Comment: Robin Williams had dementia with Lewy Bodies, so what is it? Published on: 6 November 2015 Writing for The Conversation, Professor Ian McKeith outlines how dementia with Lewy Bodies affects patients. Ian McKeith, Professor of Old Age Psychiatry , Depression, paranoia, Parkinson鈥檚 disease, confusion and dementia. The long list of symptoms suffered by Robin Williams is itself confusing, but all of these and more besides, can be accounted for by the disorder bearing the name, dementia with Lewy bodies (DLB), which his has now announced as his final . Few people have heard of DLB until, like Williams' family, they are confronted by its multiple and variable combinations of symptoms which fluctuate in severity in an alarmingly unpredictable manner. Yet is the second most common cause of dementia in older people, accounting for 10-15% of all dementia cases and affecting at least 100,000 people in the UK alone. Only Alzheimer鈥檚 disease itself is more common. Despite this, as the founder of the Consortium on Dementia with Lewy Bodies which has, over two decades, developed global consensus on guidelines for the clinical and pathological diagnosis and management of this common disorder, I am aware how little-known it is. A strange and shocking illness Lewy bodies were first described in the early 20th century by Dr Friedrich Lewy, who was studying the brains of people with Parkinson鈥檚 disease, a condition recognised by a combination of a shaking tremor, slowness of limb movements, and a shuffling walk. are, in fact, microscopic clumps of a protein called alpha-synuclein which may, under certain and as yet not understood circumstances, accumulate within nerve cells in the brain. When some critical brainstem and midbrain structures including the substantia nigra are involved, there is a loss of the neurotransmitter and is the result. But in the last 20 years or so, we have realised that Lewy body disease can also affect , producing symptoms other than those of Parkinson鈥檚. It occurs in the autonomic and peripheral nervous system producing vegetative symptoms such as low blood pressure, constipation and sweating. Defining symptoms Lewy bodies occurring in the , meanwhile, lead to the characteristic symptoms by which DLB is recognised, usually starting with mild and fluctuating disturbances in attention and wakefulness. The affected person appears vague, drowsy or frankly confused with a decrease in their interest and ability to reason or to carry out practical tasks. Apathy is one term used for this and is frequently mistaken for depression. Visuo-perceptual function is also affected early which may account for the report of Williams鈥� bruising 鈥渕iscalculation with a door鈥�, and it is this involvement of the visual system which underpins the occurrence of the lifelike visual which occur in about 80% of cases and often alert the clinician to a DLB diagnosis. Waking nightmares Hallucinations may be threatening or distressing but are often simply perplexing for patients who cannot understand why familiar faces or unknown intruders repeatedly appear to them. For others, the hallucinations occur as nightmares as part of a specific sleep disorder. As the Lewy body pathology disease progresses, generalised cognitive impairment and dementia progressively worsen, although a fluctuating pattern with intervals of lucidity often persists. Parkinsonism occurs in many but by no means all sufferers and in those like Robin Williams in whom it seems to have been quite early and prominent, the initial diagnosis given is often one of Parkinson鈥檚 disease, a dementia label following soon after as additional symptoms emerge. Short-term memory failure, the hallmark of Alzheimer鈥檚 disease may not be prominent unless, and here鈥檚 where it starts to get complicated, there is also a lot of Alzheimer鈥檚 disease pathology in the brain as well. Hard to pin down Why did it take so long to recognise the existence of DLB, especially if it is so common? The answer, is that cortical Lewy bodies are vanishingly difficult to see in the brain using conventional staining methods, unlike their brainstem counterparts observed so long ago by Dr Lewy. Nevertheless, the development of immuocytochemical staining methods in the early 1990s suddenly made them visible outside of specialised units. This was a major step forward. But what progress is the research community making with DLB now? Internationally agreed criteria for the clinical and pathological diagnosis have been agreed since a meeting held in 缅北禁地 upon Tyne in 1995, updated there in and due to be reviewed and updated again in December this year. Dedicated research centres such as the NIHR-funded have led the field by, for example, developing diagnostic tests such as the dopamine transporter SPECT scan, which can distinguish DLB from Alzheimer鈥檚 with >85% accuracy and which is now widely clinically available. New hope Therapeutic trials have been few and far between in DLB because of a combination of a lack of compounds to test, a pre-occupation with targeting Alzheimer鈥檚 and a reluctance of regulatory bodies to recognise DLB. All of these are now changing and DLB is increasingly viewed as a malleable and commercially-viable target. Pharmacological trials in DLB will undoubtedly increase public awareness and for families such as Robin Williams鈥� there are now highly-effective patient and carer that provide , advice, advocacy and support research activity. As an inter-form of Parkinson鈥檚 and Alzheimer鈥檚 disease, DLB has the potential to unlock the key to both of its related disorders. It is high time it was put in the spotlight. , Professor of Old Age Psychiatry, This article was originally published on . Read the . 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