缅北禁地

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Staff Profile

Dr Richard Gallon

Senior Research Associate

Background

Research Associate, 缅北禁地 Translational and Clinical Research Institute.

Board Member of the Care for CMMRD consortium.

Scientific Board Member for the Prospective Lynch Syndrome Database.

Conference Organisation Committee Member for the European Hereditary Tumour Group.

Co-founder of the UK Replication Repair Deficiency National Advisory Panel.

Research

My research aims to improve the diagnosis and care of people with cancer predisposition syndromes caused by mismatch repair deficiency: Lynch syndrome and Constitutional Mismatch Repair Deficiency (CMMRD) syndrome.


Highlights

  • clinical deployment of a sequencing-based microsatellite instability assay into NHS England Genomic Laboratory Hubs
  • commercialisation of the above microsatellite instability assay, in collaboration with 缅北禁地 upon Tyne Hospitals NHS Foundation Trust
  • ongoing development of urine microsatellite instability analysis for Lynch syndrome urothelial cancer surveillance
  • exploration of genotype-phenotype correlations in CMMRD
  • immunology-related cancer risk factors in Lynch syndrome, including HLA type and colorectal immune infiltrate
  • landmark study proposing three pathways of colorectal tumorigenesis in Lynch syndrome


Clinical guidelines

  • EMQN microsatellite instability analysis best practice
  • ERN GENTURIS CMMRD diagnosis and management


Grants

  • Predi-Lynch consortium member, EU Horizon Mission Cancer award, 13th Dec 2024. 800,000 euros contract.
  • Lead applicant, North Eastern Skin Research Fund, 6th September 2024. £10,000.
  • Co-applicant, NHS Small Business Research Initiative award, 20th Oct 2021. £1,800,000.


Patents

  • WO/2021/019197 (published February 4th 2021)
  • GB2114136.1 (filed October 1st 2021)



Teaching

Seminar leader for undergraduate genetics course BGM1004.

Supervisor for undergraduate and postgraduate research projects.

PhD progress assessor, 缅北禁地, Medical University of Innsbruck.

Publications

  • Articles

    • Gallon R, Holt G, Alfailakawi W, Husain A, Jones C, Sowter P, Santibanez-Koref M, Jackson MS, Burn J, Cook S, Rajan N. . Clinical and Experimental Dermatology 2025, 50(6), 1155-1162.
    • Hall R, Gallon R, Hayes C, Herrero-Belmonte P, Phelps R, Job D, Wake R, Ferrier M, Turner H, O'Donnell R, Nambiar A, Rai B, Martin R, McAnulty C, Santibanez-Koref M, Heer R, Jackson MS, Burn J. . eBioMedicine 2025, 121, 105969.
    • Sowter P, Gallon R, Hayes C, Phelps R, Borthwick G, Prior S, Combe J, Buist H, Pearlman R, Hampel H, Goodfellow P, Evans DG, Crosbie EJ, Ryan N, Burn J, Santibanez-Koref M, Jackson MS. . Cancers 2024, 16(23), 3970.
    • Gallon R, Brekelmans C, Martin M, Bours V, Schamschula E, Amberger A, Muleris M, Colas C, Dekervel J, De Hertogh G, Coupier J, Colleye O, Sepulchre E, Burn J, Brems H, Legius E, Wimmer K. . npj Precision Oncology 2024, 8, 119.
    • Gallon R, Herrero-Belmonte P, Phelps R, Hayes C, Sollars E, Egan D, Spiewak H, Nalty S, Mills S, Loo P-S, Borthwick G, Santibanez-Koref M, Burn J, McAnulty C, Jackson MS. . BJC reports 2024, 2(1), 48.
    • Rasmussen M, Sowter P, Gallon R, Durhuus JA, Hayes C, Andersen O, Nilbert M, Schejbel L, Hogdall E, Santibanez-Koref M, Jackson MS, Burn J, Therkildsen C. . Frontiers in Oncology 2023, 13, 1147591.
    • Gallon R, Phelps R, Hayes C, Brugieres L, Guerrini-Rousseau L, Colas C, Muleris M, Ryan NAJ, Evans DG, Grice H, Jessop E, Kunzemann-Martinez A, Marshall L, Schamschula E, Oberhuber K, Azizi AA, Baris Feldman H, Beilken A, Brauer N, Brozou N, Dahan K, Demirsoy U, Florkin B, Foulkes W, Januszkiewicz-Lewandowska D, Jones KJ, Kratz CP, Lobitz S, Meade J, Nathrath M, Pander HJ, Perne C, Ragab I, Ripperger T, Rosenbaum T, Rueda D, Sarosiek T, Sehested A, Spier I, Suerink M, Zimmermann SY, Zschocke J, Borthwick GM, Wimmer K, Burn J, Jackson MS, Santibanez-Koref M. . Gastroenterology 2023, 164(4), 579-592.e8.
    • Bohaumilitzky L, Kluck K, Huneburg R, Gallon R, Nattermann J, Kirchner M, Kristiansen G, Hommerding O, Pfuderer PL, Wagner L, Echterdiek F, Kosegi S, Muller N, Fischer K, Nelius N, Hartog B, Borthwick G, Busch E, Haag GM, Blaker H, Moslein G, von Knebel Doeberitz M, Seppala TT, Ahtiainen M, Mecklin J-P, Bishop DT, Burn J, Stenzinger A, Budczies J, Kloor M, Ahadova A. . Gastroenterology 2022, 162(3), 907-919.e10.
    • Schamschula E, Kinzel M, Wernstedt A, Oberhuber K, Gottschling H, Schnaiter S, Friedrichs N, Merkelbach-Bruse S, Zschocke J, Gallon R, Wimmer K. . Biomolecules 2022, 12(10), 1350.
    • Phelps R, Gallon R, Hayes C, Glover E, Gibson P, Edidi I, Lee T, Mills S, Shaw A, Heer R, Ralte A, McAnulty C, Santibanez-Koref M, Burn J, Jackson MS. . Cancers 2022, 14(15), 3838.
    • Sehested A, Meade J, Scheie D, Østrup O, Bertelsen B, Misiakou MA, Sarosiek T, Kessler E, Melchior LC, Munch-Petersen HF, Pai RK, Schmuth M, Gottschling H, Zschocke J, Gallon R, Wimmer K. . Human Mutation 2022, 43(1), 85-96.
    • Gallon R, Kibbi N, Cook S, Santibanez-Koref M, Jackson MS, Burn J, Rajan N. . British Journal of Dermatology 2021, 185(5), 1045-1046.
    • Gallon R, Sheth H, Hayes C, Redford L, Alhilal G, O'Brien O, Spiewak H, Waltham A, McAnulty C, Izuogu OG, Arends MJ, Oniscu A, Alonso AM, Laguna SM, Borthwick GM, Santibanez-Koref M, Jackson MS, Burn J. . Human Mutation 2020, 41(1), 332-341.
    • Perez-Valencia JA, Gallon R, Chen Y, Koch J, Keller M, Oberhuber K, Gomes A, Zschocke J, Burn J, Jackson MS, Santibanez-Koref M, Messiaen L, Wimmer K. . Genetics in Medicine 2020, 22, 2081-2088.
    • Nakamori M, Panigrahi GB, Lanni S, Gall-Duncan T, Hayakawa H, Tanaka H, Luo J, Otabe T, Li J, Sakata A, Caron MC, Joshi N, Prasolava T, Chiang K, Masson JY, Wold MS, Wang X, Lee MYWT, Huddleston J, Munson KM, Davidson S, Layeghifard M, Edward LM, Gallon R, Santibanez-Koref M, Murata A, Takahashi MP, Eichler EE, Shlien A, Nakatani K, Mochizuki H, Pearson CE. . Nature Genetics 2020, 52(2), 146-159.
    • Gallon R, Müglegger B, Wenzel S-S, Sheth H, Hayes C, Aretz S, Dahan K, Foulkes W, Kratz CP, Ripperger T, Azizi AA, Feldman HB, Chong AL, Demirsoy U, Florkin B, Imschweller T, Januskiewicz-Lewandowska D, Lobitz S, Nathrath M, Pander HJ, Perez-Alanso V, Perne C, Ragab I, Rosenbaum T, Rueda D, Seidel MG, Suerink M, Taeubner J, Zimmermann SY, Zschocke J, Borthwick GM, Burn J, Jackson MS, Santibanez-Koref M, Wimmer K. . Human Mutation 2019, 40(5), 649-655.
    • Ahadova A, Gallon R, Gebert J, Ballhausen A, Endris V, Kirchner M, Stenzinger A, Burn J, von Knebel Doeberitz M, Bläker H, Kloor M. . International Journal of Cancer 2018, 143(1), 139-150.
    • Izuogu O, Alhasan AA, Mellough C, Collin J, Gallon R, Hyslop J, Mastrorosa FK, Ehrmann I, Lako M, Elliott DJ, Santibanez-Koref M, Jackson MS. . BMC Genomics 2018, 19(1), 276.
    • Redford L, Alhilal G, Needham S, O'Brien O, Coaker J, Tyson J, Amorim LM, Middleton I, Izuogu O, Arends M, Oniscu A, Alonso AM, Laguna SM, Gallon R, Sheth H, Santibanez-Koref M, Jackson MS, Burn J. . PLoS ONE 2018, 13(8), e0203052.

  • Letters

    • Rajan N, Cook S, Best K, LS UK SC Workshop Group, Monahan K. . Lancet Oncology 2024, 25(1), E1-E2.
    • Gallon R, Phelps R, Betts L, Hayes C, Masic D, Irving JAE, McAnulty C, Saha V, Vora A, Wimmer K, Motwani J, Macartney C, Burn J, Jackson MS, Moorman AV, Santibanez-Koref M. . Leukemia and Lymphoma 2023, 64(1), 217-220.
    • Sowter P, Santibanez-Koref M, Jackson MS, Borthwick GM, Burn J, Rajan N, Gallon R. . British Journal of Dermatology 2022, 186(5), 913-914.

  • Reviews

    • Ahadova A, Witt J, Haupt S, Gallon R, Hüneburg R, Nattermann J, Ten Broeke S, Bohaumilitzky L, Hernandez-Sanchez A, Santibanez-Koref M, Jackson MS, Ahtiainen M, Pylvänäinen K, Andini K, Grolmusz VK, Möslein G, Dominguez-Valentin M, Møller P, Fürst D, Sijmons R, Borthwick GM, Burn J, Mecklin JP, Heuveline V, von Knebel Doeberitz M, Seppälä T, Kloor M. . International Journal of Cancer 2023, 152(10), 2024-2031.
    • Ahadova A, Seppala TT, Engel C, Gallon R, Burn J, Holinski-Feder E, Steinke-Lange V, Moslein G, Nielsen M, ten Broeke SW, Laghi L, Dominguez-Valentin M, Capella G, Macrae F, Scott R, Huneburg R, Nattermann J, Hoffmeister M, Brenner H, Blaker H, von Knebel Doeberitz M, Sampson JR, Vasen H, Mecklin J-P, Moller P, Kloor M. . International Journal of Cancer 2021, 148(4), 800-811.
    • Suerink M, Wimmer K, Brugieres L, Colas C, Gallon R, Ripperger T, Benusiglio PR, Bleiker EMA, Ghorbanoghli Z, Goldberg Y, Hardwick JCH, Kloor M, le Mentec M, Muleris M, Pineda M, Ruiz-Ponte C, Vasen HFA. . Familial Cancer 2021, 20(1), 67-73.
    • Gallon R, Gawthorpe P, Phelps RL, Hayes C, Borthwick GM, Santibanez-Koref M, Jackson MS, Burn J. . Cancers 2021, 13(3), 406.