缅北禁地

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Staff Profile

Professor Deborah Henderson

Professor of Cardiac Development

  • Telephone: +44 (0) 191 241 8644
  • Address: Biosciences Institute
    缅北禁地
    Centre for Life
    Central Parkway
    缅北禁地 upon Tyne
    NE1 3BZ
Background


Background

Conyers School, Yarm, Stockton-on-Tees 1977-1984

BSc Applied Biology - Coventry Polytechnic (including 1 year sandwich placement) 1984-1988

PhD -  Royal Postgraduate Medical School, University of London (Molecular Biology) 1989-1992

Post Doctoral research – Institute of Child Health, University College London 1993-1999

British Heart Foundation Basic Science Lectureship - Institute of Child Health, University College 1999-2002

British Heart Foundation Basic Science Lectureship (renewed in 2005) - Institute of Human Genetics, 缅北禁地 2002 – 2010 (promotion to Senior Lecturer in 2006)

Chair in Cardiovascular Development Institute Genetic Medicine, 缅北禁地 2008– present

Deputy Director Institute of Genetic Medicine 2011-2014; 2017-2018

Deputy Dean of Research, Faculty of Medical Sciences, 缅北禁地 2011-2015

Dean of Research, Faculty of Medical Sciences, 缅北禁地 2015-2016

Director of Scientific Core Facilities, Faculty of Medical Sciences, 缅北禁地 2016-2019

Director of Human Developmental Biology Resource (缅北禁地) 2018-present

Google SCHOLAR: https://scholar.google.co.uk/citations?user=56u7zckAAAAJ&hl=en

Orcid number: 000-0002-2705-5998

Research

Cardiovascular developmental and disease modelling using mice and zebrafish, asking:

What are the developmental origins of congenital heart disease? Can we stratify congenital heart disease on the basis of the lineage of origin of the malformations?

How do the arterial valves form and what are the developmental origins of valve anomalies such as bicuspid aortic valve?

How can we promote resilience in adults with congenital heart disease?

What are the morphogenetic mechanisms that underlie common outflow anomalies?

Over one third of cardiac malformations affect the outflow region of the heart. During development a number of embryonic cell lineages come together to form the complex architecture of the aorta and pulmonary trunk. Together with Bill Chaudhry, we are discovering how different cellular and molecular signalling pathways – particularly the non canonical Wnt, planar cell polarity pathway - are necessary for the normal development of the outflow vessels and are linked to outflow malformations.

The developmental origins of bicuspid aortic valve

Bicuspid aortic valve (BAV) is the most common congenital anomaly that predisposes to adult cardiovascular disease.  Bill Chaudhry and I are investigating how the normal aortic valve forms and elaborating the pathological mechanisms that lead to BAV.

Left-right signalling and planar cell polarity in cardiac development

Disturbances in the planar cell polarity pathway and in left-right specification cause heart malformations in mice and zebrafish. Together with Bill Chaudhry, I am asking if these pathways are linked and if they may point to a genetic cause for malformations such as double outlet right ventricle and atrial/ventricular septal defects.

Resilience in ACHD

Children with congenital heart disease now survive into adulthood and are a growing patient group. As part of a collaborative research effort with Louise Coats and Bill Chaudhry I am interested in understanding their issues, both medical and psychosocial, with the aim of maintaining their holistic wellbeing through finding biomarkers that will indicate problems before they become clinically apparent and by investigating how we can give this divers patient group the type and degree of support they need.

Technical expertise

Laboratory models of cardiovascular disease disease, particularly utilising Cre-lox mice.

Cardiac morphology and developmental anatomy

Co-workers

Robert Anderson, Visiting Professor of cardiac morphology

Lorraine Eley, BHF Senior Research Associate

Ahlam Alqahtani, Postdoc

Mashael Alaradi, PhD student

Teaching

My teaching responsibilities at 缅北禁地 are closely linked with my research activity. I provide undergraduate and postgraduate teaching in developmental genetics, cardiovascular development and congenital heart disease. In the laboratory I provide supervision for PhD, master’s and undergraduate students from our own biomedical sciences course and from other universities across the UK and abroad.

Genetics (BGM1004)

Cardiovascular Science in Health and Disease (MMB8037)

Publications

  • Articles

    • Derrick CJ, Szenker-Ravi E, Santos-Ledo A, Alqahtani A, Yusof A, Eley L, Coleman AHL, Tohari S, Ng AY-J, Venkatesh B, Alharby E, Mansard L, Bonnet-Dupeyron M-N, Roux A-F, Vache C, Roume J, Bouvagnet P, Almontashiri NAM, Henderson DJ, Reversade B, Chaudhry B. . Human Molecular Genetics 2024, 33(2), 150-169.
    • Eley L, Richardson RV, Alqahtani A, Chaudhry B, Henderson DJ. . Disease Models & Mechanisms 2024, 17(1), dmm050265.
    • Anderson RH, Lamers WH, Hikspoors JPJM, Mohun TJ, Bamforth SD, Chaudhry B, Eley L, Kerwin J, Crosier M, Henderson DJ. . Journal of Anatomy 2024, 244(3), 497-513.
    • Goh I, Botting R, Rose A, Webb S, Engelbert J, Gitton Y, Stephenson E, Quiroga Londoño M, Mather M, Mende N, Imaz-Rosshandler I, Horsfall D, Basurto-Lozada D, Chipampe N-J, Rook V, Yang L, Mazin P, Vijayabaskar MS, Ton M-L, Lee J, Keitley D, Hannah R, Gambardella L, Green K, Ballereau S, Inoue M, Tuck E, Lorenzi V, Kwakwa K, Alsinet C, Olabi B, Miah M, Admane C, Popescu D, Ness T, Acres M, Dixon D, Coulthard R, Lisgo S, Henderson D, Dann E, Suo C, Kinston S, Park J-E, Polanski K, van Dongen S, Meyer K, De Bruijn M, Palis J, Behjati S, Laurenti E, Wilson N, Marioni J, Vento-Tormo R, Chedotal A, Bayraktar O, Roberts I, Jardine L, Gottgens B, Teichmann S, Haniffa M. . Science 2023, 381(6659), eadd7564.
    • Queen R, Crosier M, Eley L, Kerwin J, Turner JE, Yu J, Alqahtani A, Dhanaseelan T, Overman L, Soetjoadi H, Baldock R, Coxhead J, Boczonadi V, Laude A, Cockell SJ, Kane MA, Lisgo S, Henderson DJ. . PLoS Genetics 2023, 19(11).
    • Derrick CJ, Santos-Ledo A, Eley L, Paramita IA, Henderson DJ, Chaudhry B. . Development (Cambridge) 2022, 149(9).
    • Murphy LB, Santos-Ledo A, Dhanaseelan T, Eley L, Burns D, Henderson DJ, Chaudhry B. . Disease Models and Mechanisms 2021, 14(7), dmm.049013.
    • Jardine L, Webb S, Goh I, Quiroga Londono M, Reynolds G, Mather M, Olabi B, Stephenson E, Botting RA, Horsfall D, Engelbert J, Maunder D, Mende N, Murnane C, Dann E, McGrath J, King H, Kucinski I, Queen R, Carey CD, Shrubsole C, Poyner E, Acres M, Jones C, Ness T, Coulthard R, Elliott N, O'Byrne S, Haltalli MLR, Lawrence JE, Lisgo S, Balogh P, Meyer KB, Prigmore E, Ambridge K, Jain MS, Efremova M, Pickard K, Creasey T, Bacardit J, Henderson D, Coxhead J, Filby A, Hussain R, Dixon D, McDonald D, Popescu D-M, Kowalczyk MS, Li B, Ashenberg O, Tabaka M, Dionne D, Tickle TL, Slyper M, Rozenblatt-Rosen O, Regev A, Behjati S, Laurenti E, Wilson NK, Roy A, Gottgens B, Roberts I, Teichmann SA, Haniffa M. . Nature 2021, 598, 327-331.
    • Collin J, Queen R, Darin Zerti D, Bojic S, Dorgau B, Moyse N, Molina MM, Yang C, Dey S, Reynolds G, Hussain R, Coxhead JM, Lisgo S, Henderson D, Joseph A, Rooney P, Ghosh S, Clarke L, Connon CJ, Haniffa M, Figueiredo F, Armstrong L, Lako M. . The Ocular Surface 2021, 21, 279-298.
    • Robert BJA, Moreau MM, Dos Santos Carvalho S, Barthet G, Racca C, Bhouri M, Quiedeville A, Garret M, Atchama B, Shaam Al Abed A, Guette C, Henderson D, Desmedt A, Mulle M, Marighetto A, Montcouquiol M, Sans N. . Cell Reports 2020, 31(10), 107743.
    • Dos-Santos Carvalho S, Moreau MM, Hien YE, Garcia M, Aubailly N, Henderson DJ, Studer V, Sans N, Thoumine O, Montcouquiol M. . eLife 2020, 9, e51822.
    • Stothard CA, Mazzotta S, Vyas A, Schneider JE, Mohun TJ, Henderson DJ, Phillips HM, Bamforth SD. . Journal of Cardiovascular Development and Disease 2020, 7(2), E20.
    • Alqahtani A, Skelton A, Eley L, Annavarapu S, Henderson DJ, Chaudhry B. . Journal of Anatomy 2020, 237(3), 587-600.
    • Johnson A-L, Schneider JE, Mohun TJ, Williams T, Bhattacharya S, Henderson DJ, Phillips HM, Bamforth SD. . Journal of Cardiovascular Development and Disease 2020, 7(3), 27.
    • Santos-Ledo A, Washer S, Dhanaseelan T, Eley L, Alqatani A, Chrystal PW, Papoutsi T, Henderson DJ, Chaudhry B. . PLoS Genetics 2020, 16(5), e1008782.
    • Park J-E, Botting RA, Dominguez Conde C, Popescu D-M, Lavaert M, Kunz DJ, Goh I, Stephenson E, Ragazzini R, Tuck E, Wilbrey-Clark A, Roberts K, Kedlian VR, Ferdinand JR, He X, Webb S, Maunder D, Vandamme N, Mahbubani KT, Polanski K, Mamanova L, Bolt L, Crossland D, de Rita F, Fuller A, Filby A, Reynolds G, Dixon D, Saeb-Parsy K, Lisgo S, Henderson D, Vento-Tormo R, Bayraktar OA, Barker RA, Meyer KB, Saeys Y, Bonfanti P, Behjati S, Clatworthy MR, Taghon T, Haniffa M, Teichmann SA. . Science 2020, 367(6480), eaay3224.
    • Smith P, Godde N, Rubio S, Tekeste M, Vladar EK, Axelrod JD, Henderson DJ, Milgrom-Hoffman M, Humbert PO, Hinck L. . Scientific Reports 2019, 9(1), 7079.
    • Bailey KE, MacGowan GA, Tual-Chalot S, Phillips L, Mohun TJ, Henderson DJ, Arthur HM, Bamforth SD, Phillips HM. . JCI Insight 2019, 4(8), e125172.
    • Papakrivopoulou E, Vasilopoulou E, Lindenmeyer MT, Pacheco S, Brzoska HL, Price KL, Kolatsi-Joannou M, White KE, Henderson DJ, Dean CH, Cohen CD, Salama AD, Woolf AS, Long DA. . Journal of Pathology 2018, 246(4), 485-496.
    • Galea GL, Nychyk O, Mole MA, Moulding D, Savery D, Nikolopoulou E, Henderson DJ, Greene NDE, Copp AJ. . DMM Disease Models and Mechanisms 2018, 11(3), dmm032219.
    • Richardson R, Eley L, Donald-Wilson C, Davis J, Curley N, Alqahtani A, Murphy L, Anderson RH, Henderson DJ, Chaudhry B. . Journal of Anatomy 2018, 232(4), 554-567.
    • Eley L, Alqahtani A, MacGrogan D, Richardson R, Murphy L, Salguero-Jimenez A, Rodriguez San Pedro M, Tiurma S, McCutcheon L, Gilmore A, de La Pompa JL, Chaudhry B, Henderson D. . eLife 2018, 7, e34110.
    • Crucean A, Alqahtani A, Barron DJ, Brawn WJ, Richardson RV, O'Sullivan J, Anderson RH, Henderson DJ, Chaudhry B. . Orphanet Journal of Rare Diseases 2017, 12, 138.
    • Findlay AS, Panzica DA, Walczysko P, Holt AB, Henderson DJ, West JD, Rajnicek A, Collinson JM. . Royal Society Open Science 2016, 3(10), 160658.
    • Spicer DE, Henderson DJ, Chaudhry B, Mohun TJ, Anderson RH. . Cardiology in the Young 2015, 25(8), 1493-1503.
    • Ramsbottom SA, Sharma V, Rhee HJ, Eley L, Phillips HM, Rigby HF, Dean C, Chaudhry B, Henderson DJ. . PLoS Genetics 2014, 10(12), e1004871.
    • Boczonadi V, Gillespie R, Keenan ID, Ramsbottom SA, Donald-Wilson C, Al Nazer M, Humbert P, Schwarz RJ, Chaudhry B, Henderson DJ. . Cardiovascular Research 2014, 104(1), 103-115.
    • Anderson RH, Mohun TJ, Spicer DE, Bamforth SD, Brown NA, Chaudhry B, Henderson DJ. . Journal of Cardiovascular Development and Disease 2014, 1(3), 177-200.
    • Phillips HM, Mahendran P, Singh E, Anderson RH, Chaudhry B, Henderson DJ. . Cardiovascular Research 2013, 99(3), 452-460.
    • Palomino Doza J, Topf A, Bentham J, Bhattacharya S, Cosgrove C, Brook JD, Granados-Riveron J, Bu'Lock FA, O'Sullivan J, Stuart AG, Parsons J, Relton C, Goodship J, Henderson DJ, Keavney B. . BMC Genetics 2013, 14, 57.
    • Bamforth SD, Chaudhry B, Bennett M, Wilson R, Mohun TJ, van Mierop LHS, Henderson DJ, Anderson RH. . Clinical Anatomy 2013, 26(2), 173-182.
    • Hunt NC, Shelton RM, Henderson DJ, Grover LM. . Tissue Engineering Part A 2013, 19(7-8), 905-914.
    • Keenan ID, Rhee HJ, Chaudhry B, Henderson DJ. . FEBS Letters 2012, 586(13), 1790-1794.
    • Anderson RH, Chaudhry B, Mohun TJ, Bamforth SD, Hoyland D, Phillips HM, Webb S, Moorman AF, Brown NA, Henderson DJ. . Cardiovascular Research 2012, 95(1), 108-115.
    • Phillips HM, Papoutsi T, Soenen H, Ybot-Gonzalez P, Henderson DJ, Chaudhry B. . PLoS One 2012, 7(5), e37685.
    • Bell E, Richardson G, Jahoda CA, Gledhill K, Phillips HM, Henderson D, Owens WA, Hole N. . Stem Cells and Development 2012, 21(16), 3019-3030.
    • Taylor JM, Saunter CD, Love GD, Girkin JM, Henderson DJ, Chaudhry B. . Journal of Biomedical Optics 2011, 16(11), 116021.
    • Cesca F, Yabe A, Spencer-Dene B, Arrigoni A, Al-Qatari M, Henderson D, Phillips H, Koltzenburg H, Benfenati F, Schiavo G. . Cell Death and Disease 2011, 2, e226.
    • Dhomen N, Da Rocha Dias S, Hayward R, Ogilvie L, Hedley D, Delmas V, Henderson D, Springer CJ, Pritchard C, Larue L, Marais R. . Pigment Cell & Melanoma Research 2010, 23(1), 112-120.
    • Ioannides AS, Massa V, Ferraro E, Cecconi F, Spitz L, Henderson DJ, Copp AJ. . Developmental Biology 2010, 337(2), 351-262.
    • Hildreth V, Webb S, Chaudhry B, Peat JD, Phillips HM, Brown N, Anderson RH, Henderson DJ. . Journal of Anatomy 2009, 214(6), 894-904.
    • Bradshaw L, Chaudhry B, Hildreth V, Webb S, Henderson DJ. . Journal of Anatomy 2009, 214(2), 245-257.
    • Phillips HM, Hildreth V, Peat JD, Murdoch JN, Kobayashi K, Chaudhry B, Henderson DJ. . Circulation Research 2008, 102(5), 615-623.
    • Hildreth V, Webb S, Bradshaw L, Brown NA, Anderson RH, Henderson DJ. . Journal of Anatomy 2008, 212(1), 1-11.
    • Farooqui-Kabir SR, Diss JKJ, Henderson D, Marber MS, Latchman DS, Budhram-Mahadeo V, Heads RJ. . Cell Stress and Chaperones 2008, 13(3), 297-312.
    • Phillips HM, Rhee HJ, Murdoch JN, Hildreth V, Peat JD, Anderson RH, Copp AJ, Chaudhry B, Henderson DJ. . Circulation Research 2007, 101(2), 137-145.
    • Gaston-Massuet C, Henderson DJ, Greene NDE, Copp AJ. . Developmental Dynamics 2005, 233(3), 1110-1115.
    • Phillips HM, Murdoch JN, Chaudhry B, Copp AJ, Henderson DJ. . Circulation Research 2005, 96(3), 292-299.
    • Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR, Henderson DJ, Murdoch JN, Copp AJ, Eliot M-M, Lupski JR, Kemp DT, Dollfus H, Tada M, Katsanis N, Forge A, Beales PL. . Nature Genetics 2005, 37(10), 1135-1140.
    • O'Doherty A, Ruf S, Mulligan C, Hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Vanes L, Hernandez D, Linehan JM, Sharpe PT, Brandner S, Bliss TVP, Henderson DJ, Nizetic D, Tybulewicz VLJ, Fisher EMC. . Science 2005, 309(5743), 2033-2037.
    • Sharma PR, Anderson RH, Copp AJ, Henderson DJ. . Anatomical Record 2004, 277A(2), 355-369.
    • Hudson CD, Podesta J, Henderson D, Latchman DS, Budhram-Mahadeo V. . Journal of Neuroscience Research 2004, 78(6), 803-814.
    • Ioannides AS, Henderson DJ, Spitz L, Copp AJ. . Journal of Pediatric Surgery 2003, 38(1), 29-36.
    • Curtin JA, Quint E, Tsipouri V, Arkell RM, Cattanach B, Copp AJ, Henderson DJ, Spurr N, Stanier P, Fisher EM, Nolan PM, Steel KP, Brown SDM, Gray IC, Murdoch JN. . Current Biology 2003, 13(13), 1129-1133.
    • Ioannides AS, Chaudhry B, Henderson DJ, Spitz L, Copp AJ. . Journal of Pediatric Surgery 2002, 37(2), 185-191.
    • Braybrook C, Lisgo S, Doudney K, Henderson D, Marcano ACB, Strachan T, Patton MA, Villard L, Moore GE, Stanier P, Lindsay S. . Human Molecular Genetics 2002, 11(22), 2793-2804.
    • Henderson DJ and Copp AJ. Versican expression is associated with chamber specification, septation, and valvulogenesis in the developing mouse heart. Circ. Res. 83, 523-532 1998.
    • Conway SJ, Henderson DJ and Copp AJ. Pax3 is required for cardiac neural crest cell migration in the mouse: evidence from the splotch (Sp2H) mutant. Development, 124, 505-514 1997.

  • Book Chapters

    • Anderson RH, Bamforth SD, Spicer DE, Henderson DJ, Chaudhry B, Brown NA, Mohun TJ. . In: Lacour-Gayet F; Bove EL; Hraška V; Morell V; Spray T, ed. Surgery of Conotruncal Anomalies. Cham, Switzerland: Springer International Publishing, 2016, pp.27-59.
    • Anderson RH, Moorman AFM, Brown NA, Bamforth SD, Chaudhry B, Henderson DJ, Mohun TJ. . In: Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. London: Springer-Verlag, 2014, pp.151-177.
    • Chaudhry B, Ramsbottom S, Henderson DJ. . In: Timothy J.A. Chico, ed. Genetics of Cardiovascular Disease. Academic Press, 2014, pp.19-41.

  • Conference Proceedings (inc. Abstracts)

    • Henderson DJ, Ramsbottom SA, Sharma V, Chaudhry B. . In: Frontiers in CardioVascular Biology. 2014, Barcelona, Spain: Oxford University Press.
    • Chaudhry B, Burns D, Murphy L, Henderson D. . In: Third Congress of the ESC Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2014, Barcelona, Spain: Oxford University Press.
    • Doza JP, Topf A, Bentham J, Bhattacharya S, Cosgrove C, Granados-Riveron J, Goodship J, Henderson D, O'Sullivan J, Keavney BD. . In: Congress of the European Society of Cardiology (ESC). 2012, Munchen, Germany: Oxford University Press.
    • Chaudhry B, Chrystal P, Henderson DJ. . In: 2nd Congress of the European Society of Cardiology Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2012, London, UK: Oxford University Press.
    • Hunt NC, Batsivari A, Chaudhry B, Henderson DJ. . In: Autumn Meeting of the British Society for Matrix Biology (BSMB). 2012, 缅北禁地 upon Tyne, UK: Wiley-Blackwell Publishing Ltd.
    • Henderson DJ, Boczonadi V, Humbert P, Chaudhry B. . In: 2nd Congress of the European Society of Cardiology Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2012, London, UK: Oxford University Press.
    • Chaudhry B, Burns D, Henderson DJ. . In: 2nd Congress of the European Society of Cardiology Council on Basic Cardiovascular Science: Frontiers in Cardiovascular Biology. 2012, London, UK: Oxford University Press.
    • Henderson DJ, Anderson RH. . In: Pediatric Cardiology: Riley Heart Center Symposium on Cardiac Development. 2009, Bloomington, Indiana, USA: Springer.
    • Goodship J, Henderson D. . In: European Journal of Human Genetics: European Society of Human Genetics European Human Genetics Conference in Conjuction With European Meeting on Psychosocial Aspects of Genetics. 2002, Strasbourg, France: Nature Publishing Group.

  • Editorials

    • Anderson RH, Mohun TJ, Henderson DJ. . Journal of Thoracic and Cardiovascular Surgery 2024, 168(6), 1734-1739.
    • Ybot-Gonzalez P, Greene NDE, Copp AJ, Henderson DJ, Massa V. . Frontiers in Cell and Developmental Biology 2023, 11, 1133159.
    • Anderson RH, Turner JE, Henderson DJ. . The Journal of Thoracic and Cardiovascular Surgery 2022, 164(2), 344-349.
    • Brown NA, Henderson DJ. . Journal of Cardiovascular Development and Disease 2021, 8(1), 6.
    • Anderson RH, Henderson DJ, Chaudhry B. . European Heart Journal 2017, 38(9), 687-689.

  • Reviews

    • Chaudhry B, Alqahtani A, Eley L, Coats L, Moldovan C, Annavarapu SR, Henderson DJ. . Journal of Cardiovascular Development and Disease 2022, 9(8), 279.
    • Henderson DJ, Eley L, Turner JE, Chaudhry B. . Frontiers in Cardiovascular Medicine 2022, 8, 802930.
    • Henderson DJ, Eley L, Chaudhry B. . Journal of Cardiovascular Development and Disease 2020, 7(4), 1-27.
    • Henderson DJ, Long DA, Dean CH. . Current Opinion in Cell Biology 2018, 55, 96-103.
    • Henderson DJ, Chaudhry B. . Birth Defects Research Part A: Clinical and Molecular Teratology 2011, 91(6), 460-467.
    • Hildreth V, Anderson RH, Henderson DJ. . Clinical Anatomy 2009, 22(1), 36-46.
    • Henderson DJ, Phillips HM, Chaudhry B. . Trends in Cardiovascular Medicine 2006, 16(2), 38-45.
    • Murdoch JN, Henderson DJ, Doudney K, Gaston-Massuet C, Phillips HM, Paternotte C, Arkell R, Stanier P, Copp AJ. . Human Molecular Genetics 2003, 12(2), 87-98.