缅北禁地

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Staff Profile

Dan Astley

Scientific Officer/Clinical Trials Analyst

Background

Current Role

I work in the pharmacology group where I have lab management duties covering chromatography and mass spectrometry equipment. I also lead on method development and perform clinical trial analysis. Our lab and data systems are GCP/GCLP regulated due to our involvement in clinical research.


Background

Prior to joining the University, my professional background was in the biotech and pharma industries, where I worked as a Senior Bioanalytical Scientist performing regulated PK/PD/TK studies. I also have experience working in histopathology, performing cancer diagnostics using protein and genetic biomarker assays, such as immunohistochemistry and in-situ hybridisation.


Qualifications

  • BSc (Hons), Biological Sciences, Lancaster University
  • MSc, Molecular Genetics and Diagnostics, University of Nottingham
  • Currently working towards a PhD in Cancer Pharmacology at 缅北禁地
  • Title: Development of quantitative assays for the measurement of anticancer chemotherapeutics in early phase clinical trials using liquid chromatography with tandem mass spectrometry
Research

Research

My research involves the development of novel LC-MS/MS methods for the quantitation of anti-cancer drugs in biological samples. These methods are applied to studies across clinical trials, pharmacokinetics, therapeutic drug monitoring and toxicology.


Current Lab Equipment - 缅北禁地 Cancer Centre Pharmacology Group (NCCPG)

LC-MS/MS

  • Thermo Scientific TSQ Altis Plus MS with Vanquish UHPLC
  • Sciex QTRAP 5500 with Waters ACQUITY Premier UPLC
  • Agilent 6460 QQQ with Agilent 1260 Infinity II LC

HPLC-DAD

  • Agilent 1260 Infinity II LC - Agilent 1100 Series Diode Array Detector (x2)

Atomic Absorption Spectroscopy

  • Agilent 280FS-AA
Teaching


Publications

  • Articles

    • Kelk J, Rozanska A, Sotiriadou E, Astley D, Hussain R, Unsworth A, Gangar A, Robinson A, Queen R, Coxhead J, Steel DH, Armstrong L, Parulekar M, Hardcastle I, Veal GJ, Lako M. . Molecular Therapy - Oncology 2026, 34(1), 201160.
    • Lietz G, Astley D, Goddard A, Oxley A. . Journal of Visualized Experiments 2025, e69558.
    • Bell HL, Blair HJ, Jepson Gosling SJ, Galler M, Astley D, Moorman AV, Heidenreich O, Veal GJ, van Delft FW, Lunec J, Irving JAE. . Leukemia 2024, 38, 1223-1235.