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Staff Profile

Emeritus Professor Clarke Slater

Background

Roles and Responsibilities


Qualifications

BA Biology, Harvard (1962)
PhD Biophysics, University College London (1966)

Previous Positions

Scientific Staff, Medical Research Council Laboratory for Molecular Biology (1969-1974)

Memberships

Society for Neuroscience (US)
British Neuroscience Association
Physiological Society
Association of British Neurologists

Research

Research Interests

Structure, function, molecular organisation, development and pathology of the neuromuscular junction.
Motor nerve terminal and Schwann cell plasticity.
Ion channel localisation in the postsynaptic membrane.
Electrophysiology, light- and electron-microscopy, immunocytochemistry, in situ hybridisation.

Current Work

Studies of the structure and function of neuromuscular junctions

Future Research


Funding

 

Publications

  • Articles

    • Roesl C, Evans ER, Dissanayake KN, Boczonadi V, Jones RA, Jordan GR, Ledahawsky L, Allen GCC, Scott M, Thomson A, Wishart TM, Hughes DI, Mead RJ, Shone CC, Slater CR, Gillingwater TH, Skehel PA, Ribchester RR. . Biomolecules 2021, 11(10), 1499.
    • Slater CR. . Neuroscience 2020, 439, 28-40.
    • McMacken GM, Spendiff S, Whittaker RG, O'Connor E, Howarth RM, Boczonadi V, Horvath R, Slater CR, Lochmuller H. . Human Molecular Genetics 2019, 28(14), 2339-2351.
    • Issop K, Hathazi D, Khan MM, Rudolf R, Weis J, Spendiff S, Slater CR, Roos A, Lochmuller H. . Human Molecular Genetics 2018, 27(18), 3218-3232.
    • Slater CR. . International Journal of Molecular Sciences 2017, 18(10), 2183.
    • Nicole S, Azuma Y, Bauché S, Eymard B, Lochmüller H, Slater C. . Journal of Neuromuscular Diseases 2017, 4(4), 269-284.
    • Willadt S, Nash M, Slater CR. . Scientific Reports 2016, 6, 24849.
    • Banks RW, Cahusac PM, Graca A, Kain N, Shenton F, Singh P, Nja A, Simon A, Watson S, Slater CR, Bewick GS. . Journal of Physiology 2013, 591(10), 2523-2540.
    • Belaya K, Finlayson S, Slater CR, Cossins J, Liu WW, Maxwell S, McGowan SJ, Maslau S, Twigg SRF, Walls TJ, Pascual SIP, Palace J, Beeson D. . American Journal of Human Genetics 2012, 91(1), 193-201.
    • Rogozhin A, Pang K, Bukharaeva E, Young C, Slater C. . Journal of Physiology 2008, 586(13), 3163-3182.
    • Slater CR, Fawcett PRW, Walls TJ, Lyons PR, Bailey SJ, Beeson D, Young C, Gardner-Medwin D. . Brain 2006, 129(8), 2061-2076.
    • Beeson D, Higuchi O, Palace J, Cossins J, Spearman H, Maxwell S, Newsom-Davis J, Burke G, Fawcett P, Motomura M, Muller JS, Lochmuller H, Slater C, Vincent A, Yamanashi Y. . Science 2006, 313(5795), 1975-1978.
    • Stocksley MA, Awad SS, Young C, Lightowlers RN, Brenner H-R, Slater CR. . Molecular and Cellular Neuroscience 2005, 28(4), 694-702.
    • Bailey SJ, Stocksley MA, Buckel A, Young C, Slater CR. . Journal of Neuroscience 2003, 23(6), 2102-2111.
    • Croxen R, Young C, Slater CR, Haslam S, Brydson M, Vincent A, Beeson D. . Brain 2001, 124(7), 1362-1372.
    • Awad SS, Lightowlers RN, Young C, Chrzanowska-Lightowlers ZMA, Lomo T, Slater CR. . Journal of Neuroscience 2001, 21(21), 8456-8463.
    • Croxen R, Young C, Slater C, Haslam S, Brydson M, Vincent A, Beeson D. . Brain 2001, 124(7), 1362-1372.
    • Awad SS, Stocksley MA, Young C, Lightowlers RN, Slater CR. . European Journal of Neuroscience 2000, 12(supplement), 278-278.
    • Walsh FS, Hobbs C, Wells DJ, Slater CR, Fazeli S. . Molecular and Cellular Neuroscience 2000, 15(3), 244-261.
    • Reid B, Slater CR, Bewick GS. . Journal of Neuroscience 1999, 19(7), 2511-2521.
    • R. Vater, C. Young, L. V. B. Anderson, S. Lindsay, D. J. Blake, K. E. Davies, R. Zuellig and C. R. Slater. Utrophin mRNA expression in muscle is not restricted to the neuromuscular junction. Molecular and Cellular Neuroscience 1998, 10, 229-242.
    • S. J. Wood and C. R. Slater. Quantal content at neuromuscular junctions that lack postsynaptic folds. Journal of Physiology-London 1998, 511P, 142P-142P.
    • S. J. Wood and C. R. Slater. beta-spectrin is colocalized with both voltage-gated sodium channels and ankyrin(G) at the adult rat neuromuscular junction. Journal of Cell Biology 1998, 140, 675-684.
    • Young C, Lindsay S, Vater R, Slater CR. . Histochemical Journal 1998, 30(1), 7-11.
    • S. J. Wood, K. Shewry, C. Young and C. R. Slater. An early stage in sodium channel clustering at developing rat neuromuscular junctions. Neuroreport 1998, 9, 1991-1995.
    • C. R. Slater, C. Young, S. J. Wood, G. S. Bewick, L. V. B. Anderson, P. Baxter, P. R. W. Fawcett, M. Roberts, L. Jacobson, J. Kuks, A. Vincent and J. NewsomDavis. Utrophin abundance is reduced at neuromuscular junctions of patients with both inherited and acquired acetylcholine receptor deficiencies. Brain 1997, 120, 1513-1531.
    • S. J. Wood and C. R. Slater. The contribution of postsynaptic folds to the safety factor for neuromuscular transmission in rat fast- and slow-twitch muscles. Journal of Physiology-London 1997, 500, 165-176.
    • A. E. Deconinck, A. C. Potter, J. M. Tinsley, S. J. Wood, R. Vater, C. Young, L. Metzinger, A. Vincent, C. R. Slater and K. E. Davies. Postsynaptic abnormalities at the neuromuscular junctions of utrophin-deficient mice. Journal of Cell Biology 1997, 136, 883-894.
    • N. C. Day, S. J. Wood, P. G. Ince, S. G. Volsen, W. Smith, C. R. Slater and P. J. Shaw. Differential localization of voltage-dependent calcium channel alpha(1) subunits at the human and rat neuromuscular junction. Journal of Neuroscience 1997, 17, 6226-6235.
    • G. S. Bewick, C. Young and C. R. Slater. Spatial relationships of utrophin, dystrophin, beta- dystroglycan and beta-spectrin to acetylcholine receptor clusters during postnatal maturation of the rat neuromuscular junction. Journal of Neurocytology 1996, 25, 367-379.
    • S. J. Wood, C. Young and C. R. Slater. Sodium channel concentration is related to postsynaptic folding at the neuromuscular junction. Journal of General Physiology 1996, 108, 51-51.
    • C. R. Slater. Neurobiology - Agrin signals at the junction. Nature 1996, 381, 478-479.
    • R. Vater, C. Young, S. J. Lindsay, L. V. B. Anderson and C. R. Slater. Distribution of utrophin mRNA in rat skeletal muscle. Journal of General Physiology 1996, 108, 80-80.
    • Brenner HR, Herczeg A, Slater CR. Synapse-specific expression of acetylcholine receptor genes and their products at original synaptic sites in rat soleus muscle fibres regenerating in the absence of innervation. Development 1992, 116, 41-53.
    • Slater CR, Lyons PR, Walls TJ, Fawcett PRW, Young C. Structure and function of neuromuscular junctions in man: A motor point biopsy study in two patient groups. Brain 1992, 115, 451-478.
    • Bewick GS, Nicholson LVB, Young C, O`Donnell E, Slater CR. Different distributions of dystrophin and related proteins at nerve-muscle junctions. Neuroreport 3 3 857-860 1992.
    • SLATER CR. POSTNATAL MATURATION OF NERVE MUSCLE JUNCTIONS IN HINDLIMB MUSCLES OF THE MOUSE. DEVELOPMENTAL BIOLOGY 1982, 94(1), 11-22.
    • SLATER CR. NEURAL INFLUENCE ON THE POSTNATAL CHANGES IN ACETYLCHOLINE-RECEPTOR DISTRIBUTION AT NERVE MUSCLE JUNCTIONS IN THE MOUSE. DEVELOPMENTAL BIOLOGY 1982, 94(1), 23-30.

  • Conference Proceedings (inc. Abstracts)

    • Slater CR. . In: Myasthenia Gravis and Related Disorders: 11th International Conference. 2008, Renaissance Chicago Hotel, USA: WileyBlackwell.
    • Beeson D, Webster R, Cossins J, Lashley D, Spearman H, Maxwell S, Slater CR, Newsom-Davis J, Palace J, Vincent A. . In: Myasthenia Gravis and Related Disorders: 11th International Conference. 2008, Renaissance Chicago Hotel, USA: WileyBlackwell.
    • Charlton RG, Walsh J, Davison K, Slater CR, Laval SH, Straub V, Bushby KMD, Anderson LVB. . In: Neuromuscular Disorders: 10th International Congress of the World Muscle Society. 2005, Iguassu Falls, Brazil: Elsevier Ltd.
    • Beeson D, Webster R, Ealing J, Croxen R, Brownlow S, Brydson M, Newsom-Davis J, Slater C, Hatton C, Shelley C, Colquhoun D, Vincent A. . In: Annals of the New York Academy of Sciences: 10th International Conference on Myasthenia Gravis and Related Disorders. 2003, Key Biscayne, Florida, USA: Wiley-Blackwell Publishing, Inc.
    • Awad S, Buckel A, Lightowlers RN, Slater CR. . In: British Neuroscience Assosciation Abstracts: 15th National Meeting. 1999, Liverpool, UK: British Neuroscience Association.
    • Buckel A, Young C, Slater CR. . In: British Neuroscience Assosciation Abstracts: 15th National Meeting. 1999, Liverpool, UK: British Neuroscience Association.

  • Editorials

    • Slater C. . Brain 2001, 124(5), 847-848.
    • SLATER CR. ORCHESTRATION AT THE SYNAPSE. NATURE 1985, 315(6020), 543-543.
    • SLATER CR. RE-INNERVATION OF ADULT MUSCLE. NATURE 1979, 282(5740), 672-673.

  • Reviews

    • Slater CR. . Comprehensive Physiology 2024, 14(4), 5641-5702.
    • Ribchester RR, Slater CR. . Current Opinion in Physiology 2018, 4, 82-87.
    • Willadt S, Nash M, Slater CR. . Annals of the New York Academy of Sciences 2018, 1412(1), 41-53.
    • Slater CR. . Progress in Neurobiology 2015, 134, 55-103.
    • Slater C. . Handbook of Clinical Neurology 2008, 91, 27-101.
    • Slater CR. . Journal of Neurocytology 2003, 32(5-8), 505-522.
    • Wood SJ, Slater CR. . Progress in Neurobiology 2001, 64(4), 393-429.