缅北禁地

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Staff Profile

Dr Annette Meeson

Lecturer

  • Address: 缅北禁地
    International Centre for Life
    Central Parkway
    缅北禁地 upon Tyne
    NE1 3BZ
Background

Previous positions:

2001- 2005     Instructor, Molecular Cardiology, UT Southwestern Medical Ctr, Dallas, TX

1997- 2001     Postdoctoral Fellow, Molecular Cardiology, UT Southwestern, Medical Ctr, Dallas, TX

1994-1997      Postdoctoral Fellow, Skirball Institute, New York University Medical Ctr, New York, NY

1990-1994     PhD, Neurobiology, Imperial College of Science, Technology and Medicine, London, UK  

1987-1990      Scientific Officer, National Institute of Medical Research, Mill Hill, London, UK


Honorary positions:

Research Fellow, Advanced Medical and Dental Institute, Universiti Sains, Malaysia, 1st January 2016 -Jan 2017


Research Fellow, Advanced Medical and Dental Institute, Universiti Sains, Malaysia, January 2017 - January 2018

Honorary Lecturer, Musculoskeletal Biology, University of Liverpool, 2019-2024



Google scholar:

Research

Research Focus                                        

Adult stem cells

Although many cells are fate committed before or shortly after birth some adult tissues retain stem cells that are capable of multilineage differentiation. Our research efforts focus on expanding our knowledge of the fundamental regulatory mechanisms that restrict differentiation of these cells during normal development and that regulate the cellular proliferation, differentiation and plasticity of these cells in response to injury or disease.

Stem cells and cardiac regeneration.

Recent studies suggest that the heart is capable of limited regeneration which may be due to the activation of a resident cardiac stem cell population or to the recruitment of stem cells from other tissues. We have identified and isolated stem cells known as side population (SP) cells from both human heart and bone marrow. SP cells from both these sources are capable of migration into the injured myocardium and are able to differentiation towards a cardiac lineage.

Stem cells, tumour formation and cancers.

There is an increasing body of evidence that suggests that recurrence of some cancers may be due in part to cancer stem cell like cells. Stem cells make ideal candidates for the progression of cancer as they are long lived, slow cycling and exhibit some level of drug resistance.

Breast cancer: In collaboration with surgical teams at the Royal Victoria Infirmary we have identified two putative breast cancer stem cell populations CD44 /CD24- breast cancer stem cells and breast cancer SP cells. We have been able to identify SP cells in solid breast tumours, from fluid obtained as fine needle aspirates (FNAs) associated with palpable breast tumours and in breast cancer cell lines. More importantly, we have shown that these cells are more resistant than the bulk tumour cells to drugs currently used in the treatment of breast cancer patients. Our recent analysis of FNAs suggests that the presence of SP cells is more frequently associated with triple negative cancers (associated with patients whose prognostic outcome is generally poor) and that a statistically significant relationship exists between the presence of SP cells and ER- breast tumours.

Ovarian cancer: We have also been able to identify SP cells in ascitic fluid of ovarian cancer patients and again can shown that these cells are capable of drug resistance to currently used chemotherapeutic agents.


Teaching

Module leader for Enabling Technologies and Methodologies for Biomedical Research 2022 

Education theme lead for IMA 2020 to present day

Programme leader for Stem cells and regenerative medicine MRes 2007 to 2022

Module leader for Stem cells and regenerative medicine MRes 2007 to 2022

Deputy Degree Program Director Masters of Clinical Research 2016 -2017 

Publications

  • Articles

    • Mallini P, Chen M, Mahkamova K, Lennard TWJ, Pan Y, Wei D, Stemke-Hale K, Kirby JA, Lash GE, Meeson A. . Cancers 2023, 15(4), 1108.
    • Czosseck A, Chen MM, Nguyen H, Meeson A, Hsu C, Chen C, George TA, Ruan S, Cheng Y, Lin P, Hsieh PCH, Lundy DJ. . Journal of Controlled Release 2022, 352, 879-892.
    • Latar NM, Mahkamova K, Elson J, Karnik I, Sutherland R, Aspinall S, Meeson A. . Endocrine 2022, 76, 359-368.
    • Oldershaw RA, Richardson GD, Carling P, Owens WA, Lundy DJ, Meeson A. . Biomedicines 2022, 10(12), 3143.
    • Oldershaw R, Richardson G, Carling P, Owens WA, Lundy DJ, Meeson A. Cardiac mesenchymal stem cell-like cells derived from a young patient with bicuspid aortic valve disease have a prematurely aged phenotype. Biomedicines 2022, 10(12), 3143. In Preparation.
    • Del Molino Del Barrio I, Meeson A, Cooke K, Malki MI, Barron-Millar B, Kirby JA, Ali S. . Cancers 2021, 13(14), 3462.
    • Mahkamova K, Md Latar N, Aspinall S, Meeson A. . Experimental Cell Research 2019, 374(1), 104-113.
    • Oldershaw R, Owens WA, Sutherland R, Linney M, Liddle R, Magana L, Lash GE, Gill JH, Richardson G, Meeson A. . Stem Cells and Development 2019, 28(9), 593-607.
    • Mahkamova K, Latar N, Aspinall S, Meeson A. . World Journal of Surgery 2018, 42(2), 350-357.
    • del Molino del Barrio I, Wilkins GC, Meeson A, Ali S, Kirby JA. . International Journal of Molecular Sciences 2018, 19(11), 3592.
    • Shaharuddin B, Ahmad S, MdLatar N, Ali S, Meeson A. . Stem Cells Translational Medicine 2017, 6(3), 761-766.
    • Shaharuddin B, Osei-Bempong C, Ahmad S, Rooney P, Ali S, Oldershaw R, Meeson A. . Regenerative Medicine 2016, 11(3), 273-286.
    • Eyre R, Harvey I, Stemke-Hale K, Lennard TWJ, Tyson-Capper AJ, Meeson AP. . Tumor Biology 2014.
    • Shaharuddin B, Harvey I, Ahmad S, Ali S, Meeson A. . Stem Cell Reviews and Reports 2014, 10(2), 240-250.
    • Douglass A, Meeson AP, Overbeck-Zubrzycka D, Brain JG, Bennett MR, Lamb CA, Lennard TWJ, Browell D, Ali S, Kirby JA. . The Journal of Pathology 2014, 234(1), 74-85.
    • Meeson A, Fuller A, Breault D, Owens W, Richardson G. . Stem Cell Reviews and Reports 2013, 9(5), 731-739.
    • Knuth CA, Clark ME, Meeson AP, Khan SK, Dowen DJ, Deehan DJ, Oldershaw RA. . Stem Cell Reviews and Reports 2013, 9(5), 599-608.
    • Alfakir A, Dawe N, Eyre R, Tyson-Capper A, Britton K, Robson SC, Meeson AP. . International Journal of Cardiology 2012, 156(2), 133-138.
    • Britton KM, Eyre R, Harvey IJ, Stemke-Hale K, Browell D, Lennard TWJ, Meeson AP. . Cancer Letters 2012, 323(1), 97-105.
    • Meeson AP, Shi X, Alexander MS, Williams RS, Allen RE, Jiang N, Adham IM, Goetsch SC, Hammer RE, Garry DJ. . EMBO Journal 2007, 26(7), 1902-1912.
    • Naseem RH, Meeson AP, DiMaio JM, White MD, Kallhoff J, Humphries C, Goetsch SG, De Windt LJ, Williams MA, Garry MG, Garry DJ. . Physiological Genomics 2007, 30(1), 44-52.
    • Martin CM, Meeson AP, Robertson SC, Hawke TJ, Richardson JA, Bates S, Goetsch SC, Gallardo TD, Garry DJ. . Developmental Biology 2004, 265(1), 262-275.
    • Meeson AP, Hawke TJ, Graham S, Jiang N, Elterman J, Hutcheson K, DiMaio J. Michael, Gallardo TD, Garry DJ. . Stem Cells 2004, 22(7), 1305-1320.
    • Garry DJ, Masino AM, Meeson AP, Martin CM. . Current opinion in Nephrology and Hypertension 2003, 12(4), 447-454.
    • Hawke TJ, Meeson A, Jiang N, Shalley S, Hutcheson K, Di Maio JM, Garry DJ. . AJP: Cell Physiology Online 2003, 285(5), C1019-C1027.
    • Grange RW, Meeson AP, Chin E, Lau KS, Stull JT, Shelton JM, Williams RS, Garry DJ. . American Journal of Physiology: Cell Physiology 2001, 281(5), 1487-1494.
    • Meeson AP, Radford N, Shelton J, Pradeep PA, Mammen P, Michael DiMaio J, Hutcheson K, Kong Y, Elterman J, Sanders Williams R, Garry DJ. . Circulation Research 2001, 88(7), 713-720.
    • Garry DJ, Meeson A, Elterman J, Zhao Y, Yang P, Bassel-Duby R, Williams RS. . Proceedings of the National Academy of Sciences 2000, 97(10), 5416-5426.
    • Garry DJ, Meeson A, Yang Z, Williams RS. . Cellular and Molecular Life Sciences 2000, 57(6), 896-898.
    • Meeson A, Agrilla M, Neufeld G, Lang R. . Development 1999, 126(7), 1407-1415.
    • R. Reynolds, I. Cenci di Bello, A. Meeson and S. Piddlesden. Comparison of a chemically mediated and an immunologically mediated demyelinating lesion model. Methods: A companion to Methods in Enzymology 1996, 10, 440-452.
    • A.P.Meeson, M. Palmer, M. Calfon and R. Lang. A relationship between apoptosis and flow during programmed capillary regression is revealed by vital analysis. Development 1996, 122, 3929-3938.
    • A.P. Meeson, S. Piddlesden, B.P. Morgan and R. Reynolds. The distribution of inflammatory demyelinating lesions in the CNS of rats with antibody-augmented demyelinating experimental allergic encephalomyelitis (ADEAE. Experimental Neurology 1994, 129, 2-13.
    • J. Newcombe, A.P. Meeson and M. L. Cuzner. Immunocytochemical characterization of primary glial cell cultures form normal adult human brain. Neuropathology & Applied Neurobiology 1988, 14, 453-465.

  • Book Chapters

    • Meeson A, Weisel RD. . In: Li,R-E; Weisel,RD, ed. Cardiac Regeneration and Repair. Woodhead Publishing, 2014.
    • Meeson A. Side Population Cells. In: Schwab, M, ed. Encyclopedia of Cancer. Berlin, Germany: Springer, 2012.

  • Letters

    • Meeson A. . Stem Cells and Development 2011, 20(9), 1477.
    • Nilsson J, Ali S, Harvey I, Kirby J, Meeson A. . International Journal of Cardiology 2010, 145(3), 554-555.

  • Note

    • del Molino del Barrio I, Wilkins GC, Meeson A, Ali S, Kirby JA. . International Journal of Molecular Sciences 2023, 24(23), 17108.

  • Reviews

    • Karnik I, Sutherland R, Elson J, Aspinall S, Meeson A. . Biochimica et Biophysica Acta - Reviews on Cancer 2022, 1877(4), 188752.
    • George TA, Hsu CC, Meeson A, Lundy DJ. . Pharmaceutics 2022, 14(5), 930.
    • Sutherland R, Meeson A, Lowes S. . Cancer and Metastasis Reviews 2020, 39, 919-932.
    • Md Latar N, Mahkamova K, Aspinall S, Meeson A. . Journal of Surgical Academia 2016, 6(2), 4-11.
    • Shaharuddin B, Meeson A. . Journal of Stem Cells Research, Reviews & Reports 2015, 2(1), 1-8.
    • Mallini P, Lennard T, Kirby J, Meeson A. . Cancer Treatment Reviews 2014, 40(3), 341-348.
    • Shaharuddin B, Ahmad S, Ali S, Meeson A. . Regenerative Medicine 2013, 8(3), 319-331.
    • Shaharuddin B, Ahmad S, Meeson A, Ali S. . Stem Cells Translational Medicine 2013, 2(8), 614-624.
    • Meeson A. . European Pharmaceutical Review 2013, 18(2), 29-31.
    • Douglass S, Ali S, Meeson AP, Browell D, Kirby JA. . Cancer and Metastasis Reviews 2012, 31(3-4), 843-854.
    • Britton KM, Kirby JA, Lennard TWJ, Meeson AP. . Cancers 2011, 3(2), 2106-2130.