Pharmacology Projects
Therapeutic drug monitoring for the treatment of childhood cancer patients.
Therapeutic Drug Monitoring Approaches to Patient Treatment
We have worked in therapeutic drug monitoring (TDM) for several years.
The utility of therapeutic drug monitoring (TDM) relates to the measurement of drug levels in biological samples. This can then be used to individualise patient treatment through drug dose changes. The aim is to to improve drug efficacy and/or reducing toxicity.
We have identified childhood cancer patient subpopulations who benefit from TDM treatment approaches with specific, commonly-used chemotherapeutics. These patients include:
- pre-term infants and neonates
- anephric patients
- patients receiving high dose chemotherapy
Associated publications
Millen GC, Lawford A, Duncan C, Jenkinson H, Veal GJ, Barnett S. . British Journal of Cancer 2024, 131, 491-497.
Barnett S, Makin G, Tweddle DA, Osborne C, Veal GJ. . British Journal of Cancer 2023, 129, 1773鈥�1779.
Barnett S, Nyein AC, Galler M, Jamieson D, Davies M, Connor P, Veal GJ. . Cancer Chemotherapy and Pharmacology 2023, 92, 325鈥�328.
Barnett S, Hellman F, Parke E, Makin G, Tweddle DA, Osborne C, Hempel G, Veal GJ. . European Journal of Cancer 2022, 164, 127-136.
Nijstad AL, Barnett S, Lalmohamed A, B茅r茅nos IM, Parke E, Carruthers V, Tweddle DA, Kong J, Zwaan CM, Huitema ADR, Veal GJ. . European Journal of Cancer 2022, 164, 137-154.
Carruthers V, Barnett S, Rees R, Arif T, Slater O, Ramanujachar R, Johnson K, Brown S, Graham C, Burke GAA, Veal GJ. . Pediatric Blood and Cancer 2022, 69(7), e29722.
Barnett S, Holden V, Campbell-Hewson Q, Veal GJ. . Frontiers in Oncology 2022, 11, 815040.
Barnett S, Kong J, Makin G, Veal GJ. . Br J Clin Pharmacol 2021 87: 256-262
Hawley J, Veal GJ, Errington J, McDonald LG, Tweddle DA. . Ped Blood Cancer 2019 e27825 1-3
Thomas F, Veal GJ, El Balkhi S, Lafont T, Picard N, Brugieres L, Chatelut E, Piguet C. . Cancer Chemother Pharmacol 2018 82: 361-365
Veal GJ, Errington J, Sastry J, Chisholm J, Brock P, Morgenstern D, Pritchard-Jones K, Chowdhury T. . Cancer Chemother Pharmacol 2016 77: 685-692
Veal GJ, Errington J, Hayden J, Hobin D, Murphy D, Dommett RM, Tweddle DA, Jenkinson H, Picton S. . Eur J Cancer 2015 51: 2022-2030
Bardin C, Veal G, Paci A, Chatelut E, Astier A, Leveque D, Widmer N, Beijnen J. Eur J Cancer 2014 50: 2005-2009
Veal GJ, Errington J, Rowbotham SE, Illingworth NA, Malik G, Cole M, Daly AK, Pearson ADJ, Boddy AV. . Clin Cancer Res 2013 19: 469-479