缅北禁地

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Staff Profile

Dr Claudia Racca

Senior Lecturer

  • Telephone: +44 (0) 191 208 8716
  • Address: Biosciences Institute
    The Medical School
    缅北禁地
    Framlington Place
    缅北禁地 upon Tyne
    NE2 4HH
    UK
Background

Roles and Responsibilities

Lecturer
UG, MRes, PhD and postdoc supervisor

Qualifications

Laurea in Biological Sciences, Univ of Milan, Italy, Dr
Postgrad AIRC Fellow: Cell biology & Physiology, Univ. of Milan, Italy

Research

Research Interests

Our research focuses on cellular neuroanatomy and neuronal cell biology, with a particular interest in synaptic structure and function.

1) Investigation of the functional, cellular and molecular mechanisms of synaptic and network activity relevant to the function and localisation of glutamate and glycine receptor proteins and mRNAs in neurons.

2) Characterisation of the physiology and neurochemistry of neuronal networks in various areas of the central nervous system (e.g. hippocampus, neocortex, and cerebellum). In particular, we aim to identify the key properties of neuronal networks in these areas in order to understand their functional roles in normal and pathological states, with reference to, for instance, schizophrenia and epilepsy. 

3) Neuroanatomical and functional characterisation of connections between neurons within networks. Synapses: their structure, spatial location, and regulation with respect to synaptic and neuronal network activity.

The lab research focuses on a multidisciplinary approach: 2D and 3D morphological and immunocytochemical techniques at the light and electron microscopy (TEM, SBFSEM, FIBSEM) levels are combined to electrophysiology and molecular biology. This approach allow us to relate molecular, electrophysiological, and behavioural events to specific anatomical subcellular structures.

Current Work

1) Biology and physiology of neurotransmitter receptors and associated proteins, in particular GluRs and GlyRs:

  • role of neurotransmitter receptors (e.g. AMPAR, NMDAR) and associated proteins (e.g. Scribble1, Rph3a) in regulating synaptic structure and function
  • targeting and trafficking of neurotransmitter receptors (e.g. AMPAR, GlyR) and their subunit mRNAs, and local protein synthesis in the neuronal dendritic tree

2) Functional and molecular mechanisms responsible for synaptic and neuronal network remodelling,

3) Synapses: their structure, spatial location, and regulation with respect to synaptic and neuronal network activity

Publications

  • Articles

    • Depret N, Gleizes M, Moreau MM, Poirault-Chassac S, Quiedeville A, Dos Santos Carvalho S, Venugopa V, Shaam Al Abed A, Ezan J, Barthet G, Mulle C, Desmedt A, Marighetto A, Racca C, Montcouquiol M, Sans N. . Progress in Neurobiology 2025, 246, 102728.
    • Depret N, Gleizes M, Moreau MM, Poirault-Chassac S, Quiedeville A, Dos Santos Carvalho S, Shaam Al Abed A, Barthet G, Mulle C, Desmedt A, Marighetto A, Racca C, Montcouquiol M, Sans N. . bioRxiv 2024.
    • Mackenzie-Gray Scott CA, Parrish RR, Walsh DA, Racca C, Cowell RM, Trevelyan AJ. . Journal of Neurophysiology 2022, 127(1), 86-98.
    • Simon A, Roth A, Sheridan A, Fisek M, Marra V, Racca C, Funke J, Staras K, Hausser M. . bioRxiv 2021.
    • Robert BJA, Moreau MM, Dos Santos Carvalho S, Barthet G, Racca C, Bhouri M, Quiedeville A, Garret M, Atchama B, Shaam Al Abed A, Guette C, Henderson D, Desmedt A, Mulle M, Marighetto A, Montcouquiol M, Sans N. . Cell Reports 2020, 31(10), 107743.
    • Franchini L, Stanic J, Ponzoni L, Mellone M, Carrano N, Musardo S, Zianni E, Olivero G, Marcello E, Pittaluga A, Sala M, Bellone C, Racca C, Di Luca M, Gardoni F. . iScience 2019, 19, 927-939.
    • Parrish RR, Grady J, Codadu NK, Trevelyan AJ, Racca C. . Journal of Neuroscience Methods 2018, 303, 16-29.
    • Parrish RR, Codadu NK, Racca C, Trevelyan AJ. . Journal of Neurophysiology 2018, 120(5), 2358-2367.
    • Parrish RR, Grady J, Codadu NK, Racca C, Trevelyan AJ. . Data in Brief 2018, 20, 226-233.
    • Stanic J, Mellone M, Napolitano F, Racca C, Zianni E, Minocci D, Ghiglieri V, Thiolat ML, Li Q, Longhi A, DeRosa A, Picconi B, Bezard E, Calabresi P, DiLuca M, Usiello A, Gardoni F. . Neurobiology of Disease 2017, 108, 54-64.
    • Hilal M, Moreau MM, Racca C, Pinheiro VL, Miguel NH, Santoni MJ, Dos Santos Carvalho S, Blanc JM, Abada YSK, Peyroutou R, Medina C, Doat H, Papouin T, Vuillard L, Borg JP, Rachel R, Panatier A, Montcouquiol M, Oliet SHR, Sans N. . Cerebral Cortex 2017, 27(12), 5635-5651.
    • Trevelyan A, Muldoon SF, Merricks EM, Racca C, Staley K. . Journal of Clinical Neurophysiology 2015, 32(3), 227-234.
    • Alfonsa H, Merricks EM, Codadu NK, Cunningham MO, Deisseroth K, Racca C, Trevelyan AJ. . Journal of Neuroscience 2015, 35(20), 7715-7726.
    • Stanic J, Carta M, Eberini I, Penuchi S, Marcello E, Genazzani A, Racca C, Mulle C, DiLuca M, Gardoni F. . Nature Communications 2015, 6, 10181.
    • Piguel NH, Fievre S, Blanc JM, Carta M, Moreau MM, Moutin E, Pinheiro VL, Medina C, Ezan J, Lasvaux L, Loll F, Durand CM, Chang K, Petralia RS, Wenthold RJ, Stephenson FA, Vuillard L, Darbon H, Perroy J, Mulle C, Montcouquiol M, Racca C, Sans N. . Cell Reports 2014, 9(2), 712-727.
    • Pienaar I-S, Elson JL, Racca C, Nelson G, Turnbull DM, Morris CM. . American Journal of Pathology 2013, 183(6), 1826-1840.
    • Cox DJ, Racca C. . Journal of Comparative Neurology 2013, 521(9), 1954-2007.
    • Whittington MA, Cunningham MO, LeBeau FE, Racca C, Traub RD. . Developmental Neurobiology 2011, 71(1), 92-106.
    • Moreau MM, Piguel N, Papouin T, Koehl M, Durand CM, Rubio ME, Loll F, Richard EM, Mazzocco C, Racca C, Oliet SHR, Abrous DN, Montcouquiol M, Sans N. . Journal of Neuroscience 2010, 30(29), 9738-9752.
    • Racca C, Gardiol A, Eom T, Ule J, Triller A, Darnell RB. . Frontiers in Neural Circuits 2010, 4, 5.
    • Cox DJ, Racca C, LeBeau FEN. . Journal of Comparative Neurology 2008, 509(6), 551-565.
    • Roopun AK, Cunningham MO, Racca C, Alter K, Traub RD, Whittington MA. . Schizophrenia Bulletin 2008, 34(5), 962-973.
    • Middleton SJ, Racca C, Cunningham MO, Traub RD, Monyer H, Knopfel T, Schofield IS, Jenkins A, Whittington MA. . Neuron 2008, 58(5), 763-774.
    • Driver JE, Racca C, Cunningham MO, Towers SK, Davies CH, Whittington MA, Le Beau FEN. . European Journal of Neuroscience 2007, 26(5), 1280-1288.
    • Bibbig A, Middleton S, Racca C, Gillies MJ, Garner H, Le Beau FEN, Davies CH, Whittington MA. . Journal of Neurophysiology 2007, 97(4), 2812-2823.
    • Cunningham MO, Hunt J, Middleton S, Le Beau FEN, Gillies MG, Davies CH, Maycox PR, Whittington MA, Racca C. . Journal of Neuroscience 2006, 26(10), 2767-2776.
    • Cunningham MO, Pervouchine DD, Racca C, Kopell NJ, Davies CH, Jones RSG, Traub RD, Whittington MA. . Proceedings of the National Academy of Sciences of the United States of America 2006, 103(14), 5597-5601.
    • Meier JC, Henneberger C, Melnick I, Racca C, Harvey RJ, Heinemann U, Volker Schmieden V, Grantyn R. . Nature Neuroscience 2005, 8(6), 736-744.
    • Pelkey KA, Lavezzari G, Racca C, Roche KW, McBain CJ. . Neuron 2005, 46(1), 89-102.
    • Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ. . Nature Cell Biology 2003, 5(6), 520-530.
    • Sans N, Racca C, Petralia RS, Wang Y-X, McCallum J, Wenthold RJ. . The Journal of Neuroscience 2001, 21(19), 7506-7516.
    • Racca C, Stephenson FA, Streit P, Roberts JDB, Somogyi P. . Journal of Neuroscience 2000, 20(7), 2512-2522.
    • Racca C, Stephenson FA, Streit P, Roberts JDB, Somogyi P. NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area. The Journal of Neuroscience 2000, 20, 2512-2522.
    • Gardiol A, Racca C, Triller A. . Journal of Neuroscience 1999, 19(1), 168-179.
    • Racca C, Gardiol A, Triller A. . Neuroscience 1998, 84(4), 997-1012.
    • Racca C, Gardiol A, Triller A. . The Journal of Neuroscience 1997, 17(5), 1691-1700.
    • Racca, C., Catania, M.V., Monyer, H., Sakmann, B. Expression of AMPA-glutamate receptor B subunit in rat hippocampal GABAergic neurones. Eur. J. Neurosci 1996, 8, 1580-1590.
    • Häusser, M.A., Stuart, G., Racca, C., Sakmann, B. Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons. Neuron 1995, 15, 637-647.
    • Jonas, P., Racca, C., Sakmann, B., Seeburg, P.H., Monyer, H. Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron 1994, 12, 1281-1289.
    • Giovannardi, S., Racca, C., Bertollini, L., Sturani, E., Peres, A. P2y Purinoreceptors in normal NIH 3T3 and in NIH 3T3 overexpressing c-ras. Exp. Cell Res 1992, 202, 398-404.
    • Peres, A., Racca, C., Bertollini, L., Sturani, E. Cytosolic calcium responses induced by photolytic release of 1,4,5,-inositol trisphosphate in single human fibroblasts. B.B.A 1991, 1092, 89-93.
    • Peres, A., Bertollini, L., Racca, C. Characterization of Ca2+ transients induced by intacellular photorelease of InsP3 in mouse ovarian oocytes. Cell Calcium 1991, 12, 457-465.
    • Peres, A., Racca, C., Zippel, R., Sturani, E. Cytosolic calcium and membrane conductance in response to platelet-derived growth factor and bradykinin stimulation in single human fibroblasts. European J. Cell Biol 1990, 53, 290-295.

  • Book Chapter

    • Gardiol A, Racca C, Triller A. . In: Richter, D; Tiedge, H, ed. Results and Problems in Cell Differentiation. Springer, 2001, pp.105-128.

  • Conference Proceedings (inc. Abstracts)

    • Eden DC, Whittington MA, Racca C, LeBeau FEN. Modulation of hippocampal gamma (30-80 Hz) frequency oscillations in vitro by serotonin. In: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS: ELSEVIER SCIENCE BV.
    • Whittington M, Racca C. . In: Schizophrenia Bulletin: 10th International Congress on Schizophrenia Research. 2007, Savannah, Georgia, USA: Oxford University Press.
    • Racca C, Cunningham MO, Hunt J, Middleton S, LeBeau FE, Gillies MG, Davies CH, Maycox PR, Whittington MA. . In: Neuropsychopharmacology: 45th Annual Meeting of the American College of Neuropsychopharmacolgy. 2006, Hollywood, Florida: Nature Publishing Group.