缅北禁地

I am a Clinical Senior Lecturer and Honorary Consultant Paediatric Oncologist, providing a clinical service for young people with lymphoma or Langerhans cell histiocytosis at the Great North Children's Hospital, 缅北禁地. 

Qualifications

2015 CCT Paediatrics (Paediatric Oncology)

2013 PhD, 缅北禁地

2005 Membership of the Royal College of Paediatrics and Child Health, UK

2002 MBBS (Hons), 缅北禁地

1999 BMedSci (Hons), 缅北禁地 

Memberships

International BFM Study Group (co-Chair)

Children's Cancer & Leukaemia Group (CCLG) NHL Interest Group

European Hematology Association, Pediatric Specialised Working Group

European Intergroup Collaboration for Childhood Non-Hodgkin Lymphoma (EICNHL)/SIOPE

NCRI Children's NHL subgroup

NCRI Lymphoma Science subgroup

Honours and Awards

2014   Lindau Nobel Laureate meeting alumnus, Royal Society nominee

2002   Mona McNaughton Prize - MBBS (Hons) final examination results 2002

1998   Wolfson Scholar - BMedSci (Hons)

Research Interests

Together with Dr Chris Bacon I run the Lymphoma Research Group within the Wolfson Childhood Cancer Research Centre. Our aim is to deeply characterise childhood B-cell non-Hodgkin lymphoma to provide a comprehensive understanding of factors affecting risk stratification and development of therapy resistance. Having identified the strong prognostic value of TP53 mutations in the setting of childhood B-NHL we are now trying to understand both co-operating determinants of risk and the mechanisms through which TP53 mutation/deletion impacts therapy sensitivity/resistance. Using sporadic Burkitt lymphoma as our principle disease, we are studying the genetic, transcriptomic and clonal changes which occur in response to therapeutic pressure in both patient samples and our collection of patient-derived xenograft models. 

Funding - Current Projects 

Engineering & Physical Sciences Research Council - Preventing tumour lysis syndrome using real-time biosensors

Cancer Research UK (D4CYP) - Identification of prognostic biomarkers for childhood Burkitt lymphoma through multiomic data integration. 

The Little Princess Trust - Identifying new treatment options for therapy resistant Burkitt lymphoma

缅北禁地 Hospitals Charity

Children's Cancer North

The Good Will Cause

Funding - Previous major awards

MRC Clinician Scientist Fellowship - Clonal heterogeneity and therapy resistance in Burkitt lymphoma

Funding - Training

Sir Bobby Robson Foundation Clinical Fellow

ACF/ACL posts funded by NIHR

MRC Centenary Early Career Award

MRC Clinical Research Training Fellowship

I supervise undergraduate, masters and PhD students within the Wolfson Childhood Cancer Research Centre, as well as providing clinical teaching for medical students within the Great North Children's Hospital. I lecture on Cancer Stem Cells, Heterogeneity and Evolution within the Biomedical Sciences undergraduate degree programme.

I have contributed a chapter on clinical research to the recently revised MRCPCH Science of Paediatrics Mastercourse book for candidates of the Royal College of Paediatrics and Child Health membership exam. I have also written chapters on childhood lymphoma and tumour lysis syndrome for the second edition of the Oxford University Handbook of Paediatric Haematology and Oncology.

• Articles

  • Tirtakusuma R, Milne P, Blair HJ, Shi Y, Bomken S, Heidenreich O. . Leukemia 2024, 38, 883-886.
  • Elitzur S, Shiloh R, Loeffen JLC, Pastorczak A, Takagi M, Bomken S, Baruchel A, Lehrnbecher T, Tasian SK, Abla O, Arad-Cohen N, Astigarraga I, Ben-Harosh M, Bodmer N, Brozou T, Ceppi F, Chugaeva L, Dalla Pozza L, Ducassou S, Escherich G, Farah R, Gibson A, Hasle H, Hoveyan J, Jacoby E, Jazbec J, Junk S, Kolenova A, Lazic J, Lo Nigro L, Mahlaoui N, Miller L, Papadakis V, Pecheux L, Pillon M, Sarouk I, Stary J, Stiakaki E, Strullu M, Tran TH, Ussowicz M, Verdu-Amoros J, Wakulinska A, Zawitkowska J, Stoppa-Lyonnet D, Taylor AM, Shiloh Y, Izraeli S, Minard-Colin V, Schmiegelow K, Nirel R, Attarbaschi A, Borkhardt A. . Blood 2024, 144(11), 1193-1205.
  • Bomken S, Enshaei A, Schwalbe EC, Mikulasova A, Dai Y, Zaka M, Fung K, Bashton M, Lim H, Jones L, Karataraki N, Winterman E, Ashby C, Attarbaschi A, Bertrand Y, Bradtke J, Buldini B, Burke GA, Cazzaniga G, Gohring G, de Groot-Kruseman H, Haferlach C, Lo Nigro L, Parihar M, Plesa A, Seaford E, Sonneveld E, Strehl S, van der Velden V, Rand V, Hunger SP, Harrison CJ, Bacon C, van Delft F, Loh M, Moppett J, Vormoor J, Walker B, Moorman AV, Russell L. . Haematologica 2023, 108(3), 717-731.
  • Offor UT, Hollis P, Ognjanovic M, Parry G, Khushnood A, Long HM, Gennery AR, Bacon CM, Simmonds J, Reinhardt Z, Bomken S. . BMJ Open 2023, 13(10), e079582.
  • Alexander S, Aupérin A, Bomken S, Csóka M, Kazanowska B, Chiang AK, Andres M, Uyttebroeck A, Burke A, Zsiros J, Pillon M, Bollard CM, Mussolin L, Verdu-Amoros J, Neven B, Barkauskas DA, Wheatley K, Patte C, Gross TG, Minard-Colin V. . The Lancet Haematology 2023, 10(6), E445-E457.
  • Khabirova E, Jardine L, Coorens THH, Webb S, Treger TD, Engelbert J, Porter T, Prigmore E, Collord G, Piapi A, Teichmann SA, Inglott S, Williams O, Heidenreich O, Young MD, Straathof K, Bomken S, Bartram J, Haniffa M, Behjati S. . Nature Medicine 2022, 28, 743-751.
  • Newman AM, Zaka M, Zhou P, Blain AE, Erhorn A, Barnard A, Crossland RE, Wilkinson S, Enshaei A, De Zordi J, Harding F, Taj M, Wood KM, Televantou D, Turner SD, Burke GAA, Harrison CJ, Bomken S, Bacon CM, Rand V. . Leukemia 2022, 36(3), 781-789.
  • Tirtakusuma R, Szoltysek K, Milne P, Grinev VV, Ptasinska A, Chin PS, Meyer C, Nakjang S, Hehir-Kwa JY, Williamson D, Cauchy P, Keane P, Assi SA, Ashtiani M, Kellaway SG, Imperato MR, Vogiatzi F, Schweighart EK, Lin S, Wunderlich M, Stutterheim J, Komkov A, Zerkalenkova E, Evans P, McNeill H, Elder A, Martinez-Soria N, Fordham SE, Shi Y, Russell LJ, Pal D, Smith A, Kingsbury Z, Becq J, Eckert C, Haas OA, Carey P, Bailey S, Skinner R, Miakova N, Collin M, Bigley V, Haniffa M, Marschalek R, Harrison CJ, Cargo CA, Schewe D, Olshanskaya Y, Thirman MJ, Cockerill PN, Mulloy JC, Blair HJ, Vormoor J, Allan JM, Bonifer C, Heidenreich O, Bomken S. . Blood 2022, 140(17), 1875-1890.
  • Offor UT, Bacon CM, Roberts J, Powell J, Brodlie M, Wood K, Windebank KP, Flett J, Hewitt T, Rand V, Hasan A, Parry G, Gennery AR, Reinhardt Z, Bomken S. . Journal of Heart and Lung Transplantation 2021, 35(5), 24-32.
  • Noble RA, Bell N, Blair H, Sikka A, Thomas H, Phillips N, Nakjang S, Miwa S, Crossland R, Rand V, Televantou D, Long A, Keun HC, Bacon CM, Bomken S, Critchlow SE, Wedge SR. . Haematologica 2017, 102(7), 1247-1257.
  • Milne P, Bigley V, Bacon CM, Néel A, McGovern N, Bomken S, Haniffa M, Diamond EL, Durham BH, Visser J, Hunt D, Gunawardena H, Macheta M, McClain KL, Allen C, Abdel-Wahab O, Collin M. . Blood 2017, 130(2), 167-175.
  • Elder A, Bomken S, Wilson I, Blair HJ, Cockell S, Ponthan F, Dormon K, Pal D, Heidenreich O, Vormoor J. . Leukemia 2017, 31, 2577-2586.
  • Attarbaschi A, Carraro E, Abla O, Barzilai-Birenboim S, Bomken S, Brugieres L, Bubanska E, Burkhardt B, Chiang AK, Csoka M, Fedorova A, Jazbec J, Kabickova E, Krenova Z, Lazic J, Loeffen J, Mann G, Niggli F, Miakova N, Osumi T, Ronceray L, Uyttebroeck A, Williams D, Woessmann W, Wrobel G, Pillon M. . Haematologica 2016, 101(12), 1581-1591.
  • Scherr M, Elder A, Battmer K, Barzan D, Bomken S, Ricke-Hoch M, Schröder A, Venturini L, Blair HJ, Vormoor J, Ottmann O, Ganser A, Pich A, Hilfiker-Kleiner D, Heidenreich O, Eder M. . Leukemia 2014, 28, 554-565.
  • Bomken S, Buechler L, Rehe K, Ponthan F, Elder A, Blair H, Bacon CM, Vormoor J, Heidenreich O. . Leukemia 2013, 27(3), 718-721.
  • Rehe K, Wilson K, Bomken S, Williamson D, Irving J, den Boer ML, Stanulla M, Schrappe M, Hall AG, Heidenreich O, Vormoor J. . EMBO Molecular Medicine 2013, 5(1), 38-51.
  • le Viseur C, Hotfilder M, Bomken S, Wilson K, Röttgers S, Schrauder A, Rosemann A, Irving JAE, Stam R, Shultz L, Harbott J, Jürgens H, Schrappe M, Pieters R, Vormoor HJ. . Cancer Cell 2008, 14(1), 47-58.