缅北禁地

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Staff Profile

Professor John Isaacs

Professor of Clinical Rheumatology

  • Telephone: +44 (0) 191 208 5337
  • Address: 4th Floor, William Leech Building
    Medical School
    Framlington Place
    缅北禁地 upon Tyne
    NE2 4HH

    Generously supported by the William Leech Charity
Background

My team’s work is focussed in two major areas:

· The development and testing of novel immunotherapies for autoimmunity, with a particular interest in therapeutic tolerance induction.

· Rheumatoid arthritis – immunopathogenesis, biomarkers and novel therapeutic strategies including treatment stratification


Major current therapeutic projects include the development of an autologous tolerogenic dendritic cell therapy for rheumatoid arthritis (AUTODECRA, funded by Versus Arthritis ); the first ever clinical trial of a drug targeted at the synovial fibroblast in rheumatoid arthritis (TRAFIC, funded by the Medical Research Council); an experimental medicine study to identify the biological factors that underpin disease flare in rheumatoid arthritis (BIO-FLARE, funded by the Medical Research Council); we are also part of an EU Innovative Medicines Initiaitive, Rheumatherapy-Cure (RT-CURE), which aims to prevent rheumatoid arthritis by targeting ‘at risk’ individuals with tolerogenic therapies.


Therapeutic tolerance induction remains a ‘holy grail’ for human autoimmunity although there is now a concerted international effort to demonstrate that this is an achievable aim. A major limitation is a lack of understanding of the immune dysregulation inherent in most human autoimmunity, and consequent lack of ‘tolerance biomarkers’. These are essential in order to conduct rational therapeutic tolerance trials. This is a key aim of the MRC/ABPI Immunology and Inflammation Initiative for inflammatory arthritis, RA-MAP, for which I am Chief Investigator. By performing a systems immunology analysis of a cohort of patients with early rheumatoid arthritis, we will dissect the immunopathogenesis of the disease which, in turn, will provide key biomarkers.


All of our work is supported by cutting edge facilities, including the state-of-the art Wilson Horne Immunotherapy Centre and Versus Arthritis Experimental Arthritis Treatment Centre, a clinical research facility dedicated to the investigation of novel immunotherapies which incorporates arthroscopy and high resolution ultrasound scanning. We are a member of the NOCRI Translational Research Collaboration for inflammatory arthritis, for which I was the inaugural national lead. Our laboratory is based in recently refurbished, open plan laboratory facilities alongside other internationally renowned immunology researchers. I am also a principal investigator of the Versus Arthritis Centre of Excellence in Rheumatoid Arthritis Pathogenesis, alongside colleagues in Glasgow (PI Iain McInnes) and Birmingham (PI Chris Buckley)


Local roles:


  • Professor of Clinical Rheumatology
  • Director, Therapeutics North East
  • Deputy Director, NIHR 缅北禁地 Biomedical Centre for Ageing and Long-Term Conditions.
  • Director of Research/Associate Medical Director, 缅北禁地 Hospitals NHS Trust
  • Director, 缅北禁地 Biomedicine Versus Arthritis Experimental Arthritis Treatment Centre
  • Director, Wilson Horne Immunotherapy Centre
  • Consultant Rheumatologist, 缅北禁地 upon Tyne Hospitals NHS Foundation Trust


National and International roles:

2018-20 - Scientific Chair, European League Against Rheumatism (EULAR)

2020-21 - Member, UKRI/ DHSC Oversight Committee for Covid-19 Immunology in the UK

2019-23 - NIHR Senior Investigator

2018 - MRC Precision Medicine Group

2017 – Versus Arthritis Fellowships Expert Advisory Group

2016 – Member, NIHR/NOCRI Translational Research Collaboration for Inflammatory Disease

2014 - Member, MRC Translational Research Group






Google Scholar:

Research


CURRENT MAJOR RESEARCH PROJECTS:


TRAFIC


This project aims to repurpose a small molecule anti-cancer drug as an anti-fibroblast drug for RA. The past 20 years have seen major advances in RA therapy; more aggressive use of conventional drugs, and biological targeted therapies have each made a significant impact. However, disease remission remains uncommon and around 20% of patients remain refractory to all therapies. This represents a significant unmet need and suggests key aspects of RA pathogenesis remain untargetted.


In health, a delicate nutritive synovial membrane (SM) lines joint cavities. This comprises a few macrophages and fibroblasts in a loose connective tissue stroma. In RA the SM is the focus of autoimmune attack but, in addition to inflammatory cell infiltration, resident synovial fibroblasts (SF) become hyperplastic, forming a vascularised, inflammatory, quasi-malignant pannus which invades articular cartilage and bone. The resultant joint damage underlies the disability and reduced quality of life that characterise RA.


Cell proliferation relies on the coordinated activation of specific regulatory proteins: orderly progression through the cell cycle is tightly controlled by the formation and activation of complexes comprising cyclin proteins and cyclin-dependent kinases (CDK). These complexes are in turn regulated by endogenous CDK inhibitors (CDKI). The concept of inhibiting CDKs to correct uncontrolled cell proliferation has led to the evaluation of small molecule CDKI in cancer.


RA SF have reduced endogenous CDKI levels, and correction of the deficit normalises their dysregulated phenotype. Indeed, small molecule CDKI ameliorate synovitis in pre-clinical arthritis models. In partnership with the SME Cyclacel, we propose a phase IIa repurposing study of a CDKI in patients with refractory RA. Stage 1 will focus on safety and tolerability, to determine an appropriate dose to progress to stage 2, where we will seek evidence of potential therapeutic activity alongside PK and PD biomarkers.


BIO-FLARE


Flares of immune-mediated inflammatory diseases, such as rheumatoid arthritis (RA), are a major burden for patients. They occur unpredictably, adding to the physical and psychological burden of the condition, and contribute to joint damage and comorbidities, such as cardiovascular disease. Flares are difficult to study, precisely because of their unpredictable timing. However, we have established a human model that generates a 'synchronized' population of RA patients in clinical remission, of whom about 50% flare within 6 months, the remainder maintaining remission. We propose to carefully study such a population to better understand the factors that determine disease flare.


Up to a third of patients with RA achieve disease remission with aggressive therapy. Many wish to discontinue therapy at this point and, if they do, about 50% flare in the subsequent 6 months. We will follow such a population pr ospectively, to study the biological processes underpinning flare. We will study 150 patients in clinical remission for at least 6 months, and prepared to discontinue treatment. After treatment cessation patients will be studied intensively, with blood sampling at weeks 2, 4, 6, 12 and 24. Patients will also undergo ultrasound-guided biopsy of 'flaring' synovium before reinstatement of previous treatment (with which patients readily regain remission). We will also obtain biopsies from consenting patients at baseline and in remission at 6 months.


In blood we will study immune cell subsets and their activation status; autoantibody profiles; and epigenetic profiles. Synovial biopsies will allow us to examine the cell lineages present, including stromal cell subtypes, as well as inflammatory mediators. We will additionally examine metabolic profiles in blood, urine and synoivum.


Using multivariate statistical techniques we will develop a model that predicts impending flare in RA, highlighting tractable therapeutic pathways and informative biomarkers.


AUTODECRA-2


AuToDeCRA-2 addresses two critical aspects of tolDC therapy: the route of tolDC administration and the demonstration of specific immune modulation. Our hypothesis is that tolDC will need to access seondary lymphoid tisses in order to modulate the autoreactive immune response.


We wish to identify an optimal route for tolDC administration. This should be technically practical, and enable tolDC to reach spleen, liver or lymph nodes (alone or in combination). TolDC will be labelled with a 'dye' that is visible by MRI, and loaded with cirullinated peptides prior to administration. We will then apply cutting edge immunological assays, using MHC-peptide tetramers, to identify and phenotype autoreactive T-cells, ultimately associating tolDC distribution with immune modulation.


We will study 16 patients with anti-citrullinated peptide autoantibody (ACPA) positive RA. They will be HLADR*0401 or *0404 positive and receiving non-biologic) DMARD therapy. TolDC will be manufactured according to the protocols we have developed over the past ten years, and used for AuToDeCRA-1. However, tolDC will be labelled with 19F, a stable and non-radioactive isotope that can be sensitively tracked using MRI. Additionally, tolDC will be loaded with a mixture of citrullinated peptides. 19F-cit-tolDC will be injected via three distinct routes: intradermal; intra-articular; and intra-nodal. Control groups will receive intra-nodal 19F-tolDC that have not been loaded with citrullinated peptides.


MRI will be performed immediately after tolDC administration, 24 and 72 hours later. Blood for immune monitoring will be taken at baseline, 1, 2, 6 and 13 weeks after treatment. Specific immune monitoring will utilise anti-citrullinated peptide autoantibody profiling, alongside enumeration and functional analysis of antigen-specific T-cells, identified by appropriate MHC-peptide tetramers (derived from the peptides used to load tolDC). We will study autoreactive T-cell proliferation, surface phenotype, cytokine production and transcriptional profiling. Our final analysis will compare the distribution of tolDC after administration with evidence of subsequent immune modulation. We will also record disease activity and carefully document potential adverse effects.


RA-MAP


Our primary aim is to identify clinical, molecular and cellular biomarkers of prognosis and therapeutic response in patients with early rheumatoid arthritis (RA). Clinical predictors will be identified principally from meta-analysis of data derived from the placebo arms of completed clinical trials, seeking baseline parameters that associate with subsequent clinical response. Additional clinical predictors will be identified from an inception cohort of patients with early RA, followed longitudinally (the TACERA study). These patients will also provide the substrate to identify molecular and cellular biomarkers of prognosis and therapeutic response: participants will donate blood and urine at 3 monthly intervals for transcriptomic, flow cytometric, epigenetic, proteomic and metabolomic analyses. A systems based immunology approach will be adopted to identify baseline parameters that predict 6 month outcomes. By comparison with equivalent molecular profiles obtained from healthy individuals we will seek to define elements of immune dysregulation in RA and address whether the immune system of patients who subsequently achieve remission reverts to normal or continues to manifest immune dysregulation. A parallel study will similarly analyse blood samples from vaccinated healthy individuals, to compare the immune dysregulation in RA with the evolving response to vaccination. Ultimately, molecular or cellular biomarkers that inform prognosis or therapeutic response will be developed into a data warehouse and ‘polyomic toolkit’ describing the hallmarks of RA in blood, to enable the development of in vitro assays for patient monitoring.


A secondary aim of the programme is to identify individuals at high risk of developing RA, in order to evaluate immunological factors associated with the ‘pre-RA’ state.



Publications

  • Articles

    • Bennett JL, Hollingsworth KG, Pratt AG, Degnan AEA, Gorman GS, Feeney C, Naamane N, Nsengimana J, Sayer AA, Anderson AE, Isaacs JD. . Lancet Rheumatology 2026, 8(1), e42-e52.
    • Stadler M, Bindra S, Cheung A, Yap CF, Bluett J, Plant D, Nair N, Hyrich K, Morgan A, Wilson AG, Isaacs JD, Barton A. . Rheumatology Advances in Practice 2026, 10(1), rkaf130.
    • Cope AP, Jasenecova M, Vasconcelos JC, Qureshi S, van Schie KA, Filer A, Raza K, D'Agostino MA, McInnes IB, Siebert S, Isaacs JD, Pratt AG, Fisher BA, Buckley CD, Emery P, Mankia K, Ho P, Buch MH, Ciurtin C, van Schaardenburg D, Huizinga TWJ, Toes REM, Georgiou E, Kelly J, Murphy C, Prevost AT, Norton S, Opena M, Subesinghe S, Garrood T, Menon B, Ng N, Douglas K, Koutsianas C, Cooles F, Falahee M, Nelson M, Bharadwaj A, Ramos A, Thomas J, Pande I, Collins D, Pegler S, Raizada S, Fragoulis G, Taylor Gotch R, Galloway J, Rutherford A, Barnes T, Jeffrey H, Patel Y, Batley M, O'Reilly B, Venkatachalam S, Sheeran T, Gorman C, Reynolds P, Khan A, Gullick N, Banerjee S, Schenker N, Rowlands J, Starmans-Kool M, Taylor J, Nandi P, Sahbudin I, Maybury M, Hider S, Barcroft A, McNally J, Kitchen J, Nisar M, Quick V. . The Lancet Rheumatology 2026, 8(3), e171-e180.
    • Nicorescu I, Thomson A, Merces G, Harrison JF, Barron-Millar B, Pratt AG, Anderson AE, Diboll J, Rankin KS, Somma D, Kurowska-Stolarska M, Jones LJ, Filer A, McDonald D, Filby A, Isaacs JD, Hilkens CMU. . Annals of the Rheumatic Diseases 2026, Epub ahead of print.
    • Yap CF, Nair N, Sharma SD, Bowes J, Ariff ABM, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Verstappen S, Bluett J, Morris AP, Barton A, Plant D, Viatte S. . Arthritis and Rheumatology 2026, 78(1), 59-67.
    • Ursino M, Villacampa G, Rekowski J, Dimairo M, Solovyeva O, Ashby D, Berlin J, Boix O, Calvert M, Chan A-W, Coschi CH, Evans TRJ, Garrett-Mayer E, Golub RM, Guo C, Hayward KS, Hopewell S, Isaacs JD, Ivy SP, Jaki T, Kholmanskikh O, Kightley A, Lee S, Liu R, Mander A, Marshall LV, Matcham J, Patel D, Peck R, Rantell KR, Richards DP, Rouhifard M, Seymour L, Tanaka Y, Weir CJ, de Bono J, Yap C. . eClinicalMedicine 2025, 79, 102988.
    • Ling SF, Ho P, Bukhari M, Mewar D, Chinoy H, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Barton A, Plant D. . Scandinavian Journal of Rheumatology 2025, 54(5), 325-330.
    • Gumber L, Rayner F, Bigirumurame T, Dyke B, Melville A, Kerrigan S, McGucken A, Naamane N, Prichard J, Buckley CD, Filer A, McInnes IB, Raza K, Siebert S, Wason JMS, Ng W-F, Anderson AE, Isaacs JD, Baker KF, Pratt AG. . RMD Open 2025, 11(2), e005442.
    • Yap CF, Nair N, Morgan AW, Isaacs JD, Wilson AG, Hyrich K, Barturen G, Riva-Torrubia M, Gut M, Gut I, Alarcon Riquelme ME, Barton A, Plant D. . Arthritis and Rheumatology 2025, 77(12), 1663-1672.
    • Nash P, Kerschbaumer A, Konzett V, Aletaha D, Dorner T, Fleischmann R, McInnes I, Primdahl J, Sattar N, Tanaka Y, Trauner M, Winthrop K, de Wit M, Askling J, Baraliakos X, Boehncke W-H, Emery P, Gossec L, Isaacs JD, Krauth M, Lee EB, Maksymowych W, Pope J, Scholte-Voshaar M, Schreiber K, Schreiber S, Stamm T, Taylor PC, Takeuchi T, Tam L-S, Van den Bosch F, Westhovens R, Zeitlinger M, Smolen JS. . Annals of the Rheumatic Diseases 2025, 84(5), 664-679.
    • Cooles FAH, Vidal Pedrola G, Naamane N, Pratt AG, Barron-Millar B, Anderson AE, Hilkens CMU, Casement J, Bondet V, Duffy D, Zhang F, Shukla R, Isaacs JD. . Arthritis and Rheumatology 2025, 77(6), 646-657.
    • McTaggart T, Lim JX, Smith KJ, Heaney B, McDonald D, Hulme G, Hussain R, Coxhead J, Degnan AE, Isaacs J, Pratt A, Amarnath S. . Journal of Biological Chemistry 2025, 301(1), 108059.
    • Rekowski J, Guo C, Solovyeva O, Dimairo M, Rouhifard M, Patel D, Alger E, Ashby D, Berlin J, Boix O, Calvert M, Chan A-W, Coschi CH, de Bono J, Evans TRJ, Garrett-Mayer E, Golub RM, Hayward KS, Hopewell S, Isaacs JD, Ivy SP, Jaki T, Kholmanskikh O, Kightley A, Lee S, Liu R, Maia I, Mander A, Marshall LV, Matcham J, Peck R, Rantell KR, Richards DP, Seymour L, Tanaka Y, Ursino M, Weir CJ, Yap C. . eClinicalMedicine 2025, 79, 102987.
    • Rayner F, Hiu S, Melville A, Bigirumurame T, Anderson A, Dyke B, Kerrigan S, McGucken A, Prichard J, Shojaei Shahrokhabadi M, Hilkens CMU, Buckley CD, McInnes IB, Ng W-F, Goodyear C, Teare D, Filer A, Siebert S, Raza K, Pratt A, Baker KF, Isaacs J. . BMJ Open 2025, 15(4), e092478.
    • Long E-L, Stanway J, White M, Goudie N, Phillipson J, Morton M, Abdul Malek A, Brown P, Hide G, Jackson R, Nice C, Tuckett J, Diboll J, Anderson A, Pratt A, Hilkens CMU, Isaacs J. . Trials 2025, 26, 278.
    • Chaddock NJM, Harden CJ, Sorensen L, Mathieson HR, Zulcinski M, Lawson CA, O'Sullivan E, Mollan SP, Martin J, Mackie SL, Iles MM, Morgan AW, Raashid LH, Martin S, Robinson JI, Morgan A, Mackie S, Wordsworth O, Whitwell I, Brock J, Douglas V, Hettiarachchi C, Bartholomew J, Jarrett S, Smithson G, Green M, Brown PC, Lawson C, Gordon E, Lane S, Francis R, Dasgupta B, Masunda B, Calver J, Patel Y, Thompson C, Gregory L, Levy S, Menon A, Thompson A, Dyche L, Martin M, Li C, Laxminarayan R, Wilcox L, de Guzman R, Isaacs J, Lorenzi A, Reynolds G, Farley R, Hinchcliffe-Hume H, Bejarano V, Hope S, Nandi P, Stockham L, Wilde C, Durrant D, Lloyd M, Ye C-S, Stevens R, Jilani A, Collins D, Pegler S, Rivett A, Price L, McHugh N, Skeoch S, O'Kane D, Kirkwood S, Vadivelu S, Pugmire S, Sultan S, Dooks E, Armstrong L, Sadik H, Nandagudi A, Abioye T, Ramos A, Gumus S, Sofat N, Harrison A, Seward A, Mollan S, Rahan R, Hawkins H, Emsley H, Bhargava A, Fleming V, Hare M, Raj S, George E, Allen N, Hunter K, O'Sullivan E, Bird G, Magliano M, Manzo K, Sanghera B, Hutchinson D, Hammonds F, Sharma P, Cooper R, McLintock G, Al-Saffar ZS, Green M, Elliott K, Neale T, Mallinson J, Lanyon P, Pradere M-J, Jordan N, Htut EP, Mushapaidzi T, Abercrombie D, Wright S, Rowlands J, Mukhtyar C, Kennedy J, Makkuni D, Wilhelmsen E, Kouroupis M, Bhagat S, John L, Hughes R, Walsh M, Buckley M, Mackay K, Camden-Woodley T, Redome J, Pearce K, Marianayagam T, Cruz C, Warner E, Atchia I, Walker C, Black K, Duffy S, Bukhari M, Fothergill L, Jefferey R, Toomey J, Dillon CR, Pothecary C, Green L, Toms T, Maher L, Davis D, Sayan A, Thankachen M, Abusalameh M, Record J, Khan A, Stafford S, Hussein A, Williams C, Fletcher A, Johson L, Burnett R, Moots R, Frankland H, Dale J, Moar K, Hollas C, Parker B, Ridings D, Eapen S, John S, Robson J, Guthrie LB, Fyfe R, Tait M, Marks J, Gunter E, Hernandez R, Bhat S, Johnston P, Khurshid M, Barclay C, Kapur D, Jeffrey H, Hughes A, Slack L, Thomas E, Royon A, Hall A, King J, Nyathi S, Morris V, Castelino M, Hawkins E, Tomson L, Singh A, Nunag A, O'Connor S, Rushby N, Hewitson N, O'Sunmboye K, Lewszuk A, Boyles L, Perry M, Williams E, Graver C, Defever E, Kamanth S, Kay D, Ogor J, Winter L, Horton S, Welch G, Hollinshead K, Peters J, Labao J, Dmello A, Dawson J, Graham D, De Lord D, Deery J, Hazelton T. . Annals of the Rheumatic Diseases 2025, 84(2), 329-340.
    • MacDonald L, Elmesmari A, Somma D, Frew J, Di Mario C, Madhu R, Paoletti A, Simakou T, Hardy OM, Tolusso B, Campobasso D, Perniola S, Gessi M, Gigante MR, Petricca L, Bruno D, Coletto LA, Benvenuto R, Isaacs JD, Filby A, McDonald D, Sim JPX, Jamieson N, Wei K, D'Agostino MA, Millar NL, Milling S, McSharry C, Gremese E, Affleck K, Baker KF, McInnes IB, Otto TD, Korsunsky I, Alivernini S, Kurowska-Stolarska M. . Immunity 2024, 57(12), 2843-2862.e12.
    • Baker KF, McDonald D, Hulme G, Hussain R, Coxhead J, Swan D, Schulz AR, Mei HE, MacDonald L, Pratt AG, Filby A, Anderson AE, Isaacs JD. . Nature Communications 2024, 15, 1063.
    • Ling SF, Ogungbenro K, Darwich AS, Ariff ABM, Nair N, Bluett J, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Barton A, Plant D. . Pharmaceutics 2024, 16(6), 702.
    • Dey M, Busby A, Isaac J, Pratt A, Ndosi M, Young A, Lempp H, Nikiphorou E. . RMD Open 2024, 10(1), e003483.
    • Gumber L, Agbeleye O, Inskip A, Fairbairn R, Still M, Ouma L, Lozano-Kuehne J, Bardgett M, Isaacs JD, Wason JM, Craig D, Pratt AG. . BMJ Open 2024, 14(4), e077132.
    • Gault A, Hogarth L, Williams KC, Greystoke A, Rajan N, Speight A, Lamb CA, Bridgewood A, Brown-Schofield LJ, Rayner F, Isaacs JD, Nsengimana J, Stewart CJ, Anderson AE, Plummer R, Pratt AG. . BMC Cancer 2024, 24(1), 733.
    • Brown PM, Anderson AE, Naamane N, Lendrem DW, Morgan AW, Isaacs JD, Pratt AG. . RMD Open 2024, 10(1), e003858.
    • Cope AP, Jasenecova M, Vasconcelos JC, Filer A, Raza K, Qureshi S, D'Agostino MA, McInnes IB, Isaacs JD, Pratt AG, Fisher BA, Buckley CD, Emery P, Ho P, Buch MH, Ciurtin C, van Schaardenburg D, Huizinga T, Toes R, Georgiou E, Kelly J, Murphy C, Prevost AT, Norton S, Lempp H, Opena M, Subesinghe S, Garrood T, Menon B, Ng N, Douglas K, Koutsianas C, Cooles F, Falahee M, Echavez-Naguicnic I, Bharadwaj A, Villaruel M, Pande I, Collins D, Pegler S, Raizada S, Siebert S, Fragoulis G, Guinto J, Galloway J, Rutherford A, Barnes T, Jeffrey H, Patel Y, Batley M, O'Reilly B, Venkatachalam S, Sheeran T, Gorman C, Reynolds P, Khan A, Gullick N, Banerjee S, Mankia K, Jordan D, Rowlands J, Starmans-Kool M, Taylor J, Nandi P, Sahbudin I, Maybury M, Hider S, Barcroft A, McNally J, Kitchen J, Nisar M, Quick V. . The Lancet 2024, 403(10429), 838-849.
    • Ling SF, Yap CF, Nair N, Bluett J, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Barton A, Plant D. . Rheumatology 2024, 63(4), 1015-1021.
    • Winthrop KL, Isaacs JD, Mease PJ, Boumpas DT, Baraliakos X, Gottenberg J-E, Siebert S, Mosca M, Basu N, Orange D, Lories R, Aletaha D, McInnes IB, Huizinga TWJ, Voll RE, Gravallese EM, Breedveld FC, Smolen JS. . Annals of the Rheumatic Diseases 2023, 82(5), 594-598.
    • Curry PDK, Chinoy H, Jani M, Plant D, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Morris AP, Barton A, Bluett J. . Journal of Rheumatology 2023, 50(11), 1518-1521.
    • Smith SL, Alexander S, Nair N, Viatte S, Eyre S, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Plant D, Barton A. . Annals of the Rheumatic Diseases 2023, 82(5), 611-620.
    • Morfopoulou S, Buddle S, Torres Montaguth OE, et al, Emonts M, Bell K, Isaacs JD, Lim EJ, Treloar O, DIAMONDS Consortium, PERFORM Consortium. . Nature 2023, 617(7961), 564-573.
    • Krieckaert CL, van Tubergen A, Gehin JE, Hernandez-Breijo B, Le Meledo G, Balsa A, Bohm P, Cucnik S, Elkayam O, Goll GL, Hooijberg F, Jani M, Kiely PD, McCarthy N, Mulleman D, Navarro-Compan V, Payne K, Perry ME, Plasencia-Rodriguez C, Stones SR, Syversen SW, de Vries A, Ward KM, Wolbink G, Isaacs JD. . Annals of the Rheumatic Diseases 2023, 82(1), 65-73.
    • Yap C, Solovyeva O, De Bono J, Rekowski J, Patel D, Jaki T, Mander A, Evans TRJ, Peck R, Hayward KS, Hopewell S, Ursino M, Rantell KR, Calvert M, Lee S, Kightley A, Ashby D, Chan A-W, Garrett-Mayer E, Isaacs JD, Golub R, Kholmanskikh O, Richards D, Boix O, Matcham J, Seymour L, Ivy SP, Marshall LV, Hommais A, Liu R, Tanaka Y, Berlin J, Espinasse A, Dimairo M, Weir CJ. . BMJ 2023, 383, e076387.
    • Aletaha D, Kerschbaumer A, Kastrati K, Dejaco C, Dougados M, McInnes IB, Sattar N, Stamm TA, Takeuchi T, Trauner M, Van Der Heijde D, Voshaar M, Winthrop KL, Ravelli A, Betteridge N, Burmester G-RR, Bijlsma JWJ, Bykerk V, Caporali R, Choy EH, Codreanu C, Combe B, Crow MK, De Wit M, Emery P, Fleischmann RM, Gabay C, Hetland ML, Hyrich KL, Iagnocco A, Isaacs JD, Kremer JM, Mariette X, Merkel P, Mysler EF, Nash P, Nurmohamed MT, Pavelka K, Poor G, Rubbert-Roth A, Schulze-Koops H, Strangfeld A, Tanaka Y, Smolen JS. . Annals of the Rheumatic Diseases 2023, 82(6), 773-787.
    • Vidal-Pedrola G, Naamane N, Cameron JA, Pratt AG, Mellor AL, Isaacs JD, Scheel-Toellner D, Anderson AE. . Immunology 2023, 168(4), 640-653.
    • Ho A, Orton R, Tayler R, Asamaphan P, herder V, Davis C, Tong L, Smollett K, Manali M, Allen J, Rawlik K, McDonald SE, Vink E, Pollock L, Gannon L, Evans C, McMenamin J, Roy K, Marsh K, Divala T, Holden MTG, Lockhart M, Yirrell D, Currie S, O'Leary M, Henderson D, Shepherd SJ, Jackson C, Gunson R, MacLean A, McInnes N, Bradley-Stewart A, Battle R, Hollenbach J, Henderson P, Odam M, Chikowore P, Oosthuyzen W, Chand M, Hamilton MS, Estrada-Rivadeneyra D, Levin M, Avramidis N, Pairo-Castineira E, Vitart V, Wilkie C, Ray S, Emonts,M, Bell,A, Bell,K, Fabian,D, Isaacs,J, Lim,E, Shenton,G, Treloar,O, Van Der Veldon,F, DIAMONDS Consortium, ISARIC4C Investigators. . Nature 2023, 617(7961), 555-563.
    • Busby AD, Wason J, Pratt AG, Young A, Isaacs JD, Nikiphorou E. . Rheumatology 2022, 61(11), 4297-4304.
    • Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J, Smith GR, Allen B, Casement J, Diboll J, Harry R, Cooles FAH, Cope AP, Simpson G, Toward R, Noble H, Parke A, Wu W, Clarke F, Scott D, Scott IC, Galloway J, Lempp H, Ibrahim F, Schwank S, Molyneux G, Lazarov T, Geissmann F, Goodyear CS, McInnes IB, Donnelly I, Gilmour A, Virlan AT, Porter D, Ponchel F, Emery P, El-Jawhari J, Parmar R, McDermott MF, Fisher BA, Young SP, Jones P, Raza K, Filer A, Pitzalis C, Barnes MR, Watson DS, Henkin R, Thorborn G, Fossati-Jimack L, Kelly S, Humby F, Bombardieri M, Rana S, Jia Z, Goldmann K, Lewis M, Ng S, Barbosa-Silva A, Tzanis E, Gallagher-Syed A, John CR, Ehrenstein MR, Altobelli G, Martins S, Nguyen D, Ali H, Ciurtin C, Buch M, Symmons D, Worthington J, Bruce IN, Sergeant JC, Verstappen SMM, Stirling F, Hughes-Morley A, Tom B, Farewell V, Zhong Y, Taylor PC, Buckley CD, Keidel S, Cuff C, Levesque M, Long A, Liu Z, Lipsky S, Harvey B, Macoritto M, Hong F, Kaymakcalan S, Tsuji W, Sabin T, Ward N, Talbot S, Padhji D, Sleeman M, Finch D, Herath A, Lindholm C, Jenkins M, Ho M, Hollis S, Marshall C, Parker G, Page M, Edwards H, Cuza A, Gozzard N, Pandis I, Rowe A, Capdevila FB, Loza MJ, Curran M, Verbeeck D, Dan Baker, Mela CM, Vranic I, Mela CT, Wright S, Rowell L, Vernon E, Joseph N, Payne N, Rao R, Binks M, Belson A, Ludbrook V, Hicks K, Tipney H, Ellis J, Hasan S, Didierlaurent A, Burny W, Haynes A, Larminie C, Harris R, Dastros-Pitei D, Carini C, Kola B, Jelinsky S, Hodge M, Maciejewski M, Ziemek D, Schulz-Knappe P, Zucht H-D, Budde P, Coles M, Butler JA, Read S. . Scientific Data 2022, 9(1), 196.
    • Busby AD, Wason J, Pratt AG, Young A, Isaacs JD, Nikiphorou E. . Rheumatology 2022, 61(4), 1563-1569.
    • Lin CMA, Cooles FAH, Isaacs JD. . Nature Reviews Rheumatology 2022, 18, 725-733.
    • Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CMA, Millar B, Maney NJ, Anderson AE, Thalayasingam N, Diboll J, Bondet V, Duffy D, Barnes MR, Smith GR, Ng S, Watson D, Henkin R, Cope AP, Reynard LN, Pratt AG, Isaacs JD. . Annals of the Rheumatic Diseases 2022, 81(9), 1214-1223.
    • Mirza M, Siebert S, Pratt A, Insch E, McIntosh F, Paton J, Wright C, Buckley CD, Isaacs J, McInnes IB, Raza K, Falahee M. . Musculoskeletal Care 2022, 20(1), 209-213.
    • Cooke F, Neal M, Wood MJ, de Vries IJM, Anderson AE, Diboll J, Pratt AG, Stanway J, Nicorescu I, Moyse N, Hiles D, Caulfield D, Dickinson AM, Blamire AM, Thelwall P, Isaacs JD, Hilkens CM. . Frontiers in Immunology 2022, 13(2022), 988667.
    • OIiver J, Nair N, Orozco G, Smith S, Hyrich KL, Morgan A, Isaacs J, Wilson AG, Barton A, Plant D. . Arthritis Research and Therapy 2021, 23(1), 80.
    • Cole M, Yap C, Buckley C, Ng WF, McInnes I, Filer A, Siebert S, Pratt A, Isaacs JD, Stocken DD. . Trials 2021, 22(1), 433.
    • Pratt AG, Siebert S, Cole M, Stocken DD, Yap C, Kelly S, Shaikh M, Cranston S, Morton M, Walker J, Frame S, Ng WF, Buckley CD, McInnes IB, Filer A, Isaacs JD. . The Lancet Rheumatology 2021, 3(5), e337-e346.
    • Serrano-Blesa E, Porter A, Lendrem DW, Pitzalis C, Barton A, Treumann A, Isaacs JD. . Clinical Proteomics 2021, 18(1), 20.
    • Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G, Mahto A, Montecucco C, Lauwerys B, Ng N, Ho P, Bombardieri M, Romao VC, Verschueren P, Kelly S, Sainaghi PP, Gendi N, Dasgupta B, Cauli A, Reynolds P, Canete JD, Moots R, Taylor PC, Edwards CJ, Isaacs J, Sasieni P, Choy E, Pitzalis C, Thompson C, Bugatti S, Bellan M, Congia M, Holroyd C, Pratt A, Cabral da Fonseca JE, White L, Warren L, Peel J, Hands R, Fossati-Jimack L, Hadfield G, Thorborn G, Ramirez J, Celis R. . The Lancet 2021, 397(10271), 305-317.
    • Maney NJ, Lemos H, Barron-Millar B, Carey C, Herron I, Anderson AE, Mellor AL, Isaacs JD, Pratt AG. . Arthritis and Rheumatology 2021, 73(10), 1820-1830.
    • Alunno A, Najm A, Machado PM, Bertheussen H, Burmester GR, Carubbi F, De Marco G, Giacomelli R, Hermine O, Isaacs JD, Kone-Paut I, Magro-Checa C, Mcinnes I, Meroni PL, Quartuccio L, Ramanan AV, Ramos-Casals M, Rodriguez Carrio J, Schulze-Koops H, Stamm TA, Tas SW, Terrier B, Mcgonagle DG, Mariette X. . Annals of the Rheumatic Diseases 2021, 80(6), 698-706.
    • Panaccione R, Isaacs JD, Chen LA, Wang W, Marren A, Kwok K, Wang L, Chan G, Su C. . Digestive Diseases and Sciences 2021, 66, 2732-2743.
    • Rayner F, Anderson AE, Baker KF, Buckley CD, Dyke B, Fenton S, Filer A, Goodyear CS, Hilkens CMU, Hiu S, Kerrigan S, Kurowska-Stolarska M, Matthews F, McInnes I, Ng W-F, Pratt AG, Prichard J, Raza K, Siebert S, Stocken D, Teare MD, Young S, Isaacs JD. . BMC Rheumatology 2021, 5, 22.
    • Siebert S, Pratt AG, Stocken DD, Morton M, Cranston A, Cole M, Frame S, Buckley CD, Ng W-F, Filer A, McInnes IB, Isaacs JD. . Medicine 2020, 99(26), e20458.
    • Penkava F, Velasco-Herrera MDC, Young MD, Yager N, Nwosu LN, Pratt AG, Lara AL, Guzzo C, Maroof A, Mamanova L, Cole S, Efremova M, Simone D, Filer A, Brown CC, Croxford AL, Isaacs JD, Teichmann S, Bowness P, Behjati S, Hussein Al-Mossawi M. . Nature Communications 2020, 11, 4767.
    • Gilani SSA, Nair N, Plant D, Hyrich K, Morgan AW, Morris AP, Wilson AG, Isaacs JD, Barton A, Bluett J. . Pharmacogenomics 2020, 21(16), 1151-1156.
    • Clark AD, Nair N, Anderson AE, Thalayasingam N, Naamane N, Skelton AJ, Diboll J, Barton A, Eyre S, Isaacs JD, Pratt AG, Reynard LN. . Journal of Allergy and Clinical Immunology 2020, 145(5), 1438-1451.
    • Dagliati A, Plant D, Nair N, Jani M, Amico B, Peek N, Morgan AW, Isaacs J, Wilson AG, Hyrich KL, Geifman N, Barton A. . Arthritis and Rheumatology 2020, 72(10), 1632-1642.
    • Baker KF, Thompson B, Lendrem DW, Scadeng A, Pratt AG, Isaacs JD. . Therapeutic Advances in Musculoskeletal Disease 2020, 12.
    • Landewe RB, Machado PM, Kroon F, Bijlsma HW, Burmester GR, Carmona L, Combe B, Galli M, Gossec L, Iagnocco A, Isaacs JD, Mariette X, McInnes I, Mueller-Ladner U, Openshaw P, Smolen JS, Stamm TA, Wiek D, Schulze-Koops H. . Annals of the Rheumatic Diseases 2020, 79(7), 851-858.
    • Spiering R, Jansen MAA, Wood MJ, Fath AA, Eltherington O, Anderson AE, Pratt AG, van Eden W, Isaacs JD, Broere F, Hilkens CMU. . Journal of Translational Medicine 2019, 17, 375.
    • Tarn JR, Howard-Tripp N, Lendrem DW, Mariette X, Saraux A, Devauchelle-Pensec V, Seror R, Skelton AJ, James K, McMeekin P, Al-Ali S, Hackett KL, Lendrem BC, Hargreaves B, Casement J, Mitchell S, Bowman SJ, Price E, Pease CT, Emery P, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, Johnsen SJA, Norheim KB, Omdal R, Stocken D, Everett C, Fernandez C, Isaacs JD, Gottenberg J-E, Ng W-F. . The Lancet Rheumatology 2019, 1(2), e85-e94.
    • Iqbal K, Lendrem DW, Hargreaves B, Isaacs JD, Thompson B, Pratt AG. . Rheumatology 2019, 58(7), 1268–1273.
    • Baker KF, Skelton AJ, Lendrem DW, Scadeng A, Thompson B, Pratt AG, Isaacs JD. . Journal of Autoimmunity 2019, 105, 102298.
    • Isaacs JD, Iqbal K. . Clinical Therapeutics 2019, 41(7), 1312-1322.
    • Wood MJ, Leckenby A, Reynolds G, Spiering R, Pratt AG, Rankin KS, Isaacs JD, Haniffa MA, Milling S, Hilkens CM. . JCI Insight 2019, 4(2), e125325.
    • Coles AJ, Azzopardi L, Kousin-Ezewu O, Mullay HK, Thompson SAJ, Jarvis L, Davies J, Howlett S, Rainbow D, Babar J, Sadler TJ, Brown JWL, Needham E, May K, Georgieva ZG, Handel AE, Maio S, Deadman M, Rota I, Hollander G, Dawson S, Jayne D, Seggewiss-Bernhardt R, Douek DC, Isaacs JD, Jones JL. . JCI Insight 2019, 4(12), e125377.
    • Ridgley LA, Anderson AE, Maney NJ, Naamane N, Skelton AJ, Lawson CA, Emery P, Isaacs JD, Carmody RJ, Pratt AG. . Frontiers in Immunology 2019, 10, 1535.
    • Anderson AE, Maney NJ, Nair N, Lendrem DW, Skelton AJ, Diboll J, Brown PM, Smith GR, Carmody RJ, Barton A, Isaacs JD, Pratt AG. . Rheumatology 2019, 58(7), 1250-1258.
    • Romagnoni A, Jegou S, Van Steen K, Wainrib G, Hugot J-P, International Inflammatory Bowel Disease Genetics Consortium (IIBDGC), Clee CM, Ferrier IN, Isaacs JD, Mansfield J, Young AH. . Scientific Reports 2019, 9(1), 10351.
    • Mousa AE, Okasha M, Isaacs JD, Price DA, Bhatnagar P, Joshi A, Surash S. . Annals of the Royal College of Surgeons of England 2019, 101(8), e164-e168.
    • Lendrem BC, Lendrem DW, Pratt AG, Naamane N, McMeekin P, Ng W-F, Allen AJ, Power M, Isaacs JD. . Pharmaceutical Statistics 2019, 18(6), 632-635.
    • Spiliopoulou A, Colombo M, Plant D, Nair N, Cui J, Coenen MJH, Ikari K, Yamanaka H, Saevarsdottir S, Padyukov L, Bridges SL, Kimberly RP, Okada Y, Van Riel PLCM, Wolbink G, Van Der Horst-Bruinsma IE, De Vries N, Tak PP, Ohmura K, Canhao H, Guchelaar H-J, Huizinga TWJ, Criswell LA, Raychaudhuri S, Weinblatt ME, Wilson AG, Mariette X, Isaacs JD, Morgan AW, Pitzalis C, Barton A, McKeigue P. . Annals of the Rheumatic Diseases 2019, 78(8), 1055-1061.
    • Al-Laith M, Jasenecova M, Abraham S, Bosworth A, Bruce IN, Buckley CD, Ciurtin C, D'Agostino M-A, Emery P, Gaston H, Isaacs JD, Filer A, Fisher BA, Huizinga TWJ, Ho P, Jacklin C, Lempp H, McInnes IB, Pratt AG, Ostor A, Raza K, Taylor PC, Van Schaardenburg D, Shivapatham D, Wright AJ, Vasconcelos JC, Kelly J, Murphy C, Prevost AT, Cope AP. . Trials 2019, 20(1), 429.
    • Baker KF, Isaacs JD, Thompson B. . BMC Rheumatology 2019, 3, 2.
    • Rayner F, Isaacs JD. . Seminars in Arthritis and Rheumatism 2018, 48(3), 558-562.
    • Lilleker JB, Vencovsky J, Wang G, Wedderburn LR, Diederichsen LP, Schmidt J, Oakley P, Benveniste O, Danieli MG, Danko K, Thuy NTP, Vazquez-Del Mercado M, Andersson H, De Paepe B, DeBleecker JL, Maurer B, McCann LJ, Pipitone N, McHugh N, Betteridge ZE, New P, Cooper RG, Ollier WE, Lamb JA, Krogh NS, Lundberg IE, Chinoy H, D'Hose S, Lu X, Tian X, Mann H, Krystufkova O, Plestilova L, Klein M, Barochova T, Kubinova K, Gelardi C, Pedini V, Cardinaletti P, Jara LJ, Saavedra MA, Cruz-Reyes CV, Vera-Lastra O, Andrade-Ortega L, Medrano-Ramirez G, Satoh M, Salazar-Paramo M, Gomez-Banuelos E, Aguilar-Arreola J, Duran-Barragan S, Navarro-Hernandez RE, Petri MH, Molberg O, Dastmalchi M, Notarnicola A, Gheorghe K, Ronnelid J, Liden M, Hanna B, Jalal A, Hellstrom H, Martineus JC, Lan NTN, Padyukov L, Platt H, Rothwell S, Ahmed Y, Armstrong R, Bernstein R, Black C, Bowman S, Bruce I, Butler R, Carty J, Chattopadhyay C, Chelliah E, Clarke F, Dawes P, Denton C, Devlin J, Edwards C, Emery P, Fordham J, Fraser A, Gaston H, Gordon P, Griffiths B, Gunawardena H, Hall F, Hanna M, Harrison B, Hay E, Hilton-Jones D, Horden L, Isaacs J, Isenberg D, Jones A, Kamath S, Kennedy T, Kitas G, Klimiuk P, Knights S, Lambert J, Lanyon P, Laxminarayan R, Lecky B, Luqmani R, Machado P, Marks J, Martin M, McGonagle D, McKenna F, McLaren J, McMahon M, McRorie E, Merry P, Miles S, Miller J, Nicholls A, Nixon J, Ong V, Over K, Packham J, Plant M, Pountain G, Pullar T, Roberts M, Sanders P, Scott D, Shadforth M, Sheeran T, Srinivasan A, Swinson D, The L-S, Webley M, Williams B, Winer J. . Annals of the Rheumatic Diseases 2018, 77(1), 30-39.
    • Cooles FAH, Anderson AE, Skelton A, Pratt AG, Kurowska-Stolarska MS, McInnes I, Hilkens CMU, Isaacs JD. . Frontiers in Immunology 2018, 9, 755.
    • Fuchs A, Gliwinski M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhauser M, Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Golab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grzes D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sanchez-Ramon S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P. . Frontiers in Immunology 2018, 8, 1844.
    • Williams NH, Jenkins A, Goulden N, Hoare Z, Hughes DA, Wood E, Foster NE, Walsh D, Carnes D, Sparkes V, Hay EM, Isaacs J, Konstantinou K, Morrissey D, Karppinen J, Genevay S, Wilkinson C. . Trials 2018, 19(1), 408.
    • Massey J, Plant D, Hyrich K, Morgan AW, Wilson AG, Spiliopoulou A, Colombo M, McKeigue P, Isaacs J, Cordell H, Pitzalis C, Barton A. . The Pharmacogenomics Journal 2018, 18(5), 657-664.
    • Thalayasingam N, Nair N, Skelton AJ, Massey J, Anderson AE, Clark AD, Diboll J, Lendrem DW, Reynard LN, Cordell HJ, Eyre S, Isaacs JD, Barton A, Pratt AG. . Arthritis and Rheumatology 2018, 70(3), 361-370.
    • Kearsley-Fleet L, Davies R, De Cock D, Watson KD, Lunt M, Buch MH, Isaacs JD, Hyrich KL. . Annals of the Rheumatic Diseases 2018, 77(10), 1405-1412.
    • Cowell J, Buck M, Essa AH, Clarke R, Vollmer W, Vollmer D, Hilkens CM, Isaacs JD, Hall MJ, Gray J. . ChemBioChem 2017, 18(17), 1688-1691.
    • Anderson AE, Swan DJ, Wong OY, Buck M, Eltherington O, Harry RA, Patterson AM, Pratt AG, Reynolds G, Doran JP, Kirby JA, Isaacs JD, Hilkens CM. . Clinical & Experimental Immunology 2017, 187(1), 113-123.
    • Smith SL, Plant D, Eyre S, Hyrich K, Morgan AW, Wilson AG, Isaacs JD, Barton A. . Rheumatology 2017, 56(6), 1019-1024.
    • Williams NH, Jenkins A, Goulden N, Hoare Z, Hughes DA, Wood E, Foster NE, Walsh DA, Carnes D, Sparkes V, Hay EM, Isaacs J, Konstantinou K, Morrissey D, Karppinen J, Genevay S, Wilkinson C. . Health Technology Assessment 2017, 21(60), 1-179.
    • Baker KF, Pratt AG, Thompson B, Isaacs JD. . Annals of the Rheumatic Diseases 2017, 76(6), e12.
    • Pollock J, Raza K, Pratt AG, Hanson H, Siebert S, Filer A, Isaacs JD, Buckley CD, Mcinnes IB, Falahee M. . Musculoskeletal Care 2017, 15(4), 395-399.
    • Jani M, Isaacs JD, Morgan AW, Wilson AG, Plant D, Hyrich KL, Chinoy H, Barton A, on behalf of BRAGGSS. . Annals of the Rheumatic Diseases 2017, 76(1), 208-213.
    • Hanson H, O'Brien N, Whybrow P, Isaacs JD, Rapley T. . Health Expectations 2017, 20(2), 309-320.
    • Bell GM, Anderson AE, Diboll J, Reece R, Eltherington O, Harry RA, Fouweather T, MacDonald C, Chadwick T, McColl EM, Dunn J, Dickinson AM, Hilkens CMU, Isaacs JD. . Annals of the Rheumatic Diseases 2017, 76(1), 227-234.
    • Nikiphorou E, Mackie SL, Kirwan J, Boers M, Isaacs J, Morgan AW, Young A. . Rheumatology 2017, 56(4), 550-555.
    • Lendrem DW, Lendrem BC, Linsley M, Rowland-Jones R, D'Agostino F, Owen MR, Isaacs JD. . Pharmaceutical Statistics 2016, 15(1), 90-92.
    • Reynolds G, Gibbon JR, Pratt AG, Coady D, Raftery G, Lorenzi AR, Gray A, Filer A, Buckley CD, Haniffa MA, Isaacs JD, Hilkens CM. . Annals of the Rheumatic Diseases 2016, 75(5), 899-907.
    • Smith SL, Plant D, Lee XH, Massey J, Hyrich K, Morgan AW, Wilson AG, Isaacs J, Barton A. . Pharmacogenomics 2016, 17(7), 715-720.
    • Clowse MEB, Feldman SR, Isaacs JD, Kimball AB, Strand V, Warren RB, Xibille D, Chen Y, Frazier D, Geier J, Proulx J, Marren A. . Drug Safety 2016, 39(8), 755-762.
    • Lord P, Spiering R, Aguillón JC, Anderson AE, Appel S, Benitez-Ribas D, ten-Brinke A, Broere F, Cools N, Cuturi MC, Diboll J, Geissler EK, Giannoukakis N, Gregori S, van-Ham SM, Lattimer S, Marshall L, Harry RA, Hutchinson JA, Isaacs JD, Joosten I, van-Kooten C, López-Díaz-de-Cerio A, Nikolic T, Barbaros-Oral H, Sofronic-Milosavljevic L, Ritter T, Riquelme P, Thomson AW, Trucco M, Vives-Pi M, Martinez-Caceres E, Hilkens CM. . PeerJ 2016, 4, 1-14.
    • Cooles FAH, Anderson AE, Drayton T, Harry RA, Diboll J, Munro L, Thalayasingham N, Ostor AJK, Isaacs JD. . Arthritis Research & Therapy 2016, 18, 302.
    • Anderson AE, Pratt AG, Sedhom MA, Doran JP, Routledge C, Hargreaves B, Brown PB, LeCao KA, Isaacs JD, Thomas R. . Annals of the Rheumatic Diseases 2016, 75, 466-473.
    • Plant D, Webster A, Nair N, Oliver J, Smith SL, Eyre S, Hyrich KL, Wilson AG, Morgan AW, Isaacs JD, Worthington J, Barton A. . Arthritis & Rheumatology 2016, 68(6), 1353-1360.
    • Jani M, Isaacs JD, Morgan AW, Wilson AG, Plant D, Hyrich KL, Chinoy H, Barton A. . Rheumatology 2016, 55(11), 2050-2055.
    • McInnes IB, Buckley CD, Isaacs JD. . Nature Reviews Rheumatology 2016, 12(1), 63-68.
    • Pratt AG, Lendrem D, Hargreaves B, Aslam O, Galloway JB, Isaacs JD. . Rheumatology 2016, 55(10), 1843-1848.
    • Spyridopoulos I, Martin-Ruiz C, Hilkens C, Yadegarfar ME, Isaacs J, Jagger C, Kirkwood T, von Zglinicki T. . Aging Cell 2016, 15(2), 389-392.
    • McGovern A, Schoenfelder S, Martin P, Massey J, Duffus K, Plant D, Yarwood A, Pratt AG, Anderson AE, Isaacs JD, Diboll J, Thalayasingam N, Ospelt C, Barton A, Worthington J, Fraser P, Eyre S, Orozco G. . Genome Biology 2016, 17, 212.
    • Peck RW, Lendrem DW, Grant I, Lendrem BC, Isaacs JD. . Nature Reviews Drug Discovery 2015, 14, 1-2.
    • Jopson L, Newton JL, Palmer J, Floudas A, Isaacs J, Qian J, Wilkinson J, Trenell M, Blamire A, Howel D, Jones DE. . BMJ Open 2015, 5(8), e007985.
    • Brown PM, Isaacs JD. . Current Pharmaceutical Design 2015, 21(17), 2170-2178.
    • Montes A, Perez-Pampin E, Navarro-Sarabia F, Moreira V, de la Sema AR, Magallares B, Vasilopoulos Y, Sarafidou T, Fernandez-Nebro A, Ordonez MD, Narvaez J, Canete JD, Marquez A, Pascual-Salcedo D, Joven B, Carreira P, Moreno-Ramos MJ, Caliz R, Ferrer MA, Garcia-Portales R, Blanco FJ, Magro C, Raya E, Valor L, Alegre-Sancho JJ, Balsa A, Martin J, Plant D, Isaacs J, Morgan AW, Barton A, Wilson AG, Gomez-Reino JJ, Gonzalez A, BRAGGSS. . Arthritis Research & Therapy 2015, 17, 63.
    • Lendrem DW, Lendrem BC, Peck RW, Senn SJ, Day S, Isaacs JD. . Nature Reviews Drug Discovery 2015, 14, 219-221.
    • Lendrem DW, Lendrem BC, Woods D, Rowland-Jones R, Burke M, Chatfield M, Isaacs JD, Owen MR. . Drug Discovery Today 2015, 20(11), 1365-1371.
    • Smith SL, Eyre S, Yarwood A, Hyrich K, Morgan AW, Wilson AG, Isaacs J, Plant D, Barton A, Biol Rheumatoid Arthrit Genetics. . Arthritis Research & Therapy 2015, 17, 359.
    • Bluett J, Morgan C, Thurston L, Plant D, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Cordingley L, Barton A, BRAGGSS. . Rheumatology 2015, 54(3), 494-499.
    • Kremer JM, Kivitz AJ, Simon-Campos JA, Nasonov EL, Tony HP, Lee SK, Vlahos B, Hammond C, Bukowski J, Li HH, Schulman SL, Raber S, Zuckerman A, Isaacs JD. . Arthritis Research & Therapy 2015, 17, 95.
    • Gunther C, Kind B, Reijns MAM, Berndt N, Martinez-Bueno M, Wolf C, Tungler V, Chara O, Lee YA, Hubner N, Lee YA, Bicknell L, Blum S, Krug C, Schmidt F, Krug C, Kretschmer S, Koss S, Astell KR, Ramantani G, Bauerfeind A, Morris DL, Graham DSC, Bubeck D, Leitch A, Ralston SH, Blackburn EA, Gahr M, Witte T, Vyse TJ, Melchers I, Mangold E, Nothen MM, Aringer M, Kuhn A, Luthke K, Unger L, Bley A, Lorenzi A, Isaacs JD, Alexopoulou D, Conrad K, Dahl A, Roers A, Alarcon-Riquelme ME, Jackson AP, Lee-Kirsch MA. . Pediatric Rheumatology 2015, 13(1).
    • Gunther C, Kind B, Reijns MAM, Berndt N, Martinez-Bueno M, Wolf C, Tungler V, Chara O, Lee YA, Hubner N, Bicknell L, Blum S, Krug C, Schmidt F, Kretschmer S, Koss S, Astell KR, Ramantani G, Bauerfeind A, Morris DL, Graham DSC, Bubeck D, Leitch A, Ralston SH, Blackburn EA, Gahr M, Witte T, Vyse TJ, Melchers I, Mangold E, Nothen MM, Aringer M, Kuhn A, Luthke K, Unger L, Bley A, Lorenzi A, Isaacs JD, Alexopoulou D, Conrad K, Dahl A, Roers A, Alarcon-Riquelme ME, Jackson AP, Lee-Kirsch MA. . Journal of Clinical Investigation 2015, 125(1), 413-424.
    • Jani M, Chinoy H, Warren RB, Griffiths CEM, Plant D, Fu B, Morgan AW, Wilson AG, Isaacs JD, Hyrich KL, Barton A, Biology Rheumatoid Arthrit Genetic. . Arthritis & Rheumatology 2015, 67(8), 2011-2019.
    • Viatte S, Plant D, Han B, Fu B, Yarwood A, Thomson W, Symmons DPM, Worthington J, Young A, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Raychaudhuri S, Barton A. . JAMA: The Journal of the American Medical Association 2015, 313(16), 1645-1656.
    • James K, Al-Ali S, Tarn J, Cockell SJ, Gillespie CS, Hindmarsh V, Locke J, Mitchell S, Lendrem D, Bowman S, Price E, Pease CT, Emery P, Lanyon P, Hunter JA, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, The UK Primary Sjögren’s Syndrome registry, Wipat A, Newton J, Jones DE, Isaacs J, Hallinan J, Ng W-F. . PLoS ONE 2015, 10(12), e0143970.
    • Lendrem B, Lendrem DW, Gray A, Isaacs JD. . British Medical Journal 2014, 349, g7094.
    • Malaviya AP, Ledingham J, Bloxham J, Bosworth A, Buch M, Choy E, Cope A, Isaacs J, Marshall D, Wright G, Ostor AJ. . Rheumatology 2014, 53(7), 1344-1346.
    • Brown PM, Isaacs JD. . Clinical Medicine 2014, 14(Suppl. 6), s50-s55.
    • Lendrem DW, Senn SJ, Lendrem BC, Isaacs JD. . Pharmaceutical Statistics 2014.
    • Cordingley L, Prajapati R, Plant D, Maskell D, Morgan C, Ali FR, Morgan AW, Wilson AG, Isaacs JD, the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS), Barton A. . Arthritis Care & Research 2014, 66(6), 861-868.
    • Mathews RJ, Robinson JI, Battellino M, Wong C, Taylor JC, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS), Eyre S, Churchman SM, Wilson AG, Isaacs JD, Hyrich K, Barton A, Plant D, Savic S, Cook GP, Sarzi-Puttini P, Emery P, Barrett JH, Morgan AW, McDermott MF. . Annals of the Rheumatic Diseases 2014, 73(6), 1202-1210.
    • McInnes IB, Sieper J, Braun J, Emery P, van der Heijde D, Isaacs JD, Dahmen G, Wollenhaupt J, Schulze-Koops H, Kogan J, Ma SL, Schumacher MM, Bertolino AP, Hueber W, Tak PP. . Annals of the Rheumatic Diseases 2014, 73(2), 349-356.
    • Lendrem BD, Lendrem DW, Gray A, Isaacs JD. . BMJ 2014, 349, g7094.
    • Isaacs JD, Zuckerman A, Krishnaswami S, Nduaka C, Lan SP, Hutmacher MM, Boy MG, Kowalski K, Menon S, Riese R. . Arthritis Research & Therapy 2014, 16(4), R158.
    • Bluett J, Ibrahim I, Plant D, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Barton A, BRAGGSS. . Pharmacogenomics Journal 2014, 14(2), 171-175.
    • Purvis HA, Anderson AE, Young DA, Isaacs JD, Hilkens CMU. . Journal of Immunology 2014, 193(3), 1142-1150.
    • Kremer J, Li ZG, Hall S, Fleischmann R, Genovese M, Martin-Mola E, Isaacs JD, Gruben D, Wallenstein G, Krishnaswami S, Zwillich SH, Koncz T, Riese R, Bradley J. . Annals of Internal Medicine 2013, 159(4), 253-261.
    • Pratt AG, Lorenzi AR, Wilson G, Platt PN, Isaacs JD. . Arthritis Research & Therapy 2013, 15(5), R118.
    • Richardson S, Isaacs J. Novel immunotherapies for rheumatoid arthritis. Clinical Medicine 2013, 13, 391-4.
    • Cui J, Stahl EA, Saevarsdottir S, Miceli C, Diogo D, Trynka G, Raj T, Mirkov MU, Canhao H, Ikari K, Terao C, Okada Y, Wedren S, Askling J, Yamanaka H, Momohara S, Taniguchi A, Ohmura K, Matsuda F, Mimori T, Gupta N, Kuchroo M, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Herenius M, Doorenspleet ME, Tak PP, Crusius JBA, van der Horst-Bruinsma IE, Wolbink GJ, van Riel PLCM, van de Laar M, Guchelaar HJ, Shadick NA, Allaart CF, Huizinga TWJ, Toes REM, Kimberly RP, Bridges SL, Criswell LA, Moreland LW, Fonseca JE, de Vries N, Stranger BE, De Jager PL, Raychaudhuri S, Weinblatt ME, Gregersen PK, Mariette X, Barton A, Padyukov L, Coenen MJH, Karlson EW, Plenge RM. . PLoS Genetics 2013, 9(3), e1003394.
    • Isaacs JD, Harari O, Kobold U, Lee JS, Bernasconi C. . Arthritis Research & Therapy 2013, 15(6), R204.
    • Isaacs JD, Cohen SB, Emery P, Tak PP, Wang J, Lei G, Williams S, Lal P, Read SJ. . Annals of Rheumatic Disease 2013, 72(3), 329-336.
    • Plant D, Prajapati R, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Barton A, Biol Rheumatoid Arthrit Genetics. . Arthritis and Rheumatism 2012, 64(3), 665-670.
    • Anderson AE, Lorenzi AR, Pratt A, Wooldridge T, Diboll J, Hilkens CM, Isaacs JD. . Rheumatology 2012, 51(8), 1397-1406.
    • Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C, Parker C, Dunn M, Catt M, Jagger C, von Zglinicki T, Kirkwood TB. . Mechanisms of Ageing and Development 2012, 133(6), 456-466.
    • Cooper DL, Martin SG, Robinson JI, Mackie SL, Charles CJ, Nam J, Isaacs JD, Emery P, Morgan AW, YEAR Consortium. . PLoS One 2012, 7(1), e28918.
    • Raftery G, He JB, Pearce R, Birchall D, Newton JL, Blamire AM, Isaacs JD. . Arthritis Research & Therapy 2012, 14(6), R263.
    • Deehan DJ, Dowen DJ, Sprowson AP, Ferguson LC, Prathalingam NS, Isaacs JD, Birch MA, Oldershaw RA. . American Journal of Stem Cell Research 2012, 1(1), 1-8.
    • Plant D, Ibrahim I, Lunt M, Eyre S, Flynn E, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Barton A, BRAGGGSS. . Arthritis Research & Therapy 2012, 14(5), R214.
    • Robinson JI, Carr IM, Cooper DL, Rashid LH, Martin SG, Emery P, Isaacs JD, Barton A, Wilson AG, Barrettt JH, Morgan AW, BRAGGSS. . Human Mutation 2012, 33(4), 741-749.
    • Houseman M, Potter C, Marshall N, Lakey R, Cawston T, Griffiths I, Young-Min S, Isaacs JD. . Arthritis Research & Therapy 2012, 14(1), R30.
    • Pearce SHS, Mitchell AL, Bennett S, King P, Chandran S, Nag S, Chen S, Smith BR, Isaacs JD, Vaidya B. . Journal of Clinical Endocrinology and Metabolism 2012, 97(10), E1927-E1932.
    • Pratt AG, Swan DC, Richardson S, Wilson G, Hilkens C, Young DA, Isaacs JD. . Annals of the Rheumatic Diseases 2012, 71(8), 1374-1381.
    • Buch MH, Smolen JS, Betteridge N, Breedveld FC, Burmester G, Dorner T, Ferraccioli G, Gottenberg JE, Isaacs J, Kvien TK, Mariette X, Martin-Mola E, Pavelka K, Tak PP, van der Hejide D, van Vollenhoven RF, Emery P. . Annals of the Rheumatic Diseases 2011, 70, 909-920.
    • Isaacs JD, Ferraccioli G. . Annals of the Rheumatic Diseases 2011, 70(1), 4-7.
    • Pratt AG, Charles PJ, Chowdhury M, Wilson G, Venables PJ, Isaacs JD. . Annals of the Rheumatic Diseases 2011, 70(11), 2056-2058.
    • Schiff MH, Kremer JM, Jahreis A, Vernon E, Isaacs JD, van Vollenhoven RF. . Arthritis Research & Therapy 2011, 13(5), R141.
    • Plant D, Bowes J, Potter C, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Barton A, British Soc Rheumatology Biol. . Arthritis & Rheumatism 2011, 63(3), 645-653.
    • Coulthard LR, Taylor JC, Eyre S, Robinson JI, Wilson AG, Isaacs JD, Hyrich K, Emery P, Barton A, Barrett JH, Morgan AW, McDermott MF. . Annals of the Rheumatic Diseases 2011, 70(1), 98-103.
    • Atchia I, Kane D, Reed MR, Isaacs JD, Birrell F. . Annals of the Rheumatic Diseases 2011, 70(1), 110-116.
    • Thalayasingam N, Isaacs JD. . Best Practice & Research: Clinical Rheumatology 2011, 25(4), 549-567.
    • Baldwin HM, Ito-Ihara T, Isaacs JD, Hilkens CMU. . Annals of the Rheumatic Diseases 2010, 69(6), 1200-1207.
    • Cooles FAH, Isaacs JD. . Best Practice & Research: Clinical Rheumatology 2010, 24(4), 497-511.
    • Stoop JN, Harry RA, von Delwig A, Isaacs JD, Robinson JH, Hilkens CMU. . Arthritis & Rheumatism 2010, 62(12), 3656-3665.
    • Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AHM, Nititham J, Hughes LB, de Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedren S, Ding B, Guiducci C, Wolbink GJ, Crusius JBA, van der Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M, Morgan AW, Wilson AG, Isaacs JD, Hyrich K, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell LA, Huizinga TWJ, Tak PP, Bridges SL, Toes REM, Barton A, Klareskog L, Gregersen PK, Karlson EW, Plenge RM, Biol Rheumatoid Arthrit Genet & Ge. . Arthritis & Rheumatism 2010, 62(7), 1849-1861.
    • Tudhope SJ, von Delwig A, Falconer J, Pratt A, Woolridge T, Wilson G, Isaacs JD, Ng WF. . Annals of the Rheumatic Diseases 2010, 69(10), 1873-1879.
    • Potter C, Gibbons LJ, Bowes JD, Cordell HJ, Hyrich K, Isaacs JD, Morgan AW, Wilson AG, Barton A, Biol Rheumatoid Arthrit Genetics Group. . Pharmacogenetics and Genomics 2010, 20(5), 338-341.
    • Purvis HA, Stoop JN, Mann J, Woods S, Kozijn AE, Hambleton S, Robinson JH, Isaacs JD, Anderson AE, Hilkens CMU. . Blood 2010, 116(23), 4829-4837.
    • Tan RJL, Gibbons LJ, Potter C, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Barton A, BRAGGSS. . Annals of the Rheumatic Diseases 2010, 69(6), 1029-1035.
    • Hassan B, Maxwell JR, Hyrich KL, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, Barton A, Worthington J, Isaacs JD, Morgan AW, Wilson AG. . Rheumatology 2010, 49(1), 43-47.
    • Harry RA, Anderson AE, Isaacs JD, Hilkens CM. . Annals of the Rheumatic Diseases 2010, 69(11), 2042-2050.
    • Emery P, Deodhar A, Rigby WF, Isaacs JD, Combe B, Racewicz AJ, Latinis K, Abud-Mendoza C, Szczepanski LJ, Roschmann RA, Chen A, Armstrong GK, Douglass W, Tyrrell H. . Annals of the Rheumatic Diseases 2010, 69(9), 1629-1635.
    • Robinson JI, Barrett JH, Taylor JC, Naven M, Corscadden D, Barton A, Wilson AG, Emery P, Isaacs JD, Morgan AW, YEAR Consortium, BRAGGSS. . Annals of the Rheumatic Diseases 2010, 69(6), 1054-1057.
    • Potter C, Cordell HJ, Barton A, Daly AK, Hyrich K, Mann D, Morgan A, Wilson AG, and the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS), Isaacs J. . Annals of the Rheumatic Diseases 2010, 69(7), 1315-1320.
    • Cunnington J, Marshall N, Hide G, Bracewell C, Isaacs J, Platt P, Kane D. . Arthritis & Rheumatism 2010, 62(7), 1862-1869.
    • Lorenzi A, Morgan TA, Anderson A, Catterall J, Patterson AM, Foster HE, Isaacs JD. . Annals of the Rheumatic Diseases 2009, 68(6), 983-900.
    • Vila J, Isaacs JD, Anderson AE. . Current Opinion in Hematology 2009, 16(4), 274-279.
    • Anderson AE, Swan DJ, Sayers BL, Harry RA, Patterson AM, von Delwig A, Robinson JH, Isaacs JD, Hilkens CM. . Journal of Leukocyte Biology 2009, 85(2), 243-250.
    • Bowes JD, Potter C, Gibbons LJ, Hyrich K, Plant D, Morgan AW, Wilson AG, Isaacs JD, Worthington J, Barton A, BRAGGSS. . Pharmacogenetics and Genomics 2009, 19(4), 319-323.
    • Bracewell C, Isaacs JD, Emery P, Ng WF. . Expert Opinion on Biological Therapy 2009, 9(7), 909-919.
    • Potter C, Hyrich KL, Tracey A, Lunt M, Plant D, Symmons DPM, Thomson W, Worthington J, Emery P, Morgan AW, Wilson AG, Isaacs J, Barton A, BRAGGSS. . Annals of the Rheumatic Diseases 2009, 68(1), 69-74.
    • Lakey RL, Morgan TG, Rowan AD, Isaacs JD, Cawston TE, Hilkens CM. . Rheumatology 2009, 48(5), 502-7.
    • Buch MH, Reece RJ, Quinn MA, English A, Cunnane G, Henshaw K, Bingham SJ, Bejarano V, Isaacs JD, Emery P. . Rheumatology 2008, 47(10), 1469-1475.
    • Lorenzi A, Clarke A, Wooldridge T, Waldmann H, Hale G, Symmons D, Hazleman B, Isaacs J. . Arthritis & Rheumatism 2008, 58(2), 370-375.
    • Anderson AE, Sayers BL, Haniffa MA, Swan DJ, Diboll J, Wang XN, Isaacs JD, Hilkens CMU. . Journal of Leukocyte Biology 2008, 84(1), 124-133.
    • Lorenzi AR, Patterson AM, Pratt A, Jefferson M, Chapman CE, Ponchel F, Isaacs JD. . Journal of Immunological Methods 2008, 339(2), 185-94.
    • Maxwell JR, Potter C, Hyrich KL, Barton A, Worthington J, Isaacs JD, Morgan AW, Wilson AG. . Human Molecular Genetics 2008, 17(22), 3532-3538.
    • Burgoyne CH, Field SL, Brown AK, Hensor EM, English A, Bingham SL, Verburg R, Fearon U, Lawson CA, Hamlin PJ, Straszynski L, Veale D, Conaghan P, Hull MA, van Laar JM, Tennant A, Emery P, Isaacs JD, Ponchel F. . Annals of the Rheumatic Diseases 2008, 67(6), 750-757.
    • Morgan AW, Hale G, Rebello PRUB, Richards SJ, Gooi H-C, Waldmann H, Emery P, Isaacs JD. . QJM: An International Journal of Medicine 2008, 101(4), 299-306.
    • Von Delwig A, Altmann DM, Charlton FG, McKie N, Isaacs JD, Holmdahl R, Robinson JH. . Annals of the Rheumatic Diseases 2007, 66(5), 599-604.
    • Isaacs JD. . Current Opinion in Pharmacology 2007, 7(4), 418-425.
    • Haniffa MA, Wang XN, Holtick U, Rae M, Isaacs JD, Dickinson AM, Hilkens CM, Collin MP. . Journal of Immunology 2007, 179(3), 1595-1604.
    • Von Delwig A, Altmann DM, Isaacs JD, Harding CV, Holmdahl R, Balfour-McKie JN, Robinson JH. . Arthritis and Rheumatism 2006, 54(2), 482-491.
    • von Delwig A, Hilkens CM, Altmann DM, Holmdahl R, Isaacs JD, Harding CV, Robertson H, McKie N, Robinson JH. . Arthritis Research & Therapy 2006, 8(4), R93.
    • von Delwig A, Wilson AJ, Altmann DM, Holmdahl R, Harding CV, Mckie N, Isaacs JD, Lakey JH, Robinson JH. . Arthritis & Rheumatism 2006, 54(9), S639-S639.
    • Lawson CA, Brown AK, Bejarano V, Douglas SH, Burgoyne CH, Greenstein AS, Boylston AW, Emery P, Ponchel F, Isaacs JD. . Rheumatology 2006, 45(10), 1210-1217.
    • Morgan AW, Robinson JI, Barrett JH, Martin J, Walker A, Babbage SJ, Ollier WER, Gonzalez-Gay MA, Isaacs JD. . Arthritis Research & Therapy 2006, 8(4), R109.
    • Verburg RJ, Flierman R, Sont JK, Ponchel F, Van Dreunen L, Levarht EW, Welling MM, Toes REM, Isaacs JD, Van Laar JM. . Annals of the Rheumatic Diseases 2005, 64(10), 1397-1405.
    • Lawson CA, Donaldson IJ, Bowman SJ, Shefta J, Morgan AW, Gough A, Isaacs JD, Griffiths B, Emery P, Pease CT, Boylston AW. . Annals of the Rheumatic Diseases 2005, 64(3), 468-470.
    • Morgan AW, Barrett JH, Griffiths B, Subramanian D, Robinson JI, Keyte VH, Ali M, Jones EA, Old RW, Ponchel F, Boylston AW, Situnayake RD, Markham AF, Emery P, Isaacs JD. . Arthritis Research & Therapy 2005, 8(1), R5.
    • Ali S, Robertson H, Wain JH, Isaacs JD, Malik G, Kirby JA. . Journal of Immunology 2005, 175(2), 1257-1266.
    • Ponchel F, Verburg RJ, Bingham SJ, Brown AK, Moore J, Protheroe A, Short K, Lawson CA, Morgan AW, Quinn M, Buch M, Field SL, Maltby SL, Masurel A, Douglas SH, Straszynski L, Fearon U, Veale DJ, Patel P, McGonagle D, Snowden J, Markham AF, Ma D, van Laar JM, Papadaki HA, Emery P, Isaacs JD. . Arthritis Research & Therapy 2004, 7(1), R80-R92.
    • Lawson CA, Brown AK, Greenstein A, Douglas SH, Boylston AW, Emery P, Ponchel F, Isaacs JD. . Rheumatology 2003, 42(S1), 125-126.
    • Ponchel F, Toomes C, Bransfield K, Leong FT, Field SL, Douglas SH, Bell SM, Combaret V, Puisieux A, Mighell AJ, Robinson PA, Inglehearn CF, Isaacs JD, Markham AF. . BMC Biotechnology 2003, 3, 18.
    • Drewe E, McDermott EM, Powell PT, Isaacs JD, Powell RJ. . Rheumatology 2003, 42, 235-239.
    • Ali M, Veale DJ, Reece RJ, Quinn M, Henshaw K, Zanders ED, Markham AF, Emery P, Isaacs JD. . Annals of the Rheumatic Diseases 2003, 62(7), 663-666.
    • Ponchel F, Papadaki H, Bingham SJ, Protheroe A, Douglas SH, Emery P, Isaacs JD. . Rheumatology 2003, 42(S1), 127.
    • Morgan AW, Keyte VH, Babbage SJ, Robinson JI, Ponchel F, Barrett JH, Bhakta BB, Bingham SJ, Buch MH, Conaghan PG, Gough A, Green M, Lawson CA, Pease CT, Markham AF, Ollier WER, Emery P, Worthington J, Isaacs JD. . Rheumatology 2003, 42(4), 528-533.
    • Conaghan PG, O'Connor P, McGonagle D, Astin P, Wakefield RJ, Gibbon WW, Quinn M, Karim Z, Green MJ, Proudman S, Isaacs J, Emery P. . Arthritis & Rheumatism 2003, 48(1), 64-71.
    • Ponchel F, Brown AK, Lawson CA, Douglas SH, Emery P, Isaacs JD. . Rheumatology 2003, 42(S1), 127.
    • Bingham S, Veale D, Fearon U, Isaacs JD, Morgan G, Emery P, McGonagle D, Reece R, Clague R, Snowden JA. . Arthritis & Rheumatism 2002, 46(3), 837-839.
    • Ponchel F, Morgan AW, Bingham SJ, Quinn M, Buch M, Verburg RJ, Henwood JA, Douglas SH, Masurel A, Conaghan P, Gesinde M, Taylor J, Markham AF, Emery P, van Laar JM, Isaacs JD. . Blood 2002, 100(13), 4550-4556.
    • Ali M, Ponchel F, Wilson K, Francis MJD, Wu X, Verhoeff A, Boylston AW, Veale DJ, Emery P, Markham AF, Lamb JR, Isaacs JD. . The Journal of Clinical Investigation 2001, 107(4), 519-528.
    • Ng WF, Duggan PJ, Ponchel F, Matarese G, Lombardi G, Edwards AD, Isaacs JD, Lechler RI. . Blood 2001, 98(9), 2736-2744.
    • Bingham SJ, Snowden J, McGonagle D, Richards S, Isaacs J, Morgan G, Emery P. . The Journal of Rheumatology 2001, S64, 21-24.
    • Ali M, Markham AF, Isaacs JD. . Journal of Immunological Methods 2001, 250(1-2), 29–43.
    • Proudman SM, Conachan PG, Richardson C, Griffiths B, Green MJ, McGonagle D, Wakefield RJ, Reece RJ, Miles S, Adebajo A, Gough A, Helliwell P, Martin M, Huston G, Pease C, Veale DJ, Isaacs J, Heijde vanderDMFM, Emery P. . Arthritis & Rheumatism 2000, 43(8), 1809-1819.
    • Wakefield RJ, Gibbon WW, Conaghan PG, OConnor P, McGonagle D, Pease C, Green MJ, Veale DJ, Isaacs JD, Emery P. . Arthritis and Rheumatisim 2000, 43(12), 2762-2770.
    • Morgan AW, Griffiths B, Ponchel F, Montague BMN, Ali M, Gardener PP, Gooi H-C, Situnayake RD, Markham AF, Emery P, Isaacs JD. . Arthritis & Rheumatism 2000, 43(10), 2328-2334.

  • Conference Proceedings (inc. Abstracts)

    • Reynolds G, Milne P, Bigley V, Collin M, Isaacs J, Hilkens C, Haniffa M. . In: Spring Meeting for Clinician Scientists in Training 2016. 2016, London, UK: Elsevier.
    • Baker KF, Thompson B, Lendrem DW, Pratt AG, Isaacs JD. . In: 2016 Annual European Congress of Rheumatology. 2016, London, UK: BMJ Publishing Group.
    • Gavan S, Harrison M, Barton A, Hyrich K, Isaacs J, Morgan A, Wilson AG, Payne K. . In: ISPOR 21st Annual International Meeting. 2016, Washington, DC: Elsevier.
    • Pratt AG, Massey J, Anderson AE, Nair N, Diboll J, Skelton A, Lendrem DW, Reynard LN, Cordell HJ, Eyre S, Barton A, Isaacs JD. . In: 36th European Workshop for Rheumatology Research. 2016, York: BMJ Group.
    • Hanson H, Isaacs JD, Kay LJ, Lendrem DW, O'Brien N, Pratt AG, Rapley T. . In: Rheumatology. 2016, Glasgow: Oxford University Press.
    • Cooles FAH, Anderson AE, Hilkens C, Isaacs JD. . In: 2015 ACR/ARHP Annual Meeting. 2015, San Francisco, CA, USA: Wiley.
    • Pratt AG, Anderson AE, Nair N, Massey J, Diboll J, Skelton A, Hargreaves B, Routledge C, Lendrem D, Brown P, Barton A, Isaacs JD. . In: Rheumatology 2015. 2015, Manchester, UK: Oxford University Press.
    • Pratt AG, Anderson AE, Lendrem DW, Skelton A, Massey J, Nair N, Diboll J, Hargreaves B, Brown PM, Barton A, Isaacs JD. . In: 2015 ACR/ARHP Annual Meeting. 2015, San Francisco, CA.
    • Jopson L, Newton JL, Howel D, Palmer J, Isaacs J, Qian J, Wilkinson J, Blamire A, Floudas A, Jones DE. . In: 50th Annual meeting of the European Association for the Study of the Liver. 2015, Vienna, Austria: Elsevier.
    • Baker K, Isaacs J, Thompson B. . In: Rheumatology 2015. 2015, Manchester, UK: Oxford University Press.
    • Baker K, Isaacs J, Thompson B. . In: 2015 British Society of Rheumatology Annual Conference. 2015, Manchester, UK: Oxford University Press.
    • Pratt AG, Hargreaves B, Routledge C, Tiffin L, Norris J, Humphrey C, Isaacs JD. . In: Rheumatology 2015. 2015, Manchester, UK: Oxford University Press.
    • Viatte S, Plant D, Han B, Fu B, Yarwood A, Thomson W, Symmons DPM, Worthington J, Young A, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Raychaudhuri S, Barton A. . In: Rheumatology 2015. 2015, Manchester, UK: Oxford University Press.
    • Hao CM, Plant D, Isaacs J, Hyrich KL, Morgan A, Wilson G, Barton A. . In: Rheumatology. 2015, Manchester, UK: Oxford University Press.
    • Smith SL, Plant D, Eyre S, Hyrich KL, Morgan AW, Wilson GA, Isaacs J, Barton A. . In: Rheumatology 2015. 2015, Manchester, UK: Oxford University Press.
    • James K, Al-Ali S, Tarn J, Cockell SJ, Gillespie CS, Bowman S, Isaacs J, Jones DE, Newton J, Price E, Wipat A, Hallinan J, Ng WF, UKPSSR. . In: The 13th International Symposium on Sjögren's Syndrome. 2015, Bergen, Norway: Wiley-Blackwell.
    • Pratt AG, Hargreaves B, Lendrem DW, Aslam O, Isaacs JD. . In: 2015 ACR/ARHP Annual Meeting. 2015, San Francisco, CA, USA: John Wiley & Sons, Inc.
    • Jani M, Chinoy H, Warren RB, Griffiths CEM, Plant D, Fu B, Morgan AW, Wilson AG, Isaacs JD, Hyrich KL, Barton A. . In: Rheumatology 2015. 2015, Manchester, UK: Oxford University Press.
    • Jani M, Chinoy H, Isaacs J, Morgan AW, Wilson A, Hyrich KL, Plant D, Barton A. . In: 2015 ACR/ARHP Annual Meeting. 2015, San Francisco, CA, USA: Wiley.
    • Bell G, Anderson AE, Diboll J, Harry R, McColl E, Dickinson A, Hilkens C, Isaracs JD. . In: ACR/ARHP Annual Meeting. 2014, Boston, MA, USA: Wiley-Blackwell Publishing Ltd.
    • Cooles FAH, Pratt AG, Ng WF, Aspray TJ, Isaacs JD. . In: ACR/ARHP Annual Meeting 2013. 2013, San Diego, CA, USA: Wiley-Blackwell.
    • Bell GM, Anderson AE, Harry RA, Stoop JN, Hilkens CM, Isaacs J, Dickinson A, McColl E. . In: Annual Meeting of the British Society for Rheumatology. 2012, Glasgow, UK: Oxford University Press.
    • Pratt AG, Lorenzi AR, Wilson G, Platt PN, Isaacs JD. . In: Annual Scientific Meeting of the American College of Rheumatology (ACR). 2012, Washington, DC, USA: John Wiley & Sons, Inc.
    • Pratt AG, Brown PM, Cockell SJ, Wilson G, Isaacs JD. . In: Annual Scientific Meeting of the American College of Rheumatology (ACR). 2012, Washington, DC, USA: John Wiley & Sons, Inc.
    • Isaacs JD, Harari O, Kobold U, Bernasconi C, Lee JS. . In: Arthritis & Rheumatism: 75th Annual Scientific Meeting of the American College of Rheumatology. 2011, Chicago, Illinois, USA: John Wiley & Sons, Inc.
    • Pratt AG, Swan D, Richardson S, Wilson G, Hilkens C, Young D, Isaacs JD. . In: Arthritis & Rheumatism: 75th Annual Scientific Meeting of the American College of Rheumatology. 2011, Chicago, Illinois, USA: John Wiley & Sons, Inc.
    • Atchia I, Kane D, Reed MR, Isaacs J, Birrell F. . In: Rheumatology: Annual Meeting of the British Society of Rheumatology. 2009, Glasgow, UK: Oxford University Press.
    • Anderson AE, Sayers BL, Swan DJ, Isaacs JD, Hilkens CM. . In: BSR Annual Meeting and BHPR Spring Meeting. 2008, Liverpool: Oxford University Press.
    • Sayers B, Haniffa M, Diboll J, Isaacs J, Hilkens C. . In: Arthritis Research & Therapy: 6th Global Arthritis Research Network Meeting (GARN). 2007, Zurich, Switzerland: BioMed Central Ltd.
    • Morgan AW, Gonzalez-Gay MA, Robinson JI, Babbage SJ, Haroon-Rashid L, Hajeer AH, Ollier WER, Isaacs JD. . In: Rheumatology: Third International Conference on Giant Cell Arteritis and Polymyalgia Rheumatica. 2005, Cambridge, UK: Oxford University Press.
    • Isaacs JD, Emery P. . In: Rheumatology: British Society for Rheumatology Annual Meeting. 2004, Edinburgh, UK: Oxford University Press.
    • Isaacs JD, Clarke AM, Hazleman BL, Hale G, Waldmann H, Symmons DPM. . In: Arthritis & Rheumatism: 68th Annual Scientific Meeting of the American College of Rheumatology. 2004, San Antonio, Texas, USA: John Wiley & Sons, Inc.
    • Ponchel F, Brown AK, Lawson CA, Buch M, Douglas SD, Emery P, Isaacs JD. THE EXPRESSION OF THE JAGGED/NOTCH SIGNALING PATHWAY IS ABNORMAL IN RHEUMATOID ARTHRITIS AND DOES NOT NORMALIZE IN PATIENTS IN CLINICAL REMISSION. In: RHEUMATOLOGY. 2003, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND: OXFORD UNIV PRESS.
    • Finlayson NDC, Tomlinson S, Weetman AP, Connell JMC, Hill AVS, Savage CO, Wiles CM, Williams B, Ireland J, Vallance P, Whyte M, Seckl JR, Jung R, McKillop JH, Stout RW, Atkinson AB, Tomkin GH, Adgey AAJ, Axon ATR, Beck P, Eastwood JB, Fitzgerald M, Godman MJ, Heath DA, Kendall MJ, MacGregor GA, Petrie JC, Ell RGG, Allan RN, Barry RE, Boulton Jones JM, Evans CC, George CF, Heading RC, Jewell DP, Lazarus JH, Parker AC, Rawlins MD, Thurston H, Cappuccio FP, Conlon CP, John CS, Dornhurst A, Douglas JG, Elborn JS, El-Omar E, Friedland JS, Gilks CF, Groves RW, Hall AS, Hawkey CJ, Hillhouse E, Hughes J, Isaacs J, Jardine AG, Jodrell DI, Jones DEJ, Monson JP, Price P, Pugh CW, Ray DW, Santis G, Satsangi J, Scott DGI, Scott DL, Vickers MA, Wardlaw A. . In: 95th Annual General Meeting of the Association of Physicians of Great Britain and Ireland. 2001, Edinburgh: Oxford University Press.

  • Editorials

    • Isaacs JD. . New England Journal of Medicine 2024, 390(8), 758-759.
    • Kay J, Isaacs JD. . Annals of the Rheumatic Diseases 2017, 76(1), 4-6.
    • Pratt AG, Isaacs JD. . Expert Review of Clinical Immunology 2015, 11(3), 303-305.
    • Isaacs JD. . Nature Reviews. Rheumatology 2015, 11(11), 628-630.
    • Sherlock JP, Filer AD, Isaacs JD, Buckley CD. . Arthritis Research & Therapy 2013, 15(3), 114.
    • Isaacs JD, Chinnery PF. . Current Opinion in Pharmacology 2010, 10(3), 300-301.

  • Letters

    • Lin CMA, Tabaqchali HM, White S, Pratt AG, Isaacs JD, Cooles FAH. . Rheumatology Advances in Practice 2026, 10(1), rkaf145.
    • Ling SF, Yap CF, Nair N, Verstappen SMM, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Barton A, Plant D. . Rheumatology 2025, 64(7), 4417-4419.
    • Lin CMA, Lorenzi AR, Isaacs JD, Cooles FAH. . Rheumatology Advances in Practice 2025, 9(4), rkaf105.
    • Yap CF, Nair N, De Vries A, Loeff FC, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Barton A, Plant D. . Annals of the Rheumatic Diseases 2024, 83(2), 263-265.
    • Baker KF, Pratt AG, Isaacs JD. . JAMA - Journal of the American Medical Association 2021, 326(9), 872-873.
    • Cooles FAH, Anderson AE, Lendrem DW, Norris J, Pratt AG, Hilkens CMU, Isaacs JD. . Journal of Allergy and Clinical Immunology 2017, 141(1), 445-448.e4.
    • Pratt AG, Anderson AE, Carmody RJ, Isaacs JD. . Arthritis and Rheumatology 2016, 68(3), 770-771.
    • Cooles FAH, Pratt AG, Lendrem DW, Ng WF, Aspray TJ, Isaacs JD. . Rheumatology 2015, 54(2), 374-375.
    • Yarwood A, Viatte S, Plant D, Morgan AW, Isaacs J, Wilson AG, Hyrich K, Eyre S, Barton A. . Annals of Rheumatic Diseases 2014, 73(5), 938-40.
    • Cooles FAH, Pratt AG, Wilson G, Isaacs JD, Ng WF. . Clinical Rheumatology 2011, 30(8), 1137-1138.
    • Cooles FAH, Jackson GH, Menon G, Isaacs JD. . Rheumatology 2011, 50(4), 810-812.
    • Lorenzi AR, Foster HE, Isaacs JD. . Arthritis & Rheumatism 2008, 60(1), 310-311.
    • Thompson B, Corris P, Miller JA, Cooper RG, Halsey JP, Isaacs JD. . Journal of Rheumatology 2008, 35(10), 2080-2082.
    • Ryan KR, Lawson CA, Lorenzi AR, Arkwright PD, Isaacs JD, Lilic D. . Journal of Allergy and Clinical Immunology 2005, 116(5), 1158-1159.

  • Notes

    • Isaacs JD. . Nature Reviews Rheumatology 2026, 22, 215-217.
    • Baker KF, Skelton AJ, Lendrem DW, Scadeng A, Thompson B, Pratt AG, Isaacs JD. . Journal of Autoimmunity 2022, 132, 102913.
    • Mehta P, Sanchez E, Moraitis E, Longley N, Lendrem DW, Giles IP, Chambers RC, Ciurtin C, Isaacs JD. . The Lancet Rheumatology 2021, 3(1), e9-e10.
    • Oliver J, Nair N, Orozco G, Smith S, Hyrich KL, Morgan A, Isaacs J, Wilson AG, Barton A, Plant D. . Arthritis Research and Therapy 2021, 23(1), 139.
    • McMeekin P, Lendrem DW, Lendrem BC, Pratt AG, Peck R, Isaacs JD, Jones D. . Drug Discovery Today 2020, 25(3), 480-484.

  • Online Publication

    • Crosby D, Bossutt P, Brockehurst P, Chamberlain C, Dive C, Holmes C, Isaacs J, Kennedy R, Matthews F, Parmer M, Pearce J, Westhead D, Whittaker J, Holgate S. . London: Medical Research Council, 2017. Available at: .

  • Reviews

    • Winthrop KL, Mease P, Kerschbaumer A, Voll RE, Breedveld FC, Smolen JS, Gottenberg J-E, Baraliakos X, Kiener HP, Aletaha D, Isaacs JD, Buch MH, Crow MK, Kay J, Crofford L, van Vollenhoven RF, Ospelt C, Siebert S, Kloppenburg M, McInnes IB, Huizinga TWJ, Gravallese EM. . Annals of the Rheumatic Diseases 2024, 83(4), 409-416.
    • Lin CMA, Isaacs JD, Cooles FAH. . Current Rheumatology Reports 2024, 26, 37–52.
    • Bennett JL, Pratt AG, Dodds R, Sayer AA, Isaacs JD. . Nature Reviews Rheumatology 2023, 19, 239-251.
    • Winthrop K, Isaacs J, Calabrese L, Mittal D, Desai S, Barry J, Strengholt S, Galloway J. . Seminars in Arthritis and Rheumatism 2023, 58, 152120.
    • Cooles FAH, Isaacs JD. . The Lancet Rheumatology 2022, 4(1), e61-e72.
    • Dey M, Busby A, Elwell H, Lempp H, Pratt A, Young A, Isaacs J, Nikiphorou E. . RMD Open 2022, 8(1), e002058.
    • Schett G, Tanaka Y, Isaacs JD. . Nature Reviews Rheumatology 2021, 17, 135-144.
    • Dey M, Busby A, Elwell H, Pratt A, Young A, Isaacs J, Nikiphorou E. . Rheumatology 2021, 60(7), 3058-3071.
    • Strand V, Goncalves J, Isaacs JD. . Nature Reviews Rheumatology 2021, 17(2), 81-97.
    • Baker KF, Sim JPX, Isaacs JD. . The Lancet Rheumatology 2021, 3(5), e371-e382.
    • Stanway JA, Isaacs JD. . The Lancet Rheumatology 2020, 2(9), e565-e575.
    • Mehta P, Porter JC, Manson JJ, Isaacs JD, Openshaw PJM, McInnes IB, Summers C, Chambers RC. . The Lancet Respiratory Medicine 2020, 8(8), 822-830.
    • Isaacs JD, Burmester GR. . Annals of the Rheumatic Diseases 2020, 79(8), 991-993.
    • Tarn JR, Lendrem DW, Isaacs JD. . Expert Review of Clinical Immunology 2020, 16(6), 621-630.
    • Strand V, Goncalves J, Hickling TP, Jones HE, Marshall L, Isaacs JD. . BioDrugs 2020, 34, 27-37.
    • Mosanya CH, Isaacs JD. . Annals of the Rheumatic Diseases 2019, 78(3), 297-310.
    • Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA, Goodyear CS, Emery P, Ehrenstein MR, Gozzard N, Harris R, Hollis S, Keidel S, Levesque M, Lindholm C, McDermott MF, McInnes IB, Mela CM, Parker G, Read S, Pedersen AW, Ponchel F, Porter D, Rao R, Rowe A, Schulze-Knappe P, Sleeman MA, Symmons D, Taylor PC, Tom B, Tsuji W, Verbeeck D, Isaacs JD, Anderson A, Stocks P, Lendrem D, Tarn J, Smith G, Casement J, Diboll J, Harry R, Simpson G, Toward R, Noble H, Parke A, Wu W, Clarke F, Scott D, Scott IC, Galloway J, Lempp H, Ibrahim F, Schwank S, Molyneux G, Lazarov T, Geissmann F, Donnelly I, Gilmour A, TulunayVirlan A, El-Jawhari J, Parmer R, Buch M, Buckley C, Young S, Jones P, Raza K, Filer A, Pitzalis C, Thorborn G, Fossati-Jimack L, Kelly S, Humby F, Novak T, Rana S, Goldmann K, Lewis M, Watson D, Jia Z, Altobelli G, John C, Martins S, Nguyen D, Ali H, Worthington J, Bruce I, Sergeant J, Verstappen S, D'Costa N, Stirling F, Hughes-Morley A, Farewell V, Zhong Y, Cuff C, Long A, Liu Z, Lipsky S, Harvey B, MacOritto M, Hong F, Kaymakcalan S, Sabin T, Ward N, Talbot S, Padhi D, Finch D, Herath A, Jenkins M, Ho M, Marshall C, Page M, Edwards H, Cuza A, Loza M, Curran M, Baker D, Vranic I, Mela CT, Wright S, Rowell L, Vernon E, Joseph N, Payne N, Ludbrook V, Hicks K, Tipney H, Ellis J, Hasan S, Didierlaurent A, Burny W, Haynes A, Larminie C, Dastros-Pitel D, Kola B, Jelinksy S, Hodge M, MacIejewski M, Ziemek D, Zucht H-D, Budde P. . Nature Reviews Rheumatology 2018, 14(1), 53-60.
    • Jansen MAA, Spiering R, Broere F, van Laar JM, Isaacs JD, van Eden W, Hilkens CMU. . Immunology 2018, 153(1), 51–59.
    • Baker KF, Isaacs JD. . Annals of the Rheumatic Diseases 2018, 77(2), 175-187.
    • Orr C, Sousa E, Boyle DL, Buch MH, Buckley CD, Canete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SoA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ. . Nature Reviews Rheumatology 2017, 13(8), 463-475.
    • Brown PM, Pratt AG, Isaacs JD. . Nature Reviews Rheumatology 2016, 12(12), 731-742.
    • Isaacs JD, Cutolo M, Keystone EC, Park W, Braun J. . Journal of Internal Medicine 2016, 279(1), 41-59.
    • Pratt AG, Isaacs JD. . Best Practice & Research Clinical Rheumatology 2014, 28(4), 651-659.
    • Baker KF, Isaacs JD. . Current Opinion in Rheumatology 2014, 26(2), 219-227.
    • Reynolds G, Cooles FAH, Isaacs JD, Hilkens CMU. . Human Vaccines & Immunotherapeutics 2014, 10(4), 822-837.
    • Cooles FA, Isaacs JD, Anderson AE. . Current Rheumatology Reports 2013, 15(9), 1-9.
    • Hilkens CMU, Isaacs JD. . Clinical & Experimental Immunology 2013, 172(2), 148-157.
    • Dorner T, Strand V, Castaneda-Hernandez G, Ferraccioli G, Isaacs JD, Kvien TK, Martin-Mola E, Mittendorf T, Smolen JS, Burmester GR. . Annals of the Rheumatic Diseases 2013, 72(3), 322-328.
    • Cooles FAH, Isaacs JD. . Current Opinion in Rheumatology 2011, 23(3), 233-240.
    • Bell GM, Reynolds G, Isaacs JD. . Nature Reviews Rheumatology 2011, 7(9), 507-516.
    • Isaacs JD. . Nature Reviews Immunology 2010, 10(8), 605-611.
    • Hilkens CM, Isaacs JD, Thomson AW. . International Reviews of Immunology 2010, 29(2), 156-183.
    • Moots RJ, Ostor AJK, Isaacs JD. . Expert Opinion on Investigational Drugs 2009, 18(11), 1687-1699.
    • Isaacs JD. . Expert Opinion on Biological Therapy 2009, 9(12), 1463-1475.
    • Pratt AG, Isaacs JD, Mattey DL. . Best Practice & Research: Clinical Rheumatology 2009, 23(1), 37-48.
    • Isaacs JD. . Arthritis Research & Therapy 2009, 11(3), 225.
    • Radbruch A, Isaacs J. . European Journal of Immunology 2009, 39(8), 1991-1993.
    • Isaacs J. . Rheumatology 2008, 47(10), 1461-1468.
    • Strand V, Kimberly R, Isaacs JD. . Nature Reviews Drug Discovery 2007, 6(1), 75-92.
    • Isaacs JD, Thiel A. . Best Practice and Research: Clinical Haematology 2004, 17(2), 345-358.