缅北禁地

Background

Melvin is a Biostatistician at the Translational and Clinical Research Institute. His research integrates advanced statistical methods and machine learning techniques to address critical questions in Leukaemia and Clinical Epidemiology.

He works closely with multidisciplinary teams, contributing to the entire research lifecycle from study design and advanced analytics to supporting grant writing, student supervision, publication, and collaborative problem-solving. Prior to joining 缅北禁地, he led and supported large-scale cancer and public health research initiatives in India.

Current Position

• 2022 - Present: Research Assistant - Statistics | Leukaemia Research Cytogenomics Group | Centre for Cancer | 缅北禁地

Previous Positions

• 2019 - 2022: Associate Research Officer (Biostatistics) | Department of Biostatistics | Christian Medical College, Vellore, India
• 2018 - 2019: Statistician | St. John’s Research Institute | Bangalore, India
• 2017 - 2018: Biostatistician Trainee | PSG Institute of Medical Sciences & Research | Coimbatore, India

Education and Qualifications

Master of Science. Biostatistics

St. Thomas College, Palai, Kerala, India

(Affiliation: Mahatma Gandhi University, Kerala, India)

Professional Memberships

• Royal Statistical Society (RSS)
• American Statistical Association (ASA)
• National Institute for Health and Care Research (NIHR) Statistics Group
• Indian Society for Medical Statistics (ISMS)
• Indian Association for Statistics in Clinical Trials (IASCT)

Manuscript Peer Review

Journals: Nature Communications, BMJ Public Health, Leukemia Research, Dialogues in Health, Indian Journal of Medical Research

Research Profiles

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Research Focus

Melvin's work specialises in the development and validation of prognostic models and risk stratification algorithms. By integrating complex clinical, genomic, and biomarker data, this research directly informs personalised therapy decisions and contributes to the development of precision medicine for leukaemia patients.

Methodological Expertise

His methodological expertise includes clinical trial analysis, survival analysis, longitudinal data modelling, and the integration of statistical and machine learning techniques for analysing high-dimensional biomedical data. He is proficient with a range of analytical tools, including Stata, R, SAS and SPSS, and also has experience using spatial/GIS tools.

Research Interests

• Clinical Trial Analysis
• Survival Analysis
• Prognostic Modelling and Risk Prediction
• Longitudinal Data Analysis
• Integration of Statistical and Machine Learning Methods
• Translational Cancer Research & Precision Medicine

Research Projects

Current Research Projects

• (Funded by Cancer Research UK).
• - A treatment study protocol of the ALLTogether consortium for children and young adults (0-45 years of age) with newly diagnosed acute lymphoblastic leukaemia (ALL) (Sponsor: Karolinska University Hospital, Sweden).

Completed Research Projects (2022-2025)

• Evaluating integrated and multi-biomarker driven risk stratification in paediatric acute lymphoblastic leukaemia (Funded by Cancer Research UK).

Completed Research Projects in India (2017-2022)

• Induction related mortality score in acute myeloid leukaemia: Prospective validation study (Hematology Cancer Consortium, India).
• Evaluation of the safety and efficacy of generic low-dose Dasatinib for frontline therapy in chronic phase chronic myeloid leukaemia - A multi-centre phase II single arm study (Hematology Cancer Consortium, India).
• Cytogenetic and clinicopathological features of myelodysplastic syndrome (Christian Medical College, Vellore, India).
• Estimating the burden of paediatric HIV in an "A" category district in India: Cohort study of children exposed to maternal HIV - phase 2 (Funded by Indian Council of Medical Research).
• Tea consumption and diabetes management (PSG Institute of Medical Sciences & Research, India).

Selected Conference Presentations & Invited Talks

• "Genetic determinants of relapse and survival in childhood and young adult B-cell precursor ALL" – NUTCRI Live 2025 Conference, 缅北禁地. December 2025.
• "Cytogenetic landscape and outcome in childhood B-Cell precursor ALL: Insights from UKALL2003 and UKALL2011 Trials" – NUCancer Conference, 缅北禁地. June 2025.
• "De-intensifying post-induction therapy for patients with acute lymphoblastic leukaemia, good risk genetics and intermediate MRD at the end of induction" – 21^st Annual Meeting of the Childhood Leukaemia Research UK (CLR-UK), University of Cambridge. September 2024.
• "Numbers to knowledge: A statistician's guide to research, careers, and data resources" – Invited Talk, Department of Biostatistics, St. Thomas College, Palai, India. December 2023.
• "A robust and validated prognostic index to assign post-induction therapy in adult acute lymphoblastic leukaemia" – NUTCRI Live 2023 Conference, 缅北禁地. June 2023.
• "Potential effect of BCG on COVID-19 mortality: A meta regression approach on global data" – 38^th Annual Conference of the Indian Society for Medical Statistics (ISMSCON-2020). December 2020.
• "Consumption of tea and its impact on diabetes profile" – International Conference on Recent Advances in Statistical Methodology with Applications in Clinical and Official Statistics, St. Thomas College, Palai, India. January 2018.

Student Supervision

MRes: Supervised seven master's students between 2022 - present

BSc: Supervised six undergraduate students between 2022 - present

• Articles

  • Mani T, Sappani M, Joy M, Garg C, Jeyaseelan V, Babu M, Arunachalam R, Durairaj J, Prithishkumar IJ, George S, Asirvatham ES, Sudarsanam TD, Jeyaseelan L. . PLoS One 2025, 20(12), e0336252.
  • Raj JP, Mani T, Joy M, Pandit S, Godbole C, Bendkhale S, Soni D, Lakshmanan J, Gogtay NJ. . BMC Public Health 2025, 25, 4369.
  • Babu M, Sappani M, Joy M, Chandiraseharan VK, Jeyaseelan L, Sudarsanam TD. . Journal of Postgraduate Medicine 2024, 70(4), 209-216.
  • Srivastava VM, Nair SC, Joy M, Manipadam M-T, Kulkarni UP, Devasia AJ, Fouzia NA, Korula A, Lakshmi KM, Jeyaseelan L, Abraham A, Srivastava A. . Molecular Cytogenetics 2024, 17, 21.
  • Mani T, Babu M, Mohanraj R, Kumar S, Joy M, Sappani M, Viswanathan S, Bangdiwala SI, Jeyaseelan L. . Asian Pacific Journal of Health Sciences 2024, 11(2), 5-12.
  • Prithishkumar IJ, Sappani M, Ranjan V, Garg C, Mani T, Babu M, Joy M, Rao B, Asirvatham ES, Lakshmanan J. . PLoS ONE 2024, 19(6), e0304776.
  • Enshaei A, Joy M, Butler E, Kirkwood AA, Messina M, Pavoni C, Morgades M, Harrison CJ, Foa R, Ribera J-M, Chiaretti S, Bassan R, Fielding AK, Moorman AV. . Blood Advances 2024, 8(5), 1155-1166.
  • Sappani M, Mani T, Asirvatham ES, Joy M, Babu M, Jeyaseelan L. . PLoS ONE 2023, 18(6), e0286464.
  • George TK, Sharma P, Joy M, Seelan G, Sekar A, Gunasekaran K, Abhilash KPP, George T, Rajan SJ, Hansdak SG. . Dialogues in Health 2023, 2, 100139.
  • Joy M, Mani T, Jeyaseelan L, Babu M, S M, Kumar S, Mohanraj R, Viswanathan S, Bangdiwala SI. . International Journal of Injury Control and Safety Promotion 2023, 30(3), 352-361.
  • John KJ, George TK, Joy M, John B, Abraham OC, Prasad J. . Indian Journal of Medical Research 2023, 157(6), 559-567.
  • Kundavaram APP, Selvan S, Raja V, Mathiyalagan P, Kanagarajan R, Reddy NP, Rajendiran N, Hazra D, Gunasekaran K, Moorthy M, Lenin A, Mathew D, Iyyadurai R, Varghese GM, Dj C, Joy M, Peter JV. . BMJ Open 2022, 12(11), e062724.
  • Marimuthu S, Thenmozhi M, Joy M, Babu M, Sudarsanam TD, Jeyaseelan L. . Indian Journal of Applied Research 2022, 12(10), 51-55.
  • Abhilash KPP, Mathiyalagan P, Krishnaraj VRK, Selvan S, Kanagarajan R, Reddy NP, Rajendiran N, Hazra D, Gunasekaran K, Moorthy M, Jasmine S, Davis JP, George T, George K, Varghese GM, Rupali P, Barney Isaac TJ, Gupta R, Pichamuthu K, Joy M, Jayaseelan L, Mathews P, Peter JV. . Vaccine 2022, 40(13), 2107-2113.
  • Thomas M, Chiramel M, Priyanka M, Singh M, Ponraj L, Devakumar K, Balan F, Joseph A, Joy M, Jeyaseelan L, George R. . Journal of the International Society for Telemedicine and EHealth 2022, 10(e2), 1-9.
  • Joselyn A, Suhag K, Joy M, Jeyaseelan L. . Journal of Anaesthesiology Clinical Pharmacology 2022, 38(3), 474-479.
  • S M, Mani T, Joy M, Babu M, Jeyaseelan L. . Journal of Applied Statistics and Machine Learning 2022, 1(2), 117-126.
  • Marimuthu S, Mani T, Joy M, Jeyaseelan L. . Advances in Neurology and Neuroscience 2022, 5(3), 130-137.
  • Marimuthu S, Joy M, Malavika B, Nadaraj A, Asirvatham ES, Jeyaseelan L. . Clinical Epidemiology and Global Health 2021, 9, 57-61.
  • Christal Vimala TJ, Martin R, Rao AS, Joy M. . CHRISMED Journal of Health and Research 2021, 8(1), 29-34.
  • Joy M, Malavika B, Asirvatham ES, Sudarsanam TD, Jeyaseelan L. . Clinical Epidemiology and Global Health 2021, 9, 202-203.
  • Malavika B, Marimuthu S, Joy M, Nadaraj A, Asirvatham ES, Jeyaseelan L. . Clinical Epidemiology and Global Health 2021, 9, 26-33.
  • Mammen JJ, Kumar S, Thomas L, Kumar G, Zachariah A, Jeyaseelan L, Peter JV, Agarwal A, Mukherjee A, Chatterjee P, Bhatnagar T, Rasalam JE, Chacko B, Mani T, Joy M, Rupali P, Murugesan M, Daniel D, Latha B, Bundas S, Kumar V, Dosi R, Khambholja JR, De Souza R, Chander BT, Bahadur S, Dube S, Suri A, Jindal A, Shrivastav O, Barge V, Bajpayee A, Malhotra P, Singh N, Tambe M, Sharma N, Bhat S, Kaulgud RS, Gurtoo A, Reddy DH, Upadhyay K, Jain A, Patel TC, Nagori I, Jha PR, Babu KVS, Aparna C, Panjwani SJ, Natarajan M, Baldi M, Khadke VK, Dua S, Singh R, Sharma A, Sharma J, Gokhale YA, Yadav PD, Sapkal G, Kaushal H, Kumar VS. . BMJ Open 2021, 11(10), e050571.
  • Christal Vimala TJ, Martin R, Rao AS, Joy M. . Indian Journal of Continuing Nursing Education 2021, 22(2), 200-206.
  • Mariappan R, Cherian VT, Joy M, Selvaraj KG. . The Indian Anaesthetists’ Forum 2021, 22(1), 67-72.
  • Pillai R, Nair BR, Prabhakar PK, Singh G, Lionel KR, Moorthy RK, Joy M, Mariappan R. . Indian Journal of Pain 2020, 34(3), 175-182.
  • Meenakshisundaram R, Senthilkumaran S, Thirumalaikolundusubramanian P, Joy M, Jena NN, Vadivelu R, Ayyasamy S, Chandrasekaran VP. . Mayo Clinic Proceedings: Innovations, Quality & Outcomes 2020, 4(5), 506-510.
  • Thomas AS, Moorthy RK, Raju K, Lakshmanan J, Joy M, Mariappan R. . Indian Journal of Anaesthesia 2020, 64(7), 631-636.
  • Asirvatham ES, Lakshmanan J, Sarman CJ, Joy M. . Journal of Infection in Developing Countries 2020, 14(10), 1128-1135.
  • Mathew AC, Benny JK, Philip DM, Dhanya C, Joy M, Sandhiya V, Ramesh S, Neelakandan K. . Nepal Journal of Epidemiology 2019, 9(3), 772-780.
  • George S, Joy M. . Asian Journal of Pharmaceutical and Clinical Research 2019, 12(3), 430-432.
  • Mathew AC, Joy M, Kishan S, Kavitha V, Senthil Kumar R, Yunsheng M. . Asian Pacific Journal of Health Sciences 2017, 4(3), 83-87.
  • Mathew AC, Kishan S, Joy M, Darshan Manoj S, Amirthvarshan A, Senthil Kumar R. . International Journal of Advances in Medicine 2017, 4(5), 1473-1476.

• Conference Proceedings (inc. Abstracts)

  • Gulbey O, Delft FV, Enshaei A, Joy M, Kirkwood AA, Moppett J, Samarasinghe S, Vora A, Moorman AV. . In: EHA2024 Hybrid Congress. 2024, Madrid: Wiley.
  • Moorman A, Joy M, Enshaei A, Kirkwood AA, Harrison C, Schwab C, Goulden N, Moppett J, Samarasinghe S, Hough R, Rowntree C, Lawson S, Kearns P, Mee J, Vora A. . In: EHA2024 Hybrid Congress. 2024, Madrid: Wiley.
  • Selvin Sundar Raj M, Lalwani M, Alam R, Valson AT, Athul T, Eapen JJ, John EE, Yusuf S, Vc A, Joy M, Alexander S, Varughese S, David VG. . In: The International Society of Nephrology's (ISN) World Congress of Nephrology (WCN) 2021. 2021, Montreal, Canada: Elsevier Inc.
  • Kumar S, Nagasubramanian S, Jacob Philip George A, Thampi John N, Devasia A, Joy M. . In: European Association of Urology Congress (EAU21). 2021, Virtual: Elsevier BV.

• Letters

  • Moorman AV, Enshaei A, Murdy D, Joy M, Boer JM, den Boer ML, Pieters R, de Haas V, Horstmann MA, Escherich G, Johansson B, Marquart HV, Schmiegelow K, Hancock J, Moppett J, Heyman M. . Leukemia 2024, 38, 2023-2026.
  • Connor DO, Joy M, Enshaei A, Kirkwood A, Kearns PR, Samarasinghe S, Moppett J, Moorman AV, Vora A. . Blood Advances 2023, 7(23), 7231-7234.