缅北禁地

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Staff Profile

Dr Tom McAllister

Royal Society University Research Fellow

  • Personal Website:
  • Address: School of Natural and Environmental Sciences
    Bedson Building
    缅北禁地
    缅北禁地 upon Tyne
    NE1 7RU
Background

I am a Royal Society University Research Fellow in the School of Natural and Environmental Sciences. My research group uses chemical biology approaches to investigate and modulate protein:carbohydrate interactions.

I was awarded my PhD in 2013, which I undertook with Mike Webb at the University of Leeds. I stayed in Leeds working as a postdoc with Bruce Turnbull before a brief spell as a Teaching Fellow at the University of York. From there I joined the Kawamura Group at the University of Oxford in mid-2014 and moved to 缅北禁地 in 2019.



Research

Research in the McAllister group focuses developing methods to produce glycopeptides and glycoproteins (i.e. peptides and proteins modified with carbohydrates), to investigate the roles of these fundamental biological molecules. Carbohydrates are involved in many important biological processes across all Kingdoms of life including how organisms recognise pathogens, how cancers can spread and the basis of the different A/B/O blood groups in humans.

 

We have an interest in enzymes that modify proteins with glycans, particularly O-GalNAc* glycans, and developing approaches to produce proteins with authentic glycosylation patterns. A current PhD student is investigating which proteins are modified by particular GalNAc-transferases.

*GalNAc = N-acetylgalactosamine


We use a variety of chemical biology approaches techniques including recombinant protein expression, in vitro protein synthesis, solid-phase peptide synthesis, in vitro assays, biophysics and synthetic chemistry.

 

Teaching

Currently I give lectures as part of:

NES1408 Fundamentals of Biological Chemistry

NES8403 Advanced Methods in Chemical Biology and Drug Discovery

NES8801 Modern Methods in Chemical Biology and Drug Discovery


I also supervise project students as part of:

NES8400 MChem Research Project

NES8813 Research Dissertation Project in Chemistry

Publications

  • Articles

    • Bickel JK, Ahmed AIS, Pidd AB, Morgan RM, McAllister TE, Horrell S, Couves EC, Nagaraj H, Bartlett EJ, El Omari K, Kawamura A, Bubeck D, Tate EW. . Angewandte Chemie - International Edition 2025, 64(27), e202422673.
    • Frank FJ, Lawson RA, McAllister TE. . RSC Chemical Biology 2025, (6), 851-856.
    • Simelis K, Saraç H, Salah E, Nishio K, McAllister TE, Corner TP, Tumber A, Belle R, Schofield CJ, Suga H, Kawamura A. . Bioorganic & Medicinal Chemistry 2024, 99, 117597.
    • Coleman OD, Macdonald J, Thomson B, Ward JA, Stubbs CJ, McAllister TE, Clark S, Amin S, Cao Y, Abboud MI, Zhang Y, Sanganee H, Huber KVM, Claridge TDW, Kawamura A. . Chemical Science 2023, 14(26), 7136-7146.
    • McAllister TE, Coleman OC, Roper G, Kawamura A. . Peptide Science 2021, 113(1), e24204.
    • Chowdhury R, Abboud MI, McAllister TE, Banerji B, Bhushan B, Sorensen JL, Kawamura A, Schofield CJ. . Scientific Reports 2020, 10(1), 21964.
    • McAllister TE, Yeh T-L, Abboud MI, Leung IKH, Hookway ES, King ONF, Bhushan B, Williams ST, Hopkinson RJ, Munzel M, Loik ND, Chowdhury R, Oppermann U, Claridge TDW, Goto Y, Suga H, Schofield CJ, Kawamura A. . Chemical Science 2018, 9(20), 4569-4578.
    • Abboud MI, McAllister TE, Leung IKH, Chowdhury R, Jorgensen C, Domene C, Mecinovic J, Lippl K, Hancock RL, Hopkinson RJ, Kawamura A, Claridge TDW, Schofield CJ. . Chemical Communications 2018, 54(25), 3130-3133.
    • Dobrynin G, McAllister TE, Leszczynska KB, Ramachandran S, Krieg AJ, Kawamura A, Hammond EM. . Scientific Reports 2017, 7, 11094.
    • Mahon CS, Fascione MA, Sakonsinsiri CS, McAllister TE, Turnbull WB, Fulton DA. . Organic & Biomolecular Chemistry 2015, 13(9), 2756-2761.
    • McAllister TE, Horner KA, Webb ME. . ChemBioChem 2014, 15(8), 1088-1091.
    • Branson TR, McAllister TE, Garcia-Hartjes J, Fascione MA, Ross JF, Warriner SL, Wennekes T, Zuilhof H, Turnbull WB. . Angewandte Chemie International Edition 2014, 126(32), 8463-8467.
    • McAllister TE, Hollins JJ, Webb ME. Prospects for stable analogues of phosphohistidine. Biochemical Society Transactions 2013, 41(4), 1072-1077.
    • McAllister TE, Webb ME. Triazole phosphohistidine analogues compatible with the Fmoc-strategy. Organic & Biomolecular Chemistry 2012, 10, 4043-4049.
    • McAllister TE, Nix MG, Webb ME. Fmoc-chemistry of a stable phosphohistidine analogue. Chemical Communications 2011, 47(4).

  • Review

    • McAllister TE, England KS, Hopkinson RJ, Brennan PE, Kawamura A, Schofield CJ. . Journal of Medicinal Chemistry 2016, 59(4), 1308-1329.