缅北禁地

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Staff Profile

Professor Helen Reeves

Professor of Liver Cancer & Honorary Consultant Gastroenterologist

  • Telephone: +44 (0) 191 208 4423
  • Address:
    Paul O'Gorman Building
    Medical School
    Framlington Place
    缅北禁地 upon Tyne
    NE2 4HH
Background

BACKGROUND

I am an academic hepatologist, looking after patients with primary liver cancer. My long term goal is to improve outcomes for these patients, in part by developing tools to detect their cancers earlier, but also by identifying novel therapeutic candidates to take forward into clinical use, alongside the biomarkers needed to implement them.

ROLES AND RESPONSIBILITIES

My clinical role is that of lead physician within the Hepatopancreatobiliary (HPB) 缅北禁地 Hospitals NHS Foundation Trust, co-ordinating the care of patients with hepatocellular cancer in Northern England. 

My research role and responsibility is that of a senior lecturer and lead PI in the Hepatopancreatobiliary group in the Northern Institute for cancer research. I work closely with Dr Ruchi Shukla, who has recently joined the group, as well as with Professor John Lunec and Professor Steven Wedge form the NICR, as well as with Dr Fiona Oakley and Dina Tiniakos from ICM. We presently supervise 4 PhD students, with two more joining the group in September.  

I have just completed 3 years serving as the UK representative on the European Association for Study of the Liver (EASL) governing board.

AREAS OF EXPERTISE

  • Clinical management of patients with liver cancer
  • Biomarker discovery and development for patients with liver cancer
  • Molecular and environmental regulation of liver cancer progression

ACADEMIC RECORD

  • 1998 BMedSci (Hons) 2:1 (Nottingham University Medical School, UK)      
  • 1990 BM.BS. (Nottingham University Medical School, UK)    
  • 1993 Member of Royal College of Physicians (London, UK)   
  • 1995-1997 Wellcome Trust Clinical Training Fellowship
  • 2000 PhD (University of 缅北禁地 upon Tyne, UK)
  • 2000 Peel Medical research Trust Travel Fellowship     
  • 2000-2002  American Association for Study of Liver Diseases Fellowship     
  • 2003-2008  GlaxoSmithKline Senior Fellowship       
  • 2005  Member of Association of Physicians    
  • 2007  Fellow Royal College Physicians (London, UK)
  • 2007  Founding Member ILCA (International Liver Cancer Association)
  • 2011-2014 British Association Cancer Research – Committee Member
  • 2012  Founding member HCC-UK
  • 2013-2016 European Association for Study of the Liver Governing Board – UK representative 

AWARDS AND PRIZES

  • 1994 British Liver Trust laboratory support grant                  
  • 1995-1997 Wellcome Trust Clinical Training Fellowship                               
  • 1997 Dewar Research Prize, Northern Association of Physicians
  • 2000 Peel Medical Research Trust Travel Award                   
  • 2001-2002 American Association for Study of Liver Diseases Fellowship
  • 2002-2008 GlaxoSmithKline Senior Fellowship                   
  • 2003-2005 European Brewers Association Project Grant -  (Gene profiling in ALD) (PI)
  • 2004-2006 缅北禁地 Special Trustees Set up Grant (KLF6 in Colorectal cancer) (PI) 
  • 2004 LiverNorth Laboratory Support grant     (PI)
  • 2005 缅北禁地 Special Trustees Award (DNA damage in Pancreatic cancer)     (PI) 
  • 2009 缅北禁地 Special Trustees Award (Gene profiling in NAFLD) (PI)
  • 2009-2013 LiverNorth & patient donations PhD studentship (DNA-PK in HCC) (PI)
  • 2011-2012 The Dowager Countess Eleanor Peel Trust pilot – chemotherapy induced liver injury (PI)

FUNDING 2010 onwards

  • FP7 European framework programme  - Project Grant: FLIP – Fatty Liver Inhibition of Progression.         Sub-project: HCC in NAFLD and HCC. 2010 - 2014. 1.3 million Euro (Subproject PI value €273,000).
  • 缅北禁地 Medical Faculty & 缅北禁地 Cancer Centre studentship - Detection of circulating tumour cells in Liver cancer patients using the Imagestream system.  2011- 2014. £76,737 – Principal Investigator
  • 缅北禁地 Cancer Centre Pump-priming Consumable Award - Detection of circulating tumour cells in NAFLD patients with HCC, using the Imagestream system. 2011- 2013. £22,500 – Principal Investigator.
  • EU H2020 Programme, EPOS – Elucidating Pathways of Steatohepatitis.  €6,000,000, 2015-2019. Co-investigator, Sub-project PI – SULF2 in HCC development and progression.
  • EASL Registry Grant, ‘The European NAFLD Registry’, €50,000 2015-2017. Co-investigator
  • CRUK and ASTEX Alliance – 缅北禁地 Cancer Centre Drug Discovery Programme. £3,500,000; 2012-2018, Collaborator.
  • Cancer Research UK PhD Studentship. Translating novel therapeutic approaches into treatments for patients with hepatocellular cancer. Co-supervisor. 2013-2017.
  • MRC Confidence in Concept. RNASeq to identify candidate drivers of non-alcoholic fatty liver disease progression to fibrosis and hepatocellular carcinoma. £41,500, 2015-2016. Principal Investigator
  • Cancer Research UK PhD studentship. Neutrophils as drivers of hepatocellular carcinoma progression – predictive biomarker and target for therapeutic intervention? 2016 - 2020; Principal Investigator.
  • MRC MICA- Exploring a new perspective on the mechanism of action of glucokinase activators in liver:        a preclinical study. 3 years. £746,548. 2016-2019. Co-investigator
  • CMAL (CR UK/Medimmune Alliance) collaboration - Exploring SULF2 as a therapeutic target in HCC. 
  • CRUK Programme Grant - Towards Targeting Neutrophils for Hepatocellular Carcinoma. 5 years. Joint PI 

 Google scholar:

SCOPUS:

Research

LIVER CANCER RESEARCH GROUP

Target discovery and validation

Our group is exploring the molecular pathogenesis of hepatocellular carcinoma (HCC) arising on a background of obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). We are particularly interested in the role played by the diseased tumour microenvironment / extracellular matrix in cancer development and progression.  We have developed a dietary model where mice fed a high fat and high sugar diet develop NAFLD and HCC and we have been exploring this for novel targets to exploit as preventive or antitumour therapies. These include a sulfatase (SULF2) which is overexpressed in tumour activated stromal cells, that alters the sulfation status of matrix molecules, receptors and ligands for signalling pathways, up-regulating growth and migration. We are also studying the contribution of inflammatory cells such as neutrophils in HCC development and progression.  An associated interest is in the response to damage that occurs in cancer cells – either as a result of inflammation related damage or chemo-radiotherapies.  We have shown that the cancers survive damage and resist treatment partially as a result of increased DNA damage repair – DNA-PK in particular.  We are exploring DNA-PK inhibition in models of HCC.

Prognostic and predictive biomarker development

HCC is the 6th most common cancer worldwide, but actually the 2nd commonest cause of cancer death.  This is because the majority of those affected present at an advanced stage, with poor liver function consequent to underlying chronic liver disease, and we have no effective treatments.  We do know that early detection of HCC in patients with cirrhosis can result in cure.  It is tragic therefore, that even though we know the patient group at risk, we do not have effective screening or surveillance tools.  With our liver group colleagues in the institute of cellular medicine, we have an interest in identifying genetic markers associated with HCC risk.  With national and international collaborators, we are also exploring serum surveillance biomarkers.  For patients in who we diagnose an HCC, it is often hard to know which treatment is best for them.  This is partly because we rarely have tissue from their cancer – the diagnosis is usually made on imaging and biopsy is risky.  So we have no robust biomarkers to know if one or other treatment is best.  Guidelines advise treatment based largely on the risk of making liver function worse, rather than shrinking a tumour.  We have a major interest therefore, in emerging ‘liquid biopsy’ tools – circulating tumour cells, circulating tumour DNA.  We are exploring these methods in hope that we will be able to stratify treatment for our patients, as well as monitor responses, more effectively.  We do this alongside characterising tissue samples changes in those patients where we have them – looking at SULF2 and DNA-PK amongst other things.  To support these translational studies, we have created a liver cancer tissue bank, which presently has donated samples from over 500 of our patients with HCC.

Teaching

Undergraduate Teaching

  • Informal clinical ward based teaching on a monthly basis
  • Lecturer on medical students on the yearly liver course
  • Undergraduate tutor
  • Undergraduate students

Postgraduate Teaching

  • Lecturer to Gastroenterology SpRs
  • Lecturer to Oncology SpRs
  • Lecturer to Transplant co-ordinators
  • Informal ward based clinical teaching
  • Non- clinical - 4 PhD students
Publications

  • Articles

    • Gil-Pitarch C, Serrano-Macia M, Simon J, Mosca L, Conter C, Rejano-Gordillo CM, Zapata-Pavas LE, Pena-Sanfelix P, Azkargorta M, Rodriguez-Agudo R, Lachiondo-Ortega S, Mercado-Gomez M, Delgado TC, Porcelli M, Aurrekoetxea I, Sutherland JD, Barrio R, Xirodimas D, Aspichueta P, Elortza F, Martinez-Cruz LA, Nogueiras R, Iruzubieta P, Crespo J, Masson S, McCain MV, Reeves HL, Andrade RJ, Lucena MI, Mayor U, Goikoetxea-Usandizaga N, Gonzalez-Recio I, Martinez-Chantar ML. . Cell Reports Medicine 2024, 5(7), 101653.
    • Hallsworth K, McCain MV, Fallen-Bailey R, Brown MC, Orange ST, Reeves HL. . BMJ Open 2024, 14(6), e082155.
    • Marchetti A, Pelusi S, Marella A, Malvestiti F, Ricchiuti A, Ronzoni L, Lionetti M, Moretti V, Bugianesi E, Miele L, Vespasiani-Gentilucci U, Dongiovanni P, Federico A, Soardo G, D'Ambrosio R, McCain MV, Reeves HL, La Mura V, Prati D, Bolli N, Valenti L, EPIDEMIC Study Investigators. . Hepatology 2024, 80(4), 816-827.
    • Suddle A, Reeves H, Hubner R, Marshall A, Rowe I, Tiniakos D, Hubscher S, Callaway M, Sharma D, See TC, Hawkins M, Ford-Dunn S, Selemani S, Meyer T. . Gut 2024, 73(8), 1235-1268.
    • Ford BE, Chachra SS, Rodgers K, Moonira T, Al-Oanzi ZH, Anstee QM, Reeves HL, Schattenberg JM, Fairclough RJ, Smith DM, Tiniakos D, Agius L. . Molecular Metabolism 2023, 72, 101722.
    • Zadran B, Sudhindar PD, Wainwright D, Bury Y, Luli S, Howarth R, McCain MV, Watson R, Huet H, Palinkas F, Palmini RB, Casement J, Mann DA, Oakley F, Lunec J, Reeves H, Faulkner GJ, Shukla R. . British Journal of Cancer 2023, 128, 1236-1248.
    • Permtermsin C, Lalchungnunga H, Nakjang S, Casement J, Ogle LF, Reeves HL, Strathdee G, Shukla R. . International Journal of Molecular Sciences 2023, 24(7), 6387.
    • Lu H, George J, Eslam M, Villanueva A, Bolondi L, Reeves HL, McCain M, Chambers E, Ward C, Sartika D, Sands C, Maslen L, Lewis MR, Ramaswami R, Sharma R. . Liver Cancer 2023, 12(1), 19-31.
    • Leslie J, Hunter JE, Collins A, Rushton A, Russell LG, Ramon-Gil E, Laszczewska M, McCain M, Zaki MYW, Knox A, Seow Y, Sabater L, Geh D, Perkins ND, Reeves HL, Tiniakos D, Mann DA, Oakley F. . Hepatology 2023, 78(4), 1050-1063.
    • Orange ST, Hallsworth K, Brown MC, Reeves HL. . Pilot And Feasibility Studies 2022, 8, 113.
    • Zaki MYW, Alhasan SF, Shukla R, McCain M, Laszczewska M, Geh D, Patman GL, Televantou D, Whitehead A, Mauricio JP, Barksby B, Gee LM, Paish HL, Leslie J, Younes R, Burt AD, Borthwick LA, Thomas H, Beale GS, Govaere O, Sia D, Anstee QM, Tiniakos D, Oakley F, Reeves HL. . Liver Cancer 2022, 11(6), 540-557.
    • Reeves HL, Reicher J, Priona G, Manas DM, Littler P. . Frontline Gastroenterology 2022, 14, 45-51.
    • Gonzalez-Recio I, Simon J, Goikoetxea-Usandizaga N, Serrano-Macia M, Mercado-Gomez M, Rodriguez-Agudo R, Lachiondo-Ortega S, Gil-Pitarch C, Fernandez-Rodriguez C, Castellana D, Latasa MU, Abecia L, Anguita J, Delgado TC, Iruzubieta P, Crespo J, Hardy S, Petrov PD, Jover R, Avila MA, Martin C, Schaeper U, Tremblay ML, Dear JW, Masson S, McCain MV, Reeves HL, Andrade RJ, Lucena MI, Buccella D, Martinez-Cruz LA, Martinez-Chantar ML. . Nature Communications 2022, 13(1), 6816.
    • Baselli GA, Jamialahmadi O, Pelusi S, Ciociola E, Malvestiti F, Saracino M, Santoro L, Cherubini A, Dongiovanni P, Maggioni M, Bianco C, Tavaglione F, Cespiati A, Mancina RM, D'Ambrosio R, Vaira V, Petta S, Miele L, Vespasiani-Gentilucci U, Federico A, Pihlajamaki J, Bugianesi E, Fracanzani AL, Reeves HL, Soardo G, Prati D, Romeo S, Valenti LV, Borroni V, Liguori A, Ronzoni L, Tomasi M, Lombardi A, Ostadreza M, Casirati E, Marini I, Maier S, Rosso C, Baroni GS, Santaniello C, Dallio M. . Journal of Hepatology 2022, 77(3), 596-606.
    • Munoz-Martinez S, Sapena V, Forner A, Bruix J, Sanduzzi-Zamparelli M, Rios J, Bouattour M, El-Kassas M, Leal CRG, Mocan T, Nault J-C, Alves RCP, Reeves HL, da Fonseca L, Garcia-Juarez I, Pinato DJ, Varela M, Alqahtani SA, Alvares-da-Silva MR, Bandi JC, Rimassa L, Lozano M, Gonzalez Santiago JM, Tacke F, Sala M, Anders M, Lachenmayer A, Pinero F, Franca A, Guarino M, Elvevi A, Cabibbo G, Peck-Radosavljevic M, Rojas A, Vergara M, Braconi C, Pascual S, Perello C, Mello V, Rodriguez-Lope C, Acevedo J, Villani R, Hollande C, Vilgrain V, Tawheed A, Ferguson Theodoro C, Sparchez Z, Blaise L, Viera-Alves DE, Watson R, Carrilho FJ, Moctezuma-Velazquez C, D'Alessio A, Iavarone M, Reig M. . Liver International 2022, 42(8), 1891-1901.
    • Ye H, Chen C, Wu H, Zheng K, Martin-Adrados B, Caparros E, Frances R, Nelson LJ, Gomez Del Moral M, Asensio I, Vaquero J, Banares R, Avila MA, Andrade RJ, Isabel Lucena M, Martinez-Chantar ML, Reeves HL, Masson S, Blumberg RS, Gracia-Sancho J, Nevzorova YA, Martinez-Naves E, Cubero FJ. . Cell death & disease 2022, 13, 143.
    • Leslie J, Mackey JBG, Jamieson T, Ramon-Gil E, Drake TM, Fercoq F, Clark W, Gilroy K, Hedley A, Nixon C, Luli S, Laszczewska M, Pinyol R, Esteban-Fabro R, Willoughby CE, Haber PK, Andreu-Oller C, Rahbari M, Fan C, Pfister D, Raman S, Wilson N, Muller M, Collins A, Geh D, Fuller A, Mcdonald D, Hulme G, Filby A, Cortes-Lavaud X, Mohamed N-E, Ford CA, Raffo Iraolagoitia XL, Mcfarlane AJ, Mccain MV, Ridgway RA, Roberts EW, Barry ST, Graham GJ, Heikenwalder M, Reeves HL, Llovet JM, Carlin LM, Bird TG, Sansom OJ, Mann DA. . Gut 2022, 71(10), 2093-2106.
    • Geh D, Watson R, Sen G, French JJ, Hammond J, Turner P, Hoare T, Anderson K, Mcneil M, Mcpherson S, Masson S, Dyson J, Donnelly M, Macdougal L, Patel P, Hudson M, Anstee QM, White S, Robinson S, Pandanaboyana S, Walker L, Mccain M, Bury Y, Raman S, Burt A, Parkinson D, Haugk B, Darne A, Wadd N, Asghar S, Mariappan L, Margetts J, Stenberg B, Scott J, Littler P, Manas DM, Reeves HL. . BMJ Open Gastroenterology 2022, 9(1), e000794.
    • Bianco C, Jamialahmadi O, Pelusi S, Baselli G, Dongiovanni P, Zanoni I, Santoro L, Maier S, Liguori A, Meroni M, Borroni V, DAmbrosio R, Spagnuolo R, Alisi A, Federico A, Bugianesi E, Petta S, Miele L, Vespasiani-Gentilucci U, Anstee QM, Stickel F, Hampe J, Fischer J, Berg T, Fracanzani AL, Soardo G, Reeves H, Prati D, Romeo S, Valenti L. . Journal of Hepatology 2021, 74(4), P775-782.
    • Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Grazia Vizioli M, Habiballa L, Saretzki G, Evans SA, Salmonowicz H, Hruby A, Geh D, Pavelko KD, Dolan D, Reeves HL, Grellscheid S, Wilson CH, Pandanaboyana S, Doolittle M, Von Zglinicki T, Oakley F, Gallage S, Wilson CL, Birch J, Carroll B, Chapman J, Heikenwalder M, Neretti N, Khosla S, Masuda CA, Tchkonia T, Kirkland JL, Jurk D, Mann DA, Passos JF. . The EMBO Journal 2021, 40(9), e106048.
    • Pinyol R, Torrecilla S, Wang H, Montironi C, Piqué-Gili M, Torres-Martin M, Wei-Qiang L, Willoughby CE, Ramadori P, Andreu-Oller C, Taik P, Lee YA, Moeini A, Peix J, Faure-Dupuy S, Riedl T, Schuehle S, Oliveira CP, Alves VA, Boffetta P, Lachenmayer A, Roessler S, Minguez B, Schirmacher P, Dufour JF, Thung SN, Reeves HL, Carrilho FJ, Chang C, Uzilov AV, Heikenwalder M, Sanyal A, Friedman SL, Sia D, Llovet JM. . Journal of Hepatology 2021, 75(4), 865-878.
    • Zaki MYW, Mahdi AK, Patman GL, Whitehead A, Mauricio JP, McCain MV, Televantou D, Abou-Beih S, Ramon-Gil E, Watson R, Cox C, Leslie J, Wilson C, Govaere O, Lunec J, Mann DA, Nakjang S, Oakley F, Shukla R, Anstee QM, Tiniakos D, Reeves HL. . Scientific Reports 2021, 11(1), 16727.
    • Sudhindar PD, Wainwright D, Saha S, Howarth R, McCain M, Bury Y, Saha SS, McPherson S, Reeves H, Patel AH, Faulkner GJ, Lunec J, Shukla R. . Cancers 2021, 13(20), 5079.
    • SiejkaZielinska P, Cheng J, Jackson F, Liu Y, Soonawalla Z, Reddy S, Silva M, Puta L, McCain MV, Culver E, Bekkali N, SchusterBockler B, Palamara PF, Mann D, Reeves H, Barnes E, Sivakumar S, Song C. . Science Advances 2021, 7(36).
    • Munoz-Martinez S, Sapena V, Forner A, Nault J-C, Sapisochin G, Rimassa L, Sangro B, Bruix J, Sanduzzi-Zamparelli M, Holowko W, El Kassas M, Mocan T, Bouattour M, Merle P, Hoogwater FJH, Alqahtani SA, Reeves HL, Pinato DJ, Giorgakis E, Meyer T, Villadsen GE, Wege H, Salati M, Minguez B, Di Costanzo GG, Roderburg C, Tacke F, Varela M, Galle PR, Alvares-da-Silva MR, Trojan J, Bridgewater J, Cabibbo G, Toso C, Lachenmayer A, Casadei-Gardini A, Toyoda H, Ludde T, Villani R, Matilla Pena AM, Guedes Leal CR, Ronzoni M, Delgado M, Perello C, Pascual S, Lledo JL, Argemi J, Basu B, da Fonseca L, Acevedo J, Siebenhuner AR, Braconi C, Meyers BM, Granito A, Sala M, Rodriguez-Lope C, Blaise L, Romero-Gomez M, Pinero F, Gomez D, Mello V, Pinheiro Alves RC, Franca A, Branco F, Brandi G, Pereira G, Coll S, Guarino M, Benitez C, Anders MM, Bandi JC, Vergara M, Calvo M, Peck-Radosavljevic M, Garcia-Juarez I, Cardinale V, Lozano M, Gambato M, Okolicsanyi S, Morales-Arraez D, Elvevi A, Munoz AE, Lue A, Iavarone M, Reig M. . JHEP Reports 2021, 3(3), 100260.
    • Fernandez-Tussy P, Rodriguez-Agudo R, Fernandez-Ramos D, Barbier-Torres L, Zubiete-Franco I, Davalillo SL, Herraez E, Goikoetxea-Usandizaga N, Lachiondo-Ortega S, Simon J, Lopitz-Otsoa F, Juan VG-D, McCain MV, Perugorria MJ, Mabe J, Navasa N, Rodrigues CMP, Fabregat I, Boix L, Sapena V, Anguita J, Lu SC, Mato JM, Banales JM, Villa E, Reeves HL, Bruix J, Reig M, Marin JJG, Delgado TC, Martinez-Chantar ML. . Cell Death and Disease 2021, 12(6), 555.
    • Eldafashi N, Darlay R, Shukla R, McCain MV, Watson R, Liu YL, McStraw N, Fathy M, Fawzy MA, Zaki MYW, Daly AK, Mauricio JP, Burt AD, Haugk B, Cordell HJ, Bianco C, Dufour J-F, Valenti L, Anstee QM, Reeves HL. . Cancers 2021, 13(6), 1412.
    • Shukla R, Reeves HL, McPherson S, McCain M, Sudhindar P, Bury Y, Faulkner G, Lunec G. . Journal of Hepatology 2020, 73, S401–S652.
    • Alsaleh M, Leftley Z, Barbera TA, Koomson LK, Zabron A, Crossey MME, Reeves HL, Cramp M, Ryder S, Greer S, Prince M, Sithithaworn P, Shariff M, Khuntikeo N, Loilome W, Yongvanit P, Shen Y-L, Cox IJ, Williams R, Wadsworth CA, Holmes E, Nash K, Taylor-Robinson SD. . Journal of Clinical and Experimental Hepatology 2020, 10(1), 17-29.
    • Willoughby CE, Jiang Y, Thomas HD, Willmore E, Kyle S, Wittner A, Phillips N, Zhao Y, Tudhope SJ, Prendergast L, Junge G, Lourenco LM, Finlay MRV, Turner P, Munck JM, Griffin RJ, Rennison T, Pickles J, Cano C, Newell DR, Reeves HL, Ryan AJ, Wedge SR. . Journal of Clinical Investigation 2019, 130, 1-14.
    • Pelusi S, Baselli G, Pietrelli A, Dongiovanni P, Donati B, McCain MV, Meroni M, Fracanzani AL, Romagnoli R, Petta S, Grieco A, Miele L, Soardo G, Bugianesi E, Fargion S, Aghemo A, D'Ambrosio R, Xing C, Romeo S, De Francesco R, Reeves HL, Valenti LVC. . Scientific Reports 2019, 9(1), 3682.
    • Reicher J, Mafeld S, Priona G, Reeves HL, Manas DM, Jackson R, Littler P. . CardioVascular and Interventional Radiology 2019, 42, 1563-1570.
    • Chan SL, McNally RJQ, Reeves HL. . British Journal of Cancer 2018, 119, 781-782.
    • Margetts J, Ogle LF, Chan SL, Chan AWH, Chan KCA, Jamieson D, Willoughby CE, Mann DA, Wilson CL, Manas DM, Yeo W, Reeves HL. . British Journal of Cancer 2018, 118, 248-257.
    • Mann J, Reeves HL, Feldstein AE. . Gut 2018, 67(12), 2204-2212.
    • Burt AD, Alves V, Bedossa P, Clouston A, Guido M, Hübscher S, Kakar S, Ng I, Park YN, Reeves H, Wyatt J, Yeh MM, Ellis DW. . Histopathology 2018, 73(3), 369-385.
    • Barbier-Torres L, Iruzubieta P, Fernández-Ramos D, Delgado TC, Taibo D, Guitiérrez-de-Juan V, Varela-Rey M, Azkargorta M, Navasa N, Fernández-Tussy P, Zubiete-Franco I, Simon J, Lopitz-Otsoa F, Lachiondo-Ortega S, Crespo J, Masson S, McCain MV, Villa E, Reeves H, Elortza F, Lucena MI, Hernández-Alvarez MI, Zorzano A, Andrade RJ, Lu SC, Mato JM, Anguita J, Rincon M, Martínez-Chantar ML. . Nature Communications 2017, 8, 2068.
    • Donati B, Pietrelli A, Pingitore P, Dongiovanni P, Caddeo A, Walker L, Baselli G, Pelusi S, Rosso C, Vanni E, Daly A, Mancina RM, Grieco A, Miele L, Grimaudo S, Craxi A, Petta S, De Luca L, Maier S, Soardo G, Bugianesi E, Colli F, Romagnoli R, Anstee QM, Reeves HL, Fracanzani AL, Fargion S, Romeo S, Valenti L. . Cancer Medicine 2017, 6(8), 1930-1940.
    • Al-Oanzi ZH, Fountana S, Moonira T, Tudhope SJ, Petrie JL, Alshawi A, Patman G, Arden C, Reeves HL, Agius L. . Diabetes, Obesity and Metabolism 2017, 19(8), 1078-1087.
    • Donati B, Dongiovanni P, Romeo S, Meroni M, McCain M, Miele L, Petta S, Maier S, Rosso C, De Luca L, Vanni E, Grimaudo S, Romagnoli R, Colli F, Ferri F, Mancina R, Iruzubieta P, Craxi A, Fracanzani A, Grieco A, Corradini S, Aghemo A, Colombo M, Soardo G, Bugianesi E, Reeves H, Anstee Q, Fargion S, Valenti L. . Scientific Reports 2017, 7, 4492.
    • Than NN, Ghazanfar A, Hodson J, Tehami N, Coldham C, Mergental H, Manas D, Shah T, Newsome PN, Reeves H, Shetty S. . QJM 2017, 110(2), 73–81.
    • Shariff MIF, Kim JU, Ladep GN, Crossey MME, Koomson LK, Zabron A, Reeves H, Cramp M, Ryder S, Greer S, Cox IJ, Williams R, Holmes E, Nash K, Taylor-Robinson SD. . Journal of Clinical and Experimental Hepatology 2016, 6(3), 186-194.
    • Alhasan SF, Haugk B, Ogle LF, Beale GS, Long A, Burt AD, Tiniakos D, Televantou D, Coxon F, Newell DR, Charnley R, Reeves HL. . British Journal of Cancer 2016, 115(7), 797-804.
    • Berhane S, Toyoda H, Tada T, Kumada T, Kagebayashi C, Satomura S, Schweitzer N, Vogel A, Manns MP, Benckert J, Berg T, Ebker M, Best J, Dechene A, Gerken G, Schlaak JF, Weinmann A, Worns MA, Galle P, Yeo W, Mo F, Chan SL, Reeves H, Cox T, Johnson P. . Clinical Gastroenterology and Hepatology 2016, 14(6), 875-886.
    • Toyoda H, Lai PBS, O'Beirne J, Chong CC, Berhane S, Reeves H, Manas D, Fox RP, Yeo W, Mo F, Chan AWH, Tada T, Iñarrairaegui M, Vogel A, Schweitzer N, Chan SL, Sangro B, Kumada T, Johnson PJ. . British Journal of Cancer 2016, 114, 744-750.
    • Ogle LF, Orr JG, Willoughby CE, Hutton C, McPherson S, Plummer R, Boddy AV, Curtin NC, Jamieson D, Reeves HL. . Journal of Hepatology 2016, 65(2), 305-313.
    • Dent BM, Ogle LF, O'Donnell RL, Hayes N, Mallick U, Curtin NJ, Boddy AV, Plummer ER, Edmondson RJ, Reeves HL, May FEB, Jamieson D. . International Journal of Cancer 2016, 138(1), 206-216.
    • Colombo M, Forner A, Ijzermans I, Paradis V, Reeves H, Vilgrain V, Zucman-Rossi J. . Journal of Hepatology 2016, 65(2), 386-398.
    • Reuillon T, Alhasan SF, Beale GS, Bertoli A, Brennan A, Cano C, Reeves HL, Newell DR, Golding BT, Miller DC, Griffin RJ. . Chemical Science 2016, 7(4), 2821-2826.
    • Kolly P, Reeves H, Sangro B, Knöpfli M, Candinas D, Dufour JF. . Liver International 2016, 36(6), 911-917.
    • Piguet AC, Saran U, Simillion C, Keller I, Terracciano L, Reeves HL, Dufour JF. . Journal of Hepatology 2015, 62(6), 1296-1303.
    • Miller DC, Carbain B, Beale GS, Alhasan SF, Reeves HL, Baisch U, Newell DR, Golding BT, Griffin RJ. . Organic & Biomolecular Chemistry 2015, 13(18), 5279-5284.
    • Cornell L, Munck JM, Alsinet C, Villanueva A, Ogle L, Willoughby CE, Televantou D, Thomas HD, Jackson J, Burt AD, Newell D, Rose J, Manas DM, Shapiro GI, Curtin NJ, Reeves HL. . Clinical Cancer Research 2015, 21(4), 925-933.
    • Johnson PJ, Berhane S, Kagebayashi C, Satomura S, Teng M, Reeves HL, O'Beirne J, Fox R, Skowronska A, Palmer D, Yeo W, Mo F, Lai P, Inarrairaegui M, Chan SL, Sangro B, Miksad R, Tada T, Kumada T, Toyoda H. . Journal of Clinical Oncology 2015, 33(6), 550-558.
    • Liu Y-L, Reeves HL, Burt AD, Tiniakos D, McPherson S, Leathart JBS, Allison MED, Alexander GJ, Piguet A-C, Anty R, Donaldson P, Aithal GP, Francque S, VanGaal L, Clement K, Ratziu V, Dufour J-F, Day CP, Daly AK, Anstee QM. . Nature Communications 2014, 5, 4309.
    • Johnson PJ, Pirrie SJ, Cox TF, Berhane S, Teng M, Palmer D, Morse J, Hull D, Patman G, Kagebayashi C, Hussain S, Graham J, Reeves H, Satomura S. . Cancer Epidemiology, Biomarkers & Prevention 2014, 23(1), 144-153.
    • Dyson J, Jaques B, Chattopadyhay D, Lochan R, Graham J, Das D, Aslam T, Patanwala I, Gaggar S, Cole M, Sumpter K, Stewart S, Rose J, Hudson M, Manas D, Reeves HL. . Journal of Hepatology 2014, 60(1), 110-117.
    • Liu Y-L, Patman GL, Leathart J, Piguet A-C, Burt AD, Dufour J-F, Day CP, Daly AK, Reeves HL, Anstee QM. . Journal of Hepatology 2014, 61(1), 75-81.
    • Gautheron J, Vucur M, Reisinger F, Cardenas DV, Roderburg C, Koppe C, Kreggenwinkel K, Schneider AT, Bartneck M, Neumann UP, Canbay A, Reeves HL, Luedde M, Tacke F, Trautwein C, Heikenwalder M, Luedde T. . EMBO Molecular Medicine 2014, 6(8), 1062-1074.
    • Petrie JL, Patman GL, Sinha I, Alexander TD, Reeves HL, Agius L. . American Journal of Physiology 2013, 305(10), E1255-E1265.
    • Bechmann LP, Vetter D, Ishida J, Hannivoort RA, Lang UE, Kocabayoglu P, Fiel MI, Muñoz U, Patman GL, Ge F, Yakar S, Li X, Agius L, Lee YM, Zhang W, Hui KY, Televantou D, Schwartz GJ, Leroith D, Berk PD, Nagai R, Suzuki T, Reeves HL, Friedman SL. . Journal of Hepatology 2013, 58(5), 1000-1006.
    • Patman GL, Televantou D, Whitehead A, Oakley F, Mann DA, Burt AD, Anstee QA, Reeves HL. NAFLD progression to NASH, fibrosis and hepatocellular cancer - development of a robust animal model. Journal of Hepatology 2013. In Preparation.
    • Bechmann LP, Gastaldelli A, Vetter D, Patman GL, Pascoe L, Hannivoort RA, Lee UE, Fiel I, Muñoz U, Ciociaro D, Buzzigoli E, Miele L, Hui KY, Bugianesi E, Burt AD, Day CP, Mari A, Agius L, Walker M, Friedman SL, Reeves HL. . Hepatology 2012, 55(4), 1083-1093.
    • Gray J, Chattopadhyay D, Beale GS, Patman GL, Miele L, King BP, Stewart S, Hudson M, Day CP, Manas DM, Reeves HL. . BMC Cancer 2009, 9.
    • Miele L, Beale G, Patman G, Nobili V, Leathart J, Grieco A, Abate M, Friedman S, Narla G, Bugianesi E, Day C, Reeves H. . Gastroenterology 2008, 135(1), 282-291.
    • Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Häussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J. Sorafenib in advanced hepatocellular cancer. N Engl J Med 2008, 359, 378-90.
    • Beale GS, Chattopadhyay D, Gray J, Stewart SF, Hudson M, Day CP, Trerotoli P, Giannelli G, Manas DM, Reeves HL. . BMC Cancer 2008, 8, 200.
    • Chattopadhyay D, Manas DM, Reeves HL. . Current Pharmaceutical Design 2007, 13(32), 3292-3300.
    • Narla G, DiFeo A, Yao S, Banno A, Hod E, Reeves HL, Qiao RF, Camacho-Vanegas O, Levine A, Kirschenbaum A, Chan AM, Friedman SL, Martignetti JA. . Cancer Research 2005, 65(13), 5761-5768.
    • Narla G, DiFeo A, Reeves HL, Schaid DJ, Hirshfeld J, Hod E, Katz A, Isaacs WB, Hebbring S, Komiya A, McDonnell SK, Wiley KE, Jacobsen SJ, Isaacs SD, Walsh PC, Zheng SL, Chang BL, Friedrichsen DM, Stanford JL, Ostrander EA, Chinnaiyan AM, Rubin MA, Xu J, Thibodeau SN, Friedman SL, Martignetti JA. . Cancer Research 2005, 65(4), 1213-1222.
    • Reeves, H. L., Narla, G., Ogunbiyi, O., Haq, A., Katz, A., Benzeno, S., Hod, E., Harpaz, N., Goldberg, S., Tal-Kremer, S., Eng, F., Arthur, M., Martignetti, J., Friedman, S. . Gastroenterology 2004, 126(4), 1090-1103.
    • Kremer-Tal, S., Reeves, H. L., Narla, G., Thung, S., Schwartz, M., Difeo, A., Katz, A., Bruix, J., Bioulac-Sage, P., Martignetti, J., Friedman, S. . Hepatology 2004, 40(5), 1047-1052.
    • Benzeno S, Narla G, Allina J, Cheng GZ, Reeves HL, Banck MS, Odin JA, Diehl JA, Germain D, Friedman SL. . Cancer Research 2004, 64(11), 3885-3891.
    • Reeves HL, Friedman SL. . Frontiers in Bioscience 2002, 7, 808-826.
    • Narla G, Heath KE, Reeves HL, Li D, Giono LE, Kimmelman AC, Glucksman MJ, Narla J, Eng FJ, Chan AM, Ferrari AC, Martignetti JA, Friedman SL. . Science 2001, 294(5551), 2563-2566.
    • Reeves, H. L., Thompson, M. G., Dack, C. L., Burt, A. D., Day, C. P. . Hepatology 2000, 31(1), 95-100.
    • Reeves, H. L., Dack, C. L., Peak, M., Burt, A. D., Day, C. P. . Journal of Hepatology 2000, 32(3), 465-472.
    • Reeves, H. L., Francis, R. M., Manas, D. M., Hudson, M., Day, C. P. . Liver Transplantation and Surgery 1998, 4(5), 404-409.
    • Reeves, H. L., Burt, A. D., Wood, S., Day, C. P. . Journal of Hepatology 1996, 25(5), 677-683.

  • Book Chapters

    • Tiniakos DG, Mauricio J, Reeves HL. . In: Alcohol and Cancer. Springer New York LLC, 2018, pp.55-69.
    • Chattopadhyay D, Reeves HL. . In: Rodés, J.; Benhamou, J-P.; Blei, A.; Reichen, J.; Rizzetto, M, ed. Textbook of hepatology: from basic science to clinical practice. Malden, Mass: Blackwell, 2007, pp.391-397.
    • Reeves HL, Bruix J. . In: Thomas, H.; Lemon, S.; Zuckerman, A, ed. Viral hepatitis. Malden, Mass: Blackwell, 2005, pp.740-754.

  • Conference Proceedings (inc. Abstracts)

    • Hallsworth K, Orange ST, McCain M, Fallen-bailey R, Reeves HL. . In: EASL Congress 2023. 2023, Vienna, Austria: Elsevier BV.
    • Albertella M, Rizoska B, McCain M, Kirk C, Öberg F, Bethell R, Reeves H. . In: EASL HCC Summit 2018. 2018, Geneva, Switzerland.
    • Macheka S, Jamieson D, Reeves H, McCain M. . In: 6th Christie International Student Cancer Conference. 2016, Manchester: International Institute of Anticancer Research.
    • Elameer M, French J, Manas D, Stenberg B, Reeves H, Littler P, Hammond J. . In: Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, 19th Annual Scientific Meeting. 2016, Leeds: John Wiley & Sons Ltd.
    • Berhane S, Toyoda H, Tada T, Kumada T, Kagebayashi C, Satomura S, Schweitzer N, Vogel A, Manns M, Benckert J, Berg T, Best J, Dechene A, Gerken G, Schlaak J, Reeves HL, Johnson P. . In: 50th Annual meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
    • Whitehead A, Ogle L, Patman GL, Anwar G, Tiniakos DG, Anstee QM, Reeves HL, FLIP Investigators FP7 2007-2013 H. . In: 50th Annual Meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
    • Whitehead A, Patman GL, Deuschle U, Day CP, Kremoser C, Tiniakos DG, Anstee QM, Reeves HL, FLIP Investigators FP7 2007-2013 H. . In: The International Liver Congress 2015 - 50th Annual meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
    • Kolly P, Reeves HL, Sangro B, Knopfli M, Candinas D, Dufour JF. . In: International Liver Congress 2015 - 50th Annual meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
    • Ogle L, Jamieson D, O'Donnell R, Dent B, Boddy A, Curtin N, Plummer R, Reeves H, Clinical and Translational Group. . In: The International Liver Congress 2014: 49th Annual Meeting of the European Association for the Study of the Liver. 2014, London: Elsevier BV.
    • Patman GL, Televantou D, Whitehead A, Piguet AC, Dufour JF, Day CP, Burt AD, Mann DA, Reeves HL. . In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, The Netherlands: Elsevier.
    • Patman GL, Televantou D, Whitehead A, Day CP, Oakley F, Mann DA, Burt AD, Anstee QM, Reeves HL, FLIP Investigators FP7-2007-2013. . In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, Netherlands: Elsevier BV.
    • Whitehead A, Patman GL, Cornell L, Televantou D, Curtin N, Day CP, Burt AD, Piguet AC, Dufour JF, Anstee QM, Reeves HL, FLIP Investigators FP7-2007-2013. . In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, The Netherlands: Elsevier Science BV.
    • Alhasan SF, Beale GS, Newell DR, Reeves HL. . In: Digestive Disorders Federation Meeting. 2012, Liverpool, UK: BMJ Group.
    • Patman GL, Anstee Q, Reeves HL. . In: 9th Meeting of Therapy in Liver Diseases. 2011, Barcelona, Spain.
    • Reeves HL, Dack C, Dack CP, Burt AD. . In: Eighth International Symposium on Cells of the Hepatic Sinusoid. 1997, Bordeaux, France: Kupffer Cell Foundation.

  • Editorials

    • Reeves HL, Hammond JS. . Liver International 2023, 43(11), 2346-2347.
    • Zaki MYW, Reeves HL. . Translational Cancer Research 2016, 5(Supplement 1), S1-S4.
    • Willoughby CE, Reeves HL. . Chinese Clinical Oncology 2016, 5(5), 14-14.
    • Reeves HL, Aisen AM. . Gastroenterology 2015, 148(7), 1274-1276.

  • Letter

    • Boyault, S., Hérault, A., Balabaud, C., Zucman-Rossi, J., Kremer-Tal, S., Reeves, H. L., Narla, G., Martignetti, J., Friedman, S. . Hepatology 2005, 41(3), 681-683.

  • Note

    • Pinyol R, Torrecilla S, Wang H, Montironi C, Pique-Gili M, Torres-Martin M, Wei-Qiang L, Willoughby CE, Ramadori P, Andreu-Oller C, Taik P, Lee YA, Moeini A, Peix J, Faure-Dupuy S, Riedl T, Schuehle S, Oliveira CP, Alves VA, Boffetta P, Lachenmayer A, Roessler S, Minguez B, Schirmacher P, Dufour J-F, Thung SN, Reeves HL, Carrilho FJ, Chang C, Uzilov AV, Heikenwalder M, Sanyal A, Friedman SL, Sia D, Llovet JM. . Journal of Hepatology 2021, 75(6), 1515.

  • Reviews

    • Geh D, Leslie J, Rumney R, Reeves HL, Bird TG, Mann DA. . Nature Reviews Gastroenterology and Hepatology 2022.
    • Kamarajah SK, Bundred JR, Littler P, Reeves H, Manas DM, White SA. . HPB 2021, 23(4), 495-505.
    • Anstee QM, Reeves HL, Kotsiliti E, Govaere O, Heikenwalder M. . Nature Reviews Gastroenterology and Hepatology 2019, 16, 411-428.
    • Reeves HL, Zaki MYW, Day CP. . Digestive Diseases and Sciences 2016, 61(5), 1234-1245.
    • Lochan R, Daly AK, Reeves HL, Charnley R. . ISRN Oncology 2011, 249235.