缅北禁地

Previous positions:

Junior medical doctor (General Hospital Lienz, Austria)

PhD student (DNA damage, checkpoints and telomeres)                     

                                 University of Manchester, UK

Scientific Associate, Intercytex LTD (Stem cell research)

                                  Manchester, UK (part time during my PhD).   

Postdoctoral Research Associate (David Lydall group, 缅北禁地)

Wellcome Trust Career Development Fellow, 缅北禁地 University

 Scientific interests:

My group studies factors and mechanisms that are involved in DNA damage responses and the maintenance of genomic stability. We have identified the first DNA polymerase that targets dysfunctional telomeres and contributes to the maintenance of cellular senescence and the first protein (Rif1) able to inhibit the recruitment of checkpoint proteins and Replication Protein A (RPA) to DNA damage. Moreover, we have demonstrated that cells are able to repair long single stranded DNA lesions in conjunction with osmotic pressure and the inositol pathway. Earlier discoveries include the unusual mechanism that permits eukaryotic cells to proliferate indefinitely after losing telomeres (at a time when such idea was considered absurd) and the identification of the first DNA nuclease degrading telomeres in eukaryotic cells.

BGM3063 Biochemistry of Gene Expression: 1 lecture

MMB8011 Biology of Ageing: 1 lecture

MMB8008 Chromosome Biology and Cell Cycle Control in Health and Disease: 1 lecture

BGM2056 DNA Replication, recombination and Repair: Practical and Q&A

BGM3061 Genetic variation in common disease: 1 lecture

BGM1004 Genetics: 3x2 seminars

BMS3010 Genetics and Human Disease: 1 lecture

BGM3058 Integrated Genetics: 6 lectures

BMS2014 The Biology of Ageing: 2 lectures

Module leader for BGM2056 and BGM3058

• Articles

  • Robertson CM, Xue Y, Chowdhury S, Maringele L. . Molecular and Cellular Biology 2023, 43(5), 185-199.
  • Raykov V, Marvin ME, Louis EJ, Maringele L. . Genetics 2016, 203(4), 1659-1668.
  • Xue Y, Marvin ME, Ivanova IG, Lydall D, Louis EJ, Maringele L. . Aging Cell 2016, 15(3), 553-562.
  • Ivanova I, Maringele L. . Nucleic Acids Research 2016, 44(8), 3728-3738.
  • Addinall SG, Holstein EM, Lawless C, Yu M, Chapman K, Banks AP, Ngo HP, Maringele L, Taschuk M, Young A, Ciesiolka A, Lister AL, Wipat A, Wilkinson DJ, Lydall D. . PLoS Genetics 2011, 7(4), e1001362.
  • Deshpande AM, Ivanova IG, Raykov V, Xue Y, Maringele L. . Molecular and Cellular Biology 2011, 31(8), 1637-1645.
  • Xue Y, Rushton MD, Maringele L. . PLoS Genetics 2011, 7(12), e1002417.
  • LeBel C, Rosonina E, Sealey DCF, Pryde F, Lydall D, Maringele L, Harrington LA. . Genetics 2009, 182(3), 671-684.
  • Zubko MK, Maringele L, Foster SS, Lydall D. . Methods in Enzymology 2006, 409, 285-300.
  • Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D. . Cell 2006, 124(6), 1155-1168.
  • Maringele L, Lydall D. . Cell Cycle 2005, 4(6), 747-751.
  • Maringele L, Lydall D. . Genes and Development 2004, 18(21), 2663-2675.
  • Maringele L, Lydall D. . Genetics 2004, 166(4), 1641-1649.
  • Maringele L, Lydall D. . Genes & Development 2002, 16(15), 1919-1933.

• Book Chapter

  • Maringele L, Lydall D. . In: Xiao, W, ed. Yeast Protocols. Totawa, New Jersey: Humana Press, 2005, pp.65-74.