缅北禁地

NIHR Academic Clinical Fellow in Trauma and Orthopaedic Surgery in the Translational and Clinical Research Institute and a member of the Sarcoma Research Group at 缅北禁地 Centre for Cancer, with research interests in the basic science of musculoskeletal oncology, fluorescence guided surgery, metastatic bone disease, and complex arthroplasty.

Co-Investigator of

Academic Supervisor: Mr Kenneth Rankin

ORCID:

SCOPUS:

My research investigates the basic science and translational application of fluorescence guided surgery for the treatment of sarcoma and metastatic bone disease. My work looks into the mechanisms of indocyanine green (ICG) cellular uptake to help guide its clinical use for near infrared (NIR) fluorescence guided surgery. I collaborate with research groups internationally and I am currently a co-investigator on the . I have undertaken research fellowships at Massachusetts General Hospital / Harvard Medical School, and The Princess Máxima Center for Pediatric Oncology. I currently lead the BCRT/Sarcoma UK , and sit on the National Committee of the Royal College of Surgeons of Edinburgh .

Research Projects:

• Investigating the mechanisms of indocyanine green tumour uptake in sarcoma cell lines and tissue , ,
• Development of a targeted dual-modality (PET/NIRF) radioimmunoconjugate for image-guided sarcoma surgery
• Investigating fluorescence lifetime imaging for enhanced tumour contrast using ICG
• Evaluating the role of MT1-MMP in sarcoma cell invasion using CRISPR Cas9 gene editing
• Studying the potential use of PET-MRI to improve the local staging of disease in myxofibrosarcoma
• A multicentre study on the prognostic value of the modified Glasgow Prognostic Score across bone and soft tissue sarcoma subtypes ,
• Evaluating the clinical outcomes of proximal and distal femoral replacements for non-oncological conditions (EPRO Study) ,

Research Fellowships undertaken at:

The Oxford Sarcoma Service, Nuffield Orthopaedic Centre Oxford, UK - March 2022; Supervisors:

The Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, USA – June 2022; Supervisors: and

The Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands - February 2025; Supervisor: Prof.

Funding has been generously provided by:

• Articles

  • Chan CD, Brookes MJ, Ali T, Howell E, Dildey P, Firbank M, Pearson R, Sloan P, Lowes S, Sinha R, Tuckett J, Ragbir M, Beckingsale T, Hide G, Gerrand C, Rankin KS, Petrides GS. . Diagnostics 2025, 15(8), 1039.
  • Ben Gal O, Doonan J, Lotfi N, McMahon S, Baker G, Cribb G, Chan CD, Siddiqi MA, Gupta S. . Bone & Joint Journal 2025, 107-B(6), 649-656.
  • Chan CD, Brookes MJ, Pringle TA, Pal R, Tanwani R, Burt AD, Knight JC, Kumar ATN, Rankin KS. . The Journal of Pathology 2025, 267(3), 315-328.
  • Wijesekera MP, Pandit H, Jain S, Palan J, East J, Chan CD, Hadfield JN, As-Sultany M, Abourisha E, James C, Neo C, Yapp LZ, Kassam AM, Petheram T, Wynn Jones H, Eastley NC, Scott CEH. . Bone & Joint Journal 2025, 107-B(6), 625-631.
  • Wijesekera MP, Pandit H, Jain S, Palan J, Chan CD, Hadfield JN, As-Sultany M, Talavia T, Abourisha E, James C, Neo C, Yapp LZ, Petheram T, Wynn Jones H, Eastley NC, Ashford RU, Scott CEH. . Bone & Joint Journal 2025, 107-B(6), 632-638.
  • Brookes MJ, Chan CD, Crowley TP, Ragbir M, Ghosh KM, Beckingsale T, Rankin KS. . Surgical Oncology 2024, 55, 102091.
  • Brookes MJ, Chan CD, Crowley TP, Ragbir M, Beckingsale T, Ghosh KM, Rankin KS. . Cancers 2023, 15(13), 3531.
  • Pal R, Lwin TM, Krishnamoorthy M, Collins HR, Chan CD, Prilutskiy A, Nasrallah MLP, Dijkhuis TH, Shukla S, Kendall AL, Marshall MS, Carp SA, Hung YP, Shih AR, Martinez-Lage M, Zukerberg L, Sadow PM, Faquin WC, Nahed BV, Feng AL, Emerick KS, Mieog JSD, Vahrmeijer AL, Rajasekaran K, Lee JYK, Rankin KS, Lozano-Calderon S, Varvares MA, Tanabe KK, Kumar ATN. . Nature Biomedical Engineering 2023, 7, 1649–1666.
  • Chan CD, Zhang L, Pandit RJ, Lewis CJ. . ePlasty 2023, 23, e6.
  • Pringle TA, Chan CD, Luli S, Blair HJ, Rankin KS, Knight JC. . Bioconjugate Chemistry 2022, 33(8), 1564-1573.
  • Li E, Hammond J, Moir J, Abbadessa F, Chan C, Dawe N, De Silva C, Ferrara M, Hillier R, Kadhim MR, Myszkowski S, Salisbury T, Sudworth P, Tingle S, Williams T. . Anaesthesia 2022, 77(1), 28-39.
  • Spence S, Doonan J, Farhan-Alanie OM, Chan CD, Tong D, Cho HS, Sahu MA, Traub F, Gupta S. . Bone and Joint Journal 2022, 104-B(1), 168-170.
  • Rajasekaran RB, Ashford RU, Cosker TDA, Stevenson JD, Jeys L, Pollock R, Rankin KS, Cool P, Patton JT, Whitwell D, Gibbons CLMH, Carr A. . Clinical Orthopaedics and Related Research 2021, 479(5), 1158-1166.
  • Nicoli F, Saleh DB, Ragbir M, Chan CD, Baljer B, Rankin KS. . Annals of Surgery 2021, 274(6), e782-e783.
  • Chan CD, Nyogi A, Jaffray B, Brodlie M, Gabra H. . Archives of Disease in Childhood 2021, 106(3), 291-293.
  • Brookes MJ, Chan CD, Nicoli F, Crowley TP, Ghosh KM, Beckingsale T, Saleh D, Dildey P, Gupta S, Ragbir M, Rankin KS. . Cancers 2021, 13(24), 6284.
  • Nicoli F, Saleh DB, Baljer B, Chan CD, Beckingsale T, Ghosh KM, Ragbir M, Rankin KS. . Annals of Surgery 2021, 273(2), e63-e68.
  • Chan CD, Haagensen EJ, Tensaout HA, Rennie KJ, Gamie Z, Barry J, Birch MA, Gerrand CH, Nisar S, Robson CN, Lunec J, Rankin KS. . Oncology Letters 2021, 21(2), 158.
  • Baljer BC, Kolhe S, Chan CD, Nicoli F, Ghanbasha A, Brookes MJ, Gamie Z, Ghosh KM, Beckinsale TB, Saleh DB, Ragbir M, Gerrand CH, Jeys L, Knight JC, Petrides G, Rankin KS. . Cancer Letters 2020, 483, 1-11.

• Reviews

  • Boyle AB, Chan CD, Liu AQ, Bernstein DN, Incoll IW. . ANZ Journal of Surgery 2025, 95(4), 637-646.
  • Brookes MJ, Chan CD, Baljer B, Wimalagunaratna S, Crowley TP, Ragbir M, Irwin A, Gamie Z, Beckingsale T, Ghosh KM, Rankin KS. . Cancers 2021, 13(3), 388.
  • Baljer BC, Kolhe S, Chan CD, Nicoli F, Ghanbasha A, Brookes MJ, Gamie Z, Ghosh KM, Beckinsale TB, Saleh DB, Ragbir M, Gerrand CH, Jeys L, Knight JC, Petrides G, Rankin KS. . Cancer Letters 2020, 483, 1-11.