缅北禁地

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Staff Profile

Dr Felicity May

Senior Lecturer

  • Email: felicity.may@ncl.ac.uk
  • Telephone: +44 (0) 191 208 4417
  • Address: Northern Institute for Cancer Research
    School of Clinical & Laboratory Sciences
    Medical School
    University of 缅北禁地 upon Tyne
    NE2 4HH
Background

Qualifications

B.Sc. Hons           Pure Science, University of Glasgow

D.Phil.                   Biochemistry, University of Oxford

 

Scholarship and Fellowship Awards:

MRC Training Scholarship.

Royal Society Research Fellowship.

EMBO Long Term Travelling Fellowship.

Royal Society University Research Fellowship.

 

Previous Substantive Appointments:

Chargée de Recherche, INSERM U148, Montpellier, France.

Lecturer, Department of Pathology, University of 缅北禁地..

Senior Lecturer, Department of Pathology, University of 缅北禁地.

 

Memberships

Breast Cancer Research Group

British Association for Cancer Research

European Association for Cancer Research

Oesophagogastric cancer group



Research

Overall Research Interests

The molecular basis of breast, gastric and oesophageal cancer development

Molecular diagnostics for improved treatment individualisation in breast, gastric and oesophageal cancer patients

Development and pre-clinical assessment of novel therapies for breast, gastric and oesophageal cancer patients

 We work on the dependence and response of adult adenocarcinomas, majorly of the stomach, oesophagus and breast, and gynaecological cancers, to steroidal and protein hormones. We investigate how these dependencies may be developed therapeutically, particularly by inhibition of receptors and protein kinases. We are interested in how malignant cells evolve and adapt to invade effectively, and to acquire therapeutic resistance.  We are interested in the unexploited prognostic, predictive and pharmacodynamic potential of biomarker measurements on circulating tumour cells and other disseminated malignant cells.

 Theme 1: Dependence and response of malignant of cells to endocrine stimuli.

Our research aims to understand in what way and how malignant cells respond to external growth factors in particular oestrogens, insulin-like growth factors, epidermal growth factors and trefoil factors. Future work will be informed by recent whole genomic analyses that demonstrate that individual cancers are driven by specific pathways.  It is important to validate these findings especially in oesophageal and gastric adenocarcinoma for which there are scarce effective therapeutic options.  Ex vivo analyses on disseminated tumour cells isolated directly from patients will contribute to validation of novel targets. The goal is to provide preclinical and translational evidence for clinical trials in oesophagogastric cancers.

Theme 2: Validation of predictive and pharmacodynamic biomarkers

The heterogeneity of cancer and different responses of individual tumours to cytotoxic and biological drugs necessitates effective patient stratification if response rates are to increase and novel therapies are to be adopted. The value of predictive biomarkers of response to targeted therapies is proven in breast cancer but we have demonstrated that it could be improved. Our work combines preclinical identification of potential predictive biomarkers with translation validation. The potential of biomarker measurements in disseminated disease for initial treatment stratification and for therapeutic monitoring is a particular future focus.

Theme 3: Evolution of malignant disease

We are interested in how malignant cells disseminate in individual patients, in how cells in the primary tumour evolve, and how they differ from those in the circulation, bone marrow or secondary deposits. These studies will further understanding of the disease and have the potential to improve pre-operative staging of oesophagogastric cancer patients.  Analyses on sequential samples from patients with advanced disease will increase understanding about this evolution and determine if monitoring might inform patient management. We should like to develop our work on disseminated cells isolated from patients who acquire resistance to novel therapies. The large number of circulating tumour cells identified in some oesophagogastric cancer patients suggests that we should be able to isolate the cells for individual genomic analyses and potentially to study the cells in culture.

 

Postgraduate Supervision

Masters students registered of MRes Programmes or MSc Medical Sciences Programmes

Intercalated medical students

PhD students

Clinical Research Fellows

 

Funding

Breast Cancer Campaign

Cancer Research UK (CR-UK)

JGW Patterson Foundation

Medical Research Council (MRC)

缅北禁地 Healthcare Charity

Northern Oesophagogastric Cancer Fund

Wellbeing of Women

Teaching

Postgraduate Teaching

Degree Programme Director, MSc Medical Sciences Programme 5814F

Programme Leader, MRes Cancer Programme 4816F

Chairman Board of Examiners, MSc Medical Sciences Programme 5814F

Module Leader, MMS8101 Cancer Studies Module

Module Leader, MMS8107 Medical Research Practice Module

Module Leader, MMS8199 Dissertation Module

Module Leader, MMB8007 Cancer Studies Module

 

Undergraduate Teaching

Lecturer, BMS3010 Genetics of Common Disease

Supervisor, BSc Biomedical Sciences Programme B940

Supervisor, BSc Physiological Sciences Programme B100

Supervisor, BSc Pharmacology Programme B210

Supervisor, MSci Biomedical Sciences Programme B900

 

Publications
  • Dent BM, Ogle LF, O'Donnell RL, Hayes N, Mallick U, Curtin NJ, Boddy AV, Plummer ER, Edmondson RJ, Reeves HL, May FEB, Jamieson D. . International Journal of Cancer 2016, 138(1), 206-216.
  • Saisana M, Griffin SM, May FEB. . Oncotarget 2016, 7(34), 54445-54462.
  • Luey BC, May FEB. . Molecular Cancer 2016, 15(8).
  • Wade MA, Sunter NJ, Fordham SE, Long A, Masic D, Russell J, Harrison CJ, Rand V, Elstob C, Bown N, Rowe D, Lowe C, Cuthbert G, Bennett S, Crosier S, Bacon CM, Onel K, Scott K, Scott D, Travis LB, May FEB, Allan JM. . Oncogene 2015, 34, 4985-4994.
  • Middleton FK, Patterson MJ, Elstob CJ, Fordham S, Herriott A, Wade MA, McCormick A, Edmondson R, May FEB, Allan JM, Pollard JR, Curtin NJ. . Oncotarget 2015, 6(32), 32396-32409.
  • May FEB, Westley BR. . Endocrine-Related Cancer 2015, 22, 465-479.
  • Dunne C, Kilcoyne M, Robbe-Masselot C, Kane L, Clare S, May FEB, Clyne M. . In: Irish Society of Gastroenterology – Winter Meeting. 2015, Dublin, Ireland: Spinger London.
  • Dent B, O'Donnell RL, Ogle LF, Rourke ED, Ramesh HP, Moat M, Hayes N, Mallick UK, May FE, Reeves HL, Curtain NJ, Edmondson RJ, Boddy AV, Plummer R, Jamieson D. . In: AACR Annual Meeting 2014. 2014, San Diego, CA: American Association for Cancer Research.
  • May FEB. . Cancer Management and Research 2014, 6, 225-252.
  • Westley RL, May FEB. . International Journal of Endocrinology 2013, 2013, 632461.
  • Axon A, May FEB, Gaughan LE, Williams FM, Blain PG, Wright MC. . Toxicology 2012, 298(1-3), 40-51.
  • Ahmed ARH, Griffiths AB, Tilby MT, Westley BR, May FEB. . American Journal of Pathology 2012, 180(3), 904-916.
  • Dolan B, Naughton J, Tegtmeyer N, May FEB, Clyne M. . PLoS One 2012, 7(10), e47300.
  • May FEB. . Biomarkers in Medicine 2012, 6(3), 301-304.
  • Davison Z, de Blacquière GE, Westley BR, May FEB. . Neoplasia 2011, 13(6), 504-515.
  • Arumugam T, Brandt W, Ramachandran V, Moore TT, Wang HM, May FE, Westley BR, Hwang RF, Logsdon CD. . Pancreas 2011, 40(6), 815-822.
  • Jamieson D, Cresti N, Bray J, Sludden J, Griffin MJ, Hawsawi NM, Famie E, Mould EVA, Verrill MW, May FEB, Boddy AV. . Pharmacogenetics and Genomics 2011, 21(12), 808-819.
  • Wright PK, May FEB, Darby S, Saif R, Lennard TWJ, Westley BR. . International Journal of Clinical and Experimental Pathology 2009, 2(5), 463-475.
  • de Blaquière GE, May FEB, Westley BR. . Endocrine-Related Cancer 2009, 16(2), 635-647.
  • May FEB, Griffin SM, Westley BR. . International Journal of Biochemistry & Cell Biology 2009, 41(3), 632-640.
  • Reeves EP, Ali T, Leonard P, Hearty S, O'Kennedy R, May FEB, Westley BR, Josenhans C, Rust M, Suerbaum S, Smith A, Drumm B, Clyne M. . Gastroenterology 2008, 135(6), 2043-2054.
  • Moss SF, Lee JW, Sabo E, Rubin AK, Rommel J, Westley BR, May FEB, Gao J, Meitner PA, Tavares R, Resnick MB. . Clinical Cancer Research 2008, 14(13), 4161-4167.
  • Thuwajit P, Chawengrattanachot W, Thuwajit C, Sripa B, May FEB, Westley BR, Tepsiri N, Paupairoj A, Chau-in S. . Hepatology Research 2007, 37(4), 295-304.
  • Johns C, Newton JL, Westley BR, May FEB. . Peptides 2006, 27(6), 1341-1348.
  • Westley BR, May FEB. . In: Brooks SA; Harris A, ed. Breast Cancer Research Protocols. Humana Press, 2006, pp.363-388.
  • Chutipongtanate S, Nakagawa Y, Sritippayawan S, Pittayamateekul J, Parichatikanond P, Westley B, May F, Malasit P, Thongboonkerd V. . Journal of Clinical Investigation 2005, 115(12), 3613-3622.
  • Westley BR, Griffin S, May FEB. . Biochemistry 2005, 44(22), 7967-7975.
  • Thim L, May FEB. . Cellular and Molecular Life Sciences 2005, 62(24), 2956-2973.
  • Johns CE, Newton JL, Westley BR, May FEB. . American Journal of Gastroenterology 2005, 100(7), 1491-1497.
  • Lafontaine PO, Arnal M, Buron N, Solary E, Bron AM, Westley BR, May FEB, Bara J, Gespach C, Creuzot-Garcher C. . International Journal of Oncology 2005, 27(4), 997-1003.
  • Pu M, May FEB, Playford R, Ruchaud-Sparagano M, Westley BR. . Peptides 2004, 25(5), 731-736.
  • May FEB, Semple J, Prest S, Westley BR. . Peptides 2004, 25(5), 865-872.
  • Clyne M, Dillon P, Daly S, O'Kennedy R, May F, Westley B, Drumm B. . Proceedings of the National Academy of Sciences of the United States of America 2004, 101(19), 7409-7414.
  • FitzGerald A, Pu M, Marchbank T, Westley BR, May FEB, Boyle J, Yadollahi-Farsani M, Ghosh S, Playford R. . Peptides 2004, 25(5), 793-801.
  • Newton J, Johns CE, May FEB. . Alimentary Pharmacology and Therapeutics 2004, 19(1), 39-45.
  • Ruchaud-Sparagano M, Westley BR, May FEB. . Cellular and Molecular Life Sciences 2004, 61(15), 1946-1954.
  • Carrasco R, Pera M, May F, Westley B, Martinez A, Morales L. . Journal of Pediatric Surgery 2004, 39(11), 1693-1700.
  • Soriano-Izquierdo A, Gironella M, Massaguer A, May FEB, Salas A, Sans M, Poulsom R, Thim L, Piqué J, Panés J. . Journal of Leukocyte Biology 2004, 75(2), 214-223.
  • Johns CE, Newton JL, Westley BR, May FEB. . In: Annual meeting of the British-Society-of-Gastroenterology. 2003, Birmingham: Gut.
  • Rodrigues S, Attoub S, Nguyen Q, Bruyneel E, Rodrigue C, Westley B, May F, Thim L, Mareel M, Emami S, Gespach C. . Oncogene 2003, 22(29), 4488-4497.
  • Muskett F, May FEB, Westley BR, Feeney J. . Biochemistry 2003, 42(51), 15139-15147.
  • May FEB, Church S, Major S, Westley BR. . Biochemistry 2003, 42(27), 8250-8259.
  • Rodrigues S, Van Aken E, Van Bocxlaer S, Attoub S, Nguyen Q, Bruyneel E, Westley BR, May FEB, Thim L, Mareel M, Gespach C, Emami S. . The FASEB Journal 2003, 17(1), 7-16.
  • Prest SJ, May FEB, Westley BR. . The FASEB Journal 2002, 16(2), 592-+.
  • Rodrigues S, Nguyen QD, Faivre S, Bruyneel E, Thim L, Westley B, May F, Flatau G, Mareel M, Gespach C, Emami S. . The FASEB Journal 2001, 15(9), 1517-1528.
  • Semple J, Newton JL, Westley BR, May FEB. . Gut 2001, 48(5), 648-655.
  • Crosier M, Scott D, Wilson RG, Griffiths CDM, May FEB, Westley BR. . American Journal of Pathology 2001, 159(1), 215-221.
  • Emami S, Le Floch N, Bruyneel E, Thim L, May FEB, Westley BR, Rio MC, Mareel M, Gespach C. . The FASEB Journal 2001, 15(2), 351-361.
  • Williams M, Westley B, May F, Feeney J. . FEBS Letters 2001, 493(2-3), 70-74.
  • Molloy CA, May FEB, Westley BR. . Journal of Biological Chemistry 2000, 275(17), 12565-12571.
  • Newton JL, Allen A, Westley BR, May FEB. . Gut 2000, 46(3), 312-320.
  • May FEB, Semple J, Newton JL, Westley BR. . Gut 2000, 46(4), 454-459.
  • Crosier M, Scott D, Wilson RG, Griffiths CDM, May FEB, Westley BR. . Clinical Cancer Research 1999, 5(10), 2682-2688.
  • Andersson ML, Lindeskog M, Medstrand P, Westley BR, May FEB, Blomberg J. . Journal of General Virology 1999, 80(1), 255-260.
  • Westley BR, May FEB. . British Journal of Cancer 1999, 79(2), 189-190.
  • Donaghue C, Westley BR, May FEB. . Molecular Endocrinology 1999, 13(11), 1934-1950.
  • Calnan DP, Westley BR, May FEB, Floyd DN, Marchbank T, Playford RJ. . Journal of Pathology 1999, 188(3), 312-317.
  • Marchbank T, Westley BR, May FEB, Calnan D, Playford R. . Journal of Pathology 1998, 185(2), 153-158.
  • Westley BR, Clayton SJ, Daws MR, Molloy CA, May FEB. . In: Annual Symposium on Mammary Development and Cancer, as Part of the 658th Meeting of the Biochemical-Society. 1998.
  • May FEB, Westley BR. . Human Genetics 1997, 99(3), 303-307.
  • May FEB, Westley BR. . Journal of Pathology 1997, 182(4), 404-413.
  • Polshakov V, Williams M, Gargaro A, Frenkiel T, Westley BR, Chadwick M, May FEB, Feeney J. . Journal of Molecular Biology 1997, 267(2), 418-432.
  • Chadwick MP, Westley BR, May FEB. . Biochemical Journal 1997, 327, 117-123.
  • Clayton SJ, May FEB, Westley BR. . Molecular and Cellular Endocrinology 1997, 128(1-2), 57-68.
  • May FEB, Westley BR. . Journal of Pathology 1997, 183(1), 4-7.
  • Westley BR, May FEB. . European Journal of Cancer 1996, 32A(1), 15-24.
  • Hodgson D, May FEB, Westley BR. . Regulatory Peptides 1996, 66(3), 191-196.
  • Daws MR, Westley BR, May FEB. . Endocrinology 1996, 137(4), 1177-1186.
  • Carr M, May FEB, Lennard TWJ, Westley BR. . British Journal of Cancer 1995, 72(6), 1427-1434.
  • Westley BR, May FEB. . British Journal of Cancer 1995, 72(5), 1065-1066.
  • Westley BR, May FEB. . In: International Meeting on Current Topics in Breast Cancer Research. 1995, Cambridge: Endocrine - Related Cancer.
  • Hodgson DR, May FEB, Westley BR. . European Journal of Biochemistry 1995, 233(1), 299-309.
  • Chadwick MP, May FEB, Westley BR. . Biochemical Journal 1995, 308, 1001-1007.
  • May FEB, Westley BR. . Biomedicine & Pharmacotherapy 1995, 49(9), 400-414.
  • Stewart AJ, Piggott NH, May FEB, Westley BR. . International Journal of Cancer 1994, 57(5), 715-718.
  • Westley BR, May FEB. . The Journal of Steroid Biochemistry and Molecular Biology 1994, 51(1-2), 1-9.
  • Henry JA, Hennessy C, Levett DL, Lennard TWJ, Westley BR, May FEB. . International Journal of Cancer 1993, 53(5), 774-780.
  • Healicon RM, Westley BR, May FEB. . International Journal of Cancer 1993, 53(3), 388-394.
  • May FEB, Smith DJ, Westley BR. . Gene 1993, 134(2), 277-282.
  • Wiseman LR, Johnson MD, Wakeling AE, Lykkesfeldt AE, May FEB, Westley BR. . European Journal of Cancer 1993, 29A(16), 2256-2264.
  • Collier JD, Guo K, Mathew J, May FEB, Bennett MK, Corbett IP, Bassendine MF, Burt AD. . Journal of Hepatology 1992, 14(2-3), 377-380.
  • Stewart AJ, Westley BR, May FEB. . British Journal of Cancer 1992, 66(4), 640-648.
  • Cochrane HR, May FEB, Ashcroft T, Dark JH. . Journal of Pathology 1991, 163(2), 129-131.
  • Henry JA, Bennett MK, Piggott NH, Levett DL, May FEB, Westley BR. . British Journal of Cancer 1991, 64(4), 677-682.
  • Hennessy C, Henry JA, May FEB, Westley BR, Angus B, Lennard TWJ. . British Journal of Cancer 1991, 63(6), 1024-1024.
  • Hennessy C, Henry JA, May FEB, Westley BR, Angus B, Lennard TWJ. . Journal of the National Cancer Institute 1991, 83(4), 281-285.
  • Henry JA, Piggott NH, Mallick UK, Nicholson S, Farndon JR, Westley BR, May FEB. . British Journal of Cancer 1991, 63(4), 615-622.
  • Henry JA, McCarthy AL, Piggot NH, Angus B, Levett D, Johnson SJ, Hennessy C, Lennard TWJ, May FEB, Westley BR. . Journal of Pathology 1991, 164(4), A359-A359.
  • Piggott NH, Henry JA, May FEB, Westley BR. . Journal of Pathology 1991, 163(2), 95-104.
  • Henry JA, McCarthy AL, Angus B, Westley BR, May FEB, Nicholson S, Cairns J, Harris AL, Horne CHW. . CANCER 1990, 65(2), 265-271.
  • Henry JA, Nicholson S, Hennessy C, Lennard TWJ, May FEB, Westley BR. . British Journal of Cancer 1990, 61(1), 32-38.
  • Corbett IP, Henry JA, Angus B, Watchorn CJ, Wilkinson L, Hennessy C, Gullick WJ, Tuzi NL, May FEB, Westley BR, Horne CHW. . Journal of Pathology 1990, 161(1), 15-25.
  • Stewart AJ, Johnson MD, May FEB, Westley BR. . Journal of Biological Chemistry 1990, 265(34), 21172-21178.
  • Westley BR, Holzel F, May FEB. . The Journal of Steroid Biochemistry and Molecular Biology 1989, 32(3), 365-372.
  • Johnson MD, Westley BR, May FEB. . British Journal of Cancer 1989, 59(5), 727-738.
  • May FEB, Johnson MD, Wiseman LR, Wakeling AE, Kastner P, Westley BR. . The Journal of Steroid Biochemistry and Molecular Biology 1989, 33(6), 1035-1041.
  • May FEB, Westley BR. . Cancer Research 1989, 49(14), 3879-3883.
  • Wiseman LR, Wakeling AE, May FEB, Westley BR. . The Journal of Steroid Biochemistry and Molecular Biology 1989, 33(1), 1-6.
  • Westley BR, May FEB. . Biochemical and Biophysical Research Communications 1988, 155(3), 1113-1118.
  • Henry JA, May FEB, Westley BR. . Journal of Pathology 1988, 155(4), A349-A349.
  • Franklin GC, Chretien S, Hanson IM, Rochefort H, May FEB, Westley BR. . Journal of Virology 1988, 62(4), 1203-1210.
  • May FEB, Westley BR. . Journal of Biological Chemistry 1988, 263(26), 12901-12908.
  • Henry JA, Nicholson S, Farndon JR, Westley BR, May FEB. . British Journal of Cancer 1988, 58(5), 600-605.
  • May FEB, Westley BR. . Journal of Biological Chemistry 1987, 262(33), 15894-15899.
  • Westley BR, May FEB. . Nucleic Acids Research 1987, 15(9), 3773-3786.
  • May FEB, Westley BR. . Journal of Virology 1986, 60(2), 743-749.
  • May FEB, Westley BR. . Cancer Research 1986, 46(12), 6034-6040.