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Staff Profile

Dr David Lewis-Smith

Associate Clinical Lecturer

Background

Dr David Lewis-Smith is an Associate Clinical Lecturer and specialist registrar in neurology mentored by Dr Rhys H. Thomas at 缅北禁地 University and  at Children's Hospital of Philadelphia, PA.

He has spent his Wellcome Trust Clinical PhD Research Training Fellow (4ward North Clinical PhD Academy) seeking to understand the effects of genetic factors on the clinical features of people's epilepsy and how knowledge of these relationships can facilitate precision medicine, personalising clinical care and treatment to a person's particular symptoms and disease mechanism.

His research focusses on the critical appraisal of phenotype in large collaborative genetic studies, using tools such as the , to which he . He develops computational methods to model the clinical reasoning that address the phenotypic bottleneck in large -omic projects, aiming to bridge the gap between clinical research and bioinformatics to bring people's symptoms to the centre of a platform data science approach.

He contributes to the International League Against Epilepsy (ILAE) internationally and nationally. He is junior leader of the  Task Force of the Genetics Commission, a member of the Task Force of the Big Data Commission, Vice-chairperson of the British Chapter of the of the ILAE, and a member of the  Gene Expert Curation Panel for Epilepsy.

Research

Dr David Lewis-Smith's reseach focusses on the computational analysis of epilepsy and associated neurological phenotypes to discover clinical and genetic biomarkers that will improve prognostication and treatment stratification for people with epilepsy.

His primary research tool is the (HPO), to which he . He works with research and electronic healthcare records, developing algorithms that model and formalise clinical reasoning to overcome the challenge of scalability (the phenotyping bottleneck) in modern multi-omic studies.

He has led the ILAE Epilepsiome Task Force's revision of the representation of in the HPO in collaboration with  (Jackson Laboratory, CT).

He is privileged to work with data from the , , and other collaborative repositories. He contributes to the ILAE Consortium on Complex Epilepsies (common genetic variant analysis), the EU-funded , and the led by Prof. Alfred L. George Jr. (Northwestern University, IL).

He presented his work as platform presentations at the American Epilepsy Society Annual Meeting and (Young Investigator Award) and the British ILAE Annual Scientific Meeting 2019 and 2021 (Clinical Presentation Prize), and invited to present at the American Academy of Neurology .

Beyond epilepsy phenomics and genetics he collaborates with researchers in neurophysiology, developmental biology, and human brain connectome.

Please do not hesitate to contact me if you wish to discuss potential collaboration.


Teaching

Dr David Lewis-Smith is an Associate Fellow of the Higher Education Academy and offers teaching for medical students, junior doctors, general practitioners and psychiatrists in 缅北禁地 upon Tyne.

Publications

  • Articles

    • Montanucci L, Lewis-Smith D, Collins RL, Niestroj L-M, Parthasarathy S, Xian J, Ganesan S, Macnee M, Brünger T, Thomas RH, Talkowski M, Epi25 Collaborative, Helbig I, Leu C, Lal D. . Nature Communications 2023, 14, 4392.
    • Daniali M, Galer PD, Lewis-Smith D, Parthasarathy S, Kim E, Salvucci DD, Miller JM, Haag S, Helbig I. . Artificial Intelligence in Medicine 2023, 139, 102523.
    • Stamberger H, Crosiers D, Balagura G, Bonardi CM, Basu A, Cantalupo G, Chiesa V, Christensen J, Bernardina BD, Ellis CA, Furia F, Gardiner F, Giron C, Guerrini R, Klein KM, Korff C, Krijtova H, Leffner M, Lerche H, Lesca G, Lewis-Smith David, Marini C, Marjanovic D, Mazzola L, McKeownRuggiero S, Mochel F, Ramond F, Reif PS, Richard-Mornas A, Rosenow F, Schropp C, Thomas RH, Vignoli A, Weber Y, Palmer E, Helbig I, Scheffer IE, Striano P, Møller RS, Gardella E, Weckhuysen S. . Neurology 2022, 99(3), e221-e233.
    • Elwan M, Fowkes R, Lewis-Smith D, Winder A, Baker MR, Thomas RH. . Epileptic Disorders 2022, 19, 100556.
    • Stanley K, Hostyk J, Tran L, Dugan P, Clark J, Choi H, Perucca P, Fernandes C, Andrade D, Devinsky O, Cavalleri GL, Depondt C, Sen A, O'Brien T, Heinzen E, Loddenkemper T, Goldstein DB, Mikati MA, Delanty N, Adcock J, Andrade D, Brazil C, Cavalleri G, Choi H, Costello D, Delanty N, Depondt C, Dugan P, Goldstein D, Heinzen E, Lewis-Smith D, O'Brien T, Perucca P, Radtke R, Rees M, Sen A, Stanley K, Thomas R, Amengual-Gual M, Amengual-Gual M, Arya R, Agullar CB, Clark J, Fernandes C, Gainza-Lein M, Glauser TA, Goldstein D, Joshua L, Ann G, Lurie RH, Heinzen ME, Jackson, Tran L, Loddenkemper T, McDonough TL, Mikati MA, Peariso K, Fernandez IS, Sands T, Sheehan T, Stanley K, Tasker RC, Tchapyjnikov D, Tchapyjnikov D, Vasquez A, Wainright MS, Wilfong A, Williams K. . American Journal of Medical Genetics, Part A 2022, 188(1), 138-146.
    • Lewis-Smith D, Parthasarathy S, Xian J, Kaufman MC, Ganesan S, Galer PD, Thomas RH, Helbig I. . Human Mutation 2022, 43(11), 1642-1658.
    • Lewis-Smith D, Jaiser SR, Thomas RH. . Epileptic Disorders 2022, 24(5), 961-964.
    • McLeod F, Dimtsi A, Marshall AC, Lewis-Smith DJ, Thomas R, Clowry GJ, Trevelyan AJ. . Brain 2023, 146(3), 850-857.
    • Fowkes R, Elwan M, Akay E, Mitchell CJ, Thomas RH, Lewis-Smith D. . Epilepsy & Behavior Reports 2022, 19, 100549.
    • Kohler S, Gargano M, Matentzoglu N, Carmody LC, Lewis-Smith D, Vasilevsky NA, Danis D, Balagura G, Baynam G, Brower AM, Callahan TJ, Chute CG, Est JL, Galer PD, Ganesan S, Griese M, Haimel M, Pazmandi J, Hanauer M, Harris NL, Hartnett MJ, Hastreiter M, Hauck F, He Y, Jeske T, Kearney H, Kindle G, Klein C, Knoflach K, Krause R, Lagorce D, McMurry JA, Miller JA, Munoz-Torres MC, Peters RL, Rapp CK, Rath AM, Rind SA, Rosenberg AZ, Segal MM, Seidel MG, Smedley D, Talmy T, Thomas Y, Wiafe SA, Xian J, Yuksel Z, Helbig I, Mungall CJ, Haendel MA, Robinson PN. . Nucleic Acids Research 2021, 49(D1), D1207-D1217.
    • Lewis-Smith D, Ganesan S, Galer PD, Helbig KL, McKeown SE, O'Brien M, Khankhanian P, Kaufman MC, Gonzalez AK, Felmeister AS, Krause R, Ellis CA, Helbig I. . European Journal of Human Genetics 2021, 29, 1690-1700.
    • Lewis-Smith D, Galer PD, Balagura G, Kearney H, Ganesan S, Cosico M, O'Brien M, Vaidiswaran P, Krause R, Ellis CA, Thomas RH, Robinson PN, Helbig I. . Epilepsia 2021, 62(6), 1293-1305.
    • Crawford K, Xian J, Helbig KL, Galer PD, Parthasarathy S, Lewis-Smith D, Kaufman MC, Fitch E, Ganesan S, O'Brien M, Codoni V, Ellis CA, Conway LJ, Taylor D, Krause R, Helbig I. . Genetics in Medicine 2021, 23(7), 1263-1272.
    • Accogli A, Wiegand G, Scala M, Cerminara C, Iacomino M, Riva A, Carlini B, Camerota L, Belcastro V, Prontera P, Fernández-Jaén A, Bebek N, Scudieri P, Baldassari S, Salpietro VD, Novelli G, De Luca C, von Stülpnagel C, Kluger F, Kluger GJ, Wohlrab GC, Ramantani G, Lewis-Smith D, Thomas RH, Lai M, Verrotti A, Striano S, Depienne C, Minetti C, Benfenati F, Brancati F, Zara F, Striano P. . Neurology 2021, 97(6), e577-e586.
    • Accogli A, Wiegand G, Scala M, Cerminara C, Iacomino M, Riva A, Carlini B, Camerota L, Belcastro V, Prontera P, Fernández-Jaén A, Bebek N, Scuderi P, Baldassari S, Salpietro VD, Novelli A, De Luca C, von Stulpnagel C, Kluger F, Kluger GJ, Wohlrag GC, Ramantani G, Lewis-Smith D, Thomas RH, Lai M, Verrotti A, Striano S, Depienne C, Minetti C, Benfenati F, Brancati F, Zara F, Striano P. . Neurology 2021, 97(6), e577-e586.
    • Galer PD, Ganesan S, Lewis-Smith D, McKeown SE, Pendziwiat M, Helbig KL, Ellis CA, Rademacher A, Smith L, Poduri A, Seiffert S, von Spiczak S, Muhle H, van Baalen A, NCEE Study Group, EPGP Investigators, EuroEpinomics Consortium, Genomics Research and Innovation Network, Thomas RH, Krause R, Weber Y, Helbig I. . American Journal of Human Genetics 2020, 107(4), 683-697.
    • Lewis-Smith DJ, Wolpe N, Ghosh BCP, Rowe JB. . Journal of Neurology 2020, 267, 1147-1157.
    • Bansagi B, Lewis-Smith D, Pal E, Duff J, Griffin H, Pyle A, Müller JS, Rudas G, Aranyi Z, Lochmüller H, Chinnery PF, Horvath R. . Neurology Genetics 2016, 2(6), e199.
    • Lewis-Smith DJ, Duff J, Pyle A, Griffin H, Polvikoski T, Birchall D, Horvath R, Chinnery PF. . Neurology: Genetics 2016, 2(2), e110.
    • Lewis-Smith D, Kamer KJ, Griffin H, Childs AM, Pysden K, Titov D, Duff J, Pyle A, Taylor RW, Yu-Wai-Man P, Ramesh V, Horvath R, Mootha VK, Chinnery PF. . Neurology: Genetics 2016, 2(2), e59.
    • Horvath R, Lewis-Smith D, Douroudis K, Duff J, Keogh M, Pyle A, Fletcher N, Chinnery PF. . Neurology 2015, 85(21), 1909-1911.

  • Book Chapter

    • Lewis-Smith D, Craig DP, Thomas NJP, Hamandi K, Thomas RH. . In: Clinical Molecular Medicine: Principles and Practice. Academic Press, 2020, pp.289-308.

  • Conference Proceedings (inc. Abstracts)

    • Lewis-Smith D, Galer PD, Ganesan S, Krause R, Thomas RH, Helbig I, EpiCollaborative a. . In: American Epilepsy Society Annual Meeting. 2021, Virtual: American Epilepsy Society.
    • Lewis-Smith D, Balagura G, Kearney H, Galer P, Ganesan S, Gan G, Krause R, Robinson P, Helbig I. . In: International League Against Epilepsy British Branch Annual Scientific Meeting. 2019, Birmingham: ILAE.
    • Kearney H, Lewis-Smith D, Balagura G, Ganesan S, Galer PD, Gan J, Wang Y, Kiat NTC, Lench NJ, Steward CA, Krause R, Robinson P, Delanty N, Cavalleri G, Helbig I. . In: American Epilepsy Society Annual Meeting. 2019, Baltimore: American Epilepsy Society.
    • Lewis-Smith D, Craig D, Thomas RH. . In: Association of British Neurologists Annual Meeting. 2019, Edinburgh: BMJ Publishing.
    • Hagan A, Lewis-Smith D, Thomas RH. . In: International League Against Epilepsy British Branch Annual Scientific Meeting. 2018, Birmingham: ILAE.
    • Lewis-Smith DJ, Patil B, Ramesh V, Chinnery PF, Basu AP. . In: British Paediatric Neurology Association Annual Meeting. 2017, Cambridge, UK: Wiley-Blackwell.
    • Bolton C, Chapman J, Ledingham D, Lewis-Smith D, Spyropoulos A, Guadagno J, Duddy M. . In: ABN Annual Meeting. 2016, Brighton, UK: BMJ Publishing Group.
    • Lewis-Smith D, Basu A, Hussain R, Patil B, Ramesh V, Chinnery PF. . In: 2nd Congress of the European Academy of Neurology. 2016, Copenhagen: Wiley-Blackwell.
    • Childs AM, Pysden K, Roper H, Chow G, Niks EH, Kriek M, Chinnery PF, Lewis-Smith D, Duchen M, Szabadkai G, Logan C, Sheridan E, Sewry C, Muntoni F. . In: 19th International Congress of The World Muscle Society. 2014, Berlin, Germany: Elsevier.
    • Lewis-Smith DJ, Ghosh BCP, Rowe JB. The alien limb syndrome of corticobasal degeneration is both common and independent of apraxia. In: Joint Meeting of the Association of British Neurologists and Sociedad Cubana de Neurología y Neurocirugía. 2011, Havana: BMJ Publishing: Journal of Neurology, Neurosurgery and Psychiatry. In Preparation.

  • Letters

    • Lewis-Smith D, Thomas RH. . Epilepsia 2020, 61(9), 2053-2054.
    • Lewis-Smith D, Ellis CA, Helbig I, Thomas RH. . Brain 2020, 143(3), e19.

  • Review

    • Gulcebi MI, Bartolini E, Lee O, Lisgaras CP, Onat F, Mifsud J, Striano P, Vezzani A, Hildebrand MS, Jimenez-Jimenez D, Junck L, Lewis-Smith D, Scheffer IE, Thijs RD, Zuberi SM, Blenkinsop S, Fowler HJ, Foley A, Sisodiya SM, Balestrini S, Berkovic S, Cavalleri G, Correa DJ, Martins Custodio H, Galovic M, Guerrini R, Henshall D, Howard O, Hughes K, Katsarou A, Koeleman BPC, Krause R, Lowenstein D, Mandelenaki D, Marini C, O'Brien TJ, Pace A, De Palma L, Perucca P, Pitkanen A, Quinn F, Selmer KK, Steward CA, Swanborough N, Thijs R, Tittensor P, Trivisano M, Weckhuysen S, Zara F. . Epilepsy and Behavior 2021, 116, 107791.