, Whittaker RG, Antoniadi T, Evangelista T, Miller J, Greenslade M, Forester N, Duff J, Bradshaw A, Kleinle S, Boczonadi V, Steele H, Ramesh V, Franko E, Pyle A, Lochmuller H, Chinnery PF, Horvath R. . Neurology 2017, 88(13), 1226-1234.
    • Olsen RKJ, Konarikova E, Giancaspero TA, Mosegaard S, Boczonadi V, Matakovic L, Veauville-Merllie A, Terrile C, Schwarzmayr T, Haack TB, Auranen M, Leone P, Galluccio M, Imbard A, Gutierrez-Rios P, Palmfeldt J, Graf E, Vianey-Saban C, Oppenheim M, Schiff M, Pichard S, Rigal O, Pyle A, Chinnery PF, Konstantopoulou V, Moslinger D, Feichtinger RG, Talim B, Topaloglu H, Coskun T, Gucer S, Botta A, Pegoraro E, Malena A, Vergani L, Mazza D, Zollino M, Ghezzi D, Acquaviva C, Tyni T, Boneh A, Meitinger T, Strom TM, Gregersen N, Mayr JA, Horvath R, Barile M, Prokisch H. . American Journal of Human Genetics 2016, 98(6), 1130-1145.
    • Lane M, Boczonadi V, Bachtari S, Gomez-Duran A, Langer T, Griffiths A, Kleinle S, Dineiger C, Abicht A, Holinski-Feder E, Schara U, Gerner P, Horvath R. . Journal of Inherited Metabolic Disease 2016, 39(3), 427-436.
    • Bartsakoulia M, Müller JS, Gomez-Duran A, Yu-Wai-Man P, Boczonadi V, Horvath R. . Journal of Neuromuscular Diseases 2016, 3(3), 363-379.
    • Giunta M, Edvardson S, Yaobo X, Schuelke M, GomezDuran A, Boczonadi V, Elpeleg O, Muller JS, Horvath R. . Human Molecular Genetics 2016, 25(14), 2985-2996.
    • Boczonadi V, Bansagi B, Horvath R. . Journal of Inherited Metabolic Disease 2015, 38(3), 427-435.
    • Boczonadi V, Giunta M, Lane M, Tulinius M, Schara U, Horvath R. . International Journal of Biochemistry & Cell Biology 2015, 63, 32-40.
    • Herrmann DN, Horvath R, Sowden JE, Gonzales M, Sanchez-Mejias A, Guan Z, Whittaker RG, Almodovar JL, Lane M, Bansagi B, Pyle A, Boczonadi V, Lochmuller H, Griffin H, Chinnery PE, Lloyd TE, Littleton JT, Zuchner S. . American Journal of Human Genetics 2014, 95(3), 332-339.
    • Boczonadi V, Gillespie R, Keenan ID, Ramsbottom SA, Donald-Wilson C, Al Nazer M, Humbert P, Schwarz RJ, Chaudhry B, Henderson DJ. . Cardiovascular Research 2014, 104(1), 103-115.
    • Boczonadi V, Horvath R. . International Journal of Biochemistry & Cell Biology 2014, 48, 77-84.
    • Boczonadi V, Muller JS, Pyle A, Munkley J, Dor T, Quartararo J, Ferrero I, Karcagi V, Giunta M, Polvikoski T, Birchall D, Princzinger A, Cinnamon Y, Lutzkendorf S, Piko H, Reza M, Florez L, Santibanez-Koref M, Griffin H, Schuelke M, Elpeleg O, Kalaydjieva L, Lochmuller H, Elliott DJ, Chinnery PF, Edvardson S, Horvath R. . Nature Communications 2014, 5, 4287.
    • Balreira A, Boczonadi V, Barca E, Pyle A, Bansagi B, Appleton M, Graham C, Hargreaves IP, Rasic VM, Lochmuller H, Griffin H, Taylor RW, Naini A, Chinnery PF, Hirano M, Quinzii CM, Horvath R. . Journal of Neurology 2014, 261(11), 2192-2198.
    • Boczonadi V, Smith PM, Chinnery PF, Horvath R. . Mitochondrion 2013, 13(6), 902-902.
    • Neeve VC, Pyle A, Boczonadi V, Gómez-Durán A, Griffin H, Santibanez-Koref M, Gaiser U, Bauer P, Tzschach A, Chinnery PF, Horvath R. . Mitochondrion 2013, 13(6), 743-748.
    • Boczonadi V, Smith PM, Pyle A, Gómez-Durán A, Schara U, Tulinius M, Chinnery PF, Horvath R. . Human Molecular Genetics 2013, 22(22), 4602-4615.
    • Boczonadi V, Määttä A. . FEBS Letters 2012, 19(586), 3090-3096.
    • Boczonadi V, McInroy L, Määttä A. Cytolinker cross-talk: periplakin N-terminus interacts with plectin to regulate keratin organisation and epithelial migration. Exp Cell Res 2007. In Preparation.
    • Long HA, Boczonadi V, McInroy L, Goldberg M, Maatta A. . Journal of Cell Science 2006, 119(24), 5147-5159.

  • Book Chapter

    • Boczonadi V, Maatta A. . In: Methods in Enzymology. Academic Press Inc, 2016, pp.309-329.

  • Conference Proceedings (inc. Abstracts)

    • Bartsakoulia M, Muller JS, Gomez-Duran A, Boczonadi V, Horvath R. . In: Mitochondria Research Society/United Mitochondrial Disease Foundation Meeting. 2016, Seattle: Elsevier BV.
    • Boczonadi V, Meyer K, Kaspar B, Bartsakoulia M, Bansagi B, Bruni F, Boycott K, Mueller J, Horvath R. . In: Journal of the Peripheral Nervous System. 2016, Venice-Mestre, Italy: Wiley-Blackwell Publishing, Inc.
    • Boczonadi V, Meyer K, Kaspar B, Bartsakoulia M, Bansagi B, Bruni F, Boycott K, Mueller JS, Horvath R. . In: Mitochondria Research Society/United Mitochondrial Disease Foundation Meeting. 2016, Seattle: Elsevier BV.
    • Griffiths A, Boczonadi V, Horvath R, Afridi F, Talbot D. . In: 3rd International Meeting on Ischemia Reperfusion Injury in Transplantation - IMIRT 2016. 2016, Poitiers, France: Wiley-Blackwell.
    • Boczonadi V, Smith PM, Sitarz K, Chrzanowska-Lightowlers ZMA, Lightowlers RN, Chinnery PF, Horvath R. . In: United Kingdom Neuromuscular Translational Research Conference. 2012, 缅北禁地 upon Tyne, UK: Elsevier Ltd.
    • Henderson DJ, Boczonadi V, Humbert P, Chaudhry B. . In: 2nd Congress of the European Society of Cardiology Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2012, London, UK: Oxford University Press.
    • Boczonadi V, Chen V, Henderson D, Chaudhry B. . In: Mechanisms of Development: 16th International Society of Developmental Biologists Congress. 2009, Edinburgh, UK: Elsevier Ireland Ltd.
    • Phillips H, Boczonadi V, Chaudhry B, Henderson D. . In: Mechanisms of Development: 16th Annual Conference of the International Society of Development Biologists. 2009, Edinburgh, UK: Elsevier Ireland Ltd.

  • Editorial

    • Boczonadi V, Horvath R. . EMBO Molecular Medicine 2016, 8(3), 173-175.

  • Note

    • Boczonadi V, King MS, Smith AC, Olahova M, Bansagi B, Roos A, Eyassu F, Borchers C, Ramesh V, Lochmuller H, Polvikoski T, Whittaker RG, Pyle A, Griffin H, Taylor RW, Chinnery PF, Robinson AJ, Kunji ERS, Horvath R. . Genetics in Medicine 2019, 21, 2163-2164.