缅北禁地

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Staff Profile

Professor Lyle Armstrong

Professor of Cellular Reprogramming

  • Telephone: +44 (0) 191 241 8695
  • Address: Biosciences Institute
    Faculty of Medical Sciences
    University of 缅北禁地 upon Tyne
    International Centre for Life
    Central Parkway
    缅北禁地 upon Tyne
    NE1 3BZ
Research

Research Interests:


Pluripotent stem cells to model human disease: My research focus since joining 缅北禁地 has been the understanding of the basic biology and possible clinical applications of pluripotent stem cells. These include human embryonic stem cells (hESC) and more recently induced pluripotent stem cells (hiPSC) that may be generated from somatic tissue by ectopic expression of selected transcription factors. This latter type of pluripotent cell is of great potential importance in regenerative medicine since somatic cells differentiated from hiPSC should not suffer immune rejection when re-introduced into the patient. This desire for patient specific pluripotent stem cells was the driving force behind one of my earliest projects in 缅北禁地 this being the generation of animal human interspecies embryos by somatic cell nuclear transfer. I was one of only three persons awarded a licence from the Human Fertility and Embryology Authority (HFEA) to further this work as a means of investigating the mechanism of epigenetic reprogramming in SCNT that re-imposes a pluripotent phenotype on the somatic genome.

More recently, in collaboration with Professor Majlinda Lako, I have been the first group to establish iPSC generation technology here in 缅北禁地. This has led to a number of publications and more than 400 hiPSC lines have now been generated from dermal fibroblasts and keratinocytes obtained from patient suffering from a range of monogenetic and complex diseases in addition to unaffected controls. The primary motivation behind this effort has been to develop in vitro models of human diseases for which animal models do not exist or are unsatisfactory representations of the disease. This has placed the Institute of Genetic Medicine at the forefront of iPSC research and has led to the award of major European grant funding (Innovative Medicines Initiative – StemBANNC consortium) totalling 2.3 million Euros (£1.8 million) to develop a bank of iPSC lines for use in the Pharmaceutical industry. This activity is of increasing importance since diseased patient specific iPSC may be used as a source of differentiated somatic cell types which may be used for drug discovery and toxicity trials. This importance has highlighted the marketability of iPSC to the extent that I have established a spin-out company (Newcells Biotech Ltd) to generate hiPSC based models of human disease that are used to study drug toxicity and /or efficacy within the pharmaceutical industry. More recently, my investigations have been focussed on the generation of more complex 3D structures comprising hiPSC derived somatic cells as models of disease and as mechanisms by which to increase our understanding of developmental biology. Moreover, such 3D ‘organoids’ are potentially valuable as tools to monitor the toxicity and efficacy of prospective drugs in their pre-clinical development and as such I am developing methods to generate both models of the otic vesicle and of the proximal and distal airways.


The basic biology of pluripotent stem cells: Immediately after establishing iPSC derivation it was important to demonstrate that these cells were equivalent to embryonic stem cells. Protocols for the differentiation of hiPSC are nearly all derived from work with hESC therefore the usefulness of the former relies upon their ability to differentiate in a similar manner to hESC, but some publications suggest that there are reproducible, differences in the transcriptomes of hESC and hiPSC. Some of these may result from the individual genetic backgrounds of the hESC and hiPSC compared but some differentially expressed genes seem to be common to all hiPSC lines analyzed and may arise because of inconsistent epigenetic reprogramming of the somatic genome. Some of our preliminary data suggested that the mitochondrial characteristics of hESC and hiPSC differ. Despite similar mitochondrial copy numbers, membrane potential and superoxide generation are substantially lower in hiPSC and Nuclear encoded genes involved in mitochondrial genome replication (POLG2, TFAM, TFMB1,TFMB2, MTERF) and inner mitochondrial membrane structure (UCP2, UCP4) show different expression levels to those observed in hESC thus if inconsistent reprogramming was a feature of hiPSC derivation, there was an urgent need to confirm that mitochondrial function in hiPSC lines and in their differentiated progeny was not compromised by misexpression of their nuclear encode mitochondrial genes. This led to the award a three year project grant from the BBSRC (£468,000) to investigate the transition from glycolytic to oxidative phosphorylation based metabolism during hiPSC differentiation. If incomplete epigenetic reprogramming is the cause of hiPSC mitochondrial dysfunction, it should be possible to manipulate the hiPSC epigenome to re-establish efficient mitochondrial activity. This possibility arises from earlier work in my group investigating the epigenetic changes occurring as both cause and consequence of embryonic stem cell differentiation (Stem Cells. 2009;27:1298-308, Stem Cells. 2008; 26:1174-85) and our investigations of the mechanisms by which pluripotent stem cells respond to and defend their genomes against oxidative stress (Stem Cells. 2004; 22:962-71, Stem Cells. 2005;23:516-29, Stem Cells. 2008; 26:455-64). In addition to basic biological studies, I have an ongoing research programme into the possibility of differentiation pluripotent stem cells into functional gametes. My group was one of few to demonstrate the generation and epigenetic analysis of primordial germ cells from hESC (Stem Cells. 2010;28:84-92, Stem Cells. 2008;26:3075-85). 




Publications

  • Articles

    • Watson A, Queen R, Ferrandez-Peral L, Dorgau B, Collin J, Nelson A, Hussain R, Coxhead J, McCorkindale M, Atkinson R, Zerti D, Chichagova V, Conesa A, Armstrong L, Cremers FPM, Lako M. . Cell Death and Disease 2025, 16, 108.
    • Thornton J, Harwood S, Capurro A, Henderson T, Unsworth A, Goertler F, Nagaraja-Grellscheid S, Telezhkin V, Lako M, Sernagor E, Armstrong L. . Clinical and Translational Medicine 2025. In Press.
    • Tsikandelova R, Galo E, Cerniauskas E, Hallam D, Georgiou M, Cerna-Chavez R, Atkinson R, Palmowski P, Burte F, Davies T, Steel DH, McKibbin M, Bond J, Haggarty J, Whitfield P, Korolchuk V, Armstrong L, Yang C, Dorgau B, Kurzawa-Akanbi M, Lako M. . Stem Cell Reports 2024, 19(8), 1107-1121.
    • Atkinson R, Georgiou M, Yang C, Szymanska K, Lahat A, Vasconcelos EJR, Ji Y, Moya Molina M, Collin J, Queen R, Dorgau B, Watson A, Kurzawa-Akanbi M, Laws R, Saxena A, Shyan Beh C, Siachisumo C, Goertler F, Karwatka M, Davey T, Inglehearn CF, McKibbin M, Luhrmann R, Steel DH, Elliott DJ, Armstrong L, Urlaub H, Ali RR, Grellscheid S-N, Johnson CA, Mozaffari-Jovin S, Lako M. . Nature Communications 2024, 15(1), 3138.
    • Roguski A, Needham N, MacGillivray T, Martinovic J, Dhillon B, Riha RL, Armstrong L, Campbell IH, Ferguson A, Hilgen G, Lako M, Ritter P, Santhi N, von Schantz M, Spitschan M, Smith DJ. . Wellcome Open Research 2024, 9, 64.
    • Chandrasekaran V, Wellens S, Bourguignon A, Djidrovski I, Fransen L, Ghosh S, Mazidi Z, Murphy C, Nunes C, Singh P, Zana M, Armstrong L, Dinnyes A, Grillari J, Grillari-Voglauer R, Leonard MO, Verfaillie C, Wilmes A, Zurich M-G, Exner T, Jennings P, Culot M. . Toxicology in Vitro 2024, 98, 105826.
    • Dorgau B, Collin J, Rozanska A, boczonadi V, Molina MM, Unsworth A, Hussain r, Coxhead J, Dhanaseelan T, Armstrong L, Queen R, Lako M. . iScience 2024, 27(4), 109397.
    • Moya-Molina M, Dorgau B, Flood E, Letteboer SJF, Lorentzen E, Coxhead J, Smith G, Roepman R, Nagaraja Grellscheid S, Armstrong L, Lako M. . Cell Death & Disease 2024, 15(10), 721.
    • Chichagova V, Georgiou M, Carter M, Dorgau B, Hilgen G, Collin J, Queen R, Chung G, Ajeian J, Moya-Molina M, Kustermann S, Pognan F, Hewitt P, Schmitt M, Sernagor E, Armstrong L, Lako M. . Journal of Cellular and Molecular Medicine 2023, 27(3), 435-445.
    • Djidrovski I, Georgiou M, Tasinato E, Leonard MO, Van den Bor J, Lako M, Armstrong L. . Cell Biology and Toxicology 2023, 39, 1-18.
    • Kurzawa-Akanbi M, Whitfield P, Burte F, Bertelli PM, Pathak V, Doherty M, Hilgen B, Gliaudelyte L, Platt M, Queen R, Coxhead J, Porter A, Oberg M, Fabrikova D, Davey T, Beh CS, Georgiou M, Collin J, Boczonadi V, Hartlova A, Taggart M, Al-Aama J, Korolchuk VI, Morris CM, Guduric-Fuchs J, Steel DH, Medina RJ, Armstrong L, Lako M. . Journal of Extracellular Vesicles 2022, 11(12), 12295.
    • Rozanska A, Cerna R, Queen R, Collin J, Zerti D, Dorgau B, Beh C, Davey T, Coxhead J, Hussain R, Alaama J, Steel D, Benvenisty N, Armstrong L, Parulekar M, Lako M. . Stem Cell Translational Medicine 2022, 11(4), 415-433.
    • Dorgau B, Georgiou M, Chaudhary A, Molina M, Collin J, Queen R, Hilgen G, Davey T, Hewitt P, Schmitt M, Kustermann S, Pognan F, Steel D, Sernagor E, Armstrong L, Lako M. . Stem Cell Translational Medicine 2022, 11(2), 159-177.
    • Jackson RM, Hatton CF, Spegarova JS, Georgiou M, Collin J, Stephenson E, Verdon B, Haq IJ, Hussain R, Coxhead JM, Mudhar H-S, Wagner B, Hasoon M, Davey T, Rooney P, Khan A, Ward C, Brodlie M, Haniffa M, Hambleton S, Armstrong L, Figueiredo F, Queen R, Duncan CJ, Lako M. . Stem Cell Reports 2022, 17(7), 1699-1713.
    • Georgiou M, YAng C, Atkinson R, Pan K, Buskin A, Molina M, Collin C, Alaama J, Goertler F, Ludwig S, Davey T, Luhrmann R, Grellscheid S, Johnson C, Ali R, Armstring L, Korolchuk V, Urlaub H, Mozzafari J, LAko M. . Clinical and Translational Medicine 2022, 12(3), e759.
    • Zerti D, Hilgen G, Dorgau b, Collin J, Ader M, Armstrong L, Sernagor E, Lako M. . Stem Cells 2021, 39(7), 882-896.
    • Djidrovksi I, Georgiou M, Hughes GL, Patterson EI, Casas-Sanchez A, Penington SH, Biagini GA, Moya-Molina M, van den Bor J, Smit MJ, Chung G, Lako M, Armstrong L. . Stem Cells 2021, 39(10), 1310-1321.
    • Armstrong L, Collin J, Mostafa I, Queen R, Figueiredo F, Lako M. . Stem Cells Translational Medicine 2021, 10(7), 976-986.
    • Collin J, Queen R, Darin Zerti D, Bojic S, Dorgau B, Moyse N, Molina MM, Yang C, Dey S, Reynolds G, Hussain R, Coxhead JM, Lisgo S, Henderson D, Joseph A, Rooney P, Ghosh S, Clarke L, Connon CJ, Haniffa M, Figueiredo F, Armstrong L, Lako M. . The Ocular Surface 2021, 21, 279-298.
    • Georgiou M, Chichagova V, Hilgen G, Dorgau B, Sernagor E, Armstrong L, Lako M. . PlosOne 2020, 15(6), e0233860.
    • Bojic S, Falco MM, Stojkovic P, Ljujic B, Gazdic Jankovic M, Armstrong L, Markovic N, Dopazo J, Lako M, Bauer R, Stojkovic M. . Stem Cells 2020, 38(10), 1321-1325.
    • Chichagova V, Hilgen G, Ghareeb A, Gergiou M, Carter M, Sernagor E, Lako M, Armstrong L. . Stem Cells 2020, 38(2), 195-201.
    • Cerniauskas E, Kurzawa-Akanbi M, Xie L, Hallam D, Moya-Molina M, White K, Steel D, Doherty M, Whitfield P, Al-Aama J, Armstrong L, Kavanagh D, Lambris J, Korolchuk V, Harris C, Lako M. . Stem Cells Translational Medicine 2020, 9(12), 1585-1603.
    • Collin J, Queen R, Zerti D, Dorgau B, Georgiou M, Djidrovski I, Hussain R, Coxhead JM, Joseph A, Rooney P, Lisgo S, Figueiredo FC, Armstrong L, Lako M. . The Ocular Surface 2020, 19, 190-200.
    • Atwal M, Swan RL, Rowe C, Lee KC, Lee DC, Armstrong L, Cowell IG, Austin CA. . Molecular Pharmacology 2019, 96(4), 475-484.
    • Alsaeedi F, Wilson R, Candlish C, Ibrahim I, Leitch AC, Abdelghany TM, Wilson C, Armstrong L, Wright MC. . PloS One 2019, 14(6), e0218135.
    • Chichagova V, Dorgau B, Felemban M, Georgiou M, Armstrong L, Lako M. . Current Protocols in Stem Cell Biology 2019, 50(1), e95.
    • Collin J, Zerti D, Queen R, SantoFerreira T, Bauer R, Coxhead J, Hussain R, Steel D, Mellough C, Ader M, Sernagor E, Armstrong L, Lako M. . Stem Cells (Durham) 2019, 37(5), 609-622.
    • Volpato V, Smith J, Sandor C, Ried JS, Baud A, Handel A, Newey SE, Wessely F, Attar M, Whiteley E, Chintawar S, Verheyen A, Barta T, Lako M, Armstrong L, Muschet C, Artati A, Cusulin C, Christensen K, Patsch C, Sharma E, Nicod J, Brownjohn P, Stubbs V, Heywood WE, Gissen P, De Filippis R, Janssen K, Reinhardt P, Adamski J, Royaux I, Peeters PJ, Terstappen GC, Graf M, Livesey FJ, Akerman CJ, Mills K, Bowden R, Nicholson G, Webber C, Cader MZ, Lakics V. . Stem Cell Reports 2018, 11(4), 897-911.
    • Sanchis DM, Xu Y, Taheem D, Yu M, Tilgner K, Barta T, Gassner K, Anyfanftis G, Wan T, Elango R, Alharthi S, Elharouni AA, Pryzborski S, Adam S, Saretzki G, Samarasinghe S, Armstrong L, Lako M. . Cell Death & Disease 2018, 9, 128.
    • Hallam D, Rawlings D, Steel D, Armstrong L, Lako M. . Stem Cells 2018, 36(4), 627-629.
    • Hallam D, Hilgen G, Dorgau B, Zhu L, Yu M, Bojic S, Hewitt P, Schmitt M, Uteng M, Kustermann S, STEEL D, Nicholds M, Thomas R, Treumann A, Porter A, Sernagor E, Armstrong L, Lako M. . Stem Cells 2018, 36(10), 1501-1513.
    • Jeong M, O'Reilly M, Kirkwood NK, Alaama J, Lako M, Kross J, Armstrong L. . Cell Death & Disease 2018, 9, 922.
    • Neganova I, Cotts L, Banks P, Gassner K, Armstrong L, Ladds G, Lako M. . Stem Cells 2018, 37(3), 318-331.
    • Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein V, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Pryzborski S, Zwolinski S, Alharthi S, Al-Aama J, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali R, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Luehrmann R, Grellscheid SN, Johnson CA, Lako M. . Nature Communications 2018, 9, 4234.
    • Kamarudin TA, Bojic S, Collin J, Yu M, Alharthi S, Buck H, Shortt A, Armstrong L, Figueiredo FC, Lako M. . Stem Cells 2018, 36(3), 337-348.
    • Wilmes A, Rauch C, Carta G, Kern G, Meier F, Posch W, Wilflingseder D, Armstrong L, Lako M, Beilmann M, Gstraunthaler G, Jennings P. . Toxicology in Vitro 2017, 45(3), 445-454.
    • De Sousa PA, Steeg R, Wachter E, Bruce K, King J, Hoeve M, Khadun S, McConnachie G, Holder J, Kurtz A, Seltmann S, Dewender J, Reimann S, Stacey G, O'Shea O, Chapman C, Healy L, Zimmermann H, Bolton B, Rawat T, Atkin I, Veiga A, Kuebler B, Serano BM, Saric T, Hescheler J, Brustle O, Peitz M, Thiele C, Geijsen N, Holst B, Clausen C, Lako M, Armstrong L, Gupta SK, Kvist AJ, Hicks R, Jonebring A, Brolen G, Ebneth A, Cabrera-Socorro A, Foerch P, Geraerts M, Stummann TC, Harmon S, George C, Streeter I, Clarke L, Parkinson H, Harrison PW, Faulconbridge A, Cherubin L, Burdett T, Trigueros C, Patel MJ, Lucas C, Hardy B, Predan R, Dokler J, Brajnik M, Keminer O, Pless O, Gribbon P, Claussen C, Ringwald A, Kreisel B, Courtney A, Allsopp TE. . Stem Cell Research 2017, 20, 105-114.
    • Baud A, Wessely F, Mazzacuva F, McCormick J, Camuzeaux S, Heywood WE, Little D, Vowles J, Tuefferd M, Mosaku O, Lako M, Armstrong L, Webber C, Cader MZ, Peeters P, Gissen P, Cowley SA, Mills K. . Analytical Chemistry 2017, 89(4), 2440-2448.
    • Yang C, Xu Y, Yu M, Lee D, Alharti S, Hellen N, Shaik NA, Banaganapalli B, Mohamoud H, Elango R, Przyborski S, Tenin G, Williams S, O'Sullivan J, Al-Radi OO, Atta J, Harding S, Keavney B, Lako M, Armstrong L. . Human Molecular Genetics 2017, 26(16), 3031-3045.
    • Chichagova V, Hallam D, Collin J, Buskin A, Saretzki G, Armstrong L, Yu-Wai-Man P, Lako M, Steel DH. . Scientific Reports 2017, 7, 12320.
    • Meader E, Barta T, Melguzo SD, Tilgner K, Montaner D, ElHarouni A, Armstrong L, Lako M. . Stem Cells (Durham) 2017, 36(1), 55–64.
    • Hallam D, Collin j, Bojic S, Chichagova V, Buskin A, Xu Y, Lafage L, Otten EG, Anyfantis G, Mellough C, Przyboski S, Alhart S, Korolchuk V, Lotery A, Saretzki G, McKibbin M, Armstrong L, Steel D, Kavanagh D, Lako M. . Stem Cells 2017, 35(11), 2305-2320.
    • Neganova I, Chichagova V, Armstrong L, Lako M. . Scientific Reports 2017, 7, 41693.
    • Zhu L, Gomez-Duran A, Saretzki G, Jin S, Tilgner K, Melguzo-Sanchis D, Anyfantis G, Al-Aama J, Vallier L, Chinnery P, Lako M, Armstrong L. . Journal of Cell Biology 2016, 215(2), 187-202.
    • Neganova A, Shmeleva E, Munkley J, Chichagova V, Anyfantis G, Anderson R, Passos AJ, Elliott DJ, Armstrong L, Lako M. . Stem Cells 2016, 34(5), 1198-1212.
    • Barta T, Peskova L, Collin J, Montaner D, Neganova I, Armstrong L, Lako M. . Stem Cells 2016, 34(1), 246-251.
    • Nurkovic J, Volarevic V, Lako M, Armstrong L, Arsenijevic N, Stojkovic M. . Rejuvenation Research 2016, 19(1), 3-12.
    • Jin S, Collin J, Zhu L, Montaner D, Armstrong L, Neganova I, Lako M. . Stem Cells 2016, 34(9), 2306-2317.
    • Chichagova V, Sanchez-Vera I, Armstrong L, Steel D, Lako M. . Methods in Molecular Biology 2015, 1353, 285-307.
    • Yang C, Al-Aama J, Stojkovic M, Keavney B, Trafford A, Lako M, Armstrong L. . Stem Cells 2015, 33(9), 2643-2651.
    • Jiang Y, Habibollah S, Tilgner K, Collin J, Barta T, Al-Aama JY, Tesarov L, Hussain R, Trafford AW, Kirkwood G, Sernagor E, Eleftheriou CG, Przyborski S, Stojkovic M, Lako M, Keavney B, Armstrong L. . Stem Cells Translational Medicine 2014, 3(4), 416-423.
    • Yung SK, Tilgner K, Ledran MH, Habibollah S, Neganova I, Singhapol C, Saretzki G, Stojkovic M, Armstrong L, Przyborski S, Lako M. . Stem Cells 2013, 31(5), 1022-1029.
    • Tilgner K, Neganova I, Singhapol C, Saretzki G, Al-Aama JY, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M. . Stem Cells 2013, 31(9), 2015-2023.
    • Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco O, Cates J, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R. . European Urology 2013, 64(5), 753-761.
    • Tilgner K, Neganova I, Moreno-Gimeno I, Al-Aama JY, Burks D, Yung S, Singhapol C, Saretzki G, Evans J, Gorbunova V, Gennery A, Pryzborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M. . Cell Death and Differentiation 2013, 20, 1089-1100.
    • Armstrong L. . Stem Cell Reviews and Reports 2012, 8(1), 67-77.
    • Jiang Y, Cowley SA, Siler U, Melguizo D, Tilgner K, Browne C, Dewilton A, Przyborski S, Saretzki G, James WS, Seger RA, Reichenbach J, Lako M, Armstrong L. . Stem Cells 2012, 30(4), 599-611.
    • Atkinson SP, Collin J, Irina N, Anyfantis G, Kyung BK, Lako M, Armstrong L. . Stem Cells 2012, 30(7), 1373-1384.
    • Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q, International Stem Cell Initiative. . Nature Biotechnology 2011, 29(12), 1132–1144.
    • Yung S, Ledran M, Moreno-Gimeno I, Conesa A, Montaner D, Dopazo J, Dimmick I, Slater NJ, Marenah L, Real PJ, Paraskevopoulou I, Bisbal V, Burks D, Santibanez-Koref M, Moreno R, Mountford J, Menendez P, Armstrong L, Lako M. . Human Molecular Genetics 2011, 20(24), 4932-4946.
    • Neganova I, Vilella F, Atkinson SP, Lloret M, Passos JF, von Zglinicki T, O'Connor JE, Burks D, Jones R, Armstrong L, Lako M. . Stem Cells 2011, 29(4), 651-659.
    • Yang CB, Atkinson SP, Vilella F, Lloret M, Armstrong L, Mann DA, Lako M. . Stem Cells 2010, 28(11), 1970-1980.
    • Armstrong L, Tilgner K, Saretzki G, Atkinson SP, Stojkovic M, Moreno R, Przyborski S, Lako M. . Stem Cells 2010, 28(4), 661-673.
    • Tilgner K, Atkinson SP, Yung S, Golebiewska A, Stojkovic M, Moreno R, Lako M, Armstrong L. . Stem Cells 2010, 28(1), 84-92.
    • Golebiewska A, Atkinson SP, Lako M, Armstrong L. . Stem Cells 2009, 27(6), 1298-1308.
    • Zhang X, Neganova I, Przyborski S, Yang CB, Cooke M, Atkinson SP, Anyfantis G, Fenyk S, Keith WN, Hoare SF, Hughes O, Strachan T, Stojkovic M, Hinds PW, Armstrong L, Lako M. . Journal of Cell Biology 2009, 184(1), 67-82.
    • Stewart R, Yang C, Anyfantis G, Przyborski S, Hole N, Strachan T, Stojkovic M, Keith WN, Armstrong L, Lako M. . Regenerative Medicine 2008, 3(4), 505-522.
    • Gorelik J, Ali NN, Kadir SHSA, Lab M, Stojkovic P, Armstrong L, Sviderskaya EV, Negulyaev YA, Klenerman D, Bennett DC, Lako M, Harding SE, Stojkovic M, Korchev YE. . Tissue Engineering Part C: Methods 2008, 14(4), 311-318.
    • Tilgner K, Atkinson SP, Golebiewska A, Stojkovic M, Lako M, Armstrong L. . Stem Cells 2008, 26(12), 3075-3085.
    • Atkinson SP, Koch CM, Clelland GK, Willcox S, Fowler JC, Stewart R, Lako M, Dunham I, Armstrong L. . Stem Cells 2008, 26(5), 1174-1185.
    • Ledran MH, Krassowska A, Armstrong L, Dimmick I, Renstrom J, Lang R, Yung S, Santibanez-Coref M, Dzierzak E, Stojkovic M, Oostendorp RAJ, Forrester L, Lako M. . Cell Stem Cell 2008, 3(1), 85-98.
    • Saretzki G, Walter T, Atkinson S, Passos JF, Bareth B, Keith WN, Stewart R, Hoare S, Stojkovic M, Armstrong L, Von Zglinicki T, Lako M. . Stem Cells 2008, 26(2), 455-464.
    • Maimets T, Neganova I, Armstrong L, Lako M. . Oncogene 2008, 27(40), 5277-5287.
    • Ahmad S, Kolli S, Li DQ, de Paiva CS, Pryzborski S, Dimmick I, Armstrong L, Figueiredo FC, Lako M. . Stem Cells 2008, 26(6), 1609-1619.
    • Yang C, Przyborski S, Cooke MJ, Zhang X, Stewart R, Anyfantis G, Atkinson SP, Saretzki GC, Armstrong L, Lako M. . Stem Cells 2008, 26(4), 850-863.
    • Ahmad S, Stewart R, Yung S, Kolli S, Armstrong L, Stojkovic M, Figueiredo F, Lako M. . Stem Cells 2007, 25(5), 1145-1155.
    • Armstrong L, Hughes O, Yung S, Hyslop L, Stewart R, Wappler I, Peters H, Walter T, Stojkovic P, Evans J, Stojkovic M, Lako M. . Human Molecular Genetics 2006, 15(11), 1894-1913.
    • Zhang X, Stojkovic P, Przyborski S, Cooke M, Armstrong L, Lako M, Stojkovic M. . Stem Cells 2006, 24(12), 2669-2676.
    • Ahmad S, Armstrong L, Stojkovic M, Dimmick I, Hyslop LA, Stojkovic P, Strachan T, Figueiredo FC, Lako M. . Stem Cells 2005. In Press.
    • Armstrong L, Saretzki G, Peters H, Wappler I, Evans J, Hole N, Von Zglinicki T, Lako M. . Stem Cells 2005, 23(4), 516-529.
    • Stojkovic P, Lako M, Przyborski S, Stewart R, Armstrong L, Evans J, Zhang X, Stojkovic M. . Stem Cells 2005, 23(7), 895-902.
    • Stojkovic P, Lako M, Armstrong L, Stojkovic M. . Medicus 2005, 6(1), 6-10.
    • Hyslop L, Stojkovic M, Armstrong L, Walter T, Stojkovic P, Przyborski S, Herbert M, Murdoch A, Strachan T, Lako M. . Stem Cells 2005, 23(8), 1035-1043.
    • Stojkovic M, Stojkovic P, Leary C, Hall VJ, Armstrong L, Herbert M, Nesbitt M, Lako M, Murdoch A. . Reproductive BioMedicine Online 2005, 11(2), 226-231.
    • Stojkovic P, Lako M, Stewart R, Przyborski S, Armstrong L, Evans J, Herbert M, Hyslop L, Ahmad S, Murdoch A, Strachan T, Stojkovic M. . Stem Cells 2005, 23(3), 306-314.
    • Stojkovic P, Lako M, Stewart R, Przyborski S, Armstrong L, Evans J, Murdoch A, Strachan T, Stojkovic M. . Stem Cells 2005, 23(3), 306-314.
    • Armstrong L, Saretzki G, Peters H, Wappler I, Evans J, Hole N, von Zglinicki T, Lako M. “Overexpression of Tert results in enhanced proliferation of murine ES cells, protection from oxidative stress and commitment to haematopoietic lineages”. Stem Cells 2005, 23(4), 516-529.
    • Saretzki G, Armstrong L, Leake A, Lako M, Von Zglinicki T. . Stem Cells 2004, 22(6), 962-971.
    • Armstrong L, Stojkovic M, Dimmick I, Ahmad S, Stojkovic P, Hole N, Lako M. . Stem Cells 2004, 22(7), 1142-1151.
    • Stojkovic M, Lako M, Stojkovic P, Stewart R, Przyborski S, Armstrong L, Evans J, Herbert M, Hyslop L, Ahmad S, Murdoch A, Strachan T. . Stem Cells 2004, 22(5), 790-797.
    • Armstrong L, Lako M, van Herpe I, Evans J, Saretzki G, Hole N. . Mechanisms of Development 2004, 121(12), 1509-1522.
    • Lako M, Armstrong L, Cairns PM, Harris S, Hole N, Jahoda C. . Journal of Cell Science 2002, 115(20), 3967-3974.
    • Lako M, Lindsay S, Lincoln J, Cairns PM, Armstrong L, Hole N. . Mechanisms of Development 2001, 103(1-2), 49-59.
    • Armstrong L, Lako M, Lincoln J, Cairns PM, Hole N. . Mechanics of Development 2000, 97(1-2), 109-116.
    • James AL, Chilvers KF, Perry JD, Armstrong L, Gould FK. . Applied and Environmental Microbiology 2000, 66(12), 5521-5523.

  • Conference Proceedings (inc. Abstracts)

    • Siler U, Jiang Y, Cowley SA, Melguzo D, Tilgner K, Browne C, Dewilton A, Pryzborski S, Saretzki G, James WS, Seger RA, Reichenbach J, Lako M, Armstrong L. . In: 15th Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT). 2012, Philadelphia, Pennsylvania, USA: Nature Publishing Group.
    • Siler U, Jiang Y, Cowley SA, Melguzo D, Tilgner K, Browne C, deWilton A, Pryzborski S, Saretzki G, James WS, Seger RA, Reichenbach J, Lako M, Armstrong L. . In: 15th Biennial Meeting European Society for Immunodeficiency (ESID). 2012, Florence, Italy: Springer.
    • Wanisch K, Boza-Moran MG, Tilgner K, Yang C, Neganova I, Armstrong L, Lako M, Tizzano E, Yanez-Munoz RJ. . In: Human Gene Therapy: 7th Annual Conference of the British Society for Gene Therapy. 2010, Royal Holloway University London, Egham, UK: Mary Ann Liebert, Inc. Publishers.
    • Armstrong L. . In: Summer Meeting of the Anatomical Society of Great Britain and Ireland. 2008, University of Durham, UK: Journal of Anatomy: Wiley-Blackwell.
    • Campbell SC, Ferris WF, Armstrong L, Hole N, Lako M, Macfarlane WM. . In: Journal of Gene Medicine: 1st Annual Conference of the British Society for Gene Therapy. 2004, Oxford, UK: John Wiley & Sons, Inc.
    • Lako M, Lindsay S, Cairns PM, Lincoln J, Armstrong L, Hole N. Involvement of Wnt genes in early haematopoiesis and identification of Wnt3 as a regulator of haematopoietic commitment. In: BLOOD. 2000.

  • Editorials

    • Armstrong L, Lako M. . Frontiers in Cell and Developmental Biology 2023, 11, 1298956.
    • Lako M, Armstrong L. . Blood 2014, 124(20), 3035-3036.
    • Armstrong L, Lako M, Buckley N, Lappin TRJ, Murphy MJ, Nolta JA, Pittenger M, Stojkovic M. . Stem Cells 2012, 30(1), 2-9.
    • Armstrong L. . Stem Cells 2010, 28(4), 635-635.
    • Lako M, Armstrong L, Stojkovic M. . Stem Cells 2010, 28(5), 845-850.
    • Lako M, Neganova I, Armstrong L. . Cell Cycle 2009, 8(8), 1108-1109.

  • Letter

    • St John JC, Armstrong L, Minger SL, Campbell KHS. . Nature 2008, 451(7179), 627-627.

  • Reviews

    • Zerti D, Dorgau B, Sernagor E, Armstrong L, Lako M, Hilgen G. . FEBS Journal 2025, 292(21), 5567-5579.
    • Kurzawa-Akanbi M, Tzoumas N, Corral-Serrano JC, Guarascio R, Steel D, Cheetham ME, Armstrong L, Lako M. . Progress in Retinal and Eye Research 2024, 100, 101248.
    • Yang C, Georgiou M, Atkinson R, Collin J, Al-Aama J, Nagaraja-Grellscheid S, Johnson C, Ali R, Armstrong L, Mozaffari-Jovin S, Lako M. . Frontiers in Cell and Developmental Biology 2021, 9, 700276.
    • Volarevic V, Markovic BS, Gazdic M, Volarevic A, Jovicic N, Arsenijevic N, Armstrong L, Djonov V, Lako M, Stojkovic M. . International Journal of Medical Sciences 2018, 15(1), 36-45.
    • Adam S, Melguzo Sanchis D, El-Kamah D, Samarasinghe S, Alharti S, Armstrong L, Lako M. . Stem Cells 2017, 35(2), 284-298.
    • Nikolic A, Volarevic V, Armstrong L, Lako M, Stojkovic M. . Stem Cells International 2016.
    • Armstrong L, Al-Aama J, Stojkovic M, Lako M. . Stem Cells 2014, 32(9), 2291-2298.
    • Atkinson SP, Lako M, Armstrong L. . British Journal of Pharmacology 2013, 169(2), 269-289.
    • Tilgner K, Armstrong L, Lako M. . Serbian Journal of Experimental and Clinical Research 2010, 11(1), 3-5.
    • Atkinson S, Armstrong L. . Cell and Tissue Research 2008, 331(1), 23-29.
    • Armstrong L, Lako M. . Stem Cell Reviews 2006, 2(4), 351-358.
    • Armstrong L, Lako M, Dean W, Stojkovic M. . Stem Cells 2006, 24(4), 805-814.
    • Hyslop LA, Armstrong L, Stojkovic M, Lako M. . Expert Reviews in Molecular Medicine 2005, 7(19), 1-21.