缅北禁地

Qualifications

BSc (Hons) Liverpool 1992

PhD Liverpool 1996

Previous and Current Positions

1996-1998 Grace Gill's lab at Harvard Medical School where I worked on regulation of mammalian transcription and CREG (cellular repressor of EIA-like genes).

1998-2003 Brian Morgan's lab at University of 缅北禁地 investigating the regulation of eukaryotic oxidative stress responses

2004-2008 MRC Career Development Fellow, 缅北禁地 including Visiting Fellow at Joslin Diabetes Center and Harvard Medical School in Keith Blackwell's lab.

2006-2011 RCUK Academic Fellow, 缅北禁地

2012 Reader in Molecular Biology

2023 Co-lead supporting Early Career Researchers in the Biosciences Institute

Memberships

Biochemical Society, Genetics Society, Genetics Society of America, British Society for Research on Ageing, Society for Redox Biology and Medicine, Society for Free Radical Research Europe

Honours and Awards

MRC Career Development Award (2003-2008)

2024 Elected Vice Chair Gordon Research Conference on Thiol-Based Redox Regulation and Signaling

2026 Co-Chair Gordon Research conference on Thiol-Based Redox Regulation and Signaling: Bridging Chemistry to Biology, Aging and Disease

Research Interests

Exposure to sunlight, immune cell attack and aerobic metabolism all generate highly toxic chemicals known as 'reactive oxygen species (ROS)'. These ROS, such as peroxide, cause cell damage (oxidative stress) that has been implicated in the initiation and development of many diseases, including cancer, heart disease and diabetes. Increased oxidative damage is also associated with ageing. We are interested in understanding the molecular mechanisms by which eukaryotic cells sense and respond to ROS, for example, to signal an increase in the production of protective proteins. We use the fission yeast Schizosaccharomyces pombe and the nematode worm Caenorhabditis elegans as genetically amenable model eukaryotes in which to study these ROS-sensing and signalling mechanisms. In multicellular organisms, in addition to causing oxidative stress, ROS are also generated and employed as signalling molecules to regulate various biological processes as well as part of the innate immune response to infection. The simplicity, ease of genetic manipulation and analysis, as well as the wide-range of post-genomic resources available, render C. elegans an ideal multicellular organism in which to identify cell-type specific roles for ROS-signalling mechanisms in development and ageing. Our research also exploits C. elegans as a convenient and ethical host in which to study how innate immune defences protect against pathogens, such as the opportunistic human pathogens Candida albicans and Staphylococcus aureus. In addition, we combine experimental and mathematical modelling approaches as we examine how ROS-sensing mechanisms identified in model yeast and worms are conserved in pathogenic fungi and human cells.

Lab Members

Joanne Stamford, Emilie Dwyer, Tom Foy, Sara Ilic

Former lab members and what-they-did-next/now:

Alison Day PhD (2004-13) moved to postdoc position after postdoc in Veal lab/ Now lecturer at 缅北禁地

Sarah Taylor PhD (2005-8) became NHS cytogeneticist after PhD in Veal lab;

Monika Olahova PhD (2005-11) Awarded faculty medal for PhD in Veal lab, postdoc in Veal lab, then postdoc fellow in USA and now lecturer at Northumbria University

Helen Crook PhD (2007-12) trained as high school science teacher after MRes/PhD and short postdoc in Veal lab

Emma Button PhD (2009-13) moved to Industrial R&D position after MRes/PhD in Veal lab. Now Senior Research Funding Development Manager at 缅北禁地

Jonathan Rand PhD (2007-10) moved to industrial R&D position after postdoc in Veal lab;

Jonathon Brown PhD (2009-13) moved to postdoc position after postdoc in Veal lab;

Lewis Tomalin PhD (2011-15) postdoc at Rockefeller University, USA after PhD in Veal lab, Now tenure-track Assistant Professor at Icahn School of Medicine at Mount Sinai.

Heather Latimer PhD (2012-16) became a medical writer after MRes/PhD in Veal lab

Marti Cadena Sandoval PhD student at University of Groningen

Johnathan Winter PhD (2012-16) position in biomedical research company after PhD in Veal lab

Zoe Underwood PhD (2015-18) research position at Public Health England after PhD in Veal lab. Now Senior Research Scientist at AstraZeneca.

Martin Galler PhD (2017-22) moved to postdoc position after PhD in Veal lab.

Elise Bennett (2020-23) research technician at 缅北禁地

Min Cao PhD (2019-2024) moved to postdoc position at 缅北禁地 after postdoc in Veal lab

Funding

Our work has been funded by the MRC, BBSRC, Research Councils UK and Cancer Research UK. Current work is funded by the BBSRC. We are always interested in considering applications from prospective international students or postdocs.

*iCASE PhD studentships available in Veal lab! Please contact e.a.veal@ncl.ac.uk ASAP for further details*

Latest News

2025:

• More than 10 years after Emma discovered that peroxiredoxin 6 mutant C. elegans were resistant to infection and long-lived we finally figured out why! A real team effort co-led by Emilia and involving undergraduate students Jake, Alice, Eloise and Fiona and collaborators Jennifer Watt and Madison Mortensen at Washington State University
• Congratulations to Sara and her Diagnostree team on winning Best Consideration of IP Strategy and the Social Media prize for active engagement throughout the competition awards at the national YES competition finals

2024:

• Congratulations to Tom on winning best poster award at the Thiol Redox Gordon Research Seminar!
• Review published in Current Opinion in Chemical Biology Pleased Christine Winterbourn and Yimon Aye's invite also provided opportunity to work with Paraskevi Kritsiligkou.
• Very pleased to see Diane's work published and that Lewis and I were able to contribute to this collaboration with Che Pillay at University of Kwa Zulu Natal and Johann Rohwer at Stellenbosch University.

2023:

• Great to have Sara join the lab as a BBSRC-funded NLD iCASE PhD student.
• Excited that we finally figured out how disulphide complexes between peroxiredoxin and MAPK activate the MAPK

2022:

• Congratulations Min on becoming a Mum and gaining a Returner's Support Grant!
• Congratulations Martin on successful PhD defence and becoming a Dad!

2021:

*iCASE PhD studentships available in Veal lab! Please contact e.a.veal@ncl.ac.uk ASAP for further details*

2020:

• Congratulations Martin and Min on publication of collaborative paper with Pat Eyers group at Liverpool in Science Signaling

2019:

• New BBSRC grant funding for postdoc and technician

2018:

• Registration for Biochemistry Society Redox meeting in 缅北禁地 July 1-3rd 2019 now open: https://www.biochemistry.org/Events/tabid/379/MeetingNo/SA221/view/Conference/Default.aspx   
• MRC iCASE studentship available for start in September 2019! Informal enquiries welcomed!
• Congratulations to Zoe on a successful PhD thesis defence and her new job at Public Health England
• Congratulations to Johny on publication of his joint first author paper in Aging Cell 

2016:

• Congratulations to Monika on receiving the Aging Cell Runner-Up Best Paper Prize for 2015!

for her paper: Oláhová M, Veal EA. A peroxiredoxin, PRDX-2, is required for insulin secretion and Insulin/IIS-dependent regulation of stress resistance and longevity. Aging Cell 2015, 14(4), 558-568. 

Stage 3 Integrated Biochemistry module leader and undergraduate project supervisor

Stage 2 BGM2063 Genetics practical leader and lecturer and BGM2060 Biochemistry lecturer

Stage 1 CMB1005 practical leader

• Articles

  • Button EL, Dwyer E, Lewis JB, Mortensen MS, McDonald E, Butler E, Pearson F, Tang AE, Watts J, Veal EA. . Redox Biology 2026, 91, 103992.
  • Lind DJ, Naidoo KC, Tomalin LE, Rohwer JM, Veal EA, Pillay CS. . Free Radical Biology and Medicine 2024, 218, 16-25.
  • Veal, EA,Kritsiligkou, P. . Current Opinion in Chemical Biology 2024. In Preparation.
  • Cao M, Day AM, Galler M, Latimer HR, Byrne DP, Foy TW, Dwyer E, Bennett E, Palmer J, Morgan BA, Eyers PA, Veal EA. . Molecular Cell 2023, 83(17), 3140-3154.e7.
  • Byrne DP, Shrestha S, Galler M, Cao M, Daly L, Campbell AE, Eyers CE, Veal EA, Kannan N, Eyers PA. . Science Signaling 2020, 13(639).
  • Carroll B, Otten E, Manni D, Stefanatos R, Menzies F, Smith G, Jurk D, Kenneth N, Wilkinson S, Passos J, Attems J, Veal E, Teyssou E, Seilhean D, Millecamps S, Eskelinen E-L, Bronowska A, Rubinsztein DC, Sanz A, Korolchuk V. . Nature Communications 2018, 9, 256.
  • Goh G, Winter JJ, Bhanshali F, Lai R, Lee K, Taubert S, Veal EA. . Aging Cell 2018, 17(3), e12743.
  • Ikeh MA, Kastora SL, Day AM, Herrero-de-Dios CM, Tarrant E, Waldron KJ, Banks AP, Bain JM, Lydall D, Veal EA, MacCallum DM, Erwig LP, Brown AJ, Quinn J. . Molecular Biology of the Cell 2016, 27(17), 2784-2801.
  • Tomalin LE, Day AM, Underwood ZE, Smith GR, Dalle Pezze P, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ-L, Shanley DP, Veal EA. . Free Radicals in Biology and Medicine 2016, 95, 333-348.
  • Oláhová M, Veal EA. . Aging Cell 2015, 14(4), 558-568.
  • Crook-McMahon HM, Olahova M, Button EL, Winter JJ, Veal EA. . BMC Biology 2014, 12, 64.
  • Jiménez-Hidalgo M, Kurz CL, Pedrajas JR, Naranjo-Galindo FJ, González-Barrios M, Cabello J, Sáez AG, Lozano E, Button EL, Veal EA, Fierro-González JC, Swoboda P, Miranda-Vizuete A. . Free Radical Biology and Medicine 2014, 68, 205-219.
  • Patterson M, McKenzie C, Smith D, da Silva Dantas A, Sherston S, Veal EA, Morgan B, MacCallum D, Erwig LP, Quinn J. . Antioxidants & Redox Signaling 2013, 19(18), 2244-2260.
  • Brown JD, Day AM, Taylor SR, Tomalin LE, Morgan BA, Veal EA. . Cell Reports 2013, 5(5), 1425-1435.
  • Day AM, Brown JD, Taylor SR, Rand JD, Morgan BA, Veal EA. . Molecular Cell 2012, 45(3), 398-408.
  • Day AM, Veal EA. . Journal of Biological Chemistry 2010, 285(10), 7505-7516.
  • Oláhová M, Taylor SR, Khazaiphoul S, Wang J, Morgan BA, Matsumoto K, Blackwell TK, Veal EA. . Proceedings of the National Academy of Sciences 2008, 105(50), 19839-19844.
  • Veal EA, Day AM, Morgan BA. . Molecular Cell 2007, 26(1), 1-14.
  • Morgan BA, Veal EA. . SubCellular Biochemistry 2007, 44, 253-65.
  • Bozonet SM, Findlay VJ, Day AM, Cameron J, Veal EA, Morgan BA. . Journal of Biological Chemistry 2005, 280(24), 23319-23327.
  • Veal EA, Findlay VJ, Day AM, Bozonet SM, Evans JM, Quinn J, Morgan BA. . Molecular Cell 2004, 15(1), 129-139.
  • Veal EA, Ross SJ, Malakasi P, Peacock E, Morgan BA. . Journal of Biological Chemistry 2003, 278(33), 30896-30904.
  • Veal EA, Mark Toone W, Jones N, Morgan BA. . Journal of Biological Chemistry 2002, 277(38), 35523-35531.
  • Veal E, Groisman R, Eisenstein M, Gill G. . Oncogene 2000, 19(17), 2120-2128.
  • Pic A, Lim F-L, Ross SJ, Veal EA, Johnson AL, Sultan MRA, West AG, Johnston LH, Sharrocks AD, Morgan BA. . EMBO Journal 2000, 19(14), 3750-3761.
  • Veal EA, Jackson MJ. . International Journal of Biochemistry and Cell Biology 1998, 30(7), 811-821.
  • Veal E, Eisenstein M, Tseng ZH, Gill G. . Molecular and Cellular Biology 1998, 18(9), 5032-5041.

• Book Chapter

  • Morgan BA, Veal EA. . In: Flohe, L; Harris, R, ed. Peroxiredoxin Systems: Structures and Functions. New York: Springer, 2007, pp.253-265.

• Editorials

  • Veal EA, Olahova M. . Molecular Cell 2011, 43(5), 699-701.
  • Veal EA, Day AM. . Antioxidants and Redox Signaling 2011, 15(1), 147-151.

• Reviews

  • Veal EA, Underwood ZE, Tomalin LE, Morgan BA, Pillay CS. . Antioxidants and Redox Signaling 2018, 28(7), 574-590.
  • Miranda-Vizuete A, Veal EA. . Redox Biology 2017, 11, 708-714.
  • Latimer HR, Veal EA. . Molecules and Cells 2016, 39(1), 40-45.
  • Veal EA, Tomalin LE, Morgan BA, Day AM. . Biochemistry Society Transactions 2014, 42(4), 909-916.