缅北禁地

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Staff Profile

Dr Rachel Queen

NUAcT Fellow: Ageing and Health

  • Telephone: 0191 241 8854
  • Address: Biosciences Institute
    缅北禁地
    International Centre for Life
    缅北禁地 upon Tyne
    NE1 3BZ
Background

New sequencing technologies such as spatial transcriptomic (ST) and single-cell (SC) techniques have the potential to revolutionise our understanding of disease and human development.

By developing new develop bioinformatics methods I aim to:

1) Create tools to understand spatial components of gene regulation;

2) Study transitions between states using naturally occurring cellular;

3) Investigate analysis methods for new sequencing technologies with the potential to capture additional information about genetic changes. 

Publications

  • Articles

    • Walls GM, Ghita M, Queen R, Edgar KS, Gill EK, Kuburas R, Grieve DJ, Watson CJ, McWilliam A, Van Herk M, Williams KJ, Cole AJ, Jain S, Butterworth KT. . International Journal of Radiation Oncology*Biology*Physics 2023, 115(2), 453-463.
    • Collin J, Hasoon MSR, Zerti D, Hammadi S, Dorgau B, Clarke L, Steel D, Hussain R, Coxhead J, Lisgo S, Queen R, Lako M. . Human Molecular Genetics 2023, 32(10), 1698-1710.
    • Chichagova V, Georgiou M, Carter M, Dorgau B, Hilgen G, Collin J, Queen R, Chung G, Ajeian J, Moya-Molina M, Kustermann S, Pognan F, Hewitt P, Schmitt M, Sernagor E, Armstrong L, Lako M. . Journal of Cellular and Molecular Medicine 2023, 27(3), 435-445.
    • Kurzawa-Akanbi M, Whitfield P, Burte F, Bertelli PM, Pathak V, Doherty M, Hilgen B, Gliaudelyte L, Platt M, Queen R, Coxhead J, Porter A, Oberg M, Fabrikova D, Davey T, Beh CS, Georgiou M, Collin J, Boczonadi V, Hartlova A, Taggart M, Al-Aama J, Korolchuk VI, Morris CM, Guduric-Fuchs J, Steel DH, Medina RJ, Armstrong L, Lako M. . Journal of Extracellular Vesicles 2022, 11(12), 12295.
    • Rozanska A, Cerna R, Queen R, Collin J, Zerti D, Dorgau B, Beh C, Davey T, Coxhead J, Hussain R, Alaama J, Steel D, Benvenisty N, Armstrong L, Parulekar M, Lako M. . Stem Cell Translational Medicine 2022, 11(4), 415-433.
    • Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clement K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK, LITMUS Consortium Investigators. . JHEP Reports 2022, 4(2), 100409.
    • Dorgau B, Georgiou M, Chaudhary A, Molina M, Collin J, Queen R, Hilgen G, Davey T, Hewitt P, Schmitt M, Kustermann S, Pognan F, Steel D, Sernagor E, Armstrong L, Lako M. . Stem Cell Translational Medicine 2022, 11(2), 159-177.
    • Jackson RM, Hatton CF, Spegarova JS, Georgiou M, Collin J, Stephenson E, Verdon B, Haq IJ, Hussain R, Coxhead JM, Mudhar H-S, Wagner B, Hasoon M, Davey T, Rooney P, Khan A, Ward C, Brodlie M, Haniffa M, Hambleton S, Armstrong L, Figueiredo F, Queen R, Duncan CJ, Lako M. . Stem Cell Reports 2022, 17(7), 1699-1713.
    • Muus C, Queen R, Lako M, Zerti D, HCA Lung Biological Network. . Nature Medicine 2021, 27, 546-559.
    • Armstrong L, Collin J, Mostafa I, Queen R, Figueiredo F, Lako M. . Stem Cells Translational Medicine 2021, 10(7), 976-986.
    • Collin J, Queen R, Zerti D, Steel D, Bowen C, Parulekar M, Lako M. . Investigative Ophthalmology & Visual Science (IOVS) 2021, 62(6).
    • Jardine L, Webb S, Goh I, Quiroga Londono M, Reynolds G, Mather M, Olabi B, Stephenson E, Botting RA, Horsfall D, Engelbert J, Maunder D, Mende N, Murnane C, Dann E, McGrath J, King H, Kucinski I, Queen R, Carey CD, Shrubsole C, Poyner E, Acres M, Jones C, Ness T, Coulthard R, Elliott N, O'Byrne S, Haltalli MLR, Lawrence JE, Lisgo S, Balogh P, Meyer KB, Prigmore E, Ambridge K, Jain MS, Efremova M, Pickard K, Creasey T, Bacardit J, Henderson D, Coxhead J, Filby A, Hussain R, Dixon D, McDonald D, Popescu D-M, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Regev A, Behjati S, Laurenti E, Wilson NK, Roy A, Gottgens B, Roberts I, Teichmann SA, Haniffa M. . Nature 2021, 598, 327-331.
    • Collin J, Queen R, Zerti D, Figueiredo F, Armstrong L, Lako M. . The Ocular Surface Journal 2021, 21, 279-298.
    • Khasawneh RR, Kist R, Queen R, Hussain R, Coxhead J, Schneider JE, Mohun TJ, Zaffran S, Peters H, Phillips HM, Bamforth SD. . BMC Developmental Biology 2021, 21, 14.
    • O'Keefe H, Queen R, Lord P, Elson JL. . Evolutionary Applications 2020, 12(10), 1912-1930.
    • Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Oresic M, Darlay R, Cordell H, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. . Science Translational Medicine 2020, 12(572), eaba4448.
    • Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, Talavera-López C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL, HCA Lung Biological Network, Lako M. . Nature Medicine 2020, 26, 681-687.
    • Sungnak W, Huang N, Becavin C, Berg M, Queen R, Litvinukova M, Talavera-Lopez C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL, Banovich NE, Barbry P, Brazma A, Collin J, Desai TJ, Duong TE, Eickelberg O, Falk C, Farzan M, Glass I, Gupta RK, Haniffa M, Horvath P, Hubner N, Hung D, Kaminski N, Krasnow M, Kropski JA, Kuhnemund M, Lako M, Lee H, Leroy S, Linnarson S, Lundeberg J, Meyer KB, Miao Z, Misharin AV, Nawijn MC, Nikolic MZ, Noseda M, Ordovas-Montanes J, Oudit GY, Pe'er D, Powell J, Quake S, Rajagopal J, Tata PR, Rawlins EL, Regev A, Reyfman PA, Rozenblatt-Rosen O, Saeb-Parsy K, Samakovlis C, Schiller HB, Schultze JL, Seibold MA, Seidman CE, Seidman JG, Shalek AK, Shepherd D, Spence J, Spira A, Sun X, Teichmann SA, Theis FJ, Tsankov AM, Vallier L, van den Berge M, Whitsett J, Xavier R, Xu Y, Zaragosi L-E, Zerti D, Zhang H, Zhang K, Rojas M, Figueiredo F. . Nature Medicine 2020, 26, 681-687.
    • Cytlak U, Resteu A, Pagan S, Green K, Milne P, Maisuria S, McDonald D, Hulme G, Filby A, Carpenter B, Queen R, Hambleton S, Hague R, Lango Allen H, Thaventhiran JED, Doody G, Collin M, Bigley V. . Immunity 2020, 53(2), 353-370.
    • Collin J, Queen R, Zerti D, Dorgau B, Georgiou M, Djidrovski I, Hussain R, Coxhead JM, Joseph A, Rooney P, Lisgo S, Figueiredo FC, Armstrong L, Lako M. . The Ocular Surface 2020, 19, 190-200.
    • Mellough CB, Collin J, Queen R, Hilgen G, Dorgau B, Zerti D, Felemban M, White K, Sernagor E, Lako M. . STEM CELLS Translational Medicine 2019, 8(7), 694-706.
    • Collin J, Queen R, Zerti D, Dorgau B, Hussain R, Coxhead J, Cockell S, Lako M. . Stem Cells (Durham) 2019, 37(5), 593-598.
    • Collin J, Zerti D, Queen R, SantoFerreira T, Bauer R, Coxhead J, Hussain R, Steel D, Mellough C, Ader M, Sernagor E, Armstrong L, Lako M. . Stem Cells (Durham) 2019, 37(5), 609-622.
    • O'Keefe H, Queen RA, Meldau S, Lord P, Elson JL. . Journal of Molecular Evolution 2018, 86(6), 395-403.
    • Bojic S, Hallam D, Alcada N, Ghareeb A, Queen R, Pervinder S, Buck H, Lange AA, Figueiredo G, Rooney P, Stojkovic M, Shortt A, Figueiredo FC, Lako M. . Stem Cells 2018, 36(11), 1723-1735.
    • Queen RA, Steyn JS, Lord P, Elson JL. . PLOS ONE 2017, 12(11), e0187862.

  • Review

    • Zerti Z, Collin J, Queen R, Cockell SJ, Lako M. . Current Eye Research 2020, 45(3), 385-396.