缅北禁地

I am a member of the population health sciences institute and work in the information and methodologies application theme. I joined the Evidence Synthesis Group in 2019 and contribute to a variety of evidence synthesis and health data science projects. I have an interest in progressing information retrieval methodologies through the use of innovative technologies. 

Qualifications

• MSc Public Health and Health Services Research with Distinction, 2021, 缅北禁地
• MSc Bioinformatics with Distinction, 2018, 缅北禁地
• BSc (Hons) Biomedical Genetics, 2017, 缅北禁地

Previous work

Ageing research, Camps for ageing and vitality, 缅北禁地, 2018-2019:

• Building an agent based model to demonstrate the development of breast cancer
• Building an agent based model to demonstrate the development of senescent cells in skin ageing
• Building web resources for school students which give information, provide worksheets, display the agent based models and connect to a well established modelling database to retrieve data

Mitochondrial research projects, BSc and MSc dissertations 2017-18:

• Computational mitochondrial genomics research
• Identifying the presence of human pathogenic variants in non-human species and possible masking variants 
• Exploration of Complex I genes and tRNA genes
• Research relates to the diagnostic inequalities and lack of "common" pathogenic mutations in mitochondrial disease patients with non-European haplogroups

Fertility research, Centre for Life, 缅北禁地, 2015-2016:

• Human stem cell research for pronuclear transfer techniques
• Cryosectioning and immunohistochemistry of murine tissues
• Gamete research from murine models
• Laboratory technician duties

I am an Information Specialist within the Information Research Team, embedded at the junction of the Evidence Synthesis Group and the NIHR Innovation Observatory. 

I have a keen interest in the use of pre-existing data, as researchers we have access to a wealth of data through databases and other sharing platforms. I am interested in how this data can be mined for new discoveries and what we can learn by re-examining data from different view points. Evidence syntheses are a way to collect and analyse pre-existing data for many different questions and allow us to identify knowledge gaps. To complement this, I am interested in the advancement of information specialist methodologies through novel methodologies and innovative technologies. Other medical research interests of mine include mitochondrial genetics, infertility and post-mortem care. 

• Articles

  • Eastaugh CH, Still M, Beyer FR, Wallace SA, O'Keefe H. . Cochrane Evidence Synthesis and Methods 2025, 3(5), e70049.
  • Scanlan RL, Pease L, O'Keefe H, Martinez-Guimera A, Rasmussen L, Wordsworth J, Shanley D. . Frontiers in Aging 2024, 5, 1448543.
  • Fong M, Kenny RPW, Thomson K, Jesurasa A, Lavans A, Patterson M, Sermin-Reed L, Nguyen G, Aquino MRJ, Cullen E, O'Keefe H, Moffat M, Heslehurst N. . Frontiers in Public Health 2024, 12, 1359680.
  • O'Keefe H, Rankin J, Wallace SA, Beyer F. . Research Synthesis Methods 2023, 14(1), 79-98.
  • Beyer F, Rice S, Orozco-Leal G, Still M, O'Keefe H, O'Connor N, Stoniute A, Craig D, Pereira S, Carr L, Leeds J. . Health Technology Assessment 2023, 27(7), 1-118.
  • Iqbal A, Richardson C, Iqbal Z, O'Keefe H, Hanratty B, Matthews FE, Todd A. . BMC Geriatrics 2023, 23(1), 149.
  • O'Keefe H, Shenfine R, Brown M, Beyer F, Rankin J. . BMJ Open 2023, 13(1), e064774.
  • Sutton A, O'Keefe H, Johnson E, Marshall C. . Research Synthesis Methods 2023, 14(6), 874-881.
  • Johnson EE, O'Keefe H, Sutton A, Marshall C. . Systematic Reviews 2022, 11, 258.
  • Wordsworth J, OKeefe H, Clark P, Shanley D. . Mechanisms of Aging and Development 2022, 207, 111709.
  • Thomson K, Rice S, Arisa O, Johnson E, Tanner L, Marshall C, Sotire T, Richmond C, O'Keefe H, Mohammed W, Gosney M, Raffle A, Hanratty B, McEvoy CT, Craig D, Ramsay SE. . Health Technology Assessment 2022, 26(51).
  • Stoniute A, Pearson F, O'Keefe H, Visram S. Effects of community-based interventions on mental health of individuals from low socioeconomic status backgrounds: a systematic review. Social Science & Medicine 2022. Submitted.
  • Thomson KH, Rice S, Arisa O, Johnson E, Tanner L, Marshall C, Sotire T, Richmond C, O'Keefe H, Mohammed W, Raffle A, Hanratty B, McEvoy CT, Craig D, Ramsay SE. . The Lancet Healthy Longevity 2022, 3(10), E654-E666.
  • Oyewole AO, Barrass L, Robertson EG, Woltmann J, O'Keefe H, Sarpal H, Dangova K, Richmond C, Craig D. . Diagnostics 2021, 11(2), 182.
  • Klink GV, O'Keefe H, Gogna A, Bazykin GA, Elson JL. . Scientific Reports 2021, 11, 19578.
  • O'Keefe H, Queen R, Lord P, Elson JL. . Evolutionary Applications 2020, 12(10), 1912-1930.
  • O'Keefe H, Queen RA, Meldau S, Lord P, Elson JL. . Journal of Molecular Evolution 2018, 86(6), 395-403.
  • Hyslop LA, Blakeley P, Craven L, Richardson J, Fogarty NME, Fragouli E, Lamb M, Wamaitha SE, Prathalingam N, Zhang Q, O'Keefe H, Takeda Y, Arizzi L, Alfarawati S, Tuppen H, Irving L, Kalleas D, Choudhary M, Wells D, Murdoch AP, Turnbull DM, Niakan KK, Herbert M. . Nature 2016, 534(7607), 383-386.

• Conference Proceedings (inc. Abstracts)

  • Johnson E, O'Keefe H, Sutton A, Marshall C. . In: Cochrane Colloquium 2023. 2023, London: Cochrane Collaboration.
  • Beyer F, Rice S, Orozco-Leal G, Still M, O'Keefe H, O'Connor N, Stoniute A, Craig D, Pereira S, Carr L, Leeds J. . In: British Society of Gastroenterology (BSG) Annual Meeting. 2021, Online: BMJ Publishing Group.
  • Beyer F, Rice S, Orozco-Leal G, Still M, O'Keefe H, O'Connor N, Stoniute A, Craig D, Pereira S, Carr L, Leeds J. . In: UGI Congress 2021. 2021, Belfast: Oxford University Press.
  • Jarvis H, O'Keefe H, Craig D, Stow D, Anstee Q, Hanratty B. . In: Society for Academic Primary Care (SAPC) Annual Scientific Meeting 2020. 2020, University of Leeds: Society for Academic Primary Care (SAPC).

• Review

  • Jarvis H, O'Keefe H, Craig D, Stow D, Hanratty B, Anstee QM. . BMJ Open 2022, 12(1), e049767.