缅北禁地

Qualifications

1998: B.SC (Hons) Biochemistry.
缅北禁地

2001: Ph.D Molecular Biology
Urology Research Group
School of Surgical and Reproductive Sciences
缅北禁地

Previous Positions

2001- 2006: Post-Doctoral Research Associate.
Urology Research Group,
Northern Institute For Cancer Research,
缅北禁地.
Funded by the Association for International Cancer Research (AICR)

Memberships

British Association for Cancer Research (BACR)

Endocrine Society

Honours and Awards

British Association for Cancer Research Young Translational Scientist Award 2006

Research Interests

1. Mechanisms of Androgen Receptor (AR) Regulation in Prostate Cancer

2. Epigenetics and splicing control of AR synthesis 

Current Work

The main theme of my research over the last 5 years has been to examine key molecular processes that govern and facilitate AR signalling in advanced prostate cancer with the ultimate objective to identify new targets for therapy. By developing new models of hormone

therapy-resistance that includes engineered cell lines and patient biopsy material as explants, our toolkit for prostate cancer research has evolved to enable more robust, clinically-relevant interrogation of AR function. This has resulted in productive and long-standing industrial collaborations with AstraZeneca, and more recently with CellCentric and Hox Therapeutics, to facilitate 缅北禁地-based mechanism of action and efficacy studies of several clinical candidate epigenetic and hormonal therapeutics.

In the last 5 years, the group has identified and comprehensively validated a number of key AR coregulators and splicing regulators key to PC development, such as the histone demethylase enzyme KDM4B, RBMX and TRA2 orthologues; the latter being in collaboration with our close partners at the Institute of Cancer Research. Our more recent work has focused on the use of genome editing techniques to create genetically altered cell lines (e.g. CWR22Rv1-AR-EK; Kounatidou et al., (2019) Nucleic Acids Research) and as a platform to enable locus specific BioID protein-protein interaction studies of AR isoforms.

Postgraduate Supervision

2017-2021: Cancer Research UK-funded PhD student

2018-2022: Cancer Research UK-funded PhD student

2019-2023: BBSRC CASE studentship with AstraZeneca

2019-2023: Cancer Research UK-funded PhD student

2020-2024: Prostate Cancer Research-funded PhD student

Funding

Worldwide Cancer Research

Prostate Cancer Foundation Challenge Award (2019-2021)

Prostate Cancer Research

Cancer Research UK

European Union

2008-Present: BMS3007 Research in Biomedical Sciences, Lecturer

2009-Present: BMS3012 Cancer Biology and Therapy, Lecturer

2010-Present: BMS3008 Integrated Biomedical Sciences, Module Leader

2025-Present: BMS2022 Principles of Cancer, Lecturer

2025-Present: MMB8050 Therapeutic Applications of Cell Signalling Pathways

• Articles

  • Brittain N, Paschalis A, Nelson R, Adamson B, Walker L, Duncan R, Smith GR, McGill S, Burchmore RJ, Bogdan D, Jiménez-Vacas JM, Welti J, Yuan W, Robson CN, Rescigno P, Luzzi S, Sharp A, de Bono J, Gaughan L. Splicing factor TRA2B enhances synthesis of androgen receptor variant AR-V7 in prostate cancer cells. The Journal of Clinical Investigation 2026, 136(7).
  • López JCV, Yu C, Kobilka A, Lyman J, Guo S, Munro SA, Li Y, Heer R, Gaughan L, Morris MJ, Beltran H, Ryan CJ, Antonarakis ES, Armstrong AJ, Halabi S, Dehm S. . Clinical Cancer Research 2026, Epub ahead of print.
  • Paschalis A, Figueiredo I, Bogdan D, Lundberg A, Santos R, Gurel B, Taha T, Longoria O, Ferreira A, Bertan C, Brittain N, Nelson R, Walker L, Neeb A, Welti J, Yuan W, Mitsopoulos C, Plymate SR, Haffner MC, Sowalsky AG, Carreira S, Sharp A, Gaughan L, de Bono J. Androgen receptor splice variant 7 expression levels distinguish AR-mutated from nonmutated metastatic castration-resistant prostate cancers. The Journal of Clinical Investigation 2026, 136(7).
  • Garnham R, Geh D, Nelson R, Ramon-Gil E, Wilson L, Schmidt EN, Walker L, Adamson B, Buskin A, Hepburn AC, Hodgson K, Kendall H, Frame FM, Maitland N, Coffey K, Strand DW, Robson CN, Elliott DJ, Heer R, Macauley M, Munkley J, Gaughan L, Leslie J, Scott E. . Communications Biology 2024, 7(1), 276.
  • Walker L, Duncan R, Adamson B, Kendall H, Brittain N, Luzzi S, Jones D, Chaytor L, Peel S, Crafter C, O'Neill DJ, Gaughan L. . Molecular Cancer Research 2024, 22(12), 1128-1142.
  • Knutson TP, Luo B, Kobilka A, Lyman J, Guo S, Munro SA, Li Y, Heer R, Gaughan L, Morris MJ, Beltran H, Ryan CJ, Antonarakis ES, Armstrong AJ, Halabi S, Dehm SM. . Nature Communications 2024, 15, 10648.
  • Adamson B, Brittain N, Walker L, Duncan R, Luzzi S, Rescigno P, Smith GR, McGill S, Burchmore RJS, Willmore E, Hickson I, Robson CN, Bogdan D, Jimenez-Vacas JM, Paschalis A, Welti J, Yuan W, McCracken SR, Heer R, Sharp A, de Bono J, Gaughan L. . Journal of Clinical Investigation 2023, 133(22), e169200.
  • Harris RJ, Heer M, Levasseur MD, Cartwright TN, Weston B, Mitchell JL, Coxhead JM, Gaughan L, Prendergast L, Rico D, Higgins JMG. . Nature Communications 2023, 14, 7243.
  • Martinez RS, Salji MJ, Rushworth L, Ntala C, Blanco GR, Hedley A, Clark W, Peixoto P, Hervouet E, Renaude E, Kung SHY, Galbraith LCA, Nixon C, Lilla S, MacKay GM, Fazli L, Gaughan L, Sumpton D, Gleave ME, Zanivan S, Blomme A, Leung HY. . Cancer Research 2021, 81(13), 3664-3678.
  • Hepburn AC, Curry EL, Moad M, Steele RE, Franco OE, Wilson L, Singh P, Buskin A, Crawford SE, Gaughan L, Mills IG, Hayward SW, Robson CN, Heer R. . Stem Cells Translational Medicine 2020, 9(7), 734-745.
  • Bainbridge A, Walker S, Smith J, Patterson K, Dutt D, Ng YM, Thomas HD, Wilson L, McCullough B, Jones D, Maan A, Banks P, McCracken SRC, Gaughan L, Robson CN, Coffey K. . Nucleic Acids Research 2020, 48(10), 5366-5382.
  • Blomme A, Ford CA, Mui E, Patel R, Ntala C, Jamieson LE, Planque M, McGregor GH, Peixoto P, Hervouet E, Nixon C, Salji M, Gaughan L, Markert E, Repiscak P, Sumpton D, RodriguezBlanco G, Lilla S, Kamphorst JJ, Graham D, Faulds K, MacKay GM, Fendt SM, Zanivan S, Leung HY. . Nature Communications 2020, 11, 2508.
  • Chaytor L, Simcock M, Nakjang S, Heath R, Walker L, Robson C, Jones D, Gaughan L. . Molecular Cancer Research 2019, 17(6), 1264-1278.
  • Hepburn AC, Steele RE, Veeratterapillay R, Wilson L, Kounatidou EE, Barnard A, Berry P, Cassidy JR, Moad M, El-Sherif A, Gaughan L, Mills IG, Robson CN, Heer R. . Oncogene 2019, 38, 4412-4424.
  • Jones D, Wilson L, Thomas H, Gaughan L, Wade MA. . Cancers 2019, 11(8), 1122.
  • Fletcher CE, Sulpice E, Combe S, Shibakawa A, Leach DA, Hamilton MP, Chrysostomou SL, Sharp A, Welti J, Yuan W, Dart DA, Knight E, Ning J, Francis JC, Kounatidou EE, Gaughan L, Swain A, Lupold SE, de Bono JS, McGuire SE, Gidrol X, Bevan CL. . Oncogene 2019, 38, 5700-5724.
  • Kounatidou E, Nakjang S, McCracken SRC, Dehm SM, Robson CN, Jones D, Gaughan L. . Nucleic Acids Research 2019, 47(11), 5634-5647.
  • Shuttleworth VG, Gaughan L, Nawafa L, Mooney CA, Cobb SL, Sheerin NS, Logan IR. . Journal of Cell Science 2018, 131, jcs207761.
  • Grey J, Jones D, Wilson L, Nakjang S, Clayton J, Temperley R, Clark E, Gaughan L, Robson C. . Oncotarget 2018, 9(3), 3922-3935.
  • McClurg UL, Cork DMW, Darby S, Ryan-Munden CA, Nakjang S, Mendes-Cortes L, Treumann A, Gaughan L, Robson CN. . Nucleic Acids Research 2017, 45(4), 1793-1804.
  • Jones D, Noble M, Wedge SR, Robson CN, Gaughan L. . Scientific Reports 2017, 7, 40957.
  • Logan IR, McClurg UL, Jones DL, O'Neill DJ, Shaheen FS, Lunec J, Gaughan L, Robson CN. . Oncotarget 2016, 7(46), 74724-74733.
  • McClurg UL, Harle VJ, Nabbi A, Batalha-Pereira A, Walker S, Coffey K, Gaughan L, McCracken SRC, Robson CN. . Oncotarget 2015, 6(35).
  • Wade MA, Jones D, Wilson L, Stockley J, Coffey K, Robson CN, Gaughan L. . Nucleic Acids Research 2015, 43(1), 196-207.
  • Cano LQ, Lavery DN, Sin S, Spanjaard E, Brooke GN, Tilman JD, Abroaf A, Gaughan L, Robson CN, Heer R, Mauri F, de Rooij J, Driouch K, Bevan CL. . Molecular Oncology 2015, 9(1), 295-308.
  • Jones D, Wade M, Nakjang S, Chaytor L, Grey J, Robson CN, Gaughan L. . Oncotarget 2015, 6(30), 29782-29794.
  • O'Neill D, Jones D, Wade M, Grey J, Nakjang S, Guo W, Cork D, Davies BR, Wedge SR, Robson CN, Gaughan L. . Oncotarget 2015, 6(28), 26029-26040.
  • Rodriguez-Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J. . Journal of Pathology 2015, 235(4), 581-592.
  • Rodriguez-Teja M, Gronau JH, Minamidate A, Darby S, Gaughan L, Robson C, Mauri F, Waxman J, Sturge J. . Molecular Cancer Research 2014.
  • O'Neill DJ, Williamson SC, Alkharaif D, Monteiro ICM, Goudreault M, Gaughan L, Robson CN, Gingras AC, Binda O. . Epigenetics 2014, 9(7), 942-950.
  • McClurg UL, Summerscales EE, Harle VJ, Gaughan L, Robson CN. . Oncotarget 2014, 5(16), 7081-7092.
  • Coffey K, Rogerson L, Ryan-Munden C, Alkharaif D, Stockley J, Heer R, Sahadevan K, O'Neill D, Jones D, Darby S, Staller P, Mantilla A, Gaughan L, Robson CN. . Nucleic Acids Research 2013, 41(8), 4433-4446.
  • Gaughan L, Stockley J, Coffey K, O'Neill D, Jones DL, Wade M, Wright J, Moore M, Tse S, Rogerson L, Robson CN. . Nucleic Acids Research 2013, 41(14), 6892-6904.
  • Burska UL, Harle VJ, Coffey K, Darby S, Ramsey H, O'Neill D, Logan IR, Gaughan L, Robson CN. . Journal of Biological Chemistry 2013, 288(45), 32641-32650.
  • Loddick SA, Ross SJ, Thomason AG, Robinson DM, Walker GE, Dunkley TPJ, Brave SR, Broadbent N, Stratton NC, Trueman D, Mouchet E, Shaheen FS, Jacobs VN, Cumberbatch M, Wilson J, Jones RDO, Bradbury RH, Rabow A, Gaughan L, Womack C, Barry ST, Robson CN, Critchlow SE, Wedge SR, Brooks AN. . Molecular Cancer Therapeutics 2013, 12(9), 1715-1727.
  • Axon A, May FEB, Gaughan LE, Williams FM, Blain PG, Wright MC. . Toxicology 2012, 298(1-3), 40-51.
  • Shaheen FS, Znojek P, Fisher A, Webster M, Plummer R, Gaughan L, Smith GCM, Leung HY, Curtin NJ, Robson CN. . PLoS One 2011, 6(5), e20311.
  • Gaughan L, Stockley J, Wang N, McCracken S, Truemann A, Armstrong K, Shaheen F, Watt K, McEwan I, Wang C, Pestell RG, Robson CN. . Nucleic Acids Research 2011, 39(4), 1266-1279.
  • Rajan P, Dalgliesh C, Carling PJ, Buist T, Zhang CL, Grellscheid SN, Armstrong K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN, Leung HY, Elliott DJ. . PLoS One 2011, 6(12), e29088.
  • Brooke GN, Culley RL, Dart DA, Mann DJ, Gaughan L, McCracken SR, Robson CN, Spencer-Dene B, Gamble SC, Powell SM, Wait R, Waxman J, Walker MM, Bevan CL. . Cancer Research 2011, 71(3), 914-924.
  • Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY, Elliott DJ. . Journal of Pathology 2008, 215(1), 67-77.
  • Clark EL, Coulson AC, Dalgliesh C, Rajan P, Nicol SM, Fleming S, Heer R, Gaughan L, Leung HY, Elliott DJ, Fuller-Pace FV, Robson CN. . Cancer Research 2008, 68(19), 7938-7946.
  • Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY, Elliott DJ. . Biochemical Society Transactions 2008, 36(3), 505-507.
  • Logan IR, Gaughan L, McCracken SRC, Sapountzi V, Leung HY, Robson CN. . Molecular and Cellular Biology 2006, 26(17), 6502-6510.
  • Gaughan, L., Logan, I. R., Neal, D. E., Robson, C. N. . Nucleic Acids Research 2005, 33(1), 13-26.
  • Mills, I., Gaughan, L., Robson, C. N., Ross, T., McCracken, S. R. C., Kelly, J., Neal, D. E. . Journal of Cell Biology 2005, 170(2), 191-200.
  • Awasthi, S, Sharma, A, Wong, K, Zhang, J, Matlock, E, Rogers, L, Motloch, P, Takemoto, S, Taguchi, H, Cole, MD, Lüscher, B, Dittrich, O, Tagami, H, Nakatani, Y, McGee, M, Girard, AM, Gaughan, L, Robson, CN, Monnat, RJ, Harrod, R. . Molecular and Cellular Biology 2005, 25(14), 6178-6198.
  • Halkidou, K., Gaughan, L., Cook, S., Leung, H. Y., Neal, D. E., Robson, C. N. . The Prostate 2004, 59(2), 177-189.
  • Logan, I. R., Sapountzi, V., Gaughan, L., Neal, D. E., Robson, C. N. . Journal of Biological Chemistry 2004, 279(12), 11696-11704.
  • Gaughan, L., Neal, D. E., Robson, C. N. . European Urology Supplements 2003, 2(6), 58-58.
  • Gaughan, L., Logan, I. R., Cook, S., Neal, D. E., Robson, C. N. . Journal of Biological Chemistry 2002, 277(29), 25904-25913.
  • Gaughan, L., Brady, M. E., Cook, S., Neal, D. E., Robson, C. N. . Journal of Biological Chemistry 2001, 276(50), 46841-46848.
  • Ozanne, D. M., Brady, M. E., Cook, S., Gaughan, L., Neal, D. E., Robson, C. N. . Molecular Endocrinology 2000, 14(10), 1618-1626.
  • Brady, M. E., Ozanne, D. M., Gaughan, L., Waite, I. S., Cook, S., Neal, D. E., Robson, C. N. . Journal of Biological Chemistry 1999, 274(25), 17599-17604.

• Reviews

  • DiCostanzo F, Williamson J, Robson CN, Gaughan L, Conteduca V, Mansour WY, Formisano L, Demichelis F, Oing C, Rescigno P. . Molecular Cancer Therapeutics 2026, 25(4), 556–567.
  • Buskin A, Scott E, Nelson R, Gaughan L, Robson CN, Heer R, Hepburn AC. . Oncogene 2023, 42, 2417–2427.