缅北禁地

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NuCore members

Dr Chien-Yi Chang

Lecturer

  • Email: chienyi.chang@ncl.ac.uk
  • Telephone: +44 (0) 191 208 7829
  • Personal Website:
  • Address: School of Dental Sciences
    Faculty of Medical Sciences
    缅北禁地
    Framlington Place
    缅北禁地 upon Tyne
    NE2 4BW, United Kingdom
Background

Qualifications

BSc, National Chung Hsing University, Taiwan

MSc, National Taiwan University, Taiwan

PhD, University of Nottingham, UK

PgCert in Learning and Teaching (Higher Education), Anglia Ruskin University, UK


Professional History

Lecturer in Microbiology, University of Bradford, UK

Assistant Professor, Heriot-Watt University, UK


Honours and Awards

Fellow of the Higher Education Academy (Advance HE, 2020)

Daiwa Adrian Prize (co-awardee, Daiwa Anglo-Japanese Foundation UK, 2007)

Overseas Research Scholarship (Universities UK, 2002)


Research

Understanding how simple gene regulatory events and biochemical processes become complex decision-making machines in individuals or at population levels is a key challenge in biology. The research in our group is to address fundamental questions concerning:


1) how bacterial cells sense their surroundings and coordinate their responses in population to survive or to cause infection e.g. quorum sensing; surface sensing.


2) how bacterial cells interact with other microbes or host cells in complex and diverse communities in health and diseases e.g. multi-species biofilm in oral environments; biofilm-associated infections.


3) how to harness microbial cells/communities for therapeutical or biotechnological purposes e.g. quorum quenching.


Also, we are interested in exploring the broad bio-diversities in various environmental habitats to discover novel microorganisms and biocatalysts and to study their potential roles for anti-infectious and biotechnological applications. We have established several national and international research collaborations including in Bradford, Nottingham, Malaysia, and China.


We are welcoming anyone interested in microbes to join us and to explore their good, their bad, and their useful. 


Teaching

BDS Stage 1 Director


Stage 1 BDS

Metabolism & Homeostasis (Course Lead)

Orientation and Study Skills

Cellular Physiology - Gastrointestinal Tract


Stage 2 BDS

Microbiology for Dentistry



Publications

  • Articles

    • Goh SY, Chua K-O, Khan SA, Kasim NHA, Liew YJM, Lau YY, Hong K-W, Yin W-F, Yong H-S, Chang C-Y, Chan K-G. . Progress in Microbes and Molecular Biology 2024, 7(1), a0000440.
    • Liu Z, Jiang X, Li J, Ji W, Zhou H, Gong X, Miao B, Meng S, Duan L, Shi Q, Han X, Gao P, Chang C, Dong A, Li J. . Frontiers in Microbiology 2023, 14, 1138039.
    • Wong SY, Hook AL, Gardner W, Chang C-Y, Mei Y, Davies MC, Williams P, Alexander MR, Ballabio D, Muir BW, Winkler DA, Pigram PJ. . Advanced Materials Interfaces 2023, 10(9), 2202334.
    • Dubern JF, Hook AL, Carabelli AM, Chang C-Y, Lewis-Lloyd CA, Luckett JC, Burroughs L, Dundas AA, Humes DJ, Irvine DJ, Alexander MR, Williams P. . Sciences Advances 2023, 9(4), eadd7474.
    • Jin Z, Li J, Zhou J, Wang Z, Yi L, Liu N, Du J, Chang C-Y, Ji W. . Pathogens 2022, 11, 1355.
    • Chua K-O, Norton P, Trus P, Katsikogianni M, Thornton MJ, Chan K-G, Chang C-Y. . Microbiology Resource Announcements 2022, 11(9), e00646-22.
    • Norton P, Chua K-O, Katsikogianni M, Thornton MJ, Chan K-G, Chang C-Y. . Microbiology Resource Announcements 2022, 11(9), e00448-22.
    • Chua K-O, Fatima I, Lau YY, Hong KW, Yin W-F, Mardaryev A, Chan K-G, Chang C-Y. . BMC Research Notes 2022, 15, 107.
    • Huang L, Gao K, Chen G, Zhong H, Li Z, Guan X, Deng Q, Xie Y, Ji W, McIver DJ, Chang C-Y, Liu H. . Frontiers in Cellular and Infection Microbiology 2021, 10, 77031.
    • Gao K, Gao C, Huang L, Guan X, Ji W, Chang CY, McIver DJ, Deng Q, Zhong H, Xie Y, Deng L, Gao F, Zeng L, Liu H. . Frontiers in Microbiology 2021, 11, 609526.
    • Gao K, Deng Q, Huang L, Chang C-Y, Zhong H, Xie Y, Guan X, Liu H. . Frontiers in Cellular and Infection Microbiology 2021, 11, 651968.
    • Chang C-Y, Chan K-G. . Journal of Infection 2020, 81(3), e29-e30.
    • Li J, Ji W, Gao K, Zhou H, Zhang L, Mu X, Yuan C, Guan X, Deng Q, Zhang L, Zhong H, Gao X, Gao F, Long Y, Chang C-Y, McIver DJ, Liu H. . BMC Infectious Diseases 2019, 19, 812.
    • Gao K, Fu J, Guan X, Zhu S, Zeng L, Xu X, Chang C-Y, Liu H. . Infection and Drug Resistance 2019, 12, 3797-3805.
    • Shepherd J, Swift T, Chang C-Y, Boyne JR, Rimmer S, Martin WHC. . Chemical Communications 2019, 55(66), 9765-9768.
    • Chang C-Y. . Frontiers in Microbiology 2018, 8, 2671.
    • Chen J-W, Lau YY, Krishnan T, Chan K-G, Chang C-Y. . Frontiers in Microbiology 2018, 9, 1104.
    • Guan X, Mu X, Ji W, Yuan C, He P, Zhang L, Huang Y, Li J, Chen J, Zhong H, Pang S, Tan N, Deng Q, Gao K, Huang Y-P, Chang C-Y, Liu H. . BMC Infectious Diseases 2018, 18, 14.
    • Gao K, Guan X, Zeng L, Qian J, Zhu S, Deng Q, Zhong H, Pang S, Gao F, Wang J, Long Y, Chang C-Y, Liu H. . Infection and Drug Resistance 2018, 11, 2561-2569.
    • Chan X-Y, Chen J-W, Adrian T-G, Hong K-W, Chang C-Y, Yin W-F, Chan K-G. . Genome Announcements 2017, 5(13), e00067-17.
    • Chan K-G, Priya K, Chang C-Y, Abdul Rahman AY, Tee KK, Yin W-F. . PeerJ 2016, 2016(7), e2223.
    • Adlington K, Nguyen NT, Eaves E, Yang J, Chang C-Y, Li J, Gower AL, Stimpson A, Anderson DG, Langer R, Davies MC, Hook AL, Williams P, Alexander MR, Irvine DJ. . Biomacromolecules 2016, 17(9), 2830-2838.
    • Tan WS, Yin WF, Chang CY, Chan KG. . Genome Announcements 2015, 3(1), e01548-14.
    • Chan KG, Chen JW, Tee KK, Chang CY, Yin WF, Chan XY. . Genome Announcements 2015, 3(2), e00063-15.
    • Tan WS, Chang CY, Yin WF, Chan KG. . Genome Announcements 2015, 3(1), e01509-14.
    • Yong D, Ee R, Lim YL, Chang CY, Yin WF, Chan KG. . Genome Announcements 2015, 3(3), e00409-15.
    • Chan KG, Tan WS, Chang CY, Yin WF, Yunos NYM. . Genome Announcements 2015, 3(2), e00100-15.
    • Tan KH, Sheng KY, Chang CY, Yin WF, Chan KG. . Genome Announcements 2015, 3(1), e01542-14.
    • Chan KG, Chen JW, Chang CY, Yin WF, Chan XY. . Genome Announcements 2015, 3(2), e00095-15.
    • Chan KG, Chin PS, Tee KK, Chang CY, Yin WF, Sheng KY. . Genome Announcements 2015, 3(2), e00079-15.
    • Sanni O, Chang CY, Anderson DG, Langer R, Davies MC, Williams PM, Williams P, Alexander MR, Hook AL. . Advanced Healthcare Materials 2015, 4(5), 695-701.
    • Mohamad NI, Tan WS, Chang CY, Tee KK, Yin WF, Chan KG. . Genome Announcements 2015, 3(1), e00022-15.
    • Chan KG, Kher HL, Chang CY, Yin WF, Tan KH. . Genome Announcements 2015, 3(2), e00145-15.
    • Chan KG, Yin WF, Tee KK, Chang CY, Priya K. . Genome Announcements 2015, 3(3), e00565-15.
    • Hook AL, Chang C-Y, Scurr DJ, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR. . Advanced Healthcare Materials 2014, 3(7), 1020-1025.
    • Chang CY, Krishnan T, Wang H, Chen Y, Yin WF, Chong YM, Tan LY, Chong TM, Chan KG. . Scientific Reports 2014, 4, 7245.
    • Epa VC, Hook AL, Chang C, Yang J, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR, Winkler DA. . Advanced Functional Materials 2014, 24(14), 2085-2093.
    • Chan X-Y, Chang C-Y, Hong KW, Tee KK, Yin WF, Chan KG. . Gut Pathogens 2013, 5, 29.
    • Hook AL, Chang C-Y, Yang J, Atkinson S, Langer R, Anderson DG, Davies MC, Williams P, Alexander MR. . Advanced Materials 2013, 25(18), 2542-2547.
    • Chang C-Y, Koh C-L, Sam C-K, Chan X-Y, Yin WF, Chan KG. . PLoS ONE 2012, 7(8), e44034.
    • Hook AL, Chang C-Y, Yang J, Scurr D, Langer R, Anderson DG, Atkinson S, Williams P, Davies MC, Alexander MR. . Journal of Visualized Experiments 2012, 59, e3636.
    • Hook AL, Chang C-Y, Yang J, Luckett J, Cockayne A, Atkinson S, Mei Y, Bayston R, Irvine DJ, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR. . Nature Biotechnology 2012, 30, 868-875.
    • Chang C-Y, Hobley L, Till R, Capeness M, Kanna M, Burtt W, Jagtap P, Aizawa S-I, Sockett RE. . Microbiology 2011, 157(11), 3079-3093.
    • Atkinson S, Goldstone RJ, Joshua GWP, Chang C-Y, Patrick HL, Cámara M, Wren B, Williams P. . PLoS Pathogens 2011, 7(1), e1001250.
    • Lambert C, Chang C-Y, Capeness MJ, Sockett RE. . PLoS One 2010, 5, e8599.
    • Atkinson S, Chang C-Y, Patrick HL, Buckley CMF, Wang Y, Sockett RE, Cámara M, Williams P. Functional interplay between the Yersinia pseudotuberculosis YpsRI and YtbRI quorum sensing systems modulates swimming motility by controlling expression of flhDC and fliA. Molecular Microbiology 2008, 69, 137.
    • Sockett L, Hobley L, Fenton A, Woods R, Lambert C, Chang C-Y, Atterbury R, Till R, Whitworth M, Capeness M, Fung R, Ahmad R, Milner D, Lerner T, King S. An inside job: Bdellovibrio bacteriovorus. Microbiology Today 2008, 35, 184-187.
    • Atkinson S, Chang C-Y, Sockett RE, Cámara M, Williams P. Quorum sensing in Yersinia enterocolitica controls swimming and swarming motility. Journal of Bacteriology 2006, 181, 2823.
    • Lambert C, Morehouse KA, Chang C-Y, Sockett RE. . Current Opinion in Microbiology 2006, 9(6), 639-644.

  • Book Chapters

    • Lazenby J, Chang C-Y. . In: Randall, MD, ed. Medical Sciences at a Glance. John Wiley & Sons, Inc, 2014, pp.130-133.
    • Lambert C, Hobley L, Chang C-Y, Fenton A, Capeness M, Sockett RE. A predatory patchwork: membrane and surface structures of Bdellovibrio bacteriovorus. In: Poole, RK, ed. Advances in Microbial Physiology. 2009, pp.313-361.

  • Reviews

    • Liu YC, Chan KG, Chang CY. . Frontiers in Microbiology 2015, 6, 1226.
    • Chan KG, Liu YC, Chang CY. . Frontiers in Microbiology 2015, 6, 1173.