Breakthrough in understanding inflammatory bowel disease Published on: 1 August 2024 A pioneering study has identified a new disease-inducing mechanism for inflammatory bowel disease (IBD) in which the immune system attacks its own regulatory function. Interleukin-10 (IL10) is an anti-inflammatory protein that crucially controls intestinal immunity. Children with genetic defects in IL10, or its receptors, suffer from a severe form of IBD that typically presents within the first few months of life. Symptoms are acute and include bloody diarrhoea and severe abdominal pain. This research, published in , is a collaboration between 缅北禁地, Great North Children’s Hospital, Cambridge University Hospital, the universities of Cambridge and Oxford, and identified self-directed antibodies that attacked IL10 in two patients with early onset severe IBD. Increased inflammatory response Scientists discovered that these antibodies prevented IL10 from binding to its receptor and so caused an increased inflammatory response. As a consequence of this discovery, one patient received treatment to suppress antibody production, leading to eventual disappearance of the anti-IL10 autoantibodies, and resolution of IBD. Sophie Hambleton, Professor of Paediatrics and Immunology at 缅北禁地, and honorary consultant paediatrician at 缅北禁地 upon Tyne Hospitals NHS Foundation Trust, said: “Here, we drew upon knowledge of genetic forms of IBD to uncover a new and unexpected molecular mechanism for disease. “This understanding informed our choice of therapy, an example of precision medicine in action.” Neutralizing autoantibodies against IL-10 in IBD was a development made by several research teams across the country. Rainer Döffinger, Consultant Clinical Scientist of the Department of Clinical Biochemistry and Immunology at Cambridge University Hospitals, said: “This discovery adds to a growing body of evidence showing the severe consequences when the body’s immune defence is attacking itself. “The study is the result of cutting-edge NHS diagnostics and a great and efficient collaboration between the centres to deliver results with real world implications for new therapies, that will ease the burden of suffering in patients with IBD.” 鈥榃ider implications鈥� for patients The research was supported by the National Institute for Health and Care Research (NIHR), Cambridge Biomedical Research Centre (BRC) and NIHR Oxford BRC, and by The Leona M. and Harry B. Helmsley Charitable Trust. It was funded in part by the Wellcome Trust. Holm Uhlig, Professor of Paediatric Gastroenterology at the University of Oxford, said: “While there is abundant evidence that genetic and environmental factors are a cause of IBD, the results of our joint study draw attention to autoimmunity towards the immunoregulatory cytokine IL10. “This research may have wider implications for patients beyond infancy and I am grateful for the incredible collaborative effort that made it possible.” Reference: Neutralizing Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease. Helen Griffin et al. New England Journal of Medicine. DOI: Share: Latest News New partnership to boost careers in low carbon energy 缅北禁地 and Durham universities are working together on a new regional project to strengthen the future workforce for North East England鈥檚 growing low carbon and offshore wind industries. published on: 28 May 2026 Healthy lifestyle shown to lower risk of death after cancer diagnosis New evidence shows that sticking to five lifestyle recommendations improves survival after a later cancer diagnosis. published on: 28 May 2026 World-leading climate expert recognised with Royal Society Fellowship Professor Hayley Fowler has been elected a Fellow of the Royal Society in recognition of her pioneering work on climate change impacts. published on: 27 May 2026 Facts and figures
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