缅北禁地

My lab is interested in how the gut microbiota use the complex glycans available to them within the human gut, focussing on the Bacteroidetes. We are particularly interested in glycoside hydrolase enzymes that target the glycans of pathogens such as Mycobacterium tuberculosis and Candida albicans. Finding these enzymes in gut bacteria allows us to uncover new enzymes in the pathogens themselves. We use a combination of microbiology, biochemistry, glycobiology and structural biology to understand the activity and function of these enzymes. We are also interested in the mechanisms of how Bacteroides sense and respond to the glycans they encounter using unusual hybrid two-component systems, and how they use the Type 9 Secretion System to enable extracellular glycan degradation.

Current lab members:

Dr Jennifer Ross

Omar Al-Jourani (PhD Student)

Diana Githwe (PhD student)

Joe Manion (PhD student)

Kaspar Garnham (PhD student)

CMB1003 - Microbiology and Immunology

BMS2015 - Health and Disease at Mucosal Surfaces

MMB8048 - Human Health and the Impact of Microbial Genomics

• Articles

  • Franklin A, Salgueiro VC, Layton AJ, Sullivan R, Mize T, Vazquez-Iniesta L, Benedict ST, Gurcha SS, Anso I, Besra GS, Banzhaf M, Lovering AL, Williams SJ, Guerin ME, Scott NE, Prados-Rosales R, Lowe EC, Moynihan PJ. . Nature Communications 2024, 15(1), 5740.
  • Cottam C, White RT, Beck LC, Stewart CJ, Beatson SA, Lowe EC, Grinter R, Connolly JPR. . Nature Communications 2024, 15, 4462.
  • Al-Jourani O, Benedict ST, Ross J, Layton AJ, van der Peet P, Marando VM, Bailey NP, Heunis T, Manion J, Mensitieri F, Franklin A, Abellon-Ruiz J, Oram SL, Parsons L, Cartmell A, Wright GSA, Basle A, Trost M, Henrissat B, Munoz-Munoz J, Hirt RP, Kiessling LL, Lovering AL, Williams SJ, Lowe EC, Moynihan PJ. Identification of D-arabinan-degrading enzymes in mycobacteria. Nature communications 2023, 14(1), 2233-.
  • Briliute J, Urbanowicz PA, Luis AS, Baslé A, Paterson N, Rebello O, Hendel J, Ndeh DA, Lowe EC, Martens EC, Spencer DIR, Bolam DN, Crouch LI. . Nature Microbiology 2019, 4, 1571-1581.
  • Luis AS, Briggs J, Zhang X, Farnell B, Ndeh D, Labourel A, Baslé A, Cartmell A, Terrapon N, Stott K, Lowe EC, McLean R, Shearer K, Schückel J, Venditto I, Ralet MC, Henrissat B, Martens EC, Mosimann SC, Abbott DW, Gilbert HJ. . Nature Microbiology 2018, 3(2), 210-219.
  • Cartmell A, Munoz-Munoz J, Briggs JA, Ndeh DA, Lowe EC, Basle A, Terrapon N, Stott K, Heunis T, Gray J, Yu L, Dupree P, Fernandes PZ, Shah S, Williams SJ, Labourel A, Trost M, Henrissat B, Gilbert HJ. . Nature Microbiology 2018, 3, 1314-1326.
  • Cartmell A, Lowe EC, Baslé A, Firbank SJ, Ndeh DA, Murray H, Terrapon N, Lombard V, Henrissat B, Turnbull JE, Czjzek M, Gilbert HJ, Bolam DN. . Proceedings of the National Academy of Sciences of the United States of America 2017, 114(27), 7037-7042.
  • Danne C, Ryzhakov G, Martinez-Lopez M, Ilott NE, Franchini F, Cuskin F, Lowe EC, Bullers SJ, Arthur JSC, Powrie F. . Cell Host and Microbe 2017, 22(6), 733-745.e5.
  • Temple MJ, Cuskin F, Baslé A, Hickey N, Speciale G, Williams SJ, Gilbert HJ, Lowe EC. . Journal of Biological Chemistry 2017, 292(25), 10639-10650.
  • Cuskin F, Baslé A, Ladevèze S, Day AM, Gilbert HJ, Davies GJ, Potocki-Véronèse G, Lowe EC. . Journal of Biological Chemistry 2015, 290(41), 25023-25033.
  • Cuskin F, Lowe EC, Temple MJ, Zhu YP, Cameron EA, Pudlo NA, Porter NT, Urs K, Thompson AJ, Cartmell A, Rogowski A, Hamilton BS, Chen R, Tolbert TJ, Piens K, Bracke D, Vervecken W, Hakki Z, Speciale G, Munoz-Munoz JL, Day A, Pena MJ, McLean R, Suits MD, Boraston AB, Atherly T, Ziemer CJ, Williams SJ, Davies GJ, Abbott DW, Martens EC, Gilbert HJ. . Nature 2015, 517(7533), 165-169.
  • Rogowski A, Briggs JA, Mortimer JC, Tryfona T, Terrapon N, Lowe EC, Baslé A, Morland C, Day AM, Zheng H, Rogers TE, Thompson P, Hawkins AR, Yadav MP, Henrissat B, Martens EC, Dupree P, Gilbert HJ, Bolam DN. . Nature Communications 2015, 6, 7481.
  • Abbott DW, Martens EC, Gilbert HJ, Cuskin F, Lowe EC. . Gut Microbes 2015, 6(5), 334-339.
  • Raghavan V, Lowe EC, Townsend GE, Bolam DN, Groisman EA. . Molecular Microbiology 2014, 93(5), 1010-1025.
  • Williams RJ, Iglesias-Fernandez J, Stepper J, Jackson A, Thompson AJ, Lowe EC, White JM, Gilbert HJ, Rovira C, Davies GJ, Williams SJ. . Angewandte Chemie International Edition 2014, 53(4), 1087-1091.
  • Lowe EC, Baslé A, Czjzek M, Firbank SJ, Bolam DN. . Proceedings of the National Academy of Sciences 2012, 109(19), 7298-7303.
  • Martens EC, Lowe EC, Chiang H, Pudlo NA, Wu M, McNulty NP, Abbott DW, Henrissat B, Gilbert HJ, Bolam DN, Gordon JI. . PLoS Biology 2011, 9(12), e1001221.
  • Lowe EC, Bydder S, Hartshorne RS, Tape HLU, Dridge EJ, Debieux CM, Paszkiewicz K, Singleton I, Lewis RJ, Santini JM, Richardson DJ, Butler CS. . Journal of Biological Chemistry 2010, 285(24), 18433-18442.

• Conference Proceedings (inc. Abstracts)

  • Gilbert HJ, Ndeh D, Rogowski A, Cuskin F, Lowe E, Martens EC. . In: 2016 Annual Meeting of the Society for Glycobiology. 2016, New Orleans, Louisiana: Oxford University Press.
  • Lowe EC, Cuskin F, Temple MJ, Basle A, Williams SJ, Gilbert HJ. . In: 2016 Annual Meeting of the Society for Glycobiology. 2016, New Orleans, Louisiana: Oxford University Press.

• Notes

  • Franklin A, Salgueiro VC, Layton AJ, Sullivan R, Mize T, Vazquez-Iniesta L, Benedict ST, Gurcha SS, Anso I, Besra GS, Banzhaf M, Lovering AL, Williams SJ, Guerin ME, Scott NE, Prados-Rosales R, Lowe EC, Moynihan PJ. . Nature Communications 2024, 15(1), 7155.
  • Cartmell A, Munoz-Munoz J, Briggs JA, Ndeh DA, Lowe EC, Basle A, Terrapon N, Stott K, Heunis T, Gray J, Yu L, Dupree P, Fernandes PZ, Shah S, Williams SJ, Labourel A, Trost M, Henrissat B, Gilbert HJ. . Nature Microbiology 2019, 4(11), 2021-2023.

• Review

  • La Rosa SL, Ostrowski MP, Vera-Ponce de Leon A, McKee LS, Larsbrink J, Eijsink VG, Lowe EC, Martens EC, Pope PB. . Current Opinion in Microbiology 2022, 67, 102143.