缅北禁地

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Staff Profile

Professor Rakesh Heer

Professor of Urology

  • Email: rakesh.heer@ncl.ac.uk
  • Telephone: +44 (0) 191 208 4300
  • Fax: +44 (0) 191 208 4301
  • Address: Paul O'Gorman Building
    Medical School
    Framlington Place
    缅北禁地 upon Tyne
    NE2 4HH
Background

  • Cross cutting research spanning the spectrum of major clinical trials, translational studies and basic science. 
  • A focus on urological cancers and stem cell biology.
  • Consultant Surgeon (2011-). Robotic surgery and leads regional urology for complex pelvic cancer.
  • NIHR HTA Programme Deputy Chair (2022-). 
  • NICE Guidelines Chairman (2021-). 
  • National Clinical Excellence award (2021).
  • NIHR Clinical Research Network (CRN) Executive for North East & North Cumbria (NENC) (2020-)
  • Chairman of the NCRI localised prostate cancer subgroup (2017-2022)

Research

Clinical trials in kidney, bladder and prostate cancer:

  • Chief Investigator, NIHR PARTIAL; £1.9M; 2022-2027. Randomised trial of the clinical and cost effectiveness of PARTIAL vs radical nephrectomy for clinically localised renal cell carcinoma
  • Co-Investigator, CRUK Early Detection and Diagnosis Research PACIFIC; £1.7M; 2022-2026. Evaluating the role of fast MRI and image-fusion for detection of prostate cancer (Lead PI Ahmed)
  • Chief Investigator, NIHR PHOTO; £2.4M; 2014-2021. A randomised trial comparing photodynamic guided resection with standard white light surgery
  • Chief Investigator, NIHR VARIANT; £0.3M; 2018-2021. A trial of biomarker-driven treatment in prostate cancer
  • Principle investigator, NIHR BRC; £0.2M; 2018-2021. Developing biomarkers using mitochondrial DNA mutation lineage tracing for early detection of bladder cancer
  • Principle investigator, Innovate UK CICERO; £0.3M; 2017-2018. AI-embedded image-enhanced video cystoscopy for a bladder cancer detection


The characterisation of human prostate stem cells:

  • Principle investigator, Prostate Cancer Foundation award; $1M; 2019-2021. Patient stem cell derived prostate organoids for preclinical testing and treatment stratification.
  • Principle investigator, Prostate Cancer Research grant; £0.5M; 2022-2025. Mapping the epigenetic evolution of prostate carcinogenesis (Epi-Evo study).
  • Co-investigator, Prostate Cancer Research grant; £0.5M; 2020-2024. Filling a critical knowledge gap in androgen receptor variant splicing to enable development of new prostate cancer therapies.
  • CRUK Clinician Scientist Fellowship; £0.8M; 2011-2016.In situ characterisation of prostate stem cell fate.
  • Royal College of Surgeon’s Hunterian Professorship and Medal 2010.
  • MRC Clinician PhD Fellow; £0.1M; 2003-2006. The role of KGF in prostatic stem cell differentiation.

Teaching
  • 缅北禁地 Director of MD studies and PG Associate Dean (2016-current)
  • Cystectomy Program Director for the International 缅北禁地 Robotic Surgery Course (2016-current)
  • Urology lead ACF/ACL program (2015-current)

Publications
  • Grayling MJ, McMenamin M, Chandler R, Heer R, Wason JMS. . BMC Cancer 2022, 22, 111.
  • Beyer K, Moris L, Lardas M, Omar MI, Healey J, Tripathee S, Gandaglia G, Venderbos LDF, Vradi E, van den Broeck T, Willemse P-P, Antunes-Lopes T, Pacheco-Figueiredo L, Monagas S, Esperto F, Flaherty S, Devecseri Z, Lam TBL, Williamson PR, Heer R, Smith EJ, Asiimwe A, Huber J, Roobol MJ, Zong J, Mason M, Cornford P, Mottet N, MacLennan SJ, N'Dow J, Briganti A, MacLennan S, Van Hemelrijck M. . European Urology 2022, 81(5), 503-514.
  • Grossmann S, Hooks Y, Wilson L, Moore L, O'Neill L, Martincorena I, Voet T, Stratton MR, Heer R, Campbell PJ. . Cell Stem Cell 2021, 28(7), 1262-1274.e5.
  • Tan WS, Arianayagam R, Khetrapal P, Rowe E, Kearley S, Mahrous A, Pal R, Fowler W, Heer R, Elajnaf M, Douglas-Moore J, Leyshon Griffiths TR, Voss J, Wilby D, Al Kadhi O, Noel J, Vasdev N, McKay A, Ahmad I, Abu-Nayla I, Lamb B, Hill GT, Narahari K, Kynaston H, Yousuf A, Kusuma VRM, Cresswell J, Cooke P, Chakravarti A, Barod R, Bex A, Kelly JD. . European Urology Open Science 2021, 25, 39-43.
  • Sims CHC, Autio MI, Buskin A, Cheung C, Heer R, Foo RSY, Wang X. . Stem Cell Research 2021, 52, 102238.
  • Moore L, Cagan A, Coorens THH, Neville MDC, Sanghvi R, Sanders MA, Oliver TRW, Leongamornlert D, Ellis P, Noorani A, Mitchell TJ, Butler TM, Hooks Y, Warren AY, Jorgensen M, Dawson KJ, Menzies A, O'Neill L, Latimer C, Teng M, van Boxtel R, Iacobuzio-Donahue CA, Martincorena I, Heer R, Campbell PJ, Fitzgerald RC, Stratton MR, Rahbari R. . Nature 2021, 597, 381-386.
  • Veeratterapillay R, Gravestock P, Nambiar A, Gupta A, Aboumarzouk O, Rai B, Vale L, Heer R. . European Urology Open Science 2021, 31, 17-27.
  • Smith ALM, Whitehall JC, Bradshaw C, Gay D, Robertson F, Blain AP, Hudson G, Pyle A, Houghton D, Hunt M, Sampson JN, Stamp C, Mallett G, Amarnath S, Leslie J, Oakley F, Wilson L, Baker A, Russell OM, Johnson R, Richardson CA, Gupta B, McCallum I, McDonald SAC, Kelly S, Mathers JC, Heer R, Taylor RW, Perkins ND, Turnbull DM, Sansom OJ, Greaves LC. . Nature Cancer 2020, 1, 976-989.
  • Hepburn AC, Sims CHC, Buskin A, Heer R. . International Journal of Molecular Sciences 2020, 21(3), 905.
  • Hepburn AC, Curry EL, Moad M, Steele RE, Franco OE, Wilson L, Singh P, Buskin A, Crawford SE, Gaughan L, Mills IG, Hayward SW, Robson CN, Heer R. . Stem Cells Translational Medicine 2020, 9(7), 734-745.
  • Hepburn AC, Steele RE, Veeratterapillay R, Wilson L, Kounatidou EE, Barnard A, Berry P, Cassidy JR, Moad M, El-Sherif A, Gaughan L, Mills IG, Robson CN, Heer R. . Oncogene 2019, 38, 4425.
  • Clark E, Morton M, Sharma S, Fisher H, Howel D, Walker J, Wood R, Hancock H, Maier R, Marshall J, Bahl A, Crabb S, Jain S, Pedley I, Jones R, Staffurth J, Heer R. . BMJ Open 2019, 9(12), e034708.
  • Hepburn AC, Steele RE, Veeratterapillay R, Wilson L, Kounatidou EE, Barnard A, Berry P, Cassidy JR, Moad M, El-Sherif A, Gaughan L, Mills IG, Robson CN, Heer R. . Oncogene 2019, 38, 4412-4424.
  • McClurg UL, Nabbi A, Ricordel C, Korolchuk S, McCracken S, Heer R, Wilson L, Butler LM, Irving-Hooper BK, Pedeux R, Robson CN, Riabowol KT, Binda O. . British Journal of Cancer 2018, 118, 713-726.
  • Luk ACO, Pandian RMK, Heer R. . Arab Journal of Urology 2018, 16(3), 314-320.
  • Stamp C, Zupanic A, Sachdeva A, Stoll EA, Shanley DP, Mathers JC, Kirkwood TBL, Heer R, Simons BD, Turnbull DM, Greaves LC. . EBioMedicine 2018, 31, 166-173.
  • Hatina J, Parmar HS, Kripnerova M, Hepburn A, Heer R. . In: Schulz, WA; Hoffmann, MJ; Niegisch, G, ed. Urothelial Carcinoma: Methods and Protocols. New York: Humana Press Inc, 2018, pp.121-136.
  • Hannezo E, Scheele CLGJ, Moad M, Drogo N, Heer R, Sampogna RV, van Rheenen J, Simons BD. . Cell 2017, 171(1), 242-255.
  • Moad M, Hannezo E, Buczacki SJ, Wilson L, ElSherif A, Sims D, Pickard R, Wright NA, Williamson SC, Turnbull DM, Taylor RW, Greaves L, Robson CN, Simons BD, Heer R. . Cell Reports 2017, 20(7), 1609-1622.
  • Moad M, Curry EL, Robson CN, Heer R. . In: Deepak A. Lamba, ed. Patient-Specific Stem Cells. Taylor & Francis, 2017, pp.177-194.
  • Sachdeva A, El-Sherif A, Turnbull D, Greaves L, Heer R. . In: EAU16 – 31st Annual Congress of the European Association of Urology. 2016, Munich, Germany: Elsevier.
  • Pearson RA, Thelwall PE, Snell J, McKenna J, Pieniazek P, Fitzgerald EL, Heer R, McMenemin RM, Pedley ID, Azzabi AS, Newell H, Maxwell RJ, Plummer ER, Frew JA. . In: 2016 Genitourinary Cancers Symposium. 2016, San Francisco: American Society of Clinical Oncology.
  • Pearson RA, Thelwall PE, Snell J, McKenna J, Pieniazek P, Fitzgerald E, Heer R, McMenemin RM, Pedley ID, Azzabi A, Maxwell RJ, Newell DR, Plummer ER, Frew JA. . In: Genitourinary Cancers Symposium 2016. 2016, San Francisco, California: Journal of Clinical Oncology.
  • Lazzarini N, Widera P, Williamson S, Heer R, Krasnogor N, Bacardit J. . BioData Mining 2016, 9, 28.
  • Veeratterapillay R, Heer R, Johnson MI, Persad R, Bach C. . Current Urology Reports 2016, 17, 68.
  • Veeratterapillay R, Ijabla R, Conaway D, Haslam P, Soomro N, Heer R. . Clinical Radiology 2015, 70(12), 1357-1361.
  • Iqbal MS, Pickles R, Pedley I, Frew J, Azzabi A, Heer R, Thorpe A, Johnson M, Robson L, McMenemin R. . Journal of Clinical Urology 2015, 8(4), 246-251.
  • Veeratterapillay R, Gill S, Pedley I, Frew J, Heer R, Paez E, Johnson MI, Thorpe AC. . In: British Association of Urological Surgeons Annual Meeting. 2015, Manchester, UK: Wiley.
  • Cano LQ, Lavery DN, Sin S, Spanjaard E, Brooke GN, Tilman JD, Abroaf A, Gaughan L, Robson CN, Heer R, Mauri F, de Rooij J, Driouch K, Bevan CL. . Molecular Oncology 2015, 9(1), 295-308.
  • Curry EL, Moad M, Robson CN, Heer R. . World Journal of Stem Cells 2015, 7(2), 461-469.
  • Ahmed HU, Berge V, Bottomley D, Cross W, Heer R, Kaplan R, Leslie T, Parker C, Relton C, Stephens R, Sydes MR, Turnbull L, van der Meulen J, Vickers A, Wilt T, Emberton M, Prostate Cancer RCT Consensus Group. . Nature Reviews Clinical Oncology 2014, 11(8), 482-491.
  • Williamson SC, Wilson L, Williamson GA, Greaves L, Tuppen H, Pickard R, Wright NA, Robson CN, Turnbull DM, Taylor RW, Heer R. . In: Annual Meeting of the Society-of-Academic-and-Research-Surgery. 2014, Univ Cambridge, Robinson Coll, Cambridge, ENGLAND: John Wiley & Sons Ltd.
  • Shekarchi-Khanghahi E, Curtin NJ, Heer R. . In: Annual Meeting of the Society-of-Academic-and-Research-Surgery. 2014, Univ Cambridge, Robinson Coll, Cambridge, ENGLAND: John Wiley & Sons, Inc.
  • Rogers A, Adams F, Smith J, Johnson J, Thorpe A, Robson L, Pedley I, McMenemin R, Heer R. . In: British Association of Urological Surgeons Annual Meeting. 2014, Liverpool, UK: Wiley-Blackwell Publishing, Inc.
  • Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco O, Cates J, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R. . European Urology 2013, 64(5), 753-761.
  • Williamson SC, Hartley AE, Heer R. . Drug Design, Development and Therapy 2013, 7, 167-174.
  • Williamson SC, Mitter R, Hepburn AC, Wilson L, Mantilla A, Leung HY, Robson CN, Heer R. . British Journal of Cancer 2013, 109(4), 950-956.
  • Moad M, Hepburn A, Lako M, Pal D, Williamson S, Robson C, Heer R. . In: Annual Meeting of the Society of Academic and Research Surgery. 2013, London, UK: John Wiley & Sons Ltd.
  • Hepburn AC, Gaughan L, Williamson SC, Pal D, Moad M, Kanani MK, Robson CN, Heer R. . In: Annual Meeting of the Society of Academic and Research Surgery. 2013, London, UK: Wiley-Blackwell.
  • Roushias S, Veeratterapillay R, McCracken S, Heer R. . Journal of Clinical Urology 2013, 6(3), 194-196.
  • Townes CL, Ali A, Gross N, Pal D, Williamson SC, Heer R, Robson CN, Pickard R, Hall J. . The Prostate 2013, 73(14), 1529-1537.
  • Heer R, Hepburn AC, Williamson SC, Kennedy A, El-Sherif A, Soomro NA, Brown CD, Robson CN. . Renal Failure 2013, 35(10), 1387-1391.
  • Pal D, Moad M, Hepburn AC, Williamson SC, Robson CN, Heer R. . European Urology 2013. In Press.
  • Pal D, Moad M, Hepburn AC, Williamson SC, Robson CN, Heer R. . European Urology 2013, 64(5), 764-765.
  • Williamson C, Hepburn AC, Mantilla A, Wilson L, Leung HY, Robson CN, Heer R. . In: Annual Meeting of the Society of Academic and Research Surgery. 2013, London, UK: Wiley-Blackwell.
  • Coffey K, Rogerson L, Ryan-Munden C, Alkharaif D, Stockley J, Heer R, Sahadevan K, O'Neill D, Jones D, Darby S, Staller P, Mantilla A, Gaughan L, Robson CN. . Nucleic Acids Research 2013, 41(8), 4433-4446.
  • Pal D, Rigas AC, Williamson SC, Moad M, Carr-Wilkinson J, Lako L, Robson CN, Heer R. . In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
  • Heer R, Glendinning RJ, Nesbitt CN, Pal D, Rix D, Menezes P, Johnson MI. . British Journal of Medical and Surgical Urology 2012, 5(2), 61-66.
  • Pal D, Rigas AC, Williamson SC, Moad M, Robson CN, Heer R. . In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
  • Veeratterapillay R, Simren R, El-Sherif A, Johnson MI, Soomro N, Heer R. . Journal of Clinical Pathology 2012, 65(4), 367-371.
  • Veeratterapillay R, Rakhra S, El-Sherif A, Johnson M, Soomro N, Heer R. . International Journal of Urology 2012, 19(8), 773-776.
  • Williamson SC, Hepburn AC, Wilson L, Coffey K, Ryan-Munden CA, Pal D, Leung HY, Robson CN, Heer R. . PLoS One 2012, 7(11), e48944.
  • Williamson C, Blackwood JK, Greaves L, Wilson L, Pickard RS, Lako M, Robson CN, Turnbull DM, Taylor RW, Heer R. . In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
  • Rigas AC, Williamson SC, Kennedy A, El-Sherif A, Soomro NA, Brown CDA, Robson CN, Heer R. . In: Annual Meeting of the Society of Academic and Research Surgery. 2012, Nottingham, UK: John Wiley & Sons Ltd.
  • Hepburn AC, Veeratterapillay R, Williamson SC, El-Sherif A, Sahay N, Thomas HD, Mantilla A, Pickard RS, Robson CN, Heer R. . PLoS One 2012, 7(11), e50690.
  • Blackwood JK, Williamson SC, Greaves LC, Wilson L, Rigas AC, Sandher R, Pickard RS, Robson CN, Turnbull DM, Taylor RW, Heer R. . Journal of Pathology 2011, 225(2), 181-188.
  • Williamson SC, Rigas AC, Robson CN, Heer R, Heer R. . In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
  • Jackson M, Heer R, El-Sherif A, Perros P, Thorpe A. . British Journal of Medical and Surgical Urology 2011, 4(1), 39-41.
  • Pal D, Williamson SC, Robson CN, Rigas AC, Heer R. . In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
  • Williamson SC, Mitter R, Rigas AC, Robson CN, Heer R. . In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
  • Rigas AC, Jaiswal N, Williamson SC, Pickard R, Robson CN, Heer R. . In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
  • Pal D, Robson CN, Williamson SC, Nayernia K, Soleimanpour-Lichaei HR, Heer R. . In: British Journal of Surgery: Annual Meeting of the Society of Academic and Research Surgery. 2011, Dublin, Ireland: John Wiley & Sons Ltd.
  • Pridgeon SW, Heer R, Taylor GA, Newell DR, O'Toole K, Robinson M, Xu YZ, Karran P, Boddy AV. . British Journal of Cancer 2011, 104(12), 1869-1876.
  • Heer R, Clarke N, Rigas AC, Cheek TR, Pickard R, Leung HY. . Urology 2010, 76(2), 509.e13-509.e20.
  • McCracken SRC, Ramsay A, Heer R, Mathers ME, Jenkins BL, Edwards J, Robson CN, Marquez R, Cohen P, Leung HY. . Oncogene 2008, 27(21), 2978-2988.
  • Heer R, Robson CN. . European Urology 2008, 54(6), 1353-1353.
  • Clark EL, Coulson AC, Dalgliesh C, Rajan P, Nicol SM, Fleming S, Heer R, Gaughan L, Leung HY, Elliott DJ, Fuller-Pace FV, Robson CN. . Cancer Research 2008, 68(19), 7938-7946.
  • Heer R, Robson CN, Shenton BK, Leung HY. . Journal of Cellular Physiology 2008, 215(1), 283-284.
  • Clarke N, Heer R, Cheek T, Leung T, Pickard R. . European Urology Supplements 2007, 6(2), 138-138.
  • Heer, R., Robson, C. N., Shenton, B. K., Leung, H. Y. . Journal of Cellular Physiology 2007, 212(3), 572-578.
  • Heer, R., Collins, A., Robson, C.N., Shenton, B.K., Leung, H.K. . Journal of Cell Science 2006, 119(7), 1416-1424.
  • McKie AB, Olijslagers S, Atkins H, Heer R, Robson CN, Leung HY. Control of hSprouty2 Expression Critically Regulates Cell Growth, Migration and Invasion in Human Prostate Cancer. Manuscript in preparation 2005.
  • McKie AB, Douglas DA, Olijslagers S, Graham J, Omar MM, Heer R, Gnanapragasam VJ, Robson CN, Leung HY. . Oncogene 2005, 24(13), 2166-2174.
  • McCracken SRC, Jenkins BL, Heer R, Mathers ME, Robson CN, Leung HY. . BJU International 2005, 95(s5), 82-83.
  • Heer R, Dorkin TJ, Byrne RL, Griffiths TRL, Rangecroft L. . European Journal of Pediatric Surgery 2004, 14(5), 328-332.
  • Heer, R,, Douglas, D. A., Robson, C. N., Leung, H. Y. . British Journal of Cancer 2004, 91(Supplement 1), S20-S20.
  • Heer, R., Douglas, D. A., Mathers, M. E., Robson, C. N., Leung, H. Y. . Journal of Pathology 2004, 204(5), 578-586.
  • Heer R, Shrimankar J, Griffith CDM. . Breast 2004, 13(3), 262.
  • Heer, R., Collins, A. T., Robson, C. N., Leung, H. Y. . British Journal of Cancer 2004, 91(Supplement 1), S11-S11.
  • Heer R, Shrimankar J, Griffith CDM. . The Breast 2004, 13(3), 262-262.
  • Heer R, Shrimankar J, Griffith CDM. . The Breast 2003, 12(4), 283-286.
  • Heer R, Walker S, MacSweeney S. . Current Medical Research and Opinion 2001, 17(2), 113-115.
  • Heer R, Dobson D, Plusa SM. . Journal of The Royal College of Surgeons of Edinburgh 2000, 45(6), 369-370.
  • Walker SR, Heer R, MacSweeney ST. . British Journal of Surgery 1999, 86(5), 694.