缅北禁地

I joined the Wellcome Centre for Mitochondrial Research at 缅北禁地 in 2013 to complete my PhD with Professor Doug Turnbull, Professor Robert Taylor and Dr Rita Barresi. I completed my PhD in May 2017 and continued as a post-doctoral scientist in the Centre.

In 2019, I was awarded a Sir Henry Wellcome Fellow. My fellowship aims to understand how mitochondrial DNA deletions clonally expand with age and disease, with a focus on the impact of skeletal muscle biology. I also supervise and work on a range of projects investigating mechanisms of mitochondrial dysfunction in skeletal muscle and mitochondrial disease progression.

Google Scholar:

SCOPUS:

Mitochondrial DNA mutations and mitochondrial respiratory chain deficiency arise in a mosaic pattern within the skeletal muscle of patients with mitochondrial myopathy. However, they are also found in a number of other myopathies and in aging skeletal muscle.
My work looks to investigate mitochondria dysfunction and associated pathogenic mechanisms in both mitochondrial and other myopathies. My group and I are doing this in a number of ways:

1) Attempting to understand how mtDNA mutations accumulate in skeletal muscle and the impact of this process on disease progression with age.

2) Looking at the interactions between mitochondrial structure and function and muscle structure and function

3) Looking to understand the impacts of exercise intervention.

I supervise PhD students who are mainly working on understanding the pathogenesis of mitochondrial dysfunction in skeletal muscle. However I am also involved in the supervision of student using 3D Electron microscopy in human brain and developing image analysis and in silico modelling methods for study of mitochondrial disease.

• Bury A, Vincent AE, Turnbull DM, Actis P, Hudson G. . Wellcome Open Research 2020, 5, 226.
• Mito T, Vincent AE, Faitg J, Taylor RW, Khan N, McWilliam TG, Suomalainen A. . Cell Metabolism 2022, 34(2), 197-208.
• Faitg J, Lacefield C, Davey T, White K, Laws R, Kosmidis S, Reeve AK, Kandel ER, Vincent AE, Picard M. . Cell Reports 2021, 36, 108509.
• Chen C, Mossman E, Malko P, McDonald D, Blain AP, Bone L, Erskine D, Filby A, Vincent AE, Hudson G, Reeve AK. . Movement Disorders 2022, 37(2), 302-314.
• Chen C, McDonald D, Blain A, Sachdeva A, Bone L, Smith ALM, Warren C, Pickett SJ, Hudson G, Filby A, Vincent AE, Turnbull DM, Reeve AK. . npj Parkinson's Disease 2021, 7(1), 39.
• Gomes TMB, Ng YS, Pickett SJ, Turnbull DM, Vincent AE. . Human Molecular Genetics 2021, 30(R2), R245-R253.
• Frazier AE, Vincent AE, Turnbull DM, Thorburn DR, Taylor RW. . In: Liza A. Pon, Eric A. Schon, ed. Mitochondria, 3rd Edition. London: Academic Press, 2020, pp.121-156.
• Warren C, McDonald D, Capaldi R, Deehan D, Taylor RW, Filby A, Turnbull DM, Lawless C, Vincent AE. . Scientific Reports 2020, 10(1), 15336.
• Zhang l, Evans A, Von Ruhland C, Shazli Draman M, Edkins S, Vincent A, Berlinguer-Palmini R, Rees D, Haridas A, Morris D, Tee A, Ludgate M, Turnbull D, Karpe F, Dayan C. . International Journal of Molecular Sciences 2020, 21(23), 9145.
• Chen C, Vincent AE, Blain AP, Smith AL, Turnbull DM, Reeve AK. . Neurobiology of Disease 2020, 134, 104631.
• Faitg J, Davey T, Turnbull DM, White K, Vincent AE. . Journal of Microscopy 2020, 278(2), 89-106.
• Yarnall AJ, Granic A, Waite S, Hollingsworth KG, Warren C, Vincent AE, Turnbull DM, Taylor RW, Dodds RM, Sayer AA. . Experimental Gerontology 2020, 138, 110997.
• Lawless C, Greaves L, Reeve AK, Turnbull DM, Vincent AE. . Open biology 2020, 10(5), 200061.
• Trumpff C, Marsland AL, Basualto-Alarcon C, Martin JL, Carroll JE, Sturm G, Vincent AE, Mosharov EV, Gu Z, Kaufman BA, Picard M. . Psychoneuroendocrinology 2019, 106, 268-276.
• Vincent AE, White K, Davey T, Philips J, Ogden RT, Lawless C, Warren C, Hall MG, Ng YS, Falkous G, Holden T, Deehan D, Taylor RW, Turnbull DM, Picard M. . Cell Reports 2019, 26(4), 996-1009.e4.
• Lehmann D, Tuppen HAL, Campbell G, Alston CL, Lawless C, Rosa HS, Rocha MC, Reeve AK, Nicholls TJ, Deschauer M, Zierz S, Taylor RW, Turnbull DM, Vincent AE. . Nucleic Acids Research 2019, 47(14), 7430–7443.
• Ahmed ST, Craven C, Russell OM, Turnbull DM, Vincent AE. . Neurotherapeutics 2018, 15(4), 943-953.
• Bacalhau M, Simoes M, Rocha MC, Hardy SA, Vincent AE, Duraes J, Macario MC, Santos MJ, Rebelo O, Lopes C, Pratas J, Mendes C, Zuzarte M, Rego AC, Girao H, Wong LJC, Taylor RW, Grazina M. . Neuromuscular Disorders 2018, 28(4), 350-360.
• Vincent AE, Picard M. . Journal of Pathology 2018, 246(3), 261-265.
• Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel K, Rocha MC, Reeve AK, Falkous G, Perissi V, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. . Annals of Neurology 2018, 84(2), 289-301.
• Vincent AE, Turnbull DM, Eisner V, Hajnóczky G, Picard M. . Trends in Cell Biology 2017, 27(11), 787-799.
• Vincent AE, Rosa H, Rygiel KA, Grady JP, Rocha MC, Taylor RW, Picard M, Turnbull DM. . In: Mitochondria Research Society/United Mitochondrial Disease Foundation Meeting. 2016, Elsevier BV.
• Rygiel KA, Tuppen HA, Grady JP, Vincent A, Blakely EL, Reeve AK, Taylor RW, Picard M, Miller J, Turnbull DM. . Nucleic Acids Research 2016, 44(11), 5313-5329.
• Vincent AE, Rosa HS, Alston CL, Grady JP, Rygiel KA, Rocha MC, Barresi R, Taylor RW, Turnbull DM. . Neuromuscular Disorders 2016, 26(11), 782-788.
• Picard M, Vincent AE, Turnbull DM. . Cell Metabolism 2016, 24(1), 3-4.
• Cadete VJJ, Deschenes S, Cuillerier A, Brisebois F, Sugiura A, Vincent A, Turnbull D, Picard M, McBride HM, Burelle Y. . Journal of Physiology 2016, 594(18), 5343-5362.
• Vincent AE, Grady JP, Rocha MC, Alston CL, Rygiel KA, Barresi R, Taylor RW, Turnbull DM. . Neuromuscular Disorders 2016, 26(10), 691-701.
• Vincent AE, Ng YS, White K, Davey T, Mannella C, Falkous G, Feeney C, Schaefer AM, McFarland R, Gorman GS, Taylor RW, Turnbull DM, Picard M. . Scientific Reports 2016, 6, 30610.
• Rocha MC, Grady JP, Grünewald A, Vincent A, Dobson PF, Taylor RW, Turnbull DM, Rygiel KA. . Scientific Reports 2015, 5, 15037.