缅北禁地

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Staff Profile

Dr Ella Dennis

Research Associate

  • Telephone: 0191 241 8626
  • Address: Biosciences Institute
    Faculty of Medical Sciences
    缅北禁地
    Central Parkway,
    缅北禁地 upon Tyne,
    NE1 3BZ
Background

Areas of expertise

Cartilage and Bone Biology

Mechanisms of Rare and Common Bone Diseases

Musculoskeletal Aging

Cell Stress and Chaperones


Qualifications

2018          PhD: "The role of CRELD2 in skeletal development and bone homeostasis".  缅北禁地, UK.

2014          MRes (Medical & Molecular Biosciences): "The role of ER stress in the pathology of genetic skeletal diseaes". 缅北禁地, UK

2013          BSc (Hons) Biochemistry with Industrial Experience. University of Manchester, UK. Industrial Experience at QIAGEN, Manchester, UK.



ORCID:

Scopus:

Google Scholar:

Research

Grants and Awards

2025      £711,462 - MRC Research Grant,  Drug repurposing for genetic bone diseases. Lead Investigator: Prof. Michael Briggs. Co-Investigators: Dr Ella Dennis, Dr Katarzyna Pirog, Prof. David Young.

2022      £797,793 - MRC Research Grant (MR/X001873/1), Defining the role of aggrecan and type X collagen in osteoarthritis and osteochondritis dissecans through in vivo studies of genetic bone disease. Lead Investigator: Prof. Michael Briggs. Co-Investigators: Dr Ella Dennis, Dr Katarzyna Pirog, Prof. David Young, Dr Blandine Poulet (University of Liverpool).

2022     £2,073 - MRC Versus Arthritis Centre for Integrated Research into Musculoskeletal Aging (CIMA) Post-Doctoral Bursary Award. The role of a novel chaperone as a novel non-invasive biomarker for osteoarthritis. Lead Investigator: Dr Ella Dennis.

2022     £187,180 - Healx Technology Limited commercial partnership, In vivo testing of compounds as potential therapies using transgenic mouse models of Pseudoachondroplasia. Lead Investigator: Prof. Michael Briggs. Named Researcher/Project Lead: Dr Ella Dennis.

2021     £58,186 - JGW Patterson Foundation, Targeting chondrocyte stress as a potential therapy for genetic bone diseases. Lead Investigator: Prof. Michael Briggs. Named Researcher/Project Lead: Dr Ella Dennis.

2022    £75,312 - 缅北禁地 Faculty of Medical Sciences PhD Studentship funded by the Barbour Foundation, Targeting a novel chaperone to block prostate cancer bone metastasis. Supervisors: Dr Ella Dennis, Dr Jennifer Munkley, Prof. Michael Briggs.


Teaching

Postgraduate Supervision

Adam Duxfield, 2020-present: PhD student

Bhuvanashree Ramakrishnan, 2022: MRes

Jamie Jordan, 2021: MRes 


I also regularly supervise undergraduate students and visiting summer students.


Publications

  • Articles

    • Hodgson K, Orozco-Moreno M, Goode EA, Fisher M, Garnham R, Beatson R, Turner H, Livermore K, Zhou Y, Wilson L, Visser EA, Pijnenborg JF, Eerden N, Moons SJ, Rossing E, Hysenaj G, Krishna R, Peng Z, Nangkana KP, Schmidt EN, Duxfield A, Dennis EP, Heer R, Lawson MA, Macauley M, Elliott DJ, Bull C, Scott E, Boltje TJ, Drake RR, Wang N, Munkley J. . eBioMedicine 2024, 104, 105163.
    • Dennis EP, Watson RN, McPate F, Briggs MD. . International Journal of Molecular Sciences 2023, 24(2), 1496.
    • Duxfield A, Munkley J, Briggs MD, Dennis EP. . Scientific Reports 2022, 12(1), 13884.
    • Dobson PF, Dennis EP, Hipps D, Reeve A, Laude A, Bradshaw C, Stamp C, Smith A, Deehan DJ, Turnbull DM, Greaves LC. . Scientific Reports 2020, 10(1), 11643.
    • Dennis EP, Edwards SM, Jackson RM, Hartley CL, Tsompani D, Capulli M, Teti A, Boot-Handford RP, Young DA, Piróg KA, Briggs MD. . Journal of Bone and Mineral Research 2020, 35(8), 1452-1469.
    • Piróg KA, Dennis EP, Hartley CL, Jackson RM, Soul J, Schwartz JM, Bateman JF, Boot-Handford RP, Briggs MD. . PLoS Genetics 2019, 15(7), e1008215.
    • Bell PA, Dennis EP, Hartley CL, Jackson RM, Porter A, Boot-Handford RP, Pirog KA, Briggs MD. . Cell Stress and Chaperones 2018, 24(1), 159-173.

  • Conference Proceedings (inc. Abstracts)

    • Dennis EP, Johnson FM, Pearson RD, Jackson RM, Logan J, Capulli M, Teti A, Duncan-Bassett JH, Williams GR, Kalamajski S, Pirog KA. . In: British Society for Matrix Biology Spring 2021 Meeting: “Inflammation, Fibrosis, Resolution and the Matrix”. 2021, Oxford: Wiley-Blackwell Publishing Ltd.
    • Dennis EP, Capulli M, Teti A, Pirog KA, Briggs MD. . In: 43rd Annual European Calcified Tissue Society Congress. 2016, Rome, Italy: Bone Abstracts.
    • Dennis EP, Edwards SM, Boot-Handford RP, Pirog KA, Briggs MD. . In: British Society for Matrix Biology / Bone Research Society Third Joint Meeting. 2015, Edinburgh: Wiley-Blackwell Publishing Ltd.

  • Reviews

    • Dennis EP, Briggs MD. . International Journal of Molecular Sciences 2025, 26(20), 10057.
    • Dennis EP, Greenhalgh-Maychell PL, Briggs MD. . Developmental Dynamics 2021, 250(3), 345-359.
    • Briggs MD, Dennis EP, Dietmar H, Pirog KA. . F1000Research 2020, 9, 290.