缅北禁地

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Staff Profile

Professor David Elliott

Professor of Genetics

  • Email: david.elliott@ncl.ac.uk
  • Telephone: +44 (0) 191 241 8694
  • Fax: +44 (0) 191 241 8666
  • Address: 缅北禁地 Biosciences Institute
    The International Centre for Life
    Central Parkway
    University of 缅北禁地 Upon Tyne
    NE1 3BZ
Background
I run a lab investigating RNA biology in development and disease, particularly the control of RNA splicing. Before setting up my group at 缅北禁地, I was a Royal Society of Edinburgh  fellow at the Human Genetics Unit in Edinburgh, and previously at postdoc at Brandeis University in the USA.                                     
Research

Research Interests

We use a combination of molecular and cellular biology, mouse genetics and bioinformatics to understand how gene expression is controlled at the RNA level. We are particularly interested in splicing - the process that converts precursor RNAs made from often massive human genes into smaller protein coding mRNAs.

Splicing is critical in normal development. We recently found that an RNA binding protein called RBMXL2 prevents mistakes being made in splicing during male meiosis - a special form of cell division that makes sperm. We made knockout mice who were infertile because of an arrest in meiosis. When we analysed gene expression from these mice we discovered that cells were making mistakes that would scramble mRNAs and poison gene expression.

Splicing is also important in disease. We recently have been investigating how the male hormone testosterone controls splicing in prostate cancer. We found that testosterone controls expression of a key splicing factor called ESRP2. This is important for prostate cancer development which is driven by testosterone, and also for therapy. Treatment of prostate cancer cells with a drug that interferes with testosterone function switched patterns of splicing in important genes.


Publications
  • Scott E, Elliott DJ, Munkley J. . Clinica Chimica Acta 2020, 502, 167-173.
  • Coomer AO, Black F, Greystoke A, Munkley J, Elliott DJ. . Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 2019, 1862(11-12), 194388.
  • Ehrmann I, Crichton JH, Gazzara MR, James K, Liu Y, Grellscheid SN, Curk T, de Rooij D, Steyn JS, Cockell S, Adams IR, Barash Y, Elliott DJ. . eLife 2019, 8, e39304.
  • Mellough CB, Bauer R, Collin J, Dorgau B, Zert D, Dolan D, Jones C, Izuogu OG, Yu M, Hallam D, Steyn J, White K, Steel DH, Santibanez-Koref M, Elliott DJ, Jackson M, Lindsay S, Magaraja-Grellscheid S, Lako M. . Development 2019, 146(2), dev169474.
  • Munkley J, Li L, Krishnan SRG, Hysenaj G, Scott E, Dalgliesh C, Oo HZ, Maia TM, Cheung K, Ehrmann I, Livermore KE, Zielinska H, Thompson O, Knight B, McCullagh P, McGrath J, Crundwell M, Harries LW, Daugaard M, Cockell S, Barbosa-Morais NL, Oltean S, Elliott DJ. . eLife 2019, 8, e47678.
  • Elliott DJ, Dalgliesh C, Hysenaj G, Ehrmann I. . International Journal of Biochemistry and Cell Biology 2019, 108, 1-6.
  • Izuogu O, Alhasan AA, Mellough C, Collin J, Gallon R, Hyslop J, Mastrorosa FK, Ehrmann I, Lako M, Elliott DJ, Santibanez-Koref M, Jackson MS. . BMC Genomics 2018, 19(1), 276.
  • Munkley J, Maia TM, Ibarluzea N, Livermore KE, Vodak D, Ehrmann I, James K, Rajan P, Barbosa-Morais NL, Elliott DJ. . F1000 Research 2018, 7(7), 1189.
  • Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein V, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Pryzborski S, Zwolinski S, Alharthi S, Al-Aama J, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali R, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Luehrmann R, Grellscheid SN, Johnson CA, Lako M. . Nature Communications 2018, 9, 4234.
  • Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan K-T, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Przyborski S, Zwolinski S, Al-Aama J, Alharthi S, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali RR, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Luhrmann R, Grellscheid S-N, Johnson CA, Lako M. Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa. Nature Communications 2018, 9, 4234.
  • Trincado JL, Entizne JC, Hysenaj G, Singh B, Skalic M, Elliott DJ, Eyras E. . Genome Biology 2018, 19(1), 40.
  • Danilenko M, Dalgliesh C, Pagliarini V, Naro C, Ehrmann I, Feracci M, Kheirollahi-Chadegani M, Tyson-Capper A, Clowry GJ, Fort P, Dominguez C, Sette C, Elliott DJ. . Nucleic Acids Research 2017, 45(7), 4120–4130.
  • Munkley J, Livermore K, Rajan P, Elliott DJ. . Human Genetics 2017, 136(9), 1143-1154.
  • Munkley J, McClurg UL, Livermore KE, Ehrmann I, Knight B, McCullagh P, McGrath J, Crundwell M, Harries LW, Leung HY, Mills IG, Robson CN, Rajan P, Elliott DJ. . Scientific Reports 2017, 7(1), 5249.
  • Ehrmann I, Gazzara MR, Pagliarini V, Dalgliesh C, Kheirollahi-Chadegani M, Xu Y, Cesari E, Danilenko M, Maclennan M, Lowdon K, Vogel T, Keskivali-Bond P, Wells S, Cater H, Fort P, Sanibanez-Koref M, Middei S, Sette C, Clowry GJ, Barash Y, Cunningham MO, Elliott DJ. . Cell Reports 2016, 17(12), 3269-3280.
  • Livermore KE, Munkley J, Elliott DJ. . AIMS Molecular Science 2016, 3(2), 280-299.
  • Alhasan A, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. . Blood 2016, 127(9), e1-e11.
  • Izuogu OG, Alhasan AA, Alafghani HM, Santibanez-Koref M, Elliott DJ, Jackson MS. . BMC Bioinformatics 2016, 17(1), 92.
  • Munkley J, Elliott DJ. Evaluation of Tra2 proteins as potential therapeutic targets in breast cancer. Oncotarget 2016. Submitted.
  • Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, Robson CN, Mills IG, Rajan P, Elliott DJ. . eBioMedicine 2016, 8, 103-116.
  • Munkley J, Elliott DJ. . Oncotarget 2016, 7, 35478-35489.
  • Neganova A, Shmeleva E, Munkley J, Chichagova V, Anyfantis G, Anderson R, Passos AJ, Elliott DJ, Armstrong L, Lako M. . Stem Cells 2016, 34(5), 1198-1212.
  • Ehrmann I, Fort P, Elliott DJ. . Biochemical Society Transactions 2016, 44(4), 1066-1072.
  • Feracci M, Foot JN, Grellscheid SN, Danilenko M, Stehle R, Gonchar O, Kang HS, Dalgliesh C, Meyer NH, Liu YL, Lahat A, Sattler M, Eperon IC, Elliott DJ, Dominguez C. . Nature Communications 2016, 7, 10355.
  • Munkley J, Elliott DJ. . Cancer Cell & Microenvironment 2016, 3(1), e1174.
  • Munkley J, Mills IG, Elliott DJ. . Nature Reviews Urology 2016, 13(6), 324-333.
  • Best A, James K, Hysenaj G, Tyson-Capper A, Elliott DJ. . Frontiers of Chemical Science and Engineering 2016, 10(2), 186-195.
  • Munkley J, Lafferty NP, Kalna G, Robson CN, Leung HY, Rajan P, Elliott DJ. . BMC Cancer 2015, 15, 9.
  • Madgwick A, Fort P, Hanson PS, Thibault P, Gaudreau MC, Lutfalla G, Möröy T, Abou-Elela S, Chaudhry B, Elliott DJ, Morris CM, Venables JP. . PLoS One 2015, 10(5), e0125998.
  • Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI, Johannessen B, Knight B, McCullagh P, McGrath J, Crundwell M, Skotheim RI, Robson CN, Leung HY, Harries LW, Rajan P, Mills IG, Elliott DJ. . Oncotarget 2015, 6(33), 34358-34374.
  • Munkley J, Livermore KE, McClurg UL, Kalna G, Knight B, McCullagh P, McGrath J, Crundwell M, Leung HY, Robson CN, Harries LW, Rajan P, Elliott DJ. . Oncoscience 2015, 2(9).
  • Stockley J, Markert E, Zhou Y, Robson CN, Elliott DJ, Lindberg J, Leung HY, Rajan P. . Scientific Reports 2015, 5, 13426.
  • Hong E, Best A, Gautrey H, Chin J, Razdan A, Curk T, Elliott DJ, Tyson-Capper AJ. . BioMed Research International 2015, 395816.
  • Boczonadi V, Muller JS, Pyle A, Munkley J, Dor T, Quartararo J, Ferrero I, Karcagi V, Giunta M, Polvikoski T, Birchall D, Princzinger A, Cinnamon Y, Lutzkendorf S, Piko H, Reza M, Florez L, Santibanez-Koref M, Griffin H, Schuelke M, Elpeleg O, Kalaydjieva L, Lochmuller H, Elliott DJ, Chinnery PF, Edvardson S, Horvath R. . Nature Communications 2014, 5, 4287.
  • Munkley J, Rajan P, Lafferty NP, Dalgliesh C, Jackson RM, Robson CN, Leung HY, Elliott DJ. . OncoTarget 2014, 5(1), 131-139.
  • Best A, James K, Dalgliesh C, Hong EA, Kheirolahi-Kouhestani M, Curk T, Xu Y, Danilenko M, Hussain R, Keavney B, Wipat A, Klinck R, Cowell IG, Cheong Lee K, Austin C, Venables JP, Chabot B, Santibanez Koref M, Tyson-Capper AJ, Elliott DJ. . Nature Communications 2014, 5, 4760.
  • Elliott DJ. . Genes 2014, 5(1), 235-253.
  • Hong EA, Elliott DJ, Best A, Tyson-Capper AJ. . Nucleic Acids Research 2014. In Preparation.
  • Best A, Dalgliesh C, Kheirollahi-Kouhestani M, Danilenko M, Ehrmann I, Tyson-Capper AJ, Elliott DJ. . Biochemical Society Transactions 2014, 42(4), 1152-1158.
  • Best AJ, Dalgleish C, Ehrmann I, Kheirollahi-Kouhestani M, Tyson-Capper AJ, Elliott DJ. . International Journal of Cell Biology 2013, 2013, 843781.
  • Schmid R, Grellscheid SN, Ehrmann I, Dalgliesh C, Danilenko M, Paronetto MP, Pedrotti S, Grellscheid D, Dixon RJ, Sette C, Eperon IC, Elliott DJ. . Nucleic Acids Research 2013, 41(22), 10170-10184.
  • Ehrmann I, Dalgliesh C, Liu Y, Danilenko M, Crosier M, Overman L, Arthur HM, Lindsay S, Clowry GJ, Venables JP, Fort P, Elliott DJ. . PLoS Genetics 2013, 9(4), e1003474.
  • Elliott DJ, Best A, Dalgliesh C, Ehrmann I, Grellscheid S. . Biochemical Society Transactions 2012, 40, 784-788.
  • Hong EA, Elliott DJ, Tyson-Capper AJ. . In: 59th Annual Scientific Meeting of the Society for Gynecologic Investigation. 2012, Sage.
  • Hong EA, Gautrey HL, Elliott DJ, Tyson-Capper AJ. . Biochemical Society Transactions 2012, 40(4), 826-830.
  • Grellscheid S, Dalgliesh C, Storbeck M, Best A, Liu Y, Jakubik M, Mende Y, Ehrmann I, Curk T, Rossbach K, Bourgeois CF, Stévenin J, Grellscheid D, Jackson MS, Wirth B, Elliott DJ. . PLoS Genetics 2011, 7(12), e1002390.
  • Rajan P, Dalgliesh C, Carling PJ, Buist T, Zhang CL, Grellscheid SN, Armstrong K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN, Leung HY, Elliott DJ. . PLoS One 2011, 6(12), e29088.
  • Grellscheid SN, Dalgliesh C, Rozanska A, Grellscheid D, Bourgeois CF, Stevenin J, Elliott DJ. . Nucleic Acids Research 2011, 39(18), 8092-8104.
  • Al-Balool HH, Weber D, Liu Y, Wade M, Guleria K, Nam PL, Clayton J, Rowe W, Coxhead J, Irving J, Elliott DJ, Hall AG, Santibanez-Koref M, Jackson MS. . Genome Research 2011, 21(11), 1788-1799.
  • Liu YL, Elliott DJ. . In: Biochemical Society Transactions: 13th Tenovus Scotland Symposium - Gene Expression in Development and Disease. 2010, Glasgow, UK: Portland Press Ltd.
  • Dreumont N, Bourgeois CF, Lejeune F, Liu Y, Ehrmann IE, Elliott DJ, Stevenin J. . Journal of Cell Science 2010, 123(1), 40-50.
  • Sellier C, Rau F, Liu YL, Tassone F, Hukema RK, Gattoni R, Schneider A, Richard S, Willemsen R, Elliott DJ, Hagerman PJ, Charlet-Berguerand N. . EMBO Journal 2010, 29(7), 1248-1261.
  • Rajan P, Elliott DJ, Robson CN, Leung HY. . Nature Reviews Urology 2009, 6(8), 454-460.
  • Lu Y, Ryan SL, Elliott DJ, Bignell GR, Futreal PA, Ellison DW, Bailey S, Clifford SC. . PLoS ONE 2009, 4(7), e6159.
  • Rajan P, Dalgliesh C, Bourgeois CF, Heiner M, Emami K, Clark EL, Bindereif A, Stevenin J, Robson CN, Leung HY, Elliott DJ. . BMC Cell Biology 2009, 10(1), 82.
  • Liu Y, Bourgeois CF, Pang S, Kudla M, Dreumont N, Kister L, Sun YH, Stevenin J, Elliott DJ. . PLoS Genetics 2009, 5(11), e1000707.
  • Clark EL, Fuller-Pace FV, Elliott DJ, Robson CN. . Biochemical Society Transactions 2008, 36(3), 546-547.
  • Ehrmann I, Dalgliesh C, Tsaousi A, Paronetto MP, Heinrich B, Kist R, Cairns P, Li W, Mueller C, Jackson M, Peters H, Nayernia K, Saunders P, Mitchell M, Stamm S, Sette C, Elliott DJ. . Human Molecular Genetics 2008, 17(18), 2803-2818.
  • Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY, Elliott DJ. . Biochemical Society Transactions 2008, 36(3), 505-507.
  • Clark EL, Coulson AC, Dalgliesh C, Rajan P, Nicol SM, Fleming S, Heer R, Gaughan L, Leung HY, Elliott DJ, Fuller-Pace FV, Robson CN. . Cancer Research 2008, 68(19), 7938-7946.
  • Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY, Elliott DJ. . Journal of Pathology 2008, 215(1), 67-77.
  • Sergeant KA, Bourgeois CF, Dalgliesh C, Venables JP, Stevenin J, Elliott DJ. . Journal of Cell Science 2007, 120(2), 309-319.
  • Skrisovska L, Bourgeois CF, Stefl R, Grellscheid S-N, Kister L, Wenter P, Elliott DJ, Stevenin J, Allain FH-T. . EMBO Reports 2007, 8(4), 372-379.
  • Elliott DJ, Grellscheid SN. . Reproduction 2006, 132(6), 811-819.
  • Nayernia K, Nolte J, Michelmann HW, Lee JH, Rathsack K, Drusenheimer N, Dev A, Wulf G, Ehrmann IE, Elliott DJ, Okpanyi V, Zechner U, Haaf T, Meinhardt A, Engel W. . Developmental Cell 2006, 11(1), 125-132.
  • Reis A, Levasseur M, Chang H-Y, Elliott DJ, Jones KT. . EMBO Reports 2006, 7(10), 1040-1045.
  • Thornton JK, Dalgleish C, Venables JP, Sergeant KA, Ehrmann IE, Lu X, Saunders PTK, Elliott DJ. . Oncogene 2006, 25(22), 3104-3112.
  • Jarvis S, Elliott DJ, Morgan D, Winston R, Readhead C. . Human Reproduction 2005, 20(1), 108-116.
  • McDougall A, Elliott DJ, Hunter N. . EMBO Reports 2005, 6(2), 120.
  • Ehrmann I, Elliott DJ. . Reproductive BioMedicine Online 2005, 10(1), 55-63.
  • Venables JP, Bourgeois CF, Dalgliesh C, Kister L, Stevenin J, Elliott DJ. . Human Molecular Genetics 2005, 14(16), 2289-2303.
  • Rovio AT, Abel J, Ahola AL, Andres AM, Bertranpetit J, Blancher A, Bontrop RE, Chemnick LG, Cooke HJ, Cummins JM, Davis HA, Elliott DJ, Fritsche E, Hargreave TB, Hoffman SMG, Jequier AM, Kao S-H, Kim H-S, Marchington DR, Mehmet D, Otting N, Poulton J, Ryder OA, Schuppe H-C, Takenaka O, Wei Y-H, Wichmann L, Jacobs HT. . Mammalian Genome 2004, 15(6), 492-502.
  • Hyslop LA, Nixon VL, Levasseur M, Chapman F, Chiba K, McDougall A, Venables JP, Elliott DJ, Jones KT. . Developmental Biology 2004, 269(1), 206-219.
  • Venables JP, Dalgliesh C, Paronetto MP, Skitt L, Thornton JK, Saunders PT, Sette C, Jones KT, Elliott DJ. . Human Molecular Genetics 2004, 13(14), 1525-1534.
  • Elliott DJ. . International Journal of Andrology 2004, 27(6), 328-334.
  • Saunders PTK, Turner JMA, Ruggiu M, Taggart M, Burgoyne PS, Elliott D, Cooke HJ. . Reproduction 2003, 126(5), 589-597.
  • Szot M, Grigoriev V, Mahadevaiah SK, Ojarikre OA, Tour A, Von Glasenapp E, Rattigan A, Turner JMA, Elliott DJ, Burgoyne PS. . Cytogenetic and Genome Research 2003, 103(3-4), 330-336.
  • Schreiber L, Lifschitz-Mercer B, Paz G, Yavetz H, Elliott DJ, Kula K, Slowikowska-Hilczer J, Maymon BB-S. . International Journal of Surgical Pathology 2003, 11(1), 17-20.
  • Schreiber L, Lifschitz-Mercer B, Paz G, Yavetz H, Zadik Z, Kula K, Slowikowska-Hilczer J, Rey R, Elliott DJ, Maymon BB-S. . Journal of Andrology 2003, 24(1), 78-84.
  • Elliott D. . Cytogenetic and Genome Research 2003, 103(3-4), 210-216.
  • Paronetto MP, Venables JP, Elliott DJ, Geremia R, Rossi P, Sette C. . Oncogene 2003, 22(54), 8707-8715.
  • Lifschitz-Mercer B, Elliott DJ, Issakov J, Leider-Trejo L, Schreiber L, Misonzhnik F, Eisenthal A, Maymon B. . Virchows Archiv 2002, 440(4), 387-391.
  • Maymon BB-S, Paz G, Elliott DJ, Lifschitz-Mercer B, Yogev L, Kleiman SE, Botchan A, Hauser R, Schreiber L, Yavetz H. . Acta Histochemica 2002, 104(3), 255-261.
  • Turner JMA, Mahadevaiah SK, Elliott DJ, Garchon H-J, Pehrson JR, Jaenisch R, Burgoyne PS. . Journal of Cell Science 2002, 115(21), 4097-4105.
  • Lifschitz-Mercer B, Elliott DJ, Schreiber-Bramante L, Leider-Trejo L, Eisenthal A, Maymon BB-S. . International Journal of Surgical Pathology 2001, 9(2), 93-98.
  • Rovio AT, Marchington DR, Donat S, Schuppe H-C, Abel J, Fritsche E, Elliott DJ, Laippala P, Ahola AL, McNay D, Harrison RF, Hughes B, Barrett T, Bailey DMD, Mehmet D, Jequier AM, Hargreave TB, Kao S-H, Cummins JM, Barton DE, Cooke HJ, Wei Y-H, Wichmann L, Poulton J, Jacobs HT. . Nature Genetics 2001, 29(3), 261-262.
  • Maymon B, Elliott DJ, Kleiman SE, Yogev L, Cooke HJ, Paz G, Yavetz H. . Human Pathology 2001, 32(1), 36-41.
  • Elliott DJ, Bourgeois CF, Klink A, Stevenin J, Cooke HJ. . Proceedings of the National Academy of Science (USA) 2000, 97(11), 5717-5722.
  • Elliott DJ, Venables JP, Newton CS, Lawson D, Boyle S, Eperon IC, Cooke HJ. . Human Molecular Genetics 2000, 9(14), 2117-2124.
  • Venables JP, Elliott DJ, Makarova OV, Makarov EM, Cooke HJ, Eperon IC. . Human Molecular Genetics 2000, 9(5), 685-694.
  • Elliott DJ. . Histology and Histopathology 2000, 15(1), 239-249.
  • Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC. . Human Molecular Genetics 1999, 8(6), 959-969.
  • D.J. Elliott, M.R. Millar, K. Oghene, A. Ross, F. Kiesewetter, J. Pryor, M. McIntyre, T.B. Hargreave, P.T.K. Saunders, P.H. Vogt, A.C. Chandley and H. Cooke. Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm. Proceedings of the National Academy of Sciences (USA) 1997, 94, 3848-3853.