缅北禁地

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Staff Profile

Claire Schwab

Research Cytogeneticist

  • Telephone: +44 (0) 191 241 8795
  • Address: Leukaemia Research Cytogenetics Group
    Wolfson Childhood Cancer Research Centre
    Level 6, Herschel Building
    Brewery Lane
    缅北禁地-upon-Tyne
    NE1 7RU
Background

I am a State Registered Clinical Cytogeneticist and I worked for 7 years in the National Health Service. I now have over 10 years research experience. Since moving into research in 2008, I have led a range of projects in the field of genetics of acute leukaemia in children. I have been responsible for the introduction and integration of novel molecular tests (fluorescence in situ hybridisation (FISH), multiplex ligation-dependent probe amplification (MLPA) and genome-wide SNP array) into routine practice within the UK acute leukaemia treatment trials.


Qualifications

  • PhD by published works - Identification and Characterisation of Cytogenetic Subgroups in Childhood B-cell Precursor Acute Lymphoblastic Leukaemia  缅北禁地 (2018)
  • Registered Clinical Scientist with the Health Professions Council (HPC)(Since Feb 2005)
  • BSc (Hons) Genetics 缅北禁地 (2000)   

Prizes

  • 缅北禁地 Medical Sciences Doctoral Prize for Outstanding Thesis (2019) 

Funding

  • Co-applicant on Blood Cancer UK Continuity Grant (2021-23) - “Refined risk stratification for children with acute myeloid leukaemia treated on Myechild 01 and acute lymphoblastic leukaemia on UKALL2011”


Google scholar:

Research

In contrast to childhood acute lymphoblastic leukaemia (ALL) with >90% survival rates, acute myeloid leukaemia (AML) in children has a high relapse rate (30-40%) and although a rare disease remains a major cause of childhood cancer mortality. In previous UK AML treatment trials, children were classified and treated alongside adult patients. Recently, an international treatment trial specifically for childhood AML, MyeChild 01 has recruited more than 700 patients (0-18 years) from centres in the UK, Republic of Ireland, France, Australia and New Zealand. Risk stratification for treatment was based on diagnostic cytogenetics and limited molecular markers. In ~70% of childhood AML, a fusion gene, NPM1 mutation or FLT3-ITD was detected. The remaining 30% had no prognostic marker.


As part of my role within the Leukaemia Research Cytogenetics Group (LRCG), I am the genetics co-ordinator for the Myechild 01 trial. This role involves curation and integration of all standard-of-care genetic data generated within the regional NHS genetic laboratories to ensure accuracy of results. I designed the testing algorithm for the rare (often cryptic) risk stratifying abnormalities, developing and refining specialist genetic tests throughout the trial. This algorithm was adopted in UK and Australasia.


During the trial, I also oversaw the collection of diagnostic bone marrow samples from the individual treatment centres, with approval from MyeChild 01, for transcriptome (RNAseq) and whole genome sequencing (WGS). The resulting cohort consists of >600 samples with high quality DNA and RNA, linked to excellent genetic and clinical annotation. My current research is focused on maximising the output from this precious dataset.

Teaching

Student Supervision


MRes: Project Supervisor for ten MRes students (2012-2022)

BSc: Project Supervisor for ten undergraduate students (Biomedical Sciences) (2012-2022)


Lecturing

BGM 3060 - Diagnostic Medical Genetics (2016-present)




Publications

  • Articles

    • Ryan SL, Peden JF, Kingsbury Z, Schwab CJ, James T, Polonen P, Mijuskovic M, Becq J, Yim R, Cranston RE, Hedges DJ, Roberts KG, Mullighan CG, Vora A, Russell LJ, Bain R, Moorman AV, Bentley DR, Harrison CJ, Ross MT. . Leukemia 2023, 37, 518-528.
    • Schwab C, Cranston RE, Ryan SL, Butler E, Winterman E, Hawking Z, Bashton M, Enshaei A, Russell LJ, Kingsbury Z, Peden JF, Barretta E, Murray J, Gibson J, Hinchliffe AC, Bain R, Vora A, Bentley DR, Ross MT, Moorman AV, Harrison CJ. . Leukemia 2023, 37, 529-538.
    • Masic D, Fee K, Bell H, Case M, Witherington G, Lansbury S, Ojeda-Garcia J, McDonald D, Schwab C, Van Delft FW, Filby A, Irving JAE. . Haematologica 2023, 108(4), 981-992.
    • Moorman AV, Barretta E, Butler ER, Ward EJ, Twentyman K, Kirkwood AA, Enshaei A, Schwab C, Creasey T, Leongamornlert D, Papaemmanuil E, Patrick P, Clifton-Hadley L, Patel B, Menne T, McMillan AK, Harrison CJ, Rowntree CJ, Marks DI, Fielding AK. . Leukemia 2022, 36, 625-636.
    • Pal D, Blair H, Parker J, Hockney S, Beckett M, Singh M, Tirtakusuma R, Nelson R, McNeill H, Angel SH, Wilson A, Nizami S, Nakjang S, Zhou P, Schwab C, Sinclair P, Russell LJ, Coxhead J, Halsey C, Allan JM, Harrison CJ, Moorman AV, Heidenreich O, Vormoor J. . Cell Reports Medicine 2022, 3(8), 100717.
    • Schwab CJ, Murdy D, Butler E, Enshaei A, Winterman E, Cranston RE, Ryan S, Barretta E, Hawking Z, Murray J, Antony G, Vora A, Moorman AV, Harrison CJ. . British Journal of Haematology 2022, 196(3), 753-763.
    • Creasey T, Enshaei A, Nebral K, Schwab C, Watts K, Cuthbert G, Vora A, Moppett J, Harrison CJ, Fielding AD, Haas OA, Moorman AV. . Genes Chromosomes Cancer 2021, 60(9), 604-615.
    • Bardelli V, Arniani S, Pierini V, Pierini T, Di Giacomo D, Gorello P, Moretti M, Pellanera F, Elia L, Vitale A, Storlazzi CT, Tolomeo D, Mastrodicasa E, Caniglia M, Chiaretti S, Ruggeri L, Roti G, Schwab C, Harrison CJ, Almeida A, Pieters T, Van Vlierberghe P, Mecucci C, La Starza R. . Genes Chromosomes and Cancer 2021, 60(7), 482-488.
    • Boer JM, Valsecchi MG, Hormann FM, Antic Z, Zaliova M, Schwab C, Cazzaniga G, Arfeuille C, Cave H, Attarbaschi A, Strehl S, Escherich G, Imamura T, Ohki K, Gruber TA, Sutton R, Pastorczak A, Lammens T, Lambert F, Li CK, Carrillo de Santa Pau E, Hoffmann S, Moricke A, Harrison CJ, Den Boer ML, De Lorenzo P, Stam RW, Bergmann AK, Pieters R. . Leukemia 2021, 35, 2978-2982.
    • La Starza R, Pierini V, Pierini T, Nofrini V, Matteucci C, Arniani S, Moretti M, Lema Fernandez AG, Pellanera F, Di Giacomo D, Storlazzi TC, Vitale A, Gorello P, Sammarelli G, Roti G, Basso G, Chiaretti S, Foa R, Schwab C, Harrison CJ, Van Vlierberghe P, Mecucci C. . Journal of Molecular Diagnostics 2020, 22(5), 629-639.
    • Bashton M, Hollis R, Ryan S, Schwab CJ, Moppett J, Harrison CJ, Moorman AV, Enshaei A. . Scientific Reports 2020, 10, 45.
    • Moorman AV, Schwab C, Winterman E, Hancock J, Castleton A, Cummins M, Gibson B, Goulden N, Kearns P, James B, Kirkwood AA, Lancaster D, Madi M, McMillan A, Motwani J, Norton A, O'Marcaigh A, Patrick K, Bhatnagar N, Qureshi A, Richardson D, Stokley S, Taylor G, van Delft FW, Moppett J, Harrison CJ, Samarasinghe S, Vora A. . British Journal of Haematology 2020, 191(5), 844-851.
    • Enshaei A, O'Connor D, Bartram J, Hancock J, Harrison CJ, Hough R, Samarasinghe S, den Boer ML, Boer JM, de Groot-Kruseman HA, Marquart HV, Noren-Nystrom U, Schmiegelow K, Schwab C, Horstmann MA, Escherich G, Heyman M, Pieters R, Vora A, Moppett J, Moorman AV. . Blood 2020, 135(17), 1438-1446.
    • Hamadeh L, Enshaei A, Schwab C, Alonso CN, Attarbaschi A, Barbany G, den Boer ML, Boer JM, Braun M, Dalla Pozza L, Elitzur S, Emerenciano M, Fechina L, Felice MS, Fronkova E, Haltrich I, Heyman MM, Horibe K, Imamura T, Jeison M, Kovács G, Kuiper RP, Mlynarski W, Nebral K, Ivanov Öfverholm I, Pastorczak A, Pieters R, Piko H, Pombo-de-Oliveira MS, Rubio P, Strehl S, Stary J, Sutton R, Trka J, Tsaur G, Venn N, Vora A, Yano M, Harrison CJ, Moorman AV. . Blood Advances 2019, 3(2), 148-157.
    • Sinclair PB, Ryan S, Bashton M, Hollern S, Hanna R, Case M, Schwalbe EC, Schwab CJ, Cranston RE, Young BD, Irving JAE, Vora AJ, Moorman AV, Harrison CJ. . Leukemia 2019, 33, 1881-1894.
    • Girardi T, Vereecke S, Sulima SO, Khan Y, Fancello L, Briggs JW, Schwab C, De Beeck JO, Verbeeck J, Royaert J, Geerdens E, Vicente C, Bornschein S, Harrison CJ, Meijerink JP, Cools J, Dinman JD, Kampen KR, De Keersmaecker K. . Leukemia 2018, 32(3), 809-819.
    • Sinclair PB, Blair HH, Ryan SL, Buechler L, Cheng J, Clayton J, Hanna R, Hollern S, Hawking Z, Bashton M, Schwab CJ, Jones L, Russell LJ, Marr H, Carey P, Halsey C, Heidenreich O, Moorman AV, Harrison CJ. . Haematologica 2018, 103, 634-644.
    • O'Connor D, Moorman AV, Wade R, Hancock J, Tan RMR, Bartram J, Moppett J, Schwab C, Patrick K, Harrison CJ, Hough R, Goulden N, Vora A, Samarasinghe S. . Journal of Clinical Oncology 2017, 35(6), 660-667.
    • Schwab CJ, Nebral K, Chilton L, Leschi C, Waanders E, Boer JM, Zaliova M, Sutton R, Ofverholm II, Ohki K, Yamashita Y, Groeneveld-Krentz S, Fronkova E, Bakkus M, Tchinda J, Conceicao-Barbosa T, Fazio G, Mlynarski W, Pastorczak A, Cazzaniga G, Pombo-de-Oliveira MS, Trka J, Kirschner-Schwabe R, Imamura T, Barbany G, Stanulla M, Attarbaschi A, Panzer-Grumayer R, Kuiper RP, den-Boer ML, Cave H, Moorman AV, Harrison CJ, Strehl S. . Blood Advances 2017, 1, 1473-1477.
    • Enshaei A, OConnor D, Bartram J, Hancock J, Harrison CJ, Hough R, Samarasinghe S, Schwab C, Vora A, Wade R, Moppett J, Moorman AV, Goulden N. . Journal of Clinical Oncology 2017, 36(1), 34-43.
    • Benard-Slagter A, Zondervan I, de Groot K, Ghazavi F, Sarhadi V, Van Vlierberghe P, De Moerloose B, Schwab C, Vettenranta K, Harrison CJ, Knuutila S, Schouten J, Lammens T, Savola S. . Journal of Molecular Diagnostics 2017, 19(5), 659-672.
    • Vormoor B, Veal GJ, Griffin MJ, Boddy AV, Irving J, Minto L, Case M, Banerji U, Swales KE, Tall JR, Moore AS, Toguchi M, Acton G, Dyer K, Schwab C, Harrison CJ, Grainger JD, Lancaster D, Kearns P, Hargrave D, Vormoor J. . Pediatric Blood & Cancer 2017, 64(6), e26351 1-4.
    • Ryan SL, Matheson E, Grossmann V, Sinclair P, Bashton M, Schwab C, Towers W, Partington M, Elliott A, Minto L, Richardson S, Rahman T, Keavney B, Skinner R, Bown N, Haferlach T, Vandenberghe P, Haferlach C, Santibanez-Koref M, Moorman AV, Kohlmann A, Irving JA, Harrison CJ. . Leukemia 2016, 30, 1824-1831.
    • Irving JAE, Enshaei A, Parker CA, Sutton R, Kuiper RP, Erhorn A, Minto L, Venn NC, Law T, Yu J, Schwab C, Davies R, Matheson E, Davies A, Sonneveld E, den Boer ML, Love SB, Harrison CJ, Hoogerbrugge PM, Revesz T, Saha V, Moorman AV. . Blood 2016, 128(7), 911-922.
    • La Starza R, Barba G, Demeyer S, Pierini V, Di Giacomo D, Gianfelici V, Schwab C, Matteucci C, Vicente C, Cools J, Messina M, Crescenzi B, Chiaretti S, Foà R, Basso G, Harrison CJ, Mecucci C. . Haematologica 2016, 101(8), 951-958.
    • Zaliova M, Moorman AV, Cazzaniga G, Stanulla M, Harvey RC, Roberts KG, Heatley SL, Loh ML, Konopleva M, Chen IM, Zimmermannova O, Schwab C, Smith O, Mozziconacci MJ, Chabannon C, Kim M, Falkenburg JHF, Norton A, Marshall K, Haas OA, Starkova J, Stuchly J, Hunger SP, White D, Mullighan CG, Willman CL, Stary J, Trka J, Zuna J. . Haematologica 2016, 101(9), 1082-1093.
    • Schwab C, Ryan SL, Chilton L, Elliott A, Murray J, Richardson S, Wragg C, Moppett J, Cummins M, Tunstall O, Parker CA, Saha V, Goulden N, Vora A, Moorman AV, Harrison CJ. . Blood 2016, 127(18), 2214-2218.
    • Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, Taghon T, Tremblay CS, Costa M, Ghahremani MF, De Medts J, Bartunkova S, Haigh K, Schwab C, Farla N, Pieters T, Matthijssens F, Van Roy N, Best JA, Deswarte K, Bogaert P, Carmichael C, Rickard A, Suryani S, Bracken LS, Alserihi R, Cante-Barret K, Haenebalcke L, Clappier E, Rondou P, Slowicka K, Huylebroeck D, Goldrath AW, Janzen V, McCormack MP, Lock RB, Curtis DJ, Harrison C, Berx G, Speleman F, Meijerink JPP, Soulier J, Van Vlierberghe P, Haigh JJ. . Nature Communications 2015, 6, 5794.
    • Vicente C, Schwab C, Broux M, Geerdens E, Degryse S, Demeyer S, Lahortiga I, Elliott A, Chilton L, LaStarza R, Mecucci C, Vandenberghe P, Goulden N, Vora A, Moorman AV, Soulier J, Harrison CJ, Clappier E, Cools J. . Haematologica 2015, 100, 1301-1310.
    • Nicholson L, Evans C, Matheson E, Minto L, Keilty C, Sanichar M, Case M, Schwab C, Williamson D, Rainer J, Harrison C, Kofler R, Hall AG, Rednern CPF, Wheaton AD, Irving JAE. . British Journal of Haematology 2015, 171(4), 595–605.
    • Boer JM, vanderVeer A, Rizopoulos D, Fiocco M, Sonneveld E, deGroot-Kruseman HA, Kuiper RP, Hoogerbrugge P, Horstmann M, Zaliova M, Palmi C, Trka J, Fronkova E, Emerenciano M, Pombo-de-Oliveira MS, Mlynarski W, Szczepanski T, Nebral K, Attarbaschi A, Venn N, Sutton R, Schwab CJ, Enshaei A, Vora A, Stanulla M, Schrappe M, Cazzaniga G, Conter V, Zimmermann M, Moorman AV, Pieters R, denBoer ML. . Leukemia 2015, 1-7.
    • Gabriel AS, Lafta FM, Schwalbe EC, Nakjang S, Cockell SJ, Iliasova A, Enshaei A, Schwab C, Rand V, Clifford SC, Kinsey SE, Mitchell CD, Vora A, Harrison CJ, Moorman AV, Strathdee G. . Epigenetics 2015, 10(8), 717-726.
    • Patel B, Dey A, Castleton AZ, Schwab C, Samuel E, Sivakumaran J, Beaton B, Zareian N, Zhang CY, Rai L, Enver T, Moorman AV, Fielding AK. . Blood 2014, 124(1), 96-105.
    • La Starza R, Borga C, Barba G, Pierini V, Schwab C, Matteucci C, Fernandez AGL, Leszl A, Cazzaniga G, Chiaretti S, Basso G, Harrison CJ, te Kronnie G, Mecucci C. . Blood 2014, 124(24), 3577-3582.
    • Li Y, Schwab C, Ryan SL, Papaemmanuil E, Robinson HM, Jacobs P, Moorman AV, Dyer S, Borrow J, Griffiths M, Heerema NA, Carroll AJ, Talley P, Bown N, Telford N, Ross FM, Gaunt L, McNally RJ, Young BD, Sinclair P, Rand V, Teixeira MR, Joseph O, Robinson B, Maddison M, Dastugue N, Vandenberghe P, Haferlach C, Stephens PJ, Cheng J, Van-Loo P, Stratton MR, Campbell PJ, Harrison CJ. . Nature 2014, 508(7494), 98-102.
    • Moorman AV, Enshaei A, Schwab C, Wade R, Chilton L, Elliott A, Richardson S, Hancock J, Kinsey SE, Mitchell CD, Goulden N, Vora A, Harrison CJ. . Blood 2014, 124(9), 1434-1444.
    • Moorman AV, Robinson H, Schwab C, Richards SM, Hancock J, Mitchell CD, Goulden N, Vora A, Harrison CJ. . Journal of Clinical Oncology 2013, 31(27), 3389-3396.
    • Enshaei A, Schwab CJ, Konn ZJ, Mitchell CD, Kinsey SE, Wade R, Vora A, Harrison CJ, Moorman AV. . Leukemia 2013, 27(11), 2256-2259.
    • Schwab CJ, Chilton L, Morrison H, Jones L, Al-Shehhi H, Erhorn A, Russell LJ, Moorman AV, Harrison CJ. . Haematologica 2013, 98(7), 1081-1088.
    • Harrison CJ, Moorman AV, Schwab C, Carroll AJ, Raetz EA, Devidas M, Strehl S, Nebral K, Harbott J, Teigler-Schlegel A, Zimmerman M, Dastuge N, Baruchel A, Soulier J, Auclerc MF, Attarbaschi A, Mann G, Stark B, Cazzaniga G, Chilton L, Vandenberghe P, Forestier E, Haltrich I, Raimondi SC, Parihar M, Bourquin JP, Tchinda J, Haferlach C, Vora A, Hunger SP, Heerema NA, Haas OA. . Leukemia 2013, 1-7.
    • Al-Shehhi H, Konn ZJ, Schwab CJ, Erhorn A, Barber KE, Wright SL, Gabriel AS, Harrison CJ, Moorman AV. . Genes, Chromosomes & Cancer 2013, 52(2), 202-213.
    • Attarbaschi A, Morak M, Cario G, Cazzaniga G, Ensor HM, te Kronnie T, Bradtke J, Mann G, Vendramini E, Palmi C, Schwab C, Russell LJ, Schrappe M, Conter V, Mitchell CD, Strehl S, Zimmermann M, Potschger U, Harrison CJ, Stanulla M, Panzer-Grumayer R, Haas OA, Moorman AV, Assoc Italiana Ematologia Oncologi, Natl Canc Res Inst NCRI-Childrens. . British Journal of Haematology 2012, 158(6), 772-777.
    • Buitenkamp TD, Pieters R, Gallimore NE, van der Veer A, Meijerink JPP, Beverloo HB, Zimmermann M, de Haas V, Richards SM, Vora AJ, Mitchell CD, Russell LJ, Schwab C, Harrison CJ, Moorman AV, van den Heuvel-Eibrink MM, den Boer ML, Zwaan CM. . Leukemia 2012, 26(10), 2204-2211.
    • Moorman AV, Schwab C, Ensor HM, Russell LJ, Morrison H, Jones L, Masic D, Patel B, Rowe JM, Tallman M, Goldstone AH, Fielding AK, Harrison CJ. . Journal of Clinical Oncology 2012, 30(25), 3100-3108.
    • Rand V, Parker H, Russell LJ, Schwab C, Ensor H, Irving J, Jones L, Masic D, Minto L, Morrison H, Ryan S, Robinson H, Sinclair P, Moorman A, Strefford J, Harrison CJ. . Blood 2011, 117(25), 6848-6855.
    • Ensor HM, Schwab C, Russell LJ, Richards SM, Morrison H, Masic D, Jones L, Kinsey SE, Vora AJ, Mitchell CD, Harrison CJ, Moorman AV. . Blood 2011, 117(7), 2129-2136.
    • Moorman AV, Ensor HM, Richards SM, Chilton L, Schwab C, Kinsey SE, Vora A, Mitchell CD, Harrison CJ. . Lancet Oncology 2010, 11(5), 429-438.
    • Van Vlierberghe P, Palomero T, Khiabanian H, Van der Meulen J, Castillo M, Van Roy N, De Moerloose B, Philippe J, Gonzalez-Garcia S, Toribio ML, Taghon T, Zuurbier L, Cauwelier B, Harrison CJ, Schwab C, Pisecker M, Strehl S, Langerak AW, Gecz J, Sonneveld E, Pieters R, Paietta E, Rowe JM, Wiernik PH, Benoit Y, Soulier J, Poppe B, Yao XP, Cordon-Cardo C, Meijerink J, Rabadan R, Speleman F, Ferrando A. . Nature Genetics 2010, 42(4), 338-342.
    • Schwab CJ, Jones LR, Morrison H, Ryan SL, Yigittop H, Schouten JP, Harrison CJ. . Genes, Chromosomes & Cancer 2010, 49(12), 1104-1113.
    • Russell LJ, Capasso M, Vater I, Akasaka T, Bernard OA, Calasanz MJ, Chandrasekaran T, Chapiro E, Gesk S, Griffiths M, Guttery DS, Haferlach C, Harder L, Heidenreich O, Irving JAE, Kearney L, Nguyen-Khac F, Machado L, Minto L, Majid A, Moorman AV, Morrison H, Rand V, Strefford JC, Schwab CJ, Tonnies H, Dyer MJ, Siebert R, Harrison CJ. . Blood 2009, 114(13), 2688-2698.

  • Letters

    • Schwab C, Roberts K, Boer JM, Gohring G, Steinemann D, Vora A, Macartney C, Hough R, Thorn Z, Dillon R, Escherich G, Cazzaniga G, Schlegelberger B, Loh M, den Boer ML, Moorman AV, Harrison CJ. . Blood 2021, 137(13), 1835-1838.
    • Milani G, Matthijssens F, Van Loocke W, Durinck K, Roels J, Peirs S, Thenoz M, Pieters T, Reunes L, Lintermans B, Vandamme N, Lammens T, Van Roy N, Van Nieuwerburgh F, Deforce D, Schwab C, Raimondi S, Dalla Pozza L, Carroll AJ, De Moerloose B, Benoit Y, Goossens S, Berx G, Harrison CJ, Basso G, Cave H, Sutton R, Asnafi V, Meijerink J, Mullighan C, Loh M, Van Vlierberghe P. . British Journal of Haematology 2019, 185(1), 169-174.
    • Chagaluka G, Carey P, Banda K, Schwab C, Chilton L, Schwalbe E, Skinner R, Israels T, Moorman A, Molyneux E, Bailey S. . Haematologica 2013, 98(1), e1-e3.
    • Buitenkamp TD, Pieters R, Zimmermann M, de Haas V, Richards SM, Vora AJ, Mitchell CD, Schwab C, Harrison CJ, Moorman AV, van den Heuvel-Eibrink MM, Zwaan CM. . Leukemia 2013, 27(1), 251-252.
    • Eyre T, Schwab CJ, Kinstrie R, McGuire AK, Strefford J, Peniket A, Mead A, Littlewood T, Holyoake TL, Copland M, Moorman AV, Harrison CJ, Vyas P. . Blood 2012, 120(22), 4441-4443.

  • Review

    • Harrison CJ, Schwab C. . European Journal of Medical Genetics 2016, 59(3), 162-165.