缅北禁地

Background

After finishing my DPhil with Dr. Jeremy Robertson (Oxford) entitled "Silicon Tethered Ene and Allyl Transfer Reactions", I moved to Dublin for a postdoctoral position with Dr. Donal O'Shea (UCD) where I worked on the synthesis of switchable photodynamic therapy agents. I then moved to Paris to work with Professor Janine Cossy and Dr Christophe Meyer (ESPCI) on the total synthesis of phoslactomycin. I subsequently was appointed as a Lecturer at 缅北禁地 in 2007, before being to promoted to Senior Lecturer in 2016. In 2020 Dr Mike Probert (缅北禁地) and I launched the spin-out company Indicatrix Crystallography, providing ENaCt crystallisation technology to the pharmaceutical and agrochemical industries.

Areas of Expertise

Organic Synthesis

Natural Products

Crystallisation of Small Organic Molecules

Prizes and Awards

• RSC Emerging Technologies (Health) Finalist, 2020
• Dave Kelly Cup, Gregynog Synthesis Meeting, 2019
• 缅北禁地 Innovator of the Year, 2014
• BioNow Awards, Medical Project of the Year, 2013
• Medical Futures Innovation Awards, invited finalist 2011

External Roles

• CEO, Indicatrix Crystallography ()
• External Examiner (MSc Chemistry), University of Leeds, 2023-2027
• External Examiner (BSc/MChem Chemistry), University of Kent, 2019-2023

Qualifications

• DPhil, Linacre College, Oxford, 2003
• MChem, Brasenose College, Oxford, 1999

Previous Positions

• CNRS Postdoctoral Research Fellow, ESPCI, Paris, 2006
• Postdoctoral Research Assistant, CSCB, University College Dublin, 2003-2005

@DrMichaelJHall

Research Interests

Synthetic organic chemistry: Natural Products, Bioactive molecules

Crystallisation of small organic molecules

Current Work

Current work is divided into three research areas; isolation, characterisation and synthesis of biologically active natural products, new synthetic methodology based on multicomponent "one pot" reactions and the development of new fluorophores for application in bioimaging and sensing.

Funding

2022

The UK National Crystallography Service 2022-27 (EPSRC): £1,207,136

2019

Northern Accelerator CCF (PoC): Robot Assisted Micro-crystallisation Platform for Polymorph Screening and Structural Solution – Prototype Workflow Development, Industrial Demonstrations and Market Development, £48,683

MICA: Novel mode of RNA polymerase inhibition by a new natural rifamycin, which is active against rifampicin-resistant RNA polymerase, Medical Research Council (MRC), £603,841

Industrial Demonstration of 缅北禁地 High Throughput Crystallisation Screening Platform, Higher Education Innovation Fund (HEIF), £11,845

N8 - High throughput structural elucidation of plant natural products and agrochemical metabolites, N8 Research Partnership, £31,580

2018

Metabolomics by Automated Crystallography (MbAC): Solving the Structural Elucidation Bottleneck in Natural Product Discovery and Bioengineering through Automated Crystallisation and Single Crystal X-Ray Diffraction, NPRONET, Biotechnology and Biological Sciences Research Council (BBSRC), £43,843

2017

Bill toScale-up and Structural Elucidation of Novel Natural Product Antibiotics from the Demuris Actinomycete Collection, NPRONET, Biotechnology and Biological Sciences Research Council (BBSRC), £10,000

2016

Studying the development of a new natural product antibiotic for the treatment of ESKAPE infections, Rosetrees Trust, £54,171

2014

A New Antibiotic for Gram Positive Bacterial Infections, Medical Research Council (MRC), £29,282

2013

A Novel Crosslinking Strategy for MS Structural Biology, Biotechnology and Biological Sciences Research Council (BBSRC), £116,056

2012

Probing the Mechanisms of dSTORM Reporters, Biotechnology and Biological Sciences Research Council (BBSRC), £118,521

2010

Towards commercial application of a novel method to prevent and remove bacterial biofilms, Natural Environment Research Council (NERC), £137,802

Diels-Alder/Ene Reactions for the Multi-Component Synthesis, Engineering and Physical Sciences Research Council (EPSRC), £96,013

Total Funding to Date - £2,508,773

Undergraduate Teaching (BSc/MChem)

NES2402 - Organic Chemistry

NES3402 - Advanced Organic Chemistry (Module leader

NES3406 - Advanced Organic Chemistry DL (Module leader)

NES8404 - Pericyclic and radical reactions (Module leader)

Postgraduate Teaching (MSc)

NES8807 - Pericyclic and radical reactions (Module leader)

MChem and MSc project supervision

• Articles

  • Mardiana L, Al Abdali AB, Hall MJ, Al Mamari HH, Waddell PG. . Acta Crystallographica Section C: Structural Chemistry 2025, C81(12), 687-693.
  • Lewis RA, Hayles J, Hall MJ, Gray J, Mebrate S, Li J, Allenby NEE, Errington J. . Scientific Reports 2025, 15, 39721.
  • Mastroeni P, Armstrong C, Black D, Strickland A, Hall M, Blundell T, Pridmore NE, Pal R, Stachelek P. . Dyes and Pigments 2025, 243, 113045.
  • Pierre HC, Patel DJ, Raja HA, Darveaux BA, Patel KI, Mardiana L, Longcake A, Hall MJ, Probert MR, Pearce CJ, Oberlies NA. . Phytochemistry 2025, 236, 114492.
  • Almarshad AA, Waddell PG, Dixon C, Campbell A, Armstrong R, Levshov DI, Herrebout W, Penfold TJ, Black DJ, Pal R, de la Moya S, Knight JG, Hall MJ. . Dyes and Pigments 2026, 247, 113494.
  • Weatherson J, Probert MR, Hall MJ. . Journal of the American Chemical Society 2025, 147(14), 11949-11954.
  • Metherall JP, Corner PA, McCabe JF, Probert MR, Hall MJ. . Chemical Science 2025, 16(22), 9843-9853.
  • O'Shea D, Pim S, Campbell ADG, Levshov D, Herrebout W, Durán-Sampedro D, Hall MJ, Armstrong R. . ChemPhotoChem 2025, 9(7), e202500042.
  • Voigt JC, Hall MJ, Waddell PG. . Crystals 2025, 15(7), 657.
  • Brightwell DF, Samanta K, Muldoon J, Fleming PC, Ortin Y, Mardiana L, Waddell PG, Hall MJ, Fantuzzi F, Clark ER, Palma A. . ChemistryEurope 2025, 3(1), e202400050.
  • Rangel-Grimaldo M, Earp CE, Raja HA, Wood JS, Crull EB, Mardiana L, Ho KL, Longcake A, Williamson RT, Palatinus L, Hall MJ, Probert MR, Oberlies NH. . Journal of Natural Products 2024, 87(8), 2095-2100.
  • Metherall JP, Corner PA, McCabe JF, Hall MJ, Probert MR. . Acta Crystallographica Section B 2024, 80(1), 4-12.
  • Al Mamari HH, Al Sulaimi S, Mardiana L, Waddell PG, Hall MJ. . Acta Crystallographica Section C: Structural Chemistry 2024, 80(12).
  • Ayon NJ, Earp CE, Gupta R, Butun FA, Clements AE, Lee AG, Dainko D, Robey MT, Khin M, Mardiana L, Longcake A, Rangel-Grimaldo M, Hall MJ, Probert MR, Burdette JE, Keller NP, Raja HA, Oberlies NH, Kelleher NL, Caesar LK. . Metabolomics 2024, 20(5), 90.
  • Ragbirsingh R, Hall MJ, Probert MR, Waddell PG. . Crystal Growth & Design 2024, 24(3), 1429-1437.
  • Clarke RG, Weatherston J, Taj-Aldeen RA, Waddell PG, McFarlane W, Penfold TJ, Bogaerts J, Herrebout W, Mackenzie L, Pal R, Hall MJ. . ChemPhotoChem 2023, 7(1), e202200194.
  • Zhu Q, Wei L, Zhao C, Qu H, Liu B, Fellowes T, Yang S, Longcake A, Hall MJ, Probert MR, Zhao Y, Cooper AI, Little MA. . Journal of the American Chemical Society 2023, 145(42), 23352-23360.
  • Straker H, McMillian L, Mardiana L, Hebberd G, Watson E, Waddell PG, Probert MR, Hall MJ. . CrystEngComm 2023, 25(16), 2479-2484.
  • Metherall JP, Carroll RC, Coles SJ, Hall MJ, Probert MR. . Chemical Society Reviews 2023, 52(6), 1995-2010.
  • Zhu J, Moreno I, Quinn P, Yufit DS, Song L, Young CM, Duan Z, Tyler AR, Waddell PG, Hall MJ, Probert MR, Smith AD, O'Donoghue AC. . Journal of Organic Chemistry 2022, 87(6), 4241–4253.
  • AlSubeh ZY, Waldbusser A, Raja HA, Pearce CJ, Ho KL, Hall MJ, Probert MR, Oberlies NH, Hematian S. . Journal of Organic Chemistry 2022, 87(5), 2697-2710.
  • Algoazy N, Clarke RG, Penfold TJ, Waddell PG, Probert MR, Aerts R, Herrebout W, Stachelek P, Pal R, Hall MJ, Knight JG. . ChemPhotoChem 2022, 6(9), e202200090.
  • Kepplinger B, Wen X, Tyler AR, Kim BY, Brown J, Banks P, Dashti Y, Mackenzie ES, Wills C, Kawai Y, Waldron KJ, Allenby NEE, Wu LJ, Hall MJ, Errington J. . Frontiers in Microbiology 2022, 13, 1004737.
  • Dzeha T, Hall MJ, Burgess JG. . Marine Drugs 2022, 20(2), 128.
  • Kepplinger B, Mardiana L, Cowell J, Morton-Laing S, Dashti Y, Wills C, Marrs ECL, Perry JD, Gray J, Goodfellow M, Errington J, Probert MR, Clegg W, Bogaerts J, Herrebout W, Allenby N, Hall MJ. . Scientific Reports 2022, 12, 15579.
  • Frank F, Waddell PG, Hall MJ, Knight JG. . Organic Letters 2021, 23(21), 8595-8599.
  • Abualnaja M, Cowell J, Jolliffe JD, Wills C, Waddell PG, Clegg W, Hall MJ. . Tetrahedron 2021, 89, 132144.
  • Frank F, Manzoli LA, Mauker P, Alsimaree AA, Waddell PG, Probert MR, Penfold TJ, Knight JG, Hall MJ. . Tetrahedron 2020, 76(17), 131113.
  • Tyler AR, Ragbirsingh R, McMonagle CJ, Waddell PG, Heaps SE, Steed JW, Thaw P, Hall MJ, Probert MR. . Chem 2020, 6(7), 1755-1765.
  • Dzeha T, Nyiro C, Kardasopoulos D, Mburu D, Mwafaida J, Hall MJ, Burgess JG. . MicrobiologyOpen 2019, 8(4), e00697.
  • Harriman A, Karlsson JKG, Laude A, Hall MJ. . Chemistry - A European Journal 2019, 25(65), 14983-14998.
  • Mosaei H, Molodtsov V, Kepplinger B, Harbottle J, Moon C, Jeeves R, Ceccaroni L, Shin Y, Morton-Laing S, Marrs ECL, Wills C, Clegg W, Yuzenkova J, Perry JD, Bacon J, Errington J, Allenby NEE, Hall MJ, Murakami KS, Zenkin N. . Molecular Cell 2018, 72(2), 263-274.
  • Kepplinger B, Morton S, Seistrup K, Marrs E, Hopkins A, Perry J, Strahl H, Hall M, Errington J, Allenby N. . ACS Chemical Biology 2018, 13(1), 207-214.
  • Lunn S, Hribesh S, Whitfield C, Hall M, Houlton A, Brownowska A, Tuite EM, Pike AR. . ChemBioChem 2018, 19(11), 1115-1118.
  • Basle A, Hewitt L, Koh A, Lamb HK, Thompson P, Burgess JG, Hall MJ, Hawkins AR, Murray H, Lewis RJ. . Nucleic Acids Research 2018, 46(1), 473-484.
  • Cowell J, Buck M, Essa AH, Clarke R, Vollmer W, Vollmer D, Hilkens CM, Isaacs JD, Hall MJ, Gray J. . ChemBioChem 2017, 18(17), 1688-1691.
  • Tyler A, Mosaei H, Morton S, Waddell PG, Wills C, McFarlane W, Gray J, Goodfellow M, Errington J, Allenby N, Zenkin N, Hall MJ. . Journal of Natural Products 2017, 80(5), 1558-1562.
  • Baksh A, Kepplinger B, Isah H, Probert MR, Clegg W, Wills C, Goodfellow M, Errington J, Allenby N, Hall MJ. . Natural Product Research 2017, 31(16), 1895-1900.
  • Clarke R, Ho KL, Alsimaree AA, Waddell PG, Bogaerts J, Herrebout W, Knight J, Pal R, Penfold T, Hall MJ. . ChemPhotoChem 2017, 1(11), 513-517.
  • Abualnaja M, Waddell PG, Clegg W, Hall MJ. . Tetrahedron 2016, 72(38), 5798-5806.
  • Alnoman RB, Rihn S, OConnor DC, Black FA, Costello B, Waddell PG, Clegg W, Peacock RD, Herrebout W, Knight JG, Hall MJ. . Chemistry - A European Journal 2016, 22(1), 93-96.
  • Essa AH, Lerrick RI, Çiftçi E, Harrington RW, Waddell PG, Clegg W, Hall MJ. . Organic & Biomolecular Chemistry 2015, 13(20), 5793-5803.
  • Cowell J, Harrington RW, Probert MR, Hall MJ. . Tetrahedron: Asymmetry 2015, 26(20), 1189-1196.
  • Cowell J, Abualnaja M, Morton S, Linder R, Buckingham F, Waddell PG, Probert MR, Hall MJ. . RSC Advances 2015, 5(21), 16125-16152.
  • Lerrick RI, Winstanley TPL, Haggerty K, Wills C, Clegg W, Harrington RW, Bultinck P, Herrebout W, Benniston AC, Hall MJ. . Chemical Communications 2014, 50(36), 4714-4716.
  • Oxley A, Berry P, Taylor GA, Cowell J, Hall MJ, Hesketh J, Lietz G, Boddy AV. . Journal of Lipid Research 2014, 55(2), 319-328.
  • Essa AH, Lerrick RI, Tuna F, Harrington RW, Clegg W, Hall MJ. . Chemical Communications 2013, 49(27), 2756-2758.
  • Shields RC, Mokhtar N, Ford M, Hall MJ, Burgess JG, ElBadawey MR, Jakubovics NS. . PLoS One 2013, 8(2), e55339.
  • Grossi M, Palma A, McDonnell SO, Hall MJ, Rai DK, Muldoon J, O'Shea DF. . Journal of Organic Chemistry 2012, 77(20), 9304–9312.
  • Watson LJ, Harrington RW, Clegg W, Hall MJ. . Organic & Biomolecular Chemistry 2012, 10(33), 6649-6655.
  • Cotterill LJ, Harrington RW, Clegg W, Hall MJ. . Journal of Organic Chemistry 2010, 75(13), 4604-4607.
  • Nijland N, Hall MJ, Burgess JG. . PLoS One 2010, 5(12), e15668.
  • Druais V, Hall MJ, Corsi C, Wendeborn SV, Meyer C, Cossy J. . Tetrahedron 2010, 66(33), 6358-6375.
  • Byrne AT, O'Connor AE, Hall M, Murtagh J, O'Neill K, Curran KM, Mongrain K, Rousseau JA, Lecomte R, McGee S, Callanan JJ, O'Shea DF, Gallagher WM. . British Journal of Cancer 2009, 101(9), 1565-1573.
  • Robertson J, Hall MJ, Green SP. . Tetrahedron 2009, 65(28), 5541-5551.
  • Druais V, Hall MJ, Corsi C, Wendeborn SV, Meyer C, Cossy J. . Organic Letters 2009, 11(4), 935–938.
  • Robertson J, Green SP, Hall MJ, Tyrrell AJ, Unsworth WP. . Organic and Biomolecular Chemistry 2008, 6(14), 2628-2635.
  • Loudet A, Bandichhor R, Burgess K, Palma A, McDonnell SO, Hall MJ, O'Shea DF. . Organic Letters 2008, 10(21), 4771-4774.
  • Hall MJ, Allen LT, O'Shea DF. . Organic & Biomolecular Chemistry 2006, 4(5), 776-780.
  • McDonnell SO, Hall MJ, Allen LT, Byrne A, Gallagher WM, O'Shea DF. . Journal of the American Chemical Society 2005, 127(47), 16360-16361.
  • Gallagher WM, Allen LT, O'Shea C, Kenna T, Hall M, Gorman A, Killoran J, O'Shea DF. . British Journal of Cancer 2005, 92(9), 1702-1710.
  • Hall MJ, McDonnell SO, Killoran J, O'Shea DF. . The Journal of Organic Chemistry 2005, 70(14), 5571-5578.
  • Robertson J, Hall MJ, Green SP. . Organic & Biomolecular Chemistry 2003, 1, 3635-3638.
  • Robertson J, Hall MJ, Stafford PM, Green SP. . Organic & Biomolecular Chemistry 2003, 1(21), 3758-3767.
  • Taylor PN, O'Connell MJ, McNeill LA, Hall MJ, Aplin RT, Anderson HL. . Angewandte Chemie 2000, 112(19), 3598-3602.

• Book Chapters

  • Hall MJ, de la Moya S. . In: Tadashi Mori, ed. Circularly Polarized Luminescence of Isolated Small Organic Molecules. Singapore: Springer, 2020, pp.117-150.
  • Clarke RG, Hall MJ. . In: Eric Scriven, Portland, USA and Christopher Ramsden, Keele University, Staffordshire, UK, ed. Advances in Heterocyclic Chemistry. Academic Press, 2019, pp.181-261.