缅北禁地

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Staff Profile

Professor Janet Quinn

Professor of Eukaryotic Microbiology

  • Email: janet.quinn@ncl.ac.uk
  • Telephone: +44 (0) 191 208 7434
  • Address: Biosciences Institute
    3rd Floor, Catherine Cookson Building
    Faculty of Medical Sciences
    缅北禁地
    缅北禁地 upon Tyne
    NE2 4HH

    Generously supported by the William Leech Charity
Background


Education

1987-1990     BSc Hons Class I, Biochemistry, University of Wales

1990-1993     PhD, 缅北禁地. Supervisor Prof Steve Yeaman.

 

Appointments

1994-1995   Postdoctoral Fellow, University of Massachusetts Medical Centre, USA, advisor Prof Craig Peterson

                                                             

1995-1998    Leukaemia Society of America Fellow, 缅北禁地 


1998-2000    Postdoctoral Fellow 缅北禁地, advisor Prof Brian Morgan

 

2000-2004    MRC Career Development Fellow 缅北禁地 

           

2004-2008    Lecturer, Institute for Cell and Molecular Biosciences, 缅北禁地

 

2008-2014    Reader in Molecular Biology, Institute for Cell and Molecular Biosciences, 缅北禁地

 

2014-            Professor of Eukaryotic Microbiology, Biosciences Institute, 缅北禁地 University


Google Scholar:

Click here.

Research

 

Research Interests

My laboratory’s primary research focus is on stress-sensing and signalling mechanisms in human pathogenic fungi and their importance in virulence. We study a range of pathogenic Candida spp. including Candida albicans, Candida glabrata and Candida auris. In particular, we are interested in the role of the evolutionarily conserved stress-activated MAPK pathways in promoting fungal virulence, and the diverse mechanisms employed by fungal pathogens to survive the arsenal of antimicrobial agents generated by innate immune cells. Recently, we have embarked on a project studying bacterial-imposed antifungal stresses. Specifically we are deciphering the mode of action of anti-fungal effectors elicited by the Type VI secretion system - which is widely used by bacteria to fire diverse effector proteins into neighbouring target cells.  As bacterial and fungal species co-exist in the human microbiota and disease-causing infections, we envisage that anti-fungal T6SSs will shape many diverse microbial communities relevant to human health. Finally, we are also exploiting our knowledge of fungal stress responses to design and perform high throughput screens for compounds that inhibit these vital virulence traits.

Please see publications tab for our recent publications.

Informal enquiries from prospective graduate students and post-docs are welcome at any time.

 

Current Funding

Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology

BBSRC Project Grants

Wellcome Trust Collaborative Award ‘Targeting a new kingdom: the nature and significance of Type VI secretion system-mediated anti-fungal activity’

 

Current Lab Members

Dr Alison Day (BBSRC funded)

Dr Katharina Trunk (Wellcome Trust funded)

Ms Yasmin Ahmed (BBSRC-DTP student)

Ms Ashleigh Watson (Faculty funded PhD student)

Ms Michelle Wray (Technician, Wellcome Trust/BBSRC funded)

 

 

Recent Public Engagement Activities

缅北禁地 Pint of Science 2018

 

缅北禁地 Soapbox Science 2017

Soapbox Science highlights video:  

Soapbox Science 缅北禁地 2017 – Meet the Scientists:

 

Royal Society Summer Exhibition 2016 – Killer Fungus!


 

 

 

Teaching

BGM2002 - Biochemistry and Genetics of Signalling and the Cell Cycle

BMS3007- Research in Biomedical Sciences

MIC3046- Microbiota and Pathogens: Mucosal Microbiota, Protozoa and Fungi

Publications

  • Articles

    • Day AM, Cao M, da Silva Dantas A, Ianieva O, Herrerode-Dios C, Brown AJP, Quinn J. . PLoS Pathogens 2024, 20, e1012314.
    • Stewart LJ, Hong Y, Holmes IR, Firth SJ, Ahmed Y, Quinn J, Santos Y, Cobb SL, Jakubovics NS, Djoko KY. . ACS Infectious Diseases 2023, 9(3), 631–642.
    • Ahmed Y, Ikeh MAC, MacCallum DM, Day AM, Waldron K, Quinn J. . mBio 2022, 13(3), e00342-22.
    • Trunk K, Peltier J, Liu Y-C, Dill BD, Walker L, Gow NAR, Stark MJR, Quinn J, Strahl H, Trost M, Coulthurst SJ. . Nature Microbiology 2018, 3, 920-931.
    • Herrero-de-Dios C, Day AM, Tillmann AT, Kastora SL, Stead D, Salgado PS, Quinn J, Brown AJP. . mBio 2018, 9(2), e02229-17.
    • Rzechonek DA, Day AM, Quinn J, Mironczuk AM. . Scientific Reports 2018, 8(1), 14735.
    • Day AM, NcNiff MM, da Silva Dantas A, Gow NAR, Quinn J. . mSphere 2018, 3(5), e00506-18.
    • Day AM, Herrero-de-Dios CM, MacCallum DM, Brown AJP, Quinn J. . Scientific Reports 2017, 7, 14340.
    • Brown AJP, Cowen LE, Di Pietro A, Quinn J. . Microbiology Spectrum 2017, 5(4), FUNK-0048-2016.
    • Pradhan A, Herrero-de-Dios C, Belmonte R, Budge S, Lopez-Garcia A, Kolmogorova A, Lee KK, Martin BD, Ribeiro A, Bebes A, Yuecel R, Gow NAR, Munro CA, MacCallum DM, Quinn J, Brown AJP. . PLoS Pathogens 2017, 13(5), e1006405.
    • Day AM, Smith DA, Ikeh MAC, Haider M, Herrero-de-Dios CM, Brown AJP, Morgan BAM, Erwig LP, MacCallum DM, Quinn J. . PLoS Pathogens 2017, 13(1), e1006131.
    • Ikeh MA, Kastora SL, Day AM, Herrero-de-Dios CM, Tarrant E, Waldron KJ, Banks AP, Bain JM, Lydall D, Veal EA, MacCallum DM, Erwig LP, Brown AJ, Quinn J. . Molecular Biology of the Cell 2016, 27(17), 2784-2801.
    • Kos I, Patterson MJ, Znaidi S, Kaloriti D, da Silva Dantas A, Herrero-de-Dios C, d'Enfert C, Brown AJP, Quinn J. . mBio 2016, 7(2), e00331-16.
    • Komalapriya C, Kaloriti D, Tillmann AT, Yin ZK, Herrero-de-Dios C, Jacobsen MD, Belmonte RC, Cameron G, Haynes K, Grebogi C, de Moura APS, Gow NAR, Thiel M, Quinn J, Brown AJP, Romano MC. . PLOS ONE 2015, 10(9), e0137750.
    • Kaloriti D, Jacobsen M, Yin ZK, Patterson M, Tillmann A, Smith DA, Cook E, You T, Grimm MJ, Bohovych I, Grebogi C, Segal BH, Gow NAR, Haynes K, Quinn J, Brown AJP. . MBIO 2014, 5(4), e01334-14.
    • Patterson M, McKenzie C, Smith D, da Silva Dantas A, Sherston S, Veal EA, Morgan B, MacCallum D, Erwig LP, Quinn J. . Antioxidants & Redox Signaling 2013, 19(18), 2244-2260.
    • Bain JM, Lewis LE, Okai B, Quinn J, Gow NAR, Erwig LP. . Fungal Genetics and Biology 2012, 49(9), 677-678.
    • Mukhopadhyay A, Plummer ER, Elattar A, Soohoo S, Uzir B, Quinn JE, McCluggage WG, Maxwell P, Aneke H, Curtin NJ, Edmondson RJ. . Cancer Research 2012, 72(22), 5675-5682.
    • Quinn J, Malakasi P, Smith DA, Cheetham J, Buck V, Millar J, Morgan BA. . Antioxidants & Redox Signaling 2011, 15(1), 153-165.
    • Cheetham J, MacCallum DM, Doris KS, Dantas A, Scorfield S, Odds F, Smith DA, Quinn J. . Journal of Biological Chemistry 2011, 286(49), 42002-42016.
    • Bruce CR, Smith DA, Rodgers D, Dantas AD, MacCallum DM, Morgan BA, Quinn J. . PLoS One 2011, 6(12), e27979.
    • da Silva Dantas A, Patterson MJ, Smith DA, MacCallum DM, Erwig LP, Morgan BA, Quinn J. . Molecular and Cellular Biology 2010, 30(19), 4550-4563.
    • Nikolaou E, Agrafioti I, Stumpf M, Quinn J, Stansfield I, Brown AJP. . BMC Evolutionary Biology 2009, 9(1), 44.
    • Enjalbert B, Moran GP, Vaughan C, Yeomans T, MacCallum DM, Quinn J, Coleman DC, Brown AJP, Sullivan DJ. . Molecular Microbiology 2009, 72(1), 216-228.
    • Butler G, Rasmussen MD, Lin MF, Santos MAS, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJP, Brunke S, Costanzo MC, Fitzpatrick DA, de Groot PWJ, Harris D, Hoyer LL, Hube B, Klis FM, Kodira C, Lennard N, Logue ME, Martin R, Neiman AM, Nikolaou E, Quail MA, Quinn J, Santos MC, Schmitzberger FF, Sherlock G, Shah P, Silverstein KAT, Skrzypek MS, Soll D, Staggs R, Stansfield I, Stumpf MPH, Sudbery PE, Srikantha T, Zeng QD, Berman J, Berriman M, Heitman J, Gow NAR, Lorenz MC, Birren BW, Kellis M, Cuomo CA. . Nature 2009, 459(7247), 657-662.
    • Yin ZK, Stead D, Walker J, Selway L, Smith DA, Brown AJP, Quinn J. . Proteomics 2009, 9(20), 4686-4703.
    • Cheetham J, Smith DA, da Silva Dantas A, Doris KS, Patterson MJ, Bruce CR, Quinn J. . Molecular Biology of the Cell 2007, 18(11), 4603-4614.
    • Enjalbert B, Smith DA, Cornell MJ, Alam I, Nicholls S, Brown AJP, Quinn J. . Molecular Biology of the Cell 2006, 17(2), 1018-1032.
    • Smith DA, Nicholls S, Morgan BA, Brown AJP, Quinn J. . Molecular Biology of the Cell 2004, 15(9), 4179-4190.
    • Veal EA, Findlay VJ, Day AM, Bozonet SM, Evans JM, Quinn J, Morgan BA. . Molecular Cell 2004, 15(1), 129-139.
    • Smith DA, Mark Toone W, Chen D, Bahler J, Jones N, Morgan BA, Quinn J. . Journal of Biological Chemistry 2002, 277(36), 33411-33421.
    • Quinn J, Findlay VJ, Dawson K, Millar JB, Jones N, Morgan BA, Toone WM. . Molecular Biology of the Cell 2002, 13(3), 805-816.
    • Buck V, Quinn J, Pino TS, Martin H, Saldanha J, Makino K, Morgan BA, Millar JBA. . Molecular Biology of the Cell 2001, 12(2), 407-419.
    • Gong X, Peng T, Yakhnin A, Zolkiewski M, Quinn J, Yeaman SJ, Roche TE. . Journal of Biological Chemistry 2000, 275(18), 13645-13653.
    • Palmer JM, Jones DEJ, Quinn J, McHugh A, Yeaman SJ. . Hepatology 1999, 30(1), 21-26.
    • Quinn, J., Fyrberg, A.M., Ganster, R.W., Schmidt, M.C. & Peterson, C.L. DNA-binding properties of the yeast SWI/SNF complex. Nature 1996, 379, 844-847.
    • Cote, J., Quinn, J., Workman, J.L. & Peterson, C.L (1994). Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex. Science 1994, 265, 53-60.

  • Book Chapter

    • Quinn, J. & Peterson, C.L. Mechanisms for alleviating chromatin-mediated repression of transcription. In: Roel van Driel and Arie P. Otte, ed. Nuclear Organization, Chromatin Structure and Gene Expression. Oxford University Press, 1998, pp.58-79.

  • Reviews

    • Fisher MC, Burnett F, Chandler C, Gow NAR, Gurr S, Hart A, Holmes A, May RC, Quinn J, Soliman T, Talbot NJ, West HM, West JS, White PL, Bromley M, Armstrong-James D. . npj Antimicrobial Resistance 2024, 2, 36.
    • Day AM, Quinn J. . Frontiers in Cellular and Infection Microbiology 2019, 9(261).
    • Trunk KT, Coulthurst SJ, Quinn J. . Journal of Fungi 2019, 5(2), 50.
    • Ikeh M, Ahmed Y, Quinn J. . Microorganisms 2017, 5(3), 48.
    • Dantas AS, Day A, Ikeh M, Kos I, Achan B, Quinn J. . Biomolecules 2015, 5(1), 142-165.
    • Smith DA, Morgan BA, Quinn J. . FEMS Microbiology Letters 2010, 306(1), 1-8.
    • Brown AJP, Haynes K, Quinn J. . Current Opinion in Microbiology 2009, 12(4), 384-391.