缅北禁地

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Staff Profile

Professor Georg Lietz

Professor of International Nutrition

  • Telephone: +44 (0) 191 208 6893
  • Address: Human Nutrition Research Centre
    Leech Building
    Framlington Place
    缅北禁地 upon Tyne NE2 4HH
    UK
Background

Profile

My expertise lies in the area of human nutrition, with specific focus on fat soluble vitamins, fatty acids and related micronutrients. My group is known both nationally and internationally for our research on diet-gene interactions as an important factor in the determination of high inter-individual variations, as well as in determining total body stores of vitamin A by using the isotope dilution technique. Earlier on in my carreer, I was involved in the four centre FINGEN trial, the first UK based prospective genotyping study for the ApoE gene to investigate how n-3 fatty acids could influence cardiovascular disease risk depending on ApoE genotype.  Following on from this, I was leading a research project within the European Nutrigenomics Organisation NUGO involving seven different European laboratories, which revealed through the application of genome-wide expression analysis, that β-carotene supplementation down-regulated genes affecting lipid and glucose metabolism related pathways. A milestone discovery in my research group was the discovery of novel single nucleotide polymorphisms in the beta-carotene monoxygenase (BCO1) gene. Recently, I initiated collaborations with colleagues in international nutrition (i.e. Prof. Keith West from John Hopkins University, Baltimore (US) and Dr. Marjorie Haskell from UC Davis, California (US)) to determine if a range of single nucleotide polymorphisms can influence the effectiveness of plant-based provitamin A carotenoids to increase vitamin A status in at-risk population groups.  

My research group has established the most sensitive and cost-effective method to analyse vitamin A status in humans. In collaboration with Prof. Mike Green from PennState University,  we applied compartmental modelling to stable isotope derived data, which for the first time allowed to determine vitamin A status in individuals.  Through our efforts to define the best practise of vitamin A total body store (TBS) determination, we were invited to lead an international study group which is evaluating the potential risk of vitamin A toxicity, currently funded by both the IAEA and the Gates Foundation. Our drive to develop a simpler and accurate method to measure vitamin A status in humans has informed on-going research to define new and simple approaches to determine vitamin A status in communities that suffer from both vitamin A deficiency and inflammation.  We are in the process of developing new strategies for the assessment of vitamin A status in collaboration with the IAEA and the Gates Foundation. The overall outcome of this work will be the determination of safe upper levels of vitamin A intake to aid in the monitoring of vitamin A intervention regimens and thereby optimisation of the efficacy of vitamin A intervention programmes.  


Roles and Responsibilities

Teaching undergraduate Nutrition students
Supervision of PhD students
Project lead PI for the Gates Foundation funded GlovitAs project

 

Memberships

Member of the American Nutrition Society
Member of the Deutsche Gesellschaft für Ernährung
Member of the International Carotenoid Society
Member of the European Nutrition Leadership Programme Alumni Association 

Research

Research 

My group has gained an increasing international reputation with the development of collaborations with research partners in the US (John Hopkins University, UC Davis, PennState University, Case Western, Berkeley University), and Europe (INSERM; Wageningen University; University of the Balearic Islands; Kiel University; Freiburg University). We were the first to identify key genetic variants in the pro-vitamin A metabolism [Leung et al., 2009] in a BBSRC funded project. Securing funds to lead the European Carotenoid focus team within NUGO (The European Nutrigenomics Organisation), we were able to establish for the first time a link between beta-carotene and fat metabolism [Amengual et al., 2011]. We also developed the gold standard for the determination of vitamin A status in individuals in collaboration with Prof. Green [Green et al., 2016], resulting from a BBSRC project. More recently, I secured a $2M grant from the Bill and Melinda Gates Foundation, to lead a project involving international institutions from the Philippines, Bangladesh, Guatemala and the US. This project will enable our consortium to evaluate new strategies to detect novel biomarkers of vitamin A toxicity and to refine and verify the usefulness of the isotope dilution technique in children in community settings with high rates of inflammation. Thanks to the development of the isotope dilution technique, my research group is now working with the International Atomic Energy Agency (IAEA) in Vienna (Austria). We have also trained scientists from Wageningen University (The Netherlands) and the BATAN Institute in Jakarta (Indonesia) to use this technique.  

 

Funding

Our funding comes from a range of funding bodies, including the Bill and Melinda Gates Foundation, the International Atomic Energy Agency (IAEA), BBSRC,  and Industrial sponsorship from DSM.

 

Keywords

Gene/nutrient interactions
Carotenoids/ Vitamin A

Stable isotopes

Tea polyphenols 

Teaching

Undergraduate Teaching

I have published book chapters with relevance for undergraduate and postgraduate teaching and contributed to a range of nutrition relevant courses offered at 缅北禁地.  I was the admissions tutor for the Food and Human Nutrition / Food Marketing and Nutrition Degree programme from 2013-15, during which time applications and registrations rose by 44% / 83% and 30% / 35%, respectively.

Publications

  • Articles

    • Green MH, Lopez-Teros V, Green JB, Lietz G, Kumordzie SM, Oxley A, Fuseini AD, Nyaaba KW, Becher E, Davis JN, Wessells KR, Adu-Afarwuah S, Engle-Stone R, Haskell MJ. . Current Developments in Nutrition 2024, 8(11), 104484.
    • Engle-Stone R, Wessells KR, Haskell MJ, Kumordzie SM, Arnold CD, Davis JN, Becher ER, Fuseini AD, Nyaaba KW, Tan X, Adams KP, Lietz G, Vosti SA, Adu-Afarwuah S. . PLoS ONE 2024, 19(5), e0302968.
    • Ford JL, Green MH, Brownell JN, Green JB, Oxley A, Lietz G, Schall JI, Stallings VA. . Journal of Nutrition 2023, 153(9), 2762-2771.
    • Li L, Lietz G, Seal CJ. . Food Reviews International 2023, 40(1), 1-19.
    • Friesen VM, Miller JC, Bitantes RB, Reario MFD, Arnold CD, Mbuya MNN, Neufeld LM, Wieringa FT, Stormer A, Capanzana MV, Cabanilla CVD, Lietz G, Haskell MJ, Engle-Stone R. . Maternal and Child Nutrition 2023, 19(3), e13486.
    • Oxley A, Lietz G. . Methods in Enzymology 2022, 670, 399-422.
    • Li L, Houghton D, Lietz G, Watson A, Stewart CJ, Bal W, Seal CJ. . Nutrients 2022, 14(22), 4888.
    • Engle-Stone R, Miller JC, Fatima Dolly Reario M, Arnold CD, Stormer A, Lafuente E, Oxley A, Capanzana MV, Cabanilla CVD, Ford JL, Clark A, Velavan TP, Brown KH, Lietz G, Haskell MJ. . Current Developments in Nutrition 2022, 6(8), nzac115.
    • Iqbal WA, Mendes I, Finney K, Oxley A, Lietz G. . International Journal of Food Sciences and Nutrition 2021, 72(7), 879-891.
    • Li L, Lietz G, Seal CJ. . International Journal of Food Science and Technology 2021, 56(7), 3245-3254.
    • Oxley A, Engle-Stone R, Miller JC, Reario MFD, Stormer A, Capanzana MV, Cabanilla CVD, Haskell MJ, Lietz G. . Journal of Nutrition 2021, 151(5), 1341-1346.
    • Palmer AC, Jobarteh ML, Chipili M, Greene MD, Oxley A, Lietz G, Mwanza R, Haskell MJ. . American Journal of Clinical Nutrition 2021, 113(5), 1209-1220.
    • Ford JL, Green JB, Haskell MJ, Ahmad SM, Mazariegos Cordero DI, Oxley A, Engle-Stone R, Lietz G, Green MH. . The Journal of Nutrition 2020, 150(2), 411-418.
    • Lietz G. . The Journal of Nutrition 2020, 150(11), 2849-2851.
    • Al-Mrabeh A, Zhyzhneuskaya SV, Peters C, Barnes AC, Melhem S, Jesuthasan A, Aribasala B, Hollingsworth KG, Lietz G, Mathers JC, Sattar N, Lean MEJ, Taylor R. . Cell Metabolism 2020, 31(2), 233-249.
    • Ford J, Lietz G, Oxley A, Green J, Green M. . Current Developments in Nutrition 2019, 3(Suppl. 1), FS06-07-19.
    • Lietz G, Oxley A, Finney K, Clark A, Giles T, Foster N, Southam A, Jankevics A, Lloyd G, Winder C, Dunn W. . Current Developments in Nutrition 2019, 3(Suppl. 1), OR05-06-19.
    • Ford JL, Green MH, Green JB, Oxley A, Lietz G. . Archives of Biochemistry and Biophysics 2018, 653, 121-126.
    • Li L, Lietz G, Bal W, Watson A, Morfey B, Seal C. . Nutrients 2018, 10(6), 777.
    • Sakkas P, Oikeh I, Blake DP, Nolan MJ, Bailey RA, Oxley A, Rychlik I, Lietz G, Kyriazakis I. . Veterinary Parasitology 2018, 258, 88-98.
    • LI L, Lietz G, Seal C. . Nutrients 2018, 10(5), 619.
    • Ford JL, Green JB, Lietz G, Oxley A, Green MH. . The Journal of Nutrition 2017, 147(9), 1806-1814.
    • Green MH, Ford JL, Oxley A, Green JB, Park H, Berry P, Boddy AV, Lietz G. . Journal of Nutrition 2016, 146(10), 2129-2136.
    • Bruins MJ, Kupka R, Zimmermann MB, Lietz G, Engle-Stone R, Kraemer K. . Maternal and Child Nutrition 2016, 12(4), 940-948.
    • Huebbe P, Lange J, Lietz G, Rimbach G. . BioFactors 2016, 42(4), 388-396.
    • Tanumihardjo SA, Russell RM, Stephensen CB, Gannon BM, Craft NE, Haskell MJ, Lietz G, Schulze K, Raiten DJ. . Journal of Nutrition 2016, 146(9), 1816-1848.
    • Green MH, Ford JL, Green JB, Berry P, Boddy AV, Oxley A, Lietz G. . Journal of Nutrition 2016, 146(10), 2137-2142.
    • Oxley A, Berry P, Taylor GA, Cowell J, Hall MJ, Hesketh J, Lietz G, Boddy AV. . Journal of Lipid Research 2014, 55(2), 319-328.
    • Borel P, Lietz G, Goncalves A, de Edelenyi FS, Lecompte S, Curtis P, Goumidi L, Caslake MJ, Miles EA, Packard C, Calder PC, Mathers JC, Minihane AM, Tourniaire F, Kesse-Guyot E, Galan P, Hercberg S, Breidenassel C, Gross MG, Moussa M, Meirhaeghe A, Reboul E. . Journal of Nutrition 2013, 143(4), 448-456.
    • Lietz G, Oxley A, Leung W, Hesketh J. . Journal of Nutrition 2012, 142(1), 161S-165S.
    • Prathalingam N, Ferguson L, Young L, Lietz G, Oldershaw R, Healy L, Craig A, Lister H, Binaykia R, Sheth R, Murdoch A, Herbert M. . Stem Cell Research and Therapy 2012, 3(2), 12.
    • Kofler BM, Miles EA, Curtis P, Armah CK, Tricon S, Grew J, Napper FL, Farrell L, Lietz G, Packard CJ, Caslake MJ, Mathers JC, Williams CM, Calder PC, Minihane AM. . Atherosclerosis 2012, 221(2), 467-470.
    • van Helden YGJ, Godschalk RWL, von Lintig J, Lietz G, Landrier JF, Bonet ML, van Schooten FJ, Keijer J. . Molecular Nutrition & Food Research 2011, 55(10), 1466-1474.
    • Amengual J, Gouranton E, van Helden YGJ, Hessel S, Ribot J, Kramer E, Kiec-Wilk B, Razny U, Lietz G, Wyss A, Dembinska-Kiec A, Palou A, Keijer J, Landrier JF, Bonet ML, von Lintig J. . PLoS One 2011, 6(6), e20644.
    • van Helden YGJ, Heil SG, van Schooten FJ, Kramer E, Hessel S, Amengual J, Ribot J, Teerds K, Wyss A, Lietz G, Bonet ML, von Lintig J, Godschalk RWL, Keijer J. . Cellular and Molecular Life Sciences 2010, 67(12), 2039-2056.
    • Grune T, Lietz G, Palou A, Ross AC, Stahl W, Tang GW, Thurnham D, Yin SA, Biesalski HK. . Journal of Nutrition 2010, 140(12), 2268S-2285S.
    • Tourniaire F, Gouranton E, von Lintig J, Keijer J, Bonet ML, Amengual J, Lietz G, Landrier JF. . Genes and Nutrition 2009, 4(3), 179–187.
    • Leung WC, Hessel S, Méplan C, Flint J, Oberhauser V, Tourniaire F, Hesketh JE, von Lintig J, Lietz G. . FASEB Journal 2009, 23(4), 1041-1053.
    • Hesketh JE, Lietz G. . Current Opinion in Lipidology 2009, 20(2), 112-120.
    • Williams CM, Ordovas JM, Lairon D, Hesketh J, Lietz G, Gibney M, Ommen B. . Genes and Nutrition 2008, 3(2), 41-49.
    • Caslake MJ, Miles EA, Kofler BM, Lietz G, Curtis P, Armah CK, Kimber AC, Grew JP, Farrell L, Stannard J, Napper FL, Sala-Vila A, West AL, Mathers JC, Packard C, Williams CM, Calder PC, Minihane AM. . American Journal of Clinical Nutrition 2008, 88(3), 618-629.
    • Lietz G, Mulokozi G, Henry JCK, Tomkins AM. . Journal of Nutrition 2006, 136(7), 1821-1827.
    • Bergmann MM, Bodzioch M, Bonet ML, Defoort C, Lietz G, Mathers JC. . British Journal of Nutrition 2006, 95(5), 1024-1027.
    • Mulokozi G, Lietz G, Svanberg U, Mugyabuso JK, Henry JCK, Tomkins AM. . International Journal for Vitamin and Nutrition Research 2003, 73(5), 323-333.
    • Lietz G, Barton KL, Longbottom PJ, Anderson AS. . Public Health Nutrition 2002, 5(6), 783-789.
    • Lietz G, Henry CJK, Mulokozi G, Mugyabuso JKL, Ballart A, Ndossi GD, Lorri W, Tomkins A. . American Journal of Clinical Nutrition 2001, 74(4), 501-509.
    • Lietz G, Mulokozi G, Mugyabuso JKL, Ndossi GD, Lorri W, Henry CJK, Tomkins A. . Food and Nutrition Bulletin 2000, 21(2), 215-218.

  • Book Chapters

    • Hill T, Lietz G. . In: Lanham-New S; Hill T; Gallagher A; Voster H, ed. Introduction to Human Nutrition 3rd Edition. Hoboken, NJ: Wiley-Blackwell, 2019, pp.439-452.
    • Lietz G, Oxley A, Bosch-Saadatmandi C. . In: Sommerburg, O; Siems, W; Kraemer, K, ed. Carotenoids and Vitamin A in Translational Medicine. CRC Press, 2013, pp.383-396.
    • Madden J, Williams CM, Calder PC, Lietz G, Miles EA, Cordell H, Mathers JC, Minihane AM. . In: Cousins, R.J., Bier, D.M., Bowman, B.A, ed. Annual Review of Nutrition. Palo Alto, California, USA: Annual Reviews, 2011, pp.203-234.

  • Letter

    • Lietz G, Haskell M, Melse-Boonstra A. . American Journal of Clinical Nutrition 2015, 102(2), 520-521.

  • Reviews

    • Holler U, Bakker SJL, Dusterloh A, Frei B, Kohrle J, Konz T, Lietz G, McCann A, Michels AJ, Molloy AM, Murakami H, Rein D, Saris WHM, Schmidt K, Shimbo K, Schumacher S, Vermeer C, Kaput J, Weber P, Eggersdorfer M, Rezzi S. . TrAC - Trends in Analytical Chemistry 2018, 102, 110-122.
    • Lietz G, Furr HC, Gannon BM, Green MH, Haskell M, Lopez-Teros V, Novotny JA, Palmer AC, Russell RM, Tanumihardjo SA, Van Loo-Bouwman CA. . Food and Nutrition Bulletin 2016, 37(2), S87-S103.
    • Lietz G, Oxley A, Boesch-Saadatmandi C, Kobayashi D. . Molecular Nutrition and Food Research 2012, 56(2), 241.
    • van Ommen B, El-Sohemy A, Hesketh J, Kaput J, Fenech M, Evelo CT, McArdle HJ, Bouwman J, Lietz G, Mathers JC, Fairweather-Tait S, van Kranen H, Elliott R, Wopereis S, Ferguson LR, Meplan C, Perozzi G, Allen L, Rivero D, Micronutrient Genomics Project Wor. . Genes & Nutrition 2010, 5(4), 285-296.
    • Lietz G, Lange J, Rimbach G. . Archives of Biochemistry and Biophysics 2010, 502(1), 8-16.