缅北禁地

Qualifications

BSc (Hons) University of Warwick, 1993
MSc University of 缅北禁地-upon-Tyne, 1994
PhD University of 缅北禁地-upon-Tyne, 1999

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Research Interests

Our resident gut microbiota, composed of trillions of mainly bacterial cells, have co-evolved with us and play an essential role in maintaining normal health and nutrition. Bacterial survival in the gut is dependent on the ability of members of this community to sense and respond rapidly to changes in their dynamic nutrient environment. The major nutrient source for microbes in the distal intestine are plant- and animal-derived glycans from our diets as well as host derived glycans, as the human genome does not encode the enzymes necessary to degrade many of these complex macromolecules.

In my lab we use a range of biochemical, microbiological, genetic and structural techniques to study the molecular mechanisms utilised by our resident gut bacteria to recognise, acquire and degrade complex glycans from both dietary and host sources. The results of this research have applications in a number of areas including the development of biofuels derived from plant cell wall material to personalised nutrition approaches to optimise microbiota function for the benefit of human health.

Undergraduate (Biochemistry and Biomedical Sciences degrees) and Masters. Biochemistry curriculum committee co-chair.

BGM1002 - Biochemistry

BMS2015 - Health and Disease at Mucosal Surfaces

BGM2060 - Proteins and Enzymes (Module Leader)

BGM3064 - Applied Biochemistry

MIC3046 - Microbiota and Pathogens (Module Leader)

MMB8010 - Studying Life at the Molecular Level

MMS8108 - Human Health and the Impact of Microbial Genomics

• Articles

  • Bakshani CR, Ojuri TO, Pilgaard B, Holck J, McInnes R, Kozak RP, Zakhour M, Cakaj S, Kerouedan M, Newton E, Bolam DN, Crouch LI. . Nature Microbiology 2025, 10, 585-598.
  • Crawford CJ, Tomlinson CWE, Gunawan C, Chen Z, Byrne DP, Darby C, Conti MLG, Larson T, Luis AS, Elli S, Yates EA, Bolam DN, Van Der Post S, Williams SJ, Cartmell A. . Proceedings of the National Academy of Sciences of the United States of America 2025, 122(28), e2414331122.
  • Ndeh DA, Nakjang S, Kwiatkowski KJ, Sawyers C, Koropatkin NM, Hirt RP, Bolam DN. . Nature Communications 2025, 16, 3485.
  • Liberato MV, Paixao DAA, Tomazetto G, Ndeh D, Bolam DN, Squina FM. . Biotechnology Letters 2024, 46, 201-211.
  • Morais S, Winkler S, Zorea A, Levin L, Nagies FSP, Kapust N, Lamed E, Artan-Furman A, Bolam DN, Yadav MP, Bayer EA, Martin WF, Mizrahi I. . Science 2024, 383(6688), eadj9223.
  • Wu Y, Bell A, Thomas GH, Bolam DN, Sargent F, Juge N, Palmer T, Severi E. . Microbiology 2024, 170(3), 001448.
  • White JBR, Silale A, Feasey M, Heunis T, Zhu Y, Zheng H, Gajbhiye A, Firbank S, Baslé A, Trost M, Bolam DN, van den Berg B, Ranson NA. . Nature 2023, 618(7965), 583-589.
  • Crouch LI, Urbanowicz PA, Basle A, Cai Z-P, Liu L, Voglmeir J, Melo Diaz JM, Benedict ST, Spencer DIR, Bolam DN. . Proceedings of the National Academy of Sciences of the United States of America 2022, 119(39), e2208168119.
  • Pudlo NA, Pereira GV, Parnami J, Cid M, Markert S, Tingley JP, Unfried F, Ali A, Varghese NJ, Kim KS, Campbell A, Urs K, Xiao Y, Adams R, Martin D, Bolam DN, Becher D, Eloe-Fadrosh EA, Schmidt TM, Abbott DW, Schweder T, Hehemann JH, Martens EC. . Cell Host and Microbe 2022, 30(3), 314-328.e11.
  • Gray DA, White JBR, Oluwole AO, Rath P, Glenwright AJ, Mazur A, Zahn M, Baslé A, Morland C, Evans SL, Cartmell A, Robinson CV, Hiller S, Ranson NA, Bolam DN, vandenBerg B. . Nature Communications 2021, 12(1), 44.
  • Crouch LI, Liberato MV, Urbanowicz PA, Basle A, Lamb CA, Stewart CJ, Cooke K, Doona M, Needham S, Brady RR, Berrington JE, Madunic K, Wuhrer M, Chater P, Pearson JP, Glowacki R, Martens EC, Zhang F, Linhardt RJ, Spencer DIR, Bolam DN. . Nature Communications 2020, 11(1), 4017.
  • Rebello OD, Gardner RA, Urbanowicz PA, Bolam DN, Crouch LI, Falck D, Spencer DIR. . Glycoconjugate Journal 2020, 37, 691-702.
  • Briliute J, Urbanowicz PA, Luis AS, Baslé A, Paterson N, Rebello O, Hendel J, Ndeh DA, Lowe EC, Martens EC, Spencer DIR, Bolam DN, Crouch LI. . Nature Microbiology 2019, 4, 1571-1581.
  • Joglekar P, Sonnenburg ED, Higginbottom SK, Earle KA, Morland C, Shapiro-Ward S, Bolam DN, Sonnenburg JL. . mSphere 2018, 3(3).
  • Guo B-S, Zheng F, Crouch L, Cai Z-P, Wang M, Bolam DN, Liu L, Voglmeir J. . Glycoconjugate Journal 2018, 32(3), 255-263.
  • Glenwright AJ, Pothula KR, Bhamidimarri SP, Chorev DS, Baslé A, Firbank SJ, Zheng H, Robinson CV, Winterhalter M, Kleinekathöfer U, Bolam DN, van den Berg B. . Nature 2017, 541, 407-411.
  • Cartmell A, Lowe EC, Baslé A, Firbank SJ, Ndeh DA, Murray H, Terrapon N, Lombard V, Henrissat B, Turnbull JE, Czjzek M, Gilbert HJ, Bolam DN. . Proceedings of the National Academy of Sciences of the United States of America 2017, 114(27), 7037-7042.
  • Rogowski A, Briggs JA, Mortimer JC, Tryfona T, Terrapon N, Lowe EC, Baslé A, Morland C, Day AM, Zheng H, Rogers TE, Thompson P, Hawkins AR, Yadav MP, Henrissat B, Martens EC, Dupree P, Gilbert HJ, Bolam DN. . Nature Communications 2015, 6, 7481.
  • Raghavan V, Lowe EC, Townsend GE, Bolam DN, Groisman EA. . Molecular Microbiology 2014, 93(5), 1010-1025.
  • Busse-Wicher M, Gomes TCF, Tryfona T, Nikolovski N, Stott K, Grantham NJ, Bolam DN, Skaf MS, Dupree P. . Plant Journal 2014, 79(3), 492-506.
  • Rogowski A, Basle A, Farinas CS, Solovyova A, Mortimer JC, Dupree P, Gilbert HJ, Bolam DN. . Journal of Biological Chemistry 2014, 289(1), 53-64.
  • Kovacs K, Willson BJ, Schwarz K, Heap JT, Jackson A, Bolam DN, Winzer K, Minton NP. . Biotechnology for Biofuels 2013, 6, 117.
  • Bolam DN, Koropatkin NM. . Current Opinion in Structural Biology 2012, 22(5), 563-569.
  • Lowe EC, Baslé A, Czjzek M, Firbank SJ, Bolam DN. . Proceedings of the National Academy of Sciences 2012, 109(19), 7298-7303.
  • Nakjang S, Ndeh DA, Wipat A, Bolam DN, Hirt RP. . PLoS One 2012, 7(1), 1-18.
  • Martens EC, Lowe EC, Chiang H, Pudlo NA, Wu M, McNulty NP, Abbott DW, Henrissat B, Gilbert HJ, Bolam DN, Gordon JI. . PLoS Biology 2011, 9(12), e1001221.
  • Bolam DN, Sonnenburg JS. . Gut Microbes 2011, 2(2), 86-90.
  • Sonnenburg ED, Zheng HJ, Joglekar P, Higginbottom SK, Firbank SJ, Bolam DN, Sonnenburg JL. . Cell 2010, 141(7), 1241-1252.
  • Montanier C, Flint JE, Bolam DN, Xie HF, Liu ZY, Rogowski A, Weiner DP, Ratnaparkhe S, Nurizzo D, Roberts SM, Turkenburg JP, Davies GJ, Gilbert HJ. . Journal of Biological Chemistry 2010, 285(41), 31742-31754.
  • Montanier C, Money VA, Pires VMR, Flint JE, Pinheiro BA, Goyal A, Prates JAM, Izumi A, Stålbrand H, Morland C, Cartmell A, Kolenova K, Topakas E, Dodson EJ, Bolam DN, Davies GJ, Fontes CMGA, Gilbert HJ. . PLoS Biology 2009, 7(3), e1000071.
  • Pinheiro BA, Gilbert HJ, Sakka K, Sakka K, Fernandes VO, Prates JAM, Alves VD, Bolam DN, Ferreira LMA, Fontes CMGA. . Biochemical Journal 2009, 424, 375-384.
  • Correia MAS, Pires VMR, Gilbert HJ, Bolam DN, Fernandes VO, Alves VD, Prates JAM, Ferreira LMA, Fontes CMGA. . FEMS Microbiology Letters 2009, 300(1), 48-57.
  • Bolam DN, Roberts S, Proctor MR, Turkenburg J, Dodson E, Martinez-Fleites C, Yang M, Davis B, Davies G, Gilbert HJ. . Proceedings of the National Academy of Sciences of the United States of America 2007, 104(13), 5336-5341.
  • Najmudin S, Guerreiro C, Carvalho A, Prates J, Correia M, Alves V, Ferreira L, Romão M, Gilbert HJ, Bolam DN, Fontes C. . Journal of Biological Chemistry 2006, 281(13), 8815-8828.
  • Blake A, McCartney L, Flint JP, Bolam DN, Boraston A, Gilbert HJ, Knox J. . Journal of Biological Chemistry 2006, 281(39), 29321-29329.
  • Martinez-Fleites C, Proctor MR, Roberts S, Bolam DN, Gilbert HJ, Davies G. . Chemistry and Biology 2006, 13(11), 1143-1152.
  • Henshaw J, Horne-Bitschy A, Van Bueren A, Money V, Bolam DN, Czjzek M, Ekborg N, Weiner R, Hutcheson S, Davies G, Boraston A, Gilbert HJ. . Journal of Biological Chemistry 2006, 281(25), 17099-17107.
  • McCartney L, Blake A, Flint JE, Bolam DN, Boraston A, Gilbert HJ, Knox J. . Proceedings of the National Academy of Sciences of the United States of America 2006, 103(12), 4765-4770.
  • Tunnicliffe R, Bolam DN, Pell G, Gilbert HJ, Williamson M. . Journal of Molecular Biology 2005, 347(2), 287-296.
  • Flint J, Taylor E, Yang M, Bolam DN, Tailford L, Martinez-Fleites C, Dodson E, Davis B, Gilbert HJ, Davies G. . Nature Structural and Molecular Biology 2005, 12(7), 608-614.
  • Flint JE, Bolam DN, Nurizzo D, Taylor EJ, Williamson M, Walters C, Davies G, Gilbert HJ. . Journal of Biological Chemistry 2005, 280(25), 23718-23726.
  • Yang M, Proctor M, Bolam DN, Errey J, Field R, Gilbert HJ, Davis B. . Journal of the American Chemical Society 2005, 127(26), 9336-9337.

• Review

  • Bolam DN, van den Berg B. . Current Opinion in Structural Biology 2018, 51, 35-43.