缅北禁地

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Staff Profile

Professor Brian Morgan

Professor of Yeast Molecular Biology

  • Email: brian.morgan@ncl.ac.uk
  • Telephone: +44 (0) 191 208 7694
  • Fax: +44 (0) 191 208 7424
  • Address: Institute for Cell and Molecular Biosciences
    The Medical School
    University of 缅北禁地 upon Tyne
    Framlington Place
    缅北禁地 upon Tyne
    NE2 4HH
Background

Qualifications

BSc Molecular Biology (University of Glasgow)
PhD Molecular Biology (University of Edinburgh)

Research

Research Interests

My laboratory is interested in the regulation of the oxidative stress response and the regulation of the cell division cycle in eukaryotes. Specifically we are investigating the regulation of gene expression important for these cellular events and exploring the signal transduction pathways which regulate this gene expression. We use the yeast Saccharomyces cerevisiae and Schizosaccharomyces pombe as model organisms to study these regulatory mechanisms as many aspects of these cellular processes are conserved in all eukaryotes. This choice of organisms allows us to apply a wide range of experimental tools including classical genetic and biochemical approaches as well as standard molecular biology techniques.

Publications
  • Day AM, Smith DA, Ikeh MAC, Haider M, Herrero-de-Dios CM, Brown AJP, Morgan BAM, Erwig LP, MacCallum DM, Quinn J. . PLoS Pathogens 2017, 13(1), e1006131.
  • Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI. . Autophagy 2016, 12(10), 1917-1930.
  • Veal EA, Tomalin LE, Morgan BA, Day AM. . Biochemistry Society Transactions 2014, 42(4), 909-916.
  • Brown JD, Day AM, Taylor SR, Tomalin LE, Morgan BA, Veal EA. . Cell Reports 2013, 5(5), 1425-1435.
  • Patterson M, McKenzie C, Smith D, da Silva Dantas A, Sherston S, Veal EA, Morgan B, MacCallum D, Erwig LP, Quinn J. . Antioxidants & Redox Signaling 2013, 19(18), 2244-2260.
  • Flanagan MD, Whitehall SK, Morgan BA. . Cell Cycle 2013, 12(2), 271-277.
  • Day AM, Brown JD, Taylor SR, Rand JD, Morgan BA, Veal EA. . Molecular Cell 2012, 45(3), 398-408.
  • Doris KS, Rumsby EL, Morgan BA. . Molecular and Cellular Biology 2012, 32(21), 4472-4481.
  • Darieva Z, Han N, Warwood S, Doris KS, Morgan BA, Sharrocks AD. . Molecular and Cellular Biology 2012, 32(22), 4651-4661.
  • Smith DA, MacCallum DM, Morgan BA, Quinn J. . In: 18th Congress of the International Society for Human and Animal Mycology. 2012, Berlin, Germany: Wiley-Blackwell Verlag GmbH.
  • Bruce CR, Smith DA, Rodgers D, Dantas AD, MacCallum DM, Morgan BA, Quinn J. . PLoS One 2011, 6(12), e27979.
  • Purtill FS, Whitehall SK, Williams ES, McInerny CJ, Sharrocks AD, Morgan BA. . Cell Cycle 2011, 10(4), 664-670.
  • Quinn J, Malakasi P, Smith DA, Cheetham J, Buck V, Millar J, Morgan BA. . Antioxidants & Redox Signaling 2011, 15(1), 153-165.
  • Darieva Z, Clancy A, Bulmer R, Williams E, Pic-Taylor A, Morgan BA, Sharrocks AD. . Molecular Cell 2010, 38(1), 29-40.
  • da Silva Dantas A, Patterson MJ, Smith DA, MacCallum DM, Erwig LP, Morgan BA, Quinn J. . Molecular and Cellular Biology 2010, 30(19), 4550-4563.
  • Smith DA, Morgan BA, Quinn J. . FEMS Microbiology Letters 2010, 306(1), 1-8.
  • Veal E, Olahova M, Taylor SR, Khazaipoul S, Wang J, Crook H, Day A, Morgan B, Matsumoto K, Blackwell K. . In: 31st Annual Meeting of the United Kingdom Environmental Mutagen Society. 2009, University of Northumbria, 缅北禁地 upon Tyne: Oxford University Press.
  • Oláhová M, Taylor SR, Khazaiphoul S, Wang J, Morgan BA, Matsumoto K, Blackwell TK, Veal EA. . Proceedings of the National Academy of Sciences 2008, 105(50), 19839-19844.
  • Veal EA, Day AM, Morgan BA. . Molecular Cell 2007, 26(1), 1-14.
  • Morgan BA, Veal EA. . In: Flohe, L; Harris, R, ed. Peroxiredoxin Systems: Structures and Functions. New York: Springer, 2007, pp.253-265.
  • Darieva Z, Bulmer R, Pic-Taylor A, Doris KS, Geymonat M, Sedgwick SG, Morgan BA, Sharrocks AD. . Nature 2006, 444(7118), 494-498.
  • Bozonet SM, Findlay VJ, Day AM, Cameron J, Veal EA, Morgan BA. . Journal of Biological Chemistry 2005, 280(24), 23319-23327.
  • Veal EA, Findlay VJ, Day AM, Bozonet SM, Evans JM, Quinn J, Morgan BA. . Molecular Cell 2004, 15(1), 129-139.
  • Smith DA, Nicholls S, Morgan BA, Brown AJP, Quinn J. . Molecular Biology of the Cell 2004, 15(9), 4179-4190.
  • Pic-Taylor A, Darieva Z, Morgan BA, Sharrocks AD. . Molecular and Cellular Biology 2004, 24(22), 10036-10046.
  • Bulmer R, Pic-Taylor A, Whitehall SK, Martin KA, Millar JBA, Quinn J, Morgan BA. . Eukaryotic Cell 2004, 3(4), 944-954.
  • Darieva Z, Pic-Taylor A, Boros J, Spanos A, Geymonat M, Reece RJ, Sedgwick SG, Sharrocks AD, Morgan BA. . Current Biology 2003, 13(19), 1740-1745.
  • Lim F-L, Hayes A, West AG, Pic-Taylor A, Darieva Z, Morgan BA, Oliver SG, Sharrocks AD. . Molecular and Cellular Biology 2003, 23(2), 450-461.
  • Boros J, Lim F-L, Darieva Z, Pic-Taylor A, Harman R, Morgan BA, Sharrocks AD. . Nucleic Acids Research 2003, 31(9), 2279-2288.
  • Veal EA, Ross SJ, Malakasi P, Peacock E, Morgan BA. . Journal of Biological Chemistry 2003, 278(33), 30896-30904.
  • Quinn J, Findlay VJ, Dawson K, Millar JB, Jones N, Morgan BA, Toone WM. . Molecular Biology of the Cell 2002, 13(3), 805-816.
  • Veal EA, Mark Toone W, Jones N, Morgan BA. . Journal of Biological Chemistry 2002, 277(38), 35523-35531.
  • Greenall A, Hadcroft AP, Malakasi P, Jones N, Morgan BA, Hoffman CS, Whitehall SK. . Molecular Biology of the Cell 2002, 13(9), 2977-2989.
  • Smith DA, Mark Toone W, Chen D, Bahler J, Jones N, Morgan BA, Quinn J. . Journal of Biological Chemistry 2002, 277(36), 33411-33421.
  • Buck V, Quinn J, Pino TS, Martin H, Saldanha J, Makino K, Morgan BA, Millar JBA. . Molecular Biology of the Cell 2001, 12(2), 407-419.
  • Toone WM, Morgan BA, Jones N. . Oncogene 2001, 20(19), 2336-2346.
  • Pic A, Lim F-L, Ross SJ, Veal EA, Johnson AL, Sultan MRA, West AG, Johnston LH, Sharrocks AD, Morgan BA. . EMBO Journal 2000, 19(14), 3750-3761.
  • Ross SJ, Findlay VJ, Malakasi P, Morgan BA. . Molecular Biology of the Cell 2000, 11(8), 2631-2642.
  • Raitt DC, Johnson AL, Erkine AM, Makino K, Morgan B, Gross DS, Johnston LH. . Molecular Biology of the Cell 2000, 11(7), 2335-2347.
  • Bouquin N, Johnson AL, Morgan BA, Johnston LH. . Molecular Biology of the Cell 1999, 10(10), 3389-3400.
  • W. M. Toone, S. Kuge, M. Samuels, B. A. Morgan, T. Toda and N. Jones. Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1. Genes & Development 1998, 12, 1453-1463.
  • Sedgwick S.G., Taylor I.A., Adam A.C., Spanos A., Howell S., Morgan B.A., Treiber M.K., Kanuga N., Banks G.R., Foord R. and Smerdon S.J. Structural and functional architecture of the yeast cell-cycle transcription factor Swi6. Journal of Molecular Biology 1998, 281, 763-775.
  • B. A. Morgan, G. R. Banks, W. M. Toone, D. Raitt, S. Kuge and L. H. Johnston. The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae. Embo Journal 1997, 16, 1035-1044.
  • Shieh J-C., Wilkinson M., Buck V., Morgan B.A., Makino K. and Millar J.B.A. The Mcs4 response regulator co-ordinately controls the stress activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle. Genes and Development 1997, 11, 1008-1022.
  • W. M. Toone, B. L. Aerne, B. A. Morgan and L. H. Johnston. Getting started: Regulating the initiation of DNA replication in yeast. Annual Review of Microbiology 1997, 51, 125-149.
  • Machado A.K., Morgan B.A. and Merrill G.F. Thioredoxin reductase-dependent inhibition of MCB cell cycle box activity in Saccharomyces cerevisiae. Journal of Biological Chemistry 1997, 272, 17045-17054.
  • Veal EA, Underwood ZE, Tomalin LE, Morgan BA, Pillay CS. . Antioxidants and Redox Signaling 2018, 28(7), 574-590.