缅北禁地

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Staff Profile

Emerita Professor Helen Arthur

Emerita Professor

  • Telephone: +44 (0) 191 241 8648
  • Address: Biosciences Institute
    International Centre for Life
    Central Parkway
    缅北禁地 upon Tyne
    NE1 3BZ
Background

Professor Helen Arthur is a Professor of Cardiovascular Biology for the Institute of Cardiovascular Biology at 缅北禁地. Her area of expertise is TGFβ receptors in cardiovascular development and disease.

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Research

Research Interests

TGFbeta Receptors in Cardiovascular Development and Disease

 The formation of new blood vessels, angiogenesis, is an essential developmental process that is also a target for treating many major diseases. For example, coronary heart disease causes the obstruction of blood vessels supplying heart tissue, leading to cardiac cell death. Here, increasing angiogenesis can re-establish the blood supply to minimise heart damage.

 Angiogenesis is regulated by a number of molecular signalling pathways and our work revolves around receptors in the TGFbeta family signalling pathway. The importance of the TGFbeta family of ligands in regulating angiogenesis and cardiovascular development was established in human genetic studies where inherited mutations in several TGFbeta receptors leads to congenital cardiovascular abnormalities. For example, mutations in the receptors, endoglin or activin like kinase-1 (ACVRL1), are associated with the inherited bleeding disorder, Hereditary Haemorrhagic Telangiectasia (HHT).

Using a combination of mouse genetics and cell culture systems, we have shown that endoglin is essential for cardiovascular development, is dynamically regulated during angiogenesis, and that depletion of endoglin in the context of an angiogenic trigger (such as developmental angiogenesis or inflammation) leads to arteriovenous malformations, a major clinical feature of HHT disease. This work has led to a number of powerful mouse models that are being used to understand the pathobiology of HHT disease and to test new drug treatment strategies to reduce disease pathology.

In addition, we have shown that adult heart cells, cultured from biopsies and known as cardiospheres, contribute to the repair of heart function following myocardial infarction (a heart attack). We have shown that endoglin expressed by cardiosphere derived cells is essential for promoting angiogenesis in the ischaemic heart.

More recently our work is addressing the problems caused by ischaemia reperfusion (I/R) injury in the heart. This injury occurs in acute heart attack patients who are successfully treated by an interventional cardiologist to re-open a blocked coronary artery. Much of the patient’s ischaemic myocardium can be saved by this rapid clinical intervention. However, the I/R injury that follows is due to inflammatory cells that invade the injured part of the heart and contribute to further damage. Suppressing this I/R response will improve outcomes for heart patients. We have shown that TGFbeta therapy is effective in reducing this injury and are currently investigating mechanisms that underlie this protective response and whether this therapy can be used in heart attack patients. In addition, in collaborative studies, we are investigating whether fractalkine, a protein that is dynamically regulated in cardiac I/R injury in patients, can be used as a target for therapy.

 Our goals in both HHT and heart attack patients is to use preclinical models to better understand disease mechanisms in order to inform the development of  improved therapies for patients.

Research Team  

Lilia Dragonova BSc
BHF PhD student

Sarah Marsh BSc
MRC DTP PhD student

Rachel Redgrave BSc PhD
BHF Research Associate

Esha Singh MSc
BHF Research Assistant

Catherine Park PhD
BHF Research Associate


 


Publications

  • Articles

    • Redgrave RE, Singh E, Tual-Chalot S, Park C, Hall D, Bennaceur K, Smyth DJ, Maizels RM, Spyridopoulos I, Arthur HM. . The American Journal of Pathology 2024, 194(4), 562-573.
    • Dinakaran S, Qutaina S, Zhao H, Tang Y, Wang Z, Ruiz S, Nomura-Kitabayashi A, Metz CN, Arthur HM, Meadows SM, Blanc L, Faughnan ME, Marambaud P. . Nature Cardiovascular Research 2024, 3, 1301-1317.
    • Han C, Nguyen CL, Scherschinski L, Schriber TD, Arthur HM, Lawton MT, Oh SP. . Biomedicines 2023, 11(12), 3153.
    • Snodgrass RO, Govindpani K, Plant K, Kugler EC, Doh C, Dawson T, McCormack LE, Arthur HM, Chico TJA. . Disease Models & Mechanisms 2023, 16(4), dmm049567.
    • Zhou X, Pucel JC, Nomura-Kitabayashi A, Chandakkar P, Guidroz AP, Jhangiani NL, Bao D, Fan J, Arthur HM, Ullmer C, Klein C, Marambaud P, Meadows SM. . Arteriosclerosis, Thrombosis, and Vascular Biology 2023, 43(8), 1384-1403.
    • Dookun E, Passos JF, Arthur HM, Richardson GD. . Cardiovascular Drugs and Therapy 2022, 36, 187-196.
    • Marsh SA, Park C, Redgrave RE, Singh E, Draganova L, Boag SE, Spray L, Ali S, Spyridopoulos I, Arthur HM. . FASEB Journal 2021, 35(5), e21604.
    • Jordan NP, Tingle SJ, Shuttleworth VG, Cooke K, Redgrave RE, Singh E, Glover EK, Tajuddin HBA, Kirby JA, Arthur HM, Ward C, Sheerin NS, Ali S. . International Journal of Molecular Sciences 2021, 22(16), 8629.
    • Singh E, Phillips HM, Arthur HM. . Gene Expression Patterns 2021, 39, 119165.
    • Spray L, Park C, Cormack S, Mohammad A, Panahi P, Boag S, Bennaceur K, Richardson G, Arthur H, Stellos K, Spyridopoulos I. . European Heart Journal 2020, 41(Suppl. 2), ehaa946.1289.
    • Kim YH, Vu PN, Choe SW, Jeon CJ, Arthur HM, Vary CPH, Lee Y, Oh SP. . Circulation Research 2020, 127, 1122–1137.
    • Jakobsson L, Arthur HM. . Circulation Research 2020, 127(6), 744–746.
    • Tual-Chalot S, García-Collado M, Redgrave RE, Singh E, Davison B, Park C, Lin H, Luli S, Jin Y, Wang Y, Lawrie A, Jakobsson L, Arthur HM. . Circulation Research 2020, 126(2), 243-257.
    • Martin-Ruiz C, Hoffmann J, Shmeleva E, von Zglinicki T, Richardson G, Draganova L, Redgrave R, Collerton J, Arthur H, Keavney B, Spyridopoulos I. . npj Aging and Mechanisms of Disease 2020, 6, 3.
    • Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep O, Santin Y, Mialet Perez J, Owens WA, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. . Aging Cell 2020, 19(10), e13249.
    • Singh E, Redgrave RE, Phillips HM, Arthur HA. . Angiogenesis 2020, 23, 559-566.
    • Lawera A, Zhen Tonga Z, Thorikay M, Redgrave RE, Caib J, van Dintherb M, Morrell NW, Afinkd GB, Charnock-Jonese DS, Arthur HM, ten Dijke P, Li W. . PNAS 2019, 116(36), 17800-17808.
    • Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot A, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD. . Aging Cell 2019, 18(3), e12945.
    • Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens WA, Greaves L, Kolsky K, Parini A, Douin-Echinard V, LeBrasseur N, Arthur H, Tual-Chalot S, Schafer M, Roos C, Miller J, Robertson N, Mann J, Adams P, Tchkonia T, Kirkland J, Mialet-Perez J, Richardson GD, Passos J. . The EMBO Journal 2019, 38(5), e100492.
    • Gallardo-Vara E, Tual-Chalot S, Botella LM, Arthur HM, Bernabeu C. . Disease Models & Mechanisms 2018, 11(9), dmm034397.
    • Andrejecsk JW, Hosman AE, Botella LM, Shovlin CL, Arthur HM, Dupuis-Girod S, Buscarini E, Hughes CCW, Lebrin F, Mummery CL, Post MC, Mager JJ. . Angiogenesis 2018, 21(1), 169-181.
    • Thalgott JH, Dos-Santos-Luis D, Hosman AE, Martin S, Lamande N, Bracquart D, Srun S, Galaris G, de Boer HC, Tual-Chalot S, Kroon S, Arthur HM, Cao Y, Snijder RJ, Disch F, Mager JJ, Rabelink TJ, Mummery CL, Raymond K, Lebrin F. . Circulation 2018, 138(23), 2698-2712.
    • Dingenouts CKE, Bakker W, Lodder K, Wiesmeijer KC, Moerkamp AT, Maring JA, Arthur HM, Smits AM, Goumans MJ. . PLoS One 2017, 12, e0189805.
    • Jin Y, Muhl L, Burmakin M, Wang Y, Duchez A-C, Betsholtz C, Arthur HM, Jakobsson L. . Nature Cell Biology 2017, 19, 639-652.
    • Redgrave RE, Tual-Chalot S, Davison BJ, Singh E, Hall D, Amirrasouli MM, Gilchrist D, Medvinsky A, Arthur HM. . Stem Cell Reports 2017, 8(5), 1287-1298.
    • Redgrave RE, Tual-Chalot S, Davison BJ, Greally E, Santibanez-Koref M, Schneider JE, Blamire AM, Arthur HM. . IJC Heart & Vasculature 2016, 11, 29-34.
    • Zhang R, Han Z, Degos V, Shen F, Choi E-J, Kang S, Wong M, Zhan L, Arthur HM, Oh SP, Faughnan ME, Su H. . Angiogenesis 2016, 19(4), 451-461.
    • Clarkin CE, Mahmoud M, Liu B, Sobamowo EO, King A, Arthur H, Jones PM, Wheeler-Jones CP. . BMC Research Notes 2016, 9, 362.
    • Ojeda-Fernandez L, Recio-Poveda L, Aristorena M, Lastres P, Blanco FJ, Sanz-Rodríguez F, Gallardo-Vara E, de-las-Casas-Engel M, Corbí Á, Arthur HM, Bernabeu C, Botella LM. . PLoS Genetics 2016, 12(3), e1005935.
    • Gkatzis K, Thalgott J, Dos-Santos-Luis D, Martin S, Lamandé N, Carette MF, Disch F, Snijder RJ, Westermann CJ, Mager JJ, Oh SP, Miquero lL, Arthur HM, Mummery CL, Lebrin F. . Arteriosclerosis, Thrombosis, and Vascular Biology 2016, 36(4), 707-717.
    • Young K, Krebs LT, Tweedie E, Conley B, Mancini M, Arthur HM, Liaw L, Gridley T, Vary CPH. . Developmental Biology 2016, 409(1), 95-105.
    • Arthur H, Geisthoff U, Gossage JR, Hughes CC, Lacombe P, Meek ME, Oh P, Roman BL, Trerotola SO, Velthuis S, Wooderchak-Donahue W. . Angiogenesis 2015, 18(4), 511-524.
    • Choi EJ, Chen WQ, Jun K, Arthur HM, Young WL, Su H. . PLOS One 2014, 9(2), e88511.
    • Tual-Chalot S, Mahmoud M, Allinson KR, Redgrave RE, Zhai ZH, Oh SP, Fruttiger M, Arthur HM. . PLoS One 2014, 9(6), e98646.
    • Liu Z, Lebrin F, Maring JA, van den Driesche S, van der Brink S, van Dinther M, Thorikay M, Martin S, Kobayashi K, Hawinkels LJAC, van Meeteren LA, Pardali E, Korving J, Letarte M, Arthur HM, Theuer C, Goumans MJ, Mummery C, ten Dijke P. . PLoS One 2014, 9(1), e86273.
    • Garrido-Martin EM, Nguyen HL, Cunningham TA, Choe SW, Jiang ZH, Arthur HM, Lee YJ, Oh SP. . Arteriosclerosis, Thrombosis and Vascular Biology 2014, 34(10), 2232-2236.
    • Tual-Chalot S, Allinson KR, Fruttiger M, Arthur HM. . Journal of Visualized Experiments 2013, 77, 1-5.
    • Ehrmann I, Dalgliesh C, Liu Y, Danilenko M, Crosier M, Overman L, Arthur HM, Lindsay S, Clowry GJ, Venables JP, Fort P, Elliott DJ. . PLoS Genetics 2013, 9(4), e1003474.
    • Wang X, Abraham S, McKenzie JAG, Jeffs N, Swire M, Tripathi VB, Luhmann UFO, Lange CAK, Zhai Z, Arthur HM, Bainbridge J, Moss SE, Greenwood J. . Nature 2013, 499, 306-311.
    • Anderberg C, Cunha S, Zhai Z, Cortez E, Pardali E, Johnson J, Franco M, Paez-Ribes M, Cordiner R, Fuxe J, Johansson BR, Goumans MJ, Casanovas O, ten Dijke P, Arthur HM, Pietras K. . Journal of Experimental Medicine 2013, 210(3), 563-579.
    • Tan HL, Glen E, Topf A, Hall D, O'Sulliyan JJ, Sneddon L, Wren C, Avery P, Lewis RJ, ten Dijke P, Arthur HM, Goodship JA, Keavney BD. . Human Mutation 2012, 33(4), 720-727.
    • Choi EJ, Walker EJ, Shen FX, Oh SP, Arthur HM, Young WL, Su H. . Cerebrovascular Diseases 2012, 33(6), 540-547.
    • Allinson KR, Lee HS, Fruttiger M, McCarty J, Arthur HM. . PLoS One 2012, 7(6), e39336.
    • Watkins SJ, Borthwick GM, Oakenfull R, Robson A, Arthur HM. . Hypertension Research 2012, 35(4), 393-398.
    • Watkins SJ, Borthwick GM, Arthur HM. . In Vitro Cellular & Developmental Biology: Animal 2011, 47(2), 125-131.
    • Mahmoud M, Upton P, Arthur HM. . Biochemical Society Transactions 2011, 39(6), 1659-1666.
    • Robson A, Allinson KR, Anderson RH, Henderson DJ, Arthur HM. . Developmental Dynamics 2010, 239(9), 2435-2442.
    • Lebrin F, Srun S, Raymond K, Martin S, van den Brink S, Freitas C, Breant C, Mathivet T, Larrivee B, Thomas JL, Arthur HM, Westermann CJJ, Disch F, Mager JJ, Snijder RJ, Eichmann A, Mummery CL. . Nature Medicine 2010, 16(4), 420-428.
    • Mahmoud M, Allinson KR, Zhai ZH, Oakenfull R, Ghandi P, Adams RH, Fruttiger M, Arthur HM. . Circulation Research 2010, 106(8), 1425-1433.
    • Thomas HE, Avery PJ, Ahmed JM, Edwards R, Purcell I, Zaman AG, Arthur HM, Keavney BD. . Heart 2009, 95(7), 555-558.
    • Mahmoud M, Borthwick GM, Hislop A, Arthur HM. . Laboratory Investigation 2009, 89(1), 15-25.
    • Thomas HE, Redgrave R, Cunnington MS, Avery P, Keavney BD, Arthur HM. . Arteriosclerosis, Thrombosis, and Vascular Biology 2008, 28(3), e21-e22.
    • Allinson KR, Carvalho RLC, Van Den Brink S, Mummery CL, Arthur HM. . Genesis: The Journal of Genetics and Development 2007, 45(6), 391-395.
    • Borthwick GM, Johnson AS, Partington M, Burn J, Wilson R, Arthur HM. . The FASEB Journal 2006, 20(12), 2009-2016.
    • Van Laake LW, Van Den Driesche S, Post S, Feijen A, Jansen MA, Driessens MH, Mager JJ, Snijder RJ, Westermann CJJ, Doevendans PA, Van Echteld CJA, Ten Dijke P, Arthur HM, Goumans M-J, Lebrin F, Mummery CL. . Circulation 2006, 114(21), 2288-2297.
    • Watkins SJ, Jonker L, Arthur HM. . Cardiovascular Research 2006, 69(2), 432-439.
    • Xu B, Wu YQ, Huey M, Arthur HM, Marchuk DA, Hashimoto T, Young WL, Yang G-Y. . Journal of Cerebral Blood Flow and Metabolism 2004, 24(2), 237-244.
    • Lebrin F, Goumans M-J, Jonker L, Carvalho RLC, Valdimarsdottir G, Thorikay M, Mummery C, Arthur HM, Ten Dijke P. . EMBO Journal 2004, 23(20), 4018-4028.
    • Carvalho RLC, Jonker L, Goumans M-J, Larsson J, Bouwman P, Karlsson S, ten Dijke P, Arthur HM, Mummery CL. . Development 2004, 131(24), 6237-6247.
    • Kettle C, Johnstone J, Jowett T, Arthur H, Arthur W. . Evolution and Development 2003, 5(2), 198-207.
    • Torsney E, Charlton R, Diamond AG, Burn J, Soames JV, Arthur HM. . Circulation 2003, 107(12), 1653-1657.
    • Torsney E, Charlton R, Parums D, Collis M, Arthur HM. . Inflammation Research 2002, 51(9), 464-470.
    • Jonker L, Arthur HM. . Mechanisms of Development 2002, 110(1-2), 193-196.
    • Arthur HM, Ure J, Smith AJH, Renforth G, Wilson DI, Torsney E, Charlton R, Parums DV, Jowett T, Marchuk DA, Burn J, Diamond AG. . Developmental Biology 2000, 217(1), 42-53.

  • Note

    • Marsh SA, Arthur HM, Spyridopoulos I. . Cytometry Part A 2017, 91(11), 1055-1058.

  • Reviews

    • Spyridopoulos I, Arthur HM. . Microcirculation 2017, 24(1), e12338.
    • Tual-Chalot S, Oh SP, Arthur HM. . Frontiers in Genetics 2015, 6, 25.
    • Arthur HM, Bamforth SD. . Birth Defects Research Part A: Clinical and Molecular Teratology 2011, 91(6), 423-434.
    • Ten Dijke P, Arthur HM. . Nature Reviews Molecular Cell Biology 2007, 8(11), 857-869.