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Pre Requisite Comment

N/A

Co Requisite Comment

N/A

Aims

To develop knowledge and understanding of the molecular and cell biology underlying a specific immune response, and to describe how such responses can protect against infection.

Outline Of Syllabus

Antibodies, T cell receptors and MHC molecules
Genetics of antigen recognition systems
Lymphocyte development
Lymphocyte activation
Regulation of immune responses
Antibody use in research/healthcare
Immunity against infection/immunization

Intended Knowledge Outcomes

•Describe the molecular structure of antibodies, T cell receptors and MHC class I and class II molecules

•Describe how antibodies are used in research and healthcare settings.

•Explain the part played by each of these molecules in antigen-recognition by T and B lymphocytes

•Describe the genetics of each of these types of molecule

•Discuss how the diverse repertoire of antibodies and T cell receptors is generated

•Explain how T cells are activated by antigens, and the consequences of this activation

•Explain what is meant by T-dependent and T-independent antigens and describe how these activate B cells

•Describe the stages of lymphocyte maturation from pluripotent haematopoietic stem cells

•Explain the need for immunological tolerance to self antigens and discuss how this is achieved

•Discuss how immune responses can be regulated, and the significance of qualitative regulation of immune responses

•Describe how specific immune responses can lead to the activation of effector mechanisms against infections with bacteria, viruses and eukaryotic parasites and how immunization aims to achieve protective responses

Intended Skill Outcomes

To be able to interpret scientific information, in this instance immunological data relating to case studies

Teaching Rationale And Relationship

Lectures are used to impart information in a concise manner, to highlight areas of importance and to interrelate with directed reading and self-directed study. In person seminar is for developing higher level skills, including data interpretation, problem-solving and contextualization of taught content, as well as information retrieval. Private study is used for self-directed learning including further reading and preparation for examinations.

Assessment Rationale And Relationship

Knowledge and understanding is assessed through a summative examination.

FMS Schools offering Semester One modules available as ‘Study Abroad’ will, where required, provide an alternative assessment time for examinations that take place after the Winter vacation. Coursework with submission dates after the Winter vacation will either be submitted at an earlier date or at the same time remotely. The assessment format will not normally vary from the original to ensure learning outcomes are met. Any changes to the original format must meet module learning outcomes and be approved by the school.

General Notes

N/A