缅北禁地

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Staff Profile

Professor John Common

Prof of Cutaneous Inflamm &Microbiome Bi

Background

Professor John Common is a Principal Investigator in the Dermatology Department at 缅北禁地 Medical School. He completed his PhD at Queen Mary University of London before moving to Singapore, where he established his independent research group. Now holding a joint appointment between A*STAR Skin Research Labs in Singapore and 缅北禁地, his research focuses on skin barrier function, inflammatory skin diseases, and the skin microbiome in both health and disease.



His work investigates host-microbiome and host-environment interactions to uncover how microbes and environmental stimuli contribute to skin health or disease. By exploring the molecular mechanisms underlying these processes, his lab aims to advance our understanding of skin biology and develop translational insights with potential therapeutic applications. A key focus is on how the microbiome interacts with the skin, shaping immune responses and influencing disease progression.

 

Areas of Expertise

  • Epithelial Biology
  • Genodermatoses
  • Inflammatory Skin Diseases
  • Skin Microbiome

 

Research

Professor John Common’s research is centred on understanding inflammatory skin diseases, with a particular focus on ichthyosis and other disorders affecting the skin barrier. His work combines genetics, immunology, and microbiome research to uncover the molecular mechanisms underlying these conditions. By identifying key genetic mutations and immune pathways involved in skin inflammation, he aims to develop targeted therapies that improve patient outcomes.



Previously based at A*STAR, Professor Common contributed to significant advances in skin biology, including studies on how microbial communities interact with the skin’s immune system. Now at 缅北禁地, his research continues to explore how genetic and environmental factors influence skin disease progression. His team employs cutting-edge techniques such as single-cell sequencing, CRISPR-based gene editing, and organoid models to better understand disease pathology and identify novel therapeutic targets.


Beyond fundamental science, Professor Common collaborates with clinicians and industry partners to translate discoveries into potential treatments. His work has implications for a range of skin conditions, from rare genetic disorders to more common inflammatory diseases like eczema and psoriasis. By bridging molecular research and clinical application, he aims to advance precision medicine approaches for dermatological diseases.

Publications

  • Articles

    • Rozario P, Lim YS, Ding SLS, Firdaus MJ, Wearne S, Wong BHS, Chua R, Robinson KS, Chu TSJ, Liu M, Cai SSC, Tan STE, Wee SK, Lamers MM, Verma NK, Xia Y, Yap EPH, Common JEA, Zhong F. . Journal of Investigative Dermatology 2026, Epub ahead of print.
    • Chua W, Hei Y, Koh LF, Yap BLH, Saw HL, Maciel Fernandes TH, da Silva EB, Goh S, Dawson TL, O'Donoghue AJ, Common JE, Li H. . Biochemical Journal 2026, 483(1), 23-36.
    • Chia M, Ng AHQ, Ravikrishnan A, Mohamed Naim AN, Wearne S, Common J, Nagarajan N. . Nature Biotechnology 2025, Epub ahead of print.
    • Koh LF, Firdaus MJ, Natsuaki Y, Hanakawa S, Tham K-C, Lunny DP, Yap BLH, Nakamizo S, Nam E, Lee JE, Toh YX, Teo NMH, Lim TC, Lane EB, Kabashima K, Janela B, Common JE. . Experimental Dermatology 2025, 34(7), e70132.
    • Tham K-C, Lim SS, Bonnard C, Common JEA. . STAR Protocols 2025, 6(1), 103658.
    • Gorse L, Plessis L, Wearne S, Paradis M, Pinilla M, Chua R, Lim SS, Pelluz E, TOH G-A, Mazars R, Bomfim C, Herve F, Lhaute K, Reveillon D, Suire B, Ravon-Katossky L, Benoist T, Fromont L, Pericat D, Mertens KN, Derrien A, Terre-Terrillon A, Chomerat N, Bilien G, Sechet V, Carpentier L, Fall M, Sonko A, Hakim H, Sadio N, Bourdeaux J, Cougoule C, Henras AK, Perez-Oliva AB, Brehmer P, Roca FJ, Zhong FL, Common J, Meunier E, Hess P. . EMBO Molecular Medicine 2025, 17(3), 535-562.
    • Pagac MP, Davient B, Plado LA, Lam HYI, Lee SM, Ravikrishnan A, Chua WLE, Muralidharan S, Sridharan A, Irudayaswamy AS, Srinivas R, Wearne S, Mohamed Naim AN, Ho EXP, Ng HQA, Kwah JS, Png E, Bendt AK, Wenk MR, Torta F, Nagarajan N, Common J, Chong YS, Tham EH, Shek LP-C, Loo EXL, Chambers J, Yew YW, Loh M, Dawson TL. . npj Biofilms and Microbiomes 2025, 11, 13.
    • Puppels GJ, Hourihane JO, Nico C, Chaoimh CN, Wong C, Common JE, Caspers PJ, Irvine AD. . Annals of Allergy, Asthma and Immunology 2025, 134(4), 457-464.
    • Tan JJY, Thuya WL, Zhu H, Kristo JG, Common JE, Wu C, Ho PCL, Kang L. . Biomaterials Advances 2025, 177, 214423.
    • Park EJ, Yap BLH, Wang X, Poh QZ, Tan CH, Koh LF, Common JE, Teo P. . Discover Applied Sciences 2025, 7(4), 304.
    • Vind AC, Wu Z, Firdaus MJ, Snieckute G, Toh GA, Jessen M, Martinez JF, Haahr P, Andersen TL, Blasius M, Koh LF, Maartensson NL, Common JEA, Gyrd-Hansen M, Zhong FL, Bekker-Jensen S. . Molecular Cell 2024, 84(24), 4774-4789.e9.
    • Wong C, Tham C-Y, Yang L, Benton MC, Narang V, Denil S, Duan K, Yew YW, Lee B, Florez de Sessions P, Common JEA. . Journal of Investigative Dermatology 2024, 144(8), 1883-1886.e9.
    • Chua W, Marsh CO, Poh SE, Koh WL, Lee MLY, Koh LF, Tang X-ZE, See P, Ser Z, Wang SM, Sobota RM, Dawson TL, Yew YW, Thng S, O'Donoghue AJ, Oon HH, Common JE, Li H. . Biochimie 2024, 216, 181-193.
    • Chua C, Sethi R, Ong J, Low JH, Yew YW, Tay A, Howland SW, Ginhoux F, Chen J, Common JEA, Andiappan AK. . Journal of Dermatological Science 2023, 112(3), 158-161.
    • Ni Chaoimh C, Lad D, Nico C, Puppels GJ, Wong XFCC, Common JE, Murray DM, Irvine AD, Hourihane JO. . Allergy 2023, 78(4), 984-994.
    • Robinson KS, Toh GA, Firdaus MJ, Tham KC, Rozario P, Lim CK, Toh YX, Lau ZH, Binder SC, Mayer J, Bonnard C, Schmidt FI, Common JEA, Zhong FL. . Journal of Experimental Medicine 2023, 220(10), e20230105.
    • Robinson KS, Toh GA, Rozario P, Chua R, Bauernfried S, Sun Z, Firdaus MJ, Bayat S, Nadkarni R, Poh ZS, Tham KC, Harapas CR, Lim CK, Chu W, Tay CWS, Tan KY, Zhao T, Bonnard C, Sobota R, Connolly JE, Common J, Masters SL, Chen KW, Ho L, Wu B, Hornung V, Zhong FL. . Science 2022, 377(6603), 328-335.
    • Chia M, Naim ANM, Tay ASL, Lim K, Chew KL, Yow SJ, Chen J, Common JEA, Nagarajan N, Tham EH. . Journal of Allergy and Clinical Immunology 2022, 150(4), 894-908.
    • Jabbar-Lopez ZK, Ezzamouri B, Briley A, Greenblatt D, Gurung N, Chalmers JR, Thomas KS, Frost T, Kezic S, Common JEA, Danby S, Cork MJ, Peacock JL, Flohr C. . Clinical and Experimental Allergy 2022, 52(3), 405-415.
    • Fulton RL, Margolis DJ, Sockler PG, Mitra N, Wong XFCC, Common JE. . Experimental Dermatology 2022, 31(2), 233-236.
    • Poh SE, Koh WLC, Lim SYD, Wang ECE, Yew YW, Common JEA, Oon HH, Li H. . JID Innovations 2022, 2(4), 100130.
    • Tham K-C, Lefferdink R, Duan K, Lim SS, Wong XFCC, Ibler E, Wu B, Abu-Zayed H, Rangel SM, Del Duca E, Chowdhury M, Chima M, Kim HJ, Lee B, Guttman-Yassky E, Paller AS, Common JEA. . British Journal of Dermatology 2022, 187(4), 557-570.
    • Tan KJ, Nakamizo S, Lee-Okada H-C, Sato R, Chow Z, Nakajima S, Common JEA, Saeki K, Yokomizo T, Ginhoux F, Kabashima K. . Journal of Investigative Dermatology 2022, 142(7), 2020-2023.e2.
    • Rahim AB, Lim HK, Tan CYR, Jia L, Leo VI, Uemura T, Hardman-Smart J, Common JEA, Lim TC, Bellanger S, Paus R, Igarashi K, Yang H, Vardy LA. . Journal of Investigative Dermatology 2021, 141(9), 2178-2188.e6.
    • Bishnoi P, Ng YZ, Wei H, Tan E-C, Lunny DP, Wong XFCC, Kin Fon L, Gondokaryono SP, Diana IA, Common JEA, Koh MJA, Lane EB. . American Journal of Medical Genetics, Part A 2021, 185(2), 625-630.
    • Ng PSM, Wee LWY, Ho VPY, Tan WC, Bishnoi P, Alagappan U, Wong SMY, Gan EY, Quek BH, Shen L, Su B, Common JEA, Koh MJA. . Australasian Journal of Dermatology 2021, 62(4), e539-e545.
    • Tan JJY, Nguyen D-V, Common JE, Wu C, Ho PCL, Kang L. . International Journal of Molecular Sciences 2021, 22(4), 2143.
    • Guttmann-Gruber C, Pinon Hofbauer J, Tockner B, Reichl V, Klausegger A, Hofbauer P, Wolkersdorfer M, Tham K-C, Lim SS, Common JE, Diem A, Ude-Schoder K, Hitzl W, Lagler F, Reichelt J, Bauer JW, Lang R, Laimer M. . Orphanet Journal of Rare Diseases 2021, 16, 473.
    • Nakamizo S, Honda T, Sato T, Al Mamun M, Chow Z, Duan K, Lum J, Tan KJ, Tomari K, Sato R, Kitoh A, Tay ASL, Common JEA, Guan NL, Setou M, Ginhoux F, Kabashima K. . Journal of Allergy and Clinical Immunology 2021, 148(2), 473-485.e10.
    • Wee LWY, Tan EC, Bishnoi P, Ng YZ, Lunny DP, Lim H-W, Lee S-P, Ong C, Yap TL, Mok YH, Low MY, Chu-Tian Chow C, Derrick L, Common JEA, Birgitte Lane E, Koh MJA. . Pediatric Dermatology 2021, 38(4), 908-912.
    • Tay ASL, Li C, Nandi T, Chng KR, Andiappan AK, Mettu VS, de Cevins C, Ravikrishnan A, Dutertre C-A, Wong XFCC, Ng AHQ, Matta SA, Ginhoux F, Rotzschke O, Chew FT, Tang MBY, Yew YW, Nagarajan N, Common JEA. . Journal of Allergy and Clinical Immunology 2021, 147(4), 1329-1340.
    • Tan TS, Common JEA, Lim JSY, Badowski C, Firdaus MJ, Leonardi SS, Lane EB. . Journal of Cell Science 2021, 134(19), jcs258409.
    • Chen H, Common JEA, Haines RL, Balakrishnan A, Brown SJ, Goh CSM, Cordell HJ, Sandilands A, Campbell LE, Kroboth K, Irvine AD, Goh DLM, Tang MBY, van Bever HP, Giam YC, McLean WHI, Lane EB. . British Journal of Dermatology 2011, 165(1), 106-114.

  • Editorial

    • O'Shaughnessy R, Common J, Gutowska-Owsiak D. . Frontiers in Molecular Biosciences 2023, 10, 1324920.

  • Letter

    • Zheng Y-X, Chen X-B, Wang Z-Y, Cai S-Q, Zheng M, Koh LF, Common JE, Man X-Y. . Allergy 2024, 79(5), 1361-1364.

  • Notes

    • Common JE, Payne RP. . Cell Host and Microbe 2025, 33(8), 1318-1320.
    • Puppels GJ, Hourihane JO, Nico C, Chaoimh CN, Wong C, Common JE, Caspers PJ, Irvine AD. . Annals of Allergy, Asthma and Immunology 2025, 135(1), 124-124.
    • Eisner M, Sharkey T, Common J, Rajan N. . British Journal of Dermatology 2025, 193(3), 575-575.
    • Wongvibulsin S, Sangers T, Clibborn C, Li Y-CJ, Sharma N, Common JEA, Reynolds NJ, Tanaka RJ. . JID Innovations 2024, 4(1), 100236.

  • Reviews

    • Tham EH, Chia M, Riggioni C, Nagarajan N, Common JEA, Kong HH. . Allergy 2024, 79(6), 1470-1484.
    • Koh LF, Ong RY, Common JE. . Allergology International 2022, 71(1), 31-39.
    • Vijaya Chandra SH, Srinivas R, Dawson TL, Common JE. . Frontiers in Cellular and Infection Microbiology 2021, 10, 614446.