缅北禁地

Roles and Responsibilities

Professor of Cardiology and Cardiovascular Gerontology

      Fellow of the European Society of Cardiology (FESC)

      Fellow of the Royal Society of Physicians (FRCP)

Hon. Consultant Interventional Cardiology, Freeman Hospital

Co-Lead NIHR Clinical Research Network Cardiovascular (CRN) 

        North East and North Cumbria

Translational and Clinical Research Institute

Programme director Masters course "Cardiovascular Science in Health & Disease"

Deputy Lead and Educational Lead Vascular Biology and Medicine Theme 

ORCID number 0000-0002-2750-2444

Our group is interested on the role of the immune system during cardiovascular ageing, such as how the immune system regulates inflammation (“Inflammaging”). Our approach is translational, identifying relevant questions in patients with coronary artery disease and modelling them in the lab. We will translate our results back to the patient through development of pathway-specific drugs.

What is the Role of T-lymphocytes in Myocardial ischemia/reperfusion Injury and Infarct Healing ?

Coronary artery disease is the single largest cause of mortality worldwide, with myocardial infarction being the most serious manifestation. Timely and effective myocardial reperfusion using primary PCI in acute ST elevation myocardial infarction (STEMI) has substantially improved clinical outcomes of patients. Following reopening of the blocked artery, reperfusion itself can cause myocardial injury and cell death (myocardial ischaemia/reperfusion injury). Studies in animal MI models and human therapeutic interventions indicate that ischemia/reperfusion injury is responsible for up to 50% of final infarct size. While CD4 T-lymphocytes (T-cells) have been shown to promote myocardial ischemia/reperfusion injury in the mouse model, their role during STEMI in humans is by large unknown. A low number of lymphocytes following myocardial infarction is a negative predictor of survival, and we have previously shown (PLoS One 2012) that CD4 and CD8 T-cells drop by up to 50% in the peripheral blood during the first 30 min following reperfusion. At the moment we are conducting three BHF and NIHR funded studies to investigate the role of T-cells in myocardial ischemia-reperfusion and peri-infarct inflammation. We have also previously shown (Circulation 2009) that prior infection with cytomegalovirus (CMV) is associated with shorter telomeres of CD8 T-cells in patients with previous myocardial infarction, correlating with left ventricular function. Another aim of our studies is therefore to find out if CMV seropositivity has an impact on peri-infarct inflammation and healing.

What is the Role of Telomerase in Atherosclerosis ?

Atherosclerosis is an age-related systemic disease characterized by systemic oxidative stress and low grade chronic inflammation, mediated by various leukocyte populations. Telomere dysfunction has been implicated in ageing and senescence of different cell types. Shorter leukocyte telomeres, possibly the result of decreased telomerase activity, are also associated with increased cardiovascular risk and mortality. However, so far no mechanistic link on a cellular level has been found between ageing and atherosclerosis. Telomerase as a DNA polymerase principally functions to protect and elongate telomeres; however, we and others have shown additional “non-canonical” effects of telomerase that are potentially of relevance to atherosclerosis. In our current project we aim to investigate whether telomerase could prove to be a decelerator of atherosclerosis by maintaining generation and suppressive function of CD4 regulatory T-cells, potent suppressors of inflammation and atherogenesis.

Postdoctoral Fellows

Karim Bennaceur, PhD

Sharon Cookson, PhD

PhD Students

Yasemine Ekinci

MD Students

Dr Bilal Bawamia

Dr Shu Loh

Dr Ayman Al-Atta

Original Publications since 2020  

1.      Spray L, Park C, Cormack S, Mohammed A, Panahi P, Boag S, Bennaceur K, Sopova K, Richardson G, Stangl VM, Rech L, Rainer PP, Ramos GC, Hofmann U, Stellos K, Spyridopoulos I. The Fractalkine Receptor CX₃CR1 Links Lymphocyte Kinetics in CMV-Seropositive Patients and Acute Myocardial Infarction With Adverse Left Ventricular Remodeling. Front Immunol. 2021;12:605857.

2.      Delgobo M, Heinrichs M, Hapke N, Ashour D, Appel M, Srivastava M, Heckel T, Spyridopoulos I, Hofmann U, Frantz S, Ramos GC. Terminally Differentiated CD4  T Cells Promote Myocardial Inflammaging. Front Immunol. 2021;12:584538.

3.      Owens WA, Walaszczyk A, Spyridopoulos I, Dookun E, Richardson GD. Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls. Mech Ageing Dev. 2021;198:111540.

4.      Marsh SA, Park C, Redgrave RE, Singh E, Draganova L, Boag SE, Spray L, Ali S, Spyridopoulos I, Arthur HM. Rapid fall in circulating non-classical monocytes in ST elevation myocardial infarction patients correlates with cardiac injury. FASEB J. 2021;35:e21604.

5.      Coelho-Lima J, Georgiopoulos G, Ahmed J, Adil SER, Gaskin D, Bakogiannis C, Sopova K, Ahmed F, Ahmed H, Spray L, Richardson G, Bagnall AJ, Stellos K, Stamatelopoulos K, Spyridopoulos I. Prognostic value of admission high-sensitivity troponin in patients with ST-elevation myocardial infarction. Heart. 2021heartjnl-2021.

6.      McClements J, Seumo Tchekwagep PM, Vilela Strapazon AL, Canfarotta F, Thomson A, Czulak J, Johnson RE, Novakovic K, Losada-Pérez P, Zaman A, Spyridopoulos I, Crapnell RD, Banks CE, Peeters M. Immobilization of Molecularly Imprinted Polymer Nanoparticles onto Surfaces Using Different Strategies: Evaluating the Influence of the Functionalized Interface on the Performance of a Thermal Assay for the Detection of the Cardiac Biomarker Troponin I. ACS Appl Mater Interfaces. 2021

7.      Maier R, Bawamia B, Bennaceur K, Dunn S, Marsay L, Amoah R, Kasim A, Filby A, Austin D, Hancock H, Spyridopoulos I. Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial. JMIR Res Protoc. 2020;9:e19456.

8.      Coelho-Lima J, Mohammed A, Cormack S, Jones S, Ali A, Panahi P, Barter M, Bagnall A, Ali S, Young D, Spyridopoulos I. Kinetics Analysis of Circulating MicroRNAs Unveils Markers of Failed Myocardial Reperfusion. Clin Chem. 2020;66:247-256.

9.      Granic A, Martin-Ruiz C, Dodds RM, Robinson L, Spyridopoulos I, Kirkwood TB, von Zglinicki T, Sayer AA. Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The 缅北禁地 85 Study. Mech Ageing Dev. 2020111321.

10.    Egred M, Bagnall A, Spyridopoulos I, Purcell IF, Das R, Palmer N, Grech ED, Jain A, Stone GW, Nijveldt R, McAndrew T, Zaman A. Effect of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size in anterior STEMI: PiCSO in ACS study. Int J Cardiol Heart Vasc. 2020;28:100526.

11.    Cormack S, Mohammed A, Panahi P, Das R, Steel AJ, Chadwick T, Bryant A, Egred M, Stellos K, Spyridopoulos I, CAPRI I. Effect of ciclosporin on safety, lymphocyte kinetics and left ventricular remodelling in acute myocardial infarction. Br J Clin Pharmacol. 2020;86:1387-1397.

12.    Martin-Ruiz C, Hoffmann J, Shmeleva E, Zglinicki TV, Richardson G, Draganova L, Redgrave R, Collerton J, Arthur H, Keavney B, Spyridopoulos I. CMV-independent increase in CD27-CD28 CD8 EMRA T cells is inversely related to mortality in octogenarians. NPJ Aging Mech Dis. 2020;6:3.

13.    Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual-Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep OE, Santin Y, Mialet-Perez J, Andrew Owens W, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery. Aging Cell. 2020e13249.

Invited Reviews and Editorials since 2017

1.      Hoffmann J, Richardson G, Haendeler J, Altschmied J, Andrés V, Spyridopoulos I. Telomerase as a Therapeutic Target in Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2021;41:1047-1061.

2.      Lazaridis, C, Vlachogiannis, NI, Bakogiannis, C, Spyridopoulos, I, Stamatelopoulos, K, Kanakakis, I, Vassilikos, V, Stellos, K. Involvement of cardiovascular system as the critical point in coronavirus disease 2019 (COVID-19) prognosis and recovery. Hellenic J Cardiol. 2020

3.      Nobian, A, Mohamed, A, Spyridopoulos, I. The role of arginine vasopressin in myocardial infarction and reperfusion. Kardiol Pol. 2019;77(10):908–917.

4.      Stellos, K, Spyridopoulos, I. Exercise, telomerase activity, and cardiovascular disease prevention. Eur Heart J. 2019;40(1):47–49.

5.      Coelho-Lima, J, Spyridopoulos, I. Non-coding RNA regulation of T cell biology: Implications for age-associated cardiovascular diseases. Exp Gerontol. 2018;109:38–46.

6.      Spyridopoulos, I. Molecular mechanisms and therapy of cardiovascular ageing. Exp Gerontol. 2018;109:1–4.

7.      Heiss, C, Spyridopoulos, I, Haendeler, J. Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules. Exp Gerontol. 2018;109:108–118.

8.      Marsh, SA, Arthur, HM, Spyridopoulos, I. The secret life of nonclassical monocytes. Cytometry A. 2017;91(11):1055–1058.

9.      Spyridopoulos, I, Arthur, HM. Microvessels of the heart: Formation, regeneration, and dysfunction. Microcirculation. 2017;24(1)

10.    Boag, SE, Andreano, E, Spyridopoulos, I. Lymphocyte Communication in Myocardial Ischemia/Reperfusion Injury. Antioxid Redox Signal. 2017;26(12):660–675.

I am programme lead for our Universities Masters of Research program "Cardiovascular Science in Health and Disease"

• McClements J, Seumo P, Vilalela Strapazon A, Canfarotta F, Thomson A, Czulak J, Johnson R, Novakovic K, Losada-Perez P, Zaman A, Spyridopoulos I, Crapnell R, Banks C, Peeters M. . ACS Applied Materials and Interfaces 2021, 13(24), 27868-27879.
• Coelho-Lima J, Georgiopoulos G, Ahmed J, Adil Syeda, Gaskin D, Bakogiannis C, Sopova k, Ahmed F, Ahmed H, Spray L, Richardson G, Bagnall A, Stellos K, Stamatelopoulos K, Spyridopoulos I. . Heart BMJ 2021, 107(23), 1881-1888.
• Marsh SA, Park C, Redgrave RE, Singh E, Draganova L, Boag SE, Spray L, Ali S, Spyridopoulos I, Arthur HM. . FASEB Journal 2021, 35(5), e21604.
• Owens WA, Walaszczyk A, Spyridopoulos I, Dookun E, Richardson GD. . Mechanisms of Ageing and Development 2021, 198, 111540.
• Hoffmann J, Richardson GD, Haendeler J, Altschmied J, Andrés V, Spyridopoulos I. . Arteriosclerosis, Thrombosis, and Vascular Biology 2021, 41(3), 855-865.
• Delgobo M, Heinrichs M, Hapke N, Ashour D, Appel M, Srivastava M, Heckel T, Spyridopoulos I, Hofmann U, Frantz S, Ramos GC. . Frontiers in Immunology 2021, 12, 584538.
• Spray L, Park C, Cormack S, Mohammed A, Panahi P, Boag S, Bennaceur K, Sopova K, Richardson G, Stangl V, Rech L, Rainer P, Ramos G, Hofmann U, Stellos K, Spyridopoulos I. . Frontiers in Immunology 2021, 12, 605857.
• Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep O, Santin Y, Mialet Perez J, Owens WA, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. Clearance of senescent cells during cardiac ischemia-reperfusion injury improves recovery. Aging Cell 2020, 19(10), e13249.
• Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep O, Santin Y, Mialet Perez J, Owens WA, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. . Aging Cell 2020, 19(10), e13249.
• Martin-Ruiz C, Hoffmann J, Shmeleva E, von Zglinicki T, Richardson G, Draganova L, Redgrave R, Collerton J, Arthur H, Keavney B, Spyridopoulos I. . npj Aging and Mechanisms of Disease 2020, 6, 3.
• Cormack S, Mohammed A, Panahi P, Das R, Steel AJ, Chadwick T, Bryant A, Egred M, Stellos K, Spyridopoulos I. . British Journal of Clinical Pharmacology 2020, 86(7), 1387-1397.
• Egred M, Bagnall A, Spyridopoulos I, Purcell IF, Das R, Palmer N, Grech ED, Jain A, Stone GW, Nijveldt R, McAndrew T, Zaman A. . IJC Heart and Vasculature 2020, 28, 100526.
• Granic A, Martin-Ruiz C, Dodds RM, Robinson L, Spyridopoulos I, Kirkwood TBL, von Zglinicki T, Sayer AA. . Mechanisms of Ageing and Development 2020, 190, 111321.
• Liu D, Richardson G, Benli FM, Park C, de Souza JV, Bronowska AK, Spyridopoulos I. . Clinical Science 2020, 134(17), 2243-2262.
• Lazaridis C, Vlachogiannis NI, Bakogiannis C, Spyridopoulos I, Stamatelopoulos K, Kanakakis I, Vassilikos V, Stellos K. . Hellenic Journal of Cardiology 2020, 61(6), 381-395.
• Coelho-Lima J, Mohammed A, Cormack S, Jones S, Ali A, Panahi P, Barter M, Bagnall A, Ali S, Young D, Spyridopoulos I. . Clinical Chemistry 2020, 66(1), 247-256.
• Spray L, Park C, Cormack S, Mohammad A, Panahi P, Boag S, Bennaceur K, Richardson G, Arthur H, Stellos K, Spyridopoulos I. . European Heart Journal 2020, 41(Suppl. 2), ehaa946.1289.
• Maier R, Bawamia B, Bennaceur K, Dunn S, Marsay L, Amoah R, Kasim A, Filby A, Austin D, Hancock H, Spyridopoulos I. . JMIR Research Protocols 2020, 9(9), e19456.
• Stellos K, Spyridopoulos I. . European Heart Journal 2019, 40(1), 47-49.
• Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. . In: Senescence Symposium. 2019, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, UK.
• Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot A, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD. . Aging Cell 2019, 18(3), e12945.
• Yausep Oliver, Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. . In: 24th ASEAN Federation Cardiology Congress (24th AFCC) 28th Annual Scientific Meeting of the Idonesian Heart Association (28th ASMIHA). 2019, Faculty of Medicine, University of Indonesia, Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia.
• Luke P, Eggett C, Spyridopoulos I, Irvine T. . Echo Research and Practice 2018, 5(4), 139-147.
• Dookun ER, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson GD. . In: BAS/BSCR Spring Meeting 2018. 2018, Manchester, UK: Heart.
• Dookun E, Walaszczyk A, Redgrave R, Tual-Chalot S, Yausep O, Chapman J, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. . In: 26th Northern Cardiovascular Research Group Meeting. 2018, 缅北禁地 upon Tyne.
• Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, Aufenvenne K, von Ameln F, Zurek M, Spannbrucker T, Eckermann O, Jakob S, Gorressen S, Abrams M, Grandoch M, Fischer JW, Kohrer K, Deenen R, Unfried K, Altschmied J, Haendeler J. . PLoS Biology 2018, 16(6), e2004408.
• Heiss C, Spyridopoulos I, Haendeler J. . Experimental Gerontology 2018, 109, 108-118.
• Spyridopoulos I. . Experimental Gerontology 2018, 109, 1-4.
• Coelho-Lima J, Spyridopoulos I. . Experimental Gerontology 2018, 109, 38-46.
• Coelho-Lima J, Mohammed A, Cormack S, Jones S, Das R, Egred M, Panahi P, Ali S, Spyridopoulos I. . Thrombosis and Haemostasis 2018, 118(7), 1257-1269.
• Walaszczyk A, Dookun ER, Redgrave R, Tual-Chalot S, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson GD. . In: BAS/BSCR Spring Meeting 2018. 2018, Manchester, UK: Heart.
• Walaszczyk A, Dookun E, Redgrave R, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. . In: 26th Northern Cardiovascular Research Group Meeting. 2018, 缅北禁地, UK.
• Walaszczyk A, Dookun E, Redgrave R, Anderson R, Spyridopoulos I, Owens A, Arthur H, Passos J, Richardson G. . In: 9th Annual Alliance for Healthy Aging Conference. 2018, Mayo Clinic Rochester, MN, USA.
• Richardson G, Sage A, Bennaceur K, Al Zhrany N, Coelho-Lima J, Dookun E, Draganova L, Saretzki G, Breault D, Mallat Z, Spyridopoulos I. . Arteriosclerosis, Thrombosis, and Vascular Biology 2018, 38(6), 1283-1296.
• Boag SE, Andreano E, Spyridopoulos I. . Antioxidants and Redox Signaling 2017, 26(12), 660-675.
• Spyridopoulos I, Arthur HM. . Microcirculation 2017, 24(1), e12338.
• Giannoudi M, Spyridopoulos I. . In: Telomeres, Diet and Human Disease: Advances and Therapeutic Opportunities. Boca Raton, FL, USA: CRC Press, 2017, pp.68-82.
• Andres V, Dorado B, Spyridopoulos I. . In: Mechanisms Linking Aging, Diseases and Biological Age Estimation. Boca Raton, FL, USA: CRC Press, 2017, pp.150-160.
• Marsh SA, Arthur HM, Spyridopoulos I. . Cytometry Part A 2017, 91(11), 1055-1058.
• Spyridopoulos I, Martin-Ruiz C, Hilkens C, Yadegarfar ME, Isaacs J, Jagger C, Kirkwood T, von Zglinicki T. . Aging Cell 2016, 15(2), 389-392.
• Shmeleva EV, Boag SE, Murali S, Bennaceur K, Das R, Egred M, Purcell I, Edwards R, Todryk S, Spyridopoulos I. . Immunity, Inflammation and Disease 2015, 3(2), 56-70.
• Hoffmann J, Shmeleva EV, Boag SE, Fiser K, Bagnall A, Murali S, Dimmick I, Pircher H, Martin-Ruiz C, Egred M, Keavney B, von Zglinicki T, Das R, Todryk S, Spyridopoulos I. . Circulation Research 2015, 116(1), 87-98.
• Hoffmann J, Spyridopoulos I. . Cellular & Molecular Immunology 2015, 12(4), 510-512.
• Spyridopoulos I, Noman A, Ahmed JM, Das R, Edwards R, Purcell I, Bagnall A, Zaman A, Egred M. . European Heart Journal: Acute Cardiovascular Care 2015, 4(3), 270-277.
• Boag SE, Das R, Shmeleva EV, Bagnall A, Egred M, Howard N, Bennaceur K, Zaman A, Keavney B, Spyridopoulos I. . Journal of Clinical Investigation 2015, 125(8), 3063-3076.
• Bennaceur K, Atwill M, Al Zhrany N, Hoffmann J, Keavney B, Breault D, Richardson G, von Zglinicki T, Saretzki G, Spyridopoulos I. . Atherosclerosis 2014, 236(2), 312-320.
• Al-Ajmi N, Saretzki G, Miles C, Spyridopoulos I. . Experimental Gerontology 2014, 58, 113-119.
• Boag S, Schmeleva E, Das R, Egred M, Zaman A, Bagnall A, Owens WA, Keavney B, Ahmed J, Spyridopoulos I. . In: British Cardiovascular Society Annual Conference 2014. 2014, Manchester, UK: BMJ Publishing Group.
• Shmeleva E, Boag S, Murali S, Bennaceur K, Todryk S, Spyridopoulos I. . In: The British Society for Immunology Annual Congress 2014. 2014, Brighton, UK: Wiley-Blackwell.
• Spyridopoulos I, Noman A, Ahmed J, Egred M. . In: British Cardiovascular Society Annual Conference 2014. 2014, Manchester, UK: BMJ Publishing Group.
• Spyridopoulos I, von Zglinicki T. . British Medical Journal 2014, 349, g4373.
• Bagnall A, Spyridopoulos I. . Current Cardiology Reviews 2014, 10(2), 88-98.
• Honold J, DeRosa S, Spyridopoulos I, Fischer-Rasokat U, Seeger FH, Leistner D, Lotz S, Levy WC, Zeiher AM, Assmus B. . Clinical Cardiology 2013, 36(3), 153-159.
• Schwietz T, Ehrlich JR, DeRosa S, Fichtlscherer S, Schächinger V, Baier G, Laskowski R, Zeiher AM, Spyridopoulos I, Lehmann R. . Journal of Cardiology 2013, 61(1), 38-43.
• Badar A, Scaife J, Yan AT, Robinson SD, Zaman AG, Purcell IF, Ahmed JM, Egred M, Edwards RJ, Spyridopoulos I, Keavney BD, Bagnall AJ. . Journal of Invasive Cardiology 2013, 25(8), 397-401.
• Badar A, Scaife J, Yan AT, Robinson SD, Zaman AG, Purcell IF, Ahmed JM, Egred M, Edwards RJ, Spyridopoulos I, Keavney BD, Bagnall AJ. . Journal of Invasive Cardiology 2013, 25(8), 397-401.
• Wald DS, Morris JK, Wald NJ, Chase AJ, Edwards RJ, Hughes LO, Berry C, Oldroyd KG, PRAMI Investigators. . New England Journal of Medicine 2013, 369(12), 1115-1123.
• Schwietz T, Spyridopoulos I, Pfeiffer S, Laskowski R, Palm S, De Rosa S, Jens K, Zeiher AM, Schachinger V, Fichtlscherer S, Lehmann R. . Journal of Interventional Cardiology 2013, 26(1), 29-37.
• Hoffmann J, Fiser K, Weaver J, Dimmick I, Loeher M, Pircher H, Martin-Ruiz C, Veerasamy M, Keavney B, von Zglinicki T, Spyridopoulos I. . PLoS one 2012, 7(10), e47155.
• Lehmann R, Ehrlich JR, DeRosa S, Spyridopoulos I, Laskowski R, Kremer J, Herrmann E, Zeiher AM, Schächinger V, Fichtlscherer S. . Canadian Journal of Cardiology 2012, 28(5), 553-560.
• Noman A, Egred M, Bagnall A, Spyridopoulos I, Jamieson S, Ahmed J. . European Heart Journal 2012, 33(24), 3054-3061.
• Fischer-Rasokat U, Spyridopoulos I, Walter J, Honold J, Zeiher AM, Fichtlscherer S. . Vasa 2012, 41(3), 192-199.
• Noman A, Ahmed JM, Spyridopoulos I, Bagnall A, Egred M. . European Heart Journal 2012, 33(24), 3046-3053.
• Spyridopoulos I. . Atherosclerosis 2011, 216(1), 19-20.
• Lehmann R, Fichtlscherer S, Schachinger V, Held L, Hobler C, Baier G, Zeiher AM, Spyridopoulos I. . Journal of Interventional Cardiology 2010, 23(3), 256-263.
• Lehmann R, Luxembourg B, Miesbach W, Suess C, Leus M, Lindhoff-Last E, Zeiher AM, Spyridopoulos I. . Blood Coagulation & Fibrinolysis 2010, 21(1), 70-76.
• Spyridopoulos I, Hoffmann J, Aicher A, Brummendorf TH, Doerr HW, Zeiher AM, Dimmeler S. . Circulation 2009, 120(14), 1364-1372.
• Seeger FH, Chen L, Spyridopoulos I, Altschmied J, Aicher A, Haendeler J. . PLoS ONE 2009, 4(2), e4529.
• Lehmann R, Fichtlscherer S, Schachinger V, Held L, Hobler C, Baier G, Zeiher AM, Spyridopoulos I. . Journal of Interventional Cardiology 2009, 22(6), 511-519.
• Lehmann R, Suess C, Leus M, Luxembourg B, Miesbach W, Lindhoff Last E, Zeiher AM, Spyridopoulos I. . European Heart Journal 2009, 30(2), 233-241.
• Haendeler J, Drose S, Buchner N, Jakob S, Altschmied J, Goy C, Spyridopoulos I, Zeiher AM, Brandt U, Dimmeler S. . Arteriosclerosis, Thrombosis, and Vascular Biology 2009, 29(6), 929-935.
• Fischer-Rasokat U, Brenck F, Zeiher AM, Spyridopoulos I. . Blood Pressure Monitoring 2009, 14(2), 59-67.
• Linzbach S, Samigullin A, Yilmaz S, Tsioga M, Zeiher AM, Spyridopoulos I. . American Journal of Cardiology 2009, 103(8), 1128-1133.
• Hoffmann J, Erben Y, Zeiher AM, Dimmeler S, Spyridopoulos I. . Experimental Gerontology 2009, 44(5), 363-366.
• Spyridopoulos I, Fichtlscherer S, Popp R, Toennes SW, Fisslthaler B, Trepels T, Zernecke A, Liehn EA, Weber C, Zeiher AM, Dimmeler S, Haendeler J. . Arteriosclerosis, Thrombosis, and Vascular Biology 2008, 28(11), 1967-1974.
• Jakob S, Schroeder P, Lukosz M, Buchner N, Spyridopoulos I, Altschmied J, Haendeler J. . Journal of Biological Chemistry 2008, 283(48), 33155-33161.
• Spyridopoulos I, Erben Y, Brummendorf TH, Haendeler J, Dietz K, Seeger F, Kissel CK, Martin H, Hoffmann J, Assmus B, Zeiher AM, Dimmeler S. . Arteriosclerosis, Thrombosis, and Vascular Biology 2008, 28(5), 968-974.
• Honold J, Geiger L, Assmus B, Fischer Rasokat U, Schachinger V, Zeiher AM, Spyridopoulos I. . Clinical Research in Cardiology 2008, 97(12), 882-890.