缅北禁地

Skip to main content

Staff Profile

Emeritus Professor Robert Lightowlers

Deputy Director Wellcome Centre for Mitochondrial Research and Professor of Molecular Neuroscience

  • Telephone: +44 (0) 191 208 8028
  • Address: Wellcome Centre for Mitochondrial Research
    缅北禁地
    The Medical School
    Framlington Place
    缅北禁地 uponTyne
    NE2 4HH
    England
Background

Qualifications


  • B.Sc. Biological Sciences University of East Anglia (1983)
  • Ph.D in Microbial Genetics, JCSMR Australian National University (1988)


Previous Positions


  • Director, Institute for Cell and Molecular Biosciences, 缅北禁地  (2011 - 2019)
  • Professor of Molecular Neuroscience, 缅北禁地 (2000- )
  • Lister Institute Research Fellow, 缅北禁地 (1991-1996)
  • Postdoctoral Research Fellow, Institute of Molecular Biology University of Oregon, Eugene Oregon USA (1988-1990)


Prizes and Awards


  • Lister Institute Research Fellowship (1991-1996)
  • Henry Wellcome Commemorative Award for Innovative Science (1997) 
  • Erskine Fellowship (New Zealand, 1998)
  • Cenci-Bolognetti Visiting Professorship (Rome, 2011) 


Research

 

Research Interests

My main research interest is mitochondriology in health and disease. This broad interest encompasses the spectrum of research covered by our Wellcome Centre for Mitochondrial Research. Currently, I have projects that focus on the molecular aetiology of mitochondrial disease, treatment regimes for these disorders, mitochondrial genetics and a large concern in mitochondrial gene expression in man. Most recently, my colleagues and I have been establishing methods to visualise nascent mitochondrial protein synthesis using super resolution nanoscopy.

CURRENT VACANCIES IN THE LIGHTOWLERS LABORATORY

 We are currently advertising for Ph.D students, postdoctoral students and scientific officers in the area of mitochondrial gene expression and its role in disease. If anyone has an interest in this area, please contact me by email (robert.lightowlers@ncl.ac.uk) or by 'phone for informal discussions (01912228028) 




Teaching


  •  Programme Leader, MRes in Neuroscience


                Module leader, Scientific Basis of Neurological Disease 


  • Supervisor/co-supervisor currently for 9 Ph.D students 


Publications

  • Articles

    • Olahova M, Guerra RM, Collier JJ, Heidler J, Thompson K, White CR, Castaneda-Tamez P, Cabrera-Orefice A, Lightowlers RN, Chrzanowska-Lightowlers ZMA, Galkin A, Wittig I, Pagliarini DJ, Taylor RW. . EMBO Journal 2025, 44, 5482-5508.
    • Albus C, Berlinguer-Palmini R, Hewison C, Fiona McFarlane F, Savu E-A, Lightowlers RN, Chrzanowska-Lightowlers ZM, Zorkau M. . Biology 2021, 10(10), 1050.
    • Bruni F, Proctor-Kent Y, Lightowlers RN, Chrzanowska-Lightowlers ZN. . The FEBS Journal 2021, 288(2), 437-451.
    • Zorkau M, Albus CA, Berlinguer-Palmini R, Chrzanowska-Lightowlers ZMA, RN Lightowlers. . PNAS 2021, 118(6), e2008778118.
    • Chrzanowska-Lightowlers ZMA, Lightowlers RN. . Molecular Therapy 2020, 28(8), 1749-1751.
    • Al-Faresi RAZ, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Biochemical Society Transactions 2019, 47(5), 1429-1436.
    • Li J, Dang M, MartinezLopez N, Jowsey PA, Huang D, Lightowlers RN, Gao F, Huang JY. . Cell Division 2019, 14(5).
    • Chrzanowska-Lightowlers ZM, Lightowlers RN. . EMBO Molecular Medicine 2019, 11(1), e9899.
    • Gao F, Wesolowska M, Agami R, Rooijers K, Loayza-Puch F, Lawless C, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Wellcome Open Research 2018, 2, 116.
    • Russell OM, Fruh I, Rai PK, Marcellin D, Doll T, Reeve A, Germain M, Bastien J, Rygiel KA, Cerino R, Sailer AW, Lako M, Taylor RW, Mueller M, Lightowlers RN, Turnbull DM, Helliwell SB. . Scientific Reports 2018, 8(1), 1799.
    • Bradley P, Waddington CL, Sommerville EW, Hopton S, Pyle A, Champion M, Ohlson M, Siibak T, Chrzanowska-Lightowlers ZMA, Taylor RW, Falkenberg M, Lightowlers RN. . Human Molecular Genetics 2018, 27(10), 1743-1753.
    • Thompson K, Mai N, Oláhová M, Scialó F, Formosa LE, Stroud DA, Garrett M, Lax NZ, Robertson FM, Jou C, Nascimento A, Ortez C, Jimenez-Mallebrera C, Hardy SA, He L, Brown GK, Marttinen P, McFarland R, Sanz A, Battersby BJ, Bonnen PE, Ryan MT, Chrzanowska-Lightowlers ZMA, Lightowlers RN, Taylor RW. . EMBO Molecular Medicine 2018, 10(9), e9060.
    • Gao F, Wesolowska M, Agami R, Rooijers K, Loayza-Puch F, Lawless C, Lightowlers RN, Chrzanowska-Lightowlers ZM. . Wellcome Open Research 2017, 2, 116.
    • Zaganelli S, Rebelo-Guiomar P, Maundrell K, Rozanska A, Pierredon S, Powell CA, Jourdain AA, Hulo N, Lightowlers RN, Chrzanowska-Lightowlers ZM, Minczuk M, Martinou J-C. . Journal of Biological Chemistry 2017, 292(11), 4519-4532.
    • Rozanska A, Richter-Dennerlein R, Rorbach J, Gao F, Lewis RJ, Chrzanowska-Lightowlers ZM, Lightowlers RN. . Biochemical Journal 2017, 474(13), 2145-2158.
    • Oláhová M, Thompson K, Hardy SA, Barbosa IA, Besse A, Anagnostou ME, White K, Davey T, Simpson MA, Champion M, Enns G, Schelley S, Lightowlers RN, Chrzanowska-Lightowlers ZMA, McFarland R, Deshpande C, Bonnen PE, Taylor RW. . Journal of Inherited Metabolic Disease 2017, 40(1), 121-130.
    • Hoogewijs K, James AM, Smith RAJ, Abendroth F, Gait MJ, Murphy MP, Lightowlers RN. . Interface Focus 2017, 7(2).
    • Feichtinger RG, Olahova M, Kishita Y, Garone C, Kremer LS, Yagi M, Uchiumi T, Jourdain AA, Thompson K, D'Souza AR, Kopajtich R, Alston CL, Koch J, Sperl W, Mastantuono E, Strom TM, Wortmann SB, Meitinger T, Pierre G, Chinnery PF, Chrzanowska-Lightowlers ZM, Lightowlers RN, DiMauro S, Calvo SE, Mootha VK, Moggio M, Sciacco M, Comi GP, Ronchi D, Murayama K, Ohtake A, Rebelo-Guiomar P, Kohda M, Kang D, Mayr JA, Taylor RW, Okazaki Y, Minczuk M, Prokisch H. . American Journal of Human Genetics 2017, 101(4), 525-538.
    • Spahr H, Rozanska A, Li XP, Atanassov I, Lightowlers RN, Chrzanowska-Lightowlers ZMA, Rackham O, Larsson NG. . Nucleic Acids Research 2016, 44(14), 6868-6882.
    • Rorbach J, Gao F, Powell CA, D'Souza A, Lightowlers RN, Minczuk M, Chrzanowska-Lightowlers ZM. . Proceedings of the National Academy of Sciences 2016, 113(43), 12198-12201.
    • Phillips J, Laude A, Lightowlers R, Morris CM, Turnbull DM, Lax NZ. . Scientific Reports 2016, 6, 26013.
    • Alfonsa H, Lakey JH, Lightowlers RN, Trevelyan AJ. . Nature Communications 2016, 7, 13495.
    • Hoogewijs K, James AM, Smith RAJ, Gait MJ, Murphy MP, Lightowlers RN. . ChemBioChem 2016, 17(14), 1312-1316.
    • Elson JL, Smith PM, Greaves LC, Lightowlers RN, Chrzanowska-Lightowlers ZMA, Taylor RW, Vila-Sanjurjo A. . Mitochondrion 2015, 25, 17-27.
    • Rai PK, Russell OM, Lightowlers RN, Turnbull DM. . British Medical Bulletin 2015, 116(1), 5-18.
    • Wesolowska M, Gorman GS, Alston CL, Pajak A, Pyle A, He L, Griffin H, Chinnery PF, Miller JAL, Schaefer AM, Taylor RW, Lightowlers RN, Chrzanowska-Lightowlers ZM. . Journal of Neuromuscular Diseases 2015, 2(4), 409-419.
    • Olahova M, Haack TB, Alston CL, Houghton JAC, He L, Morris AAM, Brown GK, McFarland R, Chrzanowska-Lightowlers ZMA, Lightowlers RN, Prokisch H, Taylor RW. . European Journal of Human Genetics 2015, 23(7), 935-939.
    • Olahova M, Hardy SA, Hall J, Yarham JW, Haack TB, Wilson WC, Alston CL, He L, Aznauryan E, Brown RM, Brown GK, Morris AAM, Mundy H, Broomfield A, Barbosa IA, Simpson MA, Deshpande C, Moeslinger D, Koch J, Stettner GM, Bonnen PE, Prokisch H, Lightowlers RN, McFarland R, Chrzanowska-Lightowlers ZMA, Taylor RW. . Brain 2015, 138(12), 3503-3519.
    • Lightowlers RN, Chrzanowska-Lightowlers ZMA. . EMBO Molecular Medicine 2014, 6(6), 705-707.
    • Wesolowska MT, Richter-Dennerlein R, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Frontiers in Microbiology 2014, 5, 374.
    • Almalki A, Alston CL, Parker A, Simonic I, Mehta SG, He LP, Reza M, Oliveira JMA, Lightowlers RN, McFarland R, Taylor RW, Chrzanowska-Lightowlers ZMA. . Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease 2014, 1842(1), 56-64.
    • Hornig-Do H-T, Montanari A, Rozanska A, Tuppen HA, Almalki AA, Abg-Kamaludin DP, Frontali L, Francisci S, Lightowlers RN, Chrzanowska-Lightowlers ZM. . EMBO Molecular Medicine 2014, 6(2), 183-193.
    • Weber-Lotfi F, Mileshina DV, Ibrahim N, Koulintchenko MV, D'Souza GGM, Saxena V, Konstantinov YM, Lightowlers RN, Dietrich A. . Biopolymers and Cell 2014, 30(1), 71-73.
    • Wilson WC, Hornig-Do HT, Bruni F, Chang JC, Jourdain AA, Martinou JC, Falkenberg M, Spåhr H, Larsson NG, Lewis RJ, Hewitt L, Baslé A, Cross HE, Tong L, Lebel RR, Crosby AH, Chrzanowska-Lightowlers ZMA, Lightowlers RN. . Human Molecular Genetics 2014, 23(23), 6345-6355.
    • Smith PM, Elson JL, Greaves LC, Wortmann SB, Rodenburg RJT, Lightowlers RN, Chrzanowska-Lightowlers ZMA, Taylor RW, Vila-Sanjurjo A. . Human Molecular Genetics 2013, 23(4), 949-969.
    • Bruni F, Gramegna P, Oliveira JM, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . PLoS One 2013, 8(5), e64670.
    • Jourdain AA, Koppen M, Wydro M, Rodley CD, Lightowlers RN, Chrzanowska-Lightowlers ZM, Martinou JC. . Cell Metabolism 2013, 17(3), 399-410.
    • Wessels HJCT, Vogel RO, Lightowlers RN, Spelbrink JN, Rodenburg RJ, van den Heuvel LP, van Gool AJ, Gloerich J, Smeitink JAM, Nijtmans LG. . PLoS ONE 2013, 8(7), e68340.
    • Bruni F, Gramegna P, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Biochemical Society Transactions 2012, 40(4), 865-869.
    • Wanschers BFJ, Szklarczyk R, Pajak A, van den Brand MAM, Gloerich J, Rodenburg RJT, Lightowlers RN, Nijtmans LG, Huynen MA. . Nucleic Acids Research 2012, 40(9), 4040-4051.
    • Kemp JP, Smith PM, Pyle A, Neeve VCM, Tuppen HAL, Schara U, Talim B, Topaloglu H, Holinski-Feder E, Abicht A, Czermin B, Lochmuller H, McFarland R, Chinnery PF, Chrzanowska-Lightowlers ZM, Lightowlers RN, Taylor RW, Horvath R. . Brain 2011, 134(1), 183-195.
    • Kolanczyk M, Pech M, Zemojtel T, Yamamoto H, Mikula I, Calvaruso MA, van den Brand M, Richter R, Fischer B, Ritz A, Kossler N, Thurisch B, Spoerle R, Smeitink J, Kornak U, Chan D, Vingron M, Martasek P, Lightowlers RN, Nijtmans L, Schuelke M, Nierhaus KH, Mundlos S. . Molecular Biology of the Cell 2011, 22(1), 1-11.
    • Ibrahim N, Handa H, Cosset A, Koulintchenko M, Konstantinov Y, Lightowlers RN, Dietrich A, Weber-Lotfi F. . Pharmaceutical Research 2011, 28(11), 2871-2882.
    • Lightowlers RN, Chrzanowska-Lightowlers ZMA. . RNA Biology 2010, 7(3), 282-286.
    • Wydro M, Bobrowicz A, Temperley RJ, Lightowlers RN, Chrzanowska-Lightowlers ZM. . Nucleic Acids Research 2010, 38(11), 3732-3742.
    • Craven L, Tuppen HA, Greggains GD, Harbottle SJ, Murphy JL, Cree LM, Murdoch AP, Chinnery PF, Taylor RW, Lightowlers RN, Herbert M, Turnbull DM. . Nature 2010, 465(7294), 82-85.
    • Wang G, Chen HW, Oktay Y, Zhang J, Allen EL, Smith GM, Fan KC, Hong JS, French SW, McCaffery JM, Lightowlers RN, Morse HC, Koehler CM, Teitell MA. . Cell 2010, 142(3), 456-467.
    • Trevelyan AJ, Kirby DM, Smulders-Srinivasan TK, Nooteboom M, Acin-Perez R, Enriquez JA, Whittington MA, Lightowlers RN, Turnbull DM. . Brain 2010, 133(3), 787-796.
    • Boesch P, Ibrahim N, Dietrich A, Lightowlers RN. . Nucleic Acids Research 2010, 38(5), 1478-1488.
    • Abramov AY, Smulders-Srinivasan TK, Kirby DM, Acin-Perez R, Enriquez JA, Lightowlers RN, Duchen MR, Turnbull DM. . Brain 2010, 133(3), 797-807.
    • Temperley R, Richter R, Dennerlein S, Lightowlers RN, Chrzanowska-Lightowlers ZM. . Science 2010, 327(5963), 301-301.
    • Dennerlein S, Rozanska A, Wydro M, Chrzanowska-Lightowlers ZMA, Lightowlers RN. . Biochemical Journal (Cell) 2010, 430(3), 551-558.
    • Crosby AH, Patel H, Chioza BA, Proukakis C, Gurtz K, Patton MA, Sharifi R, Harlalka G, Simpson MA, Dick K, Reed JA, Al-Memar A, Chrzanowska-Lightowlers ZMA, Cross HE, Lightowlers RN. . American Journal of Human Genetics 2010, 87(5), 655-660.
    • Oliveira JMA, Lightowlers RN. . EMBO Molecular Medicine 2010, 2(12), 487-489.
    • Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, Huynen MA, Smeitink JA, Lightowlers RN, Chrzanowska-Lightowlers ZM. . EMBO Journal 2010, 29(6), 1116-1125.
    • McDonald BM, Wydro MM, Lightowlers RN, Lakey JH. . FEBS Letters 2009, 583(4), 739-742.
    • Horvath R, Kemp JP, Tuppen HAL, Hudson G, Oldfors A, Marie SKN, Moslemi AR, Servidei S, Holme E, Shanske S, Kollberg G, Jayakar P, Pyle A, Marks HM, Holinski-Feder E, Scavina M, Walter MC, Coku J, Gunther-Scholz A, Smith PM, McFarland R, Chrzanowska-Lightowlers ZMA, Lightowlers RN, Hirano M, Lochmuller H, Taylor RW, Chinnery PF, Tulinius M, DiMauro S. . Brain 2009, 132(11), 3165-3174.
    • Kirby DM, Rennie KJ, Smulders-Srinivasan TK, Acin-Perez R, Whittington M, Enriquez JA, Trevelyan AJ, Turnbull DM, Lightowlers RN. . Cell Proliferation 2009, 42(4), 413-424.
    • Rorbach J, Richter R, Wessels HJ, Wydro M, Pekalski M, Farhoud M, Kuhl I, Gaisne M, Bonnefoy N, Smeitink JA, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Nucleic Acids Research 2008, 36(18), 5787-5799.
    • Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Biochemical Journal 2008, 416(1), e5-e6.
    • Bobrowicz AJ, Lightowlers RN, Chrzanowska-Lightowlers Z. . Biochemical Society Transactions 2008, 36(3), 517-519.
    • Rorbach J, Yusoff A, Tuppen H, Abg-Kamaludin D, Chrzanowska-Lightowlers Z, Taylor R, Turnbull D, Mcfarland R, Lightowlers R. . Nucleic Acids Research 2008, 36(9), 3065-3074.
    • Reeve AK, Krishnan KJ, Elson JL, Morris CM, Bender A, Lightowlers RN, Turnbull DM. . American Journal of Human Genetics 2008, 82(1), 228-235.
    • Soleimanpour-Lichaei HR, Kuhl I, Gaisne M, Passos JF, Wydro M, Rorbach J, Temperley R, Bonnefoy N, Tate W, Lightowlers R, Chrzanowska-Lightowlers Z. . Molecular Cell 2007, 27(5), 745-757.
    • Leontiou C, Watters GP, Gilroy KL, Heslop P, Cowell IG, Craig K, Lightowlers RN, Lakey JH, Austin CA. . Molecular Pharmacology 2007, 71(4), 1006-1014.
    • Brown D, Herbert M, Lamb V, Chinnery PF, Taylor R, Lightowlers R, Craven L, Cree L, Gardner JL, Turnbull DM. . Lancet 2006, 368(9529), 87-89.
    • Pye D, Kyriakouli DS, Taylor GA, Johnson R, Elstner M, Meunier B, Chrzanowska-Lightowlers ZMA, Taylor RW, Turnbull DM, Lightowlers RN. . Nucleic Acids Research 2006, 34(13), e95.
    • Keresztessy Z, Csosz E, Harsfalvi J, Csomos K, Gray J, Lightowlers RN, Lakey JH, Balajthy Z, Fesus L. . Protein Science 2006, 15(11), 2466-2480.
    • Koulintchenko M, Temperley RJ, Mason PA, Dietrich A, Lightowlers RN. . Human Molecular Genetics 2006, 15(1), 143-154.
    • Leontiou C, Lakey JH, Lightowlers R, Turnbull RM, Austin CA. . Molecular Pharmacology 2006, 69(1), 130-139.
    • Betts J, Jaros E, Perry RH, Schaefer AM, Taylor RW, Abdel-All Z, Lightowlers RN, Turnbull DM. . Neuropathology and Applied Neurobiology 2006, 32(4), 359-373.
    • Maniura-Weber K, Helm M, Engemann K, Eckertz S, Mollers M, Schauen M, Hayrapetyan A, von Kleist-Retzow J-C, Lightowlers RN, Bindoff LA, Wiesner RJ. . Nucleic Acids Research 2006, 34(22), 6404-6415.
    • Elson JL, Lightowlers RN. . Trends in Genetics 2006, 22(11), 603-607.
    • Seal R, Temperley RJ, Wilusz J, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Nucleic Acids Research 2005, 33(1), 376-387.
    • Stocksley MA, Awad SS, Young C, Lightowlers RN, Brenner H-R, Slater CR. . Molecular and Cellular Neuroscience 2005, 28(4), 694-702.
    • Kolesnikova OA, Entelis NS, Jacquin-Becker C, Goltzene F, Chrzanowska-Lightowlers ZM, Lightowlers RN, Martin RP, Tarassov I. . Human Molecular Genetics 2004, 13(20), 2519-2534.
    • Blakely EL, He L, Taylor RW, Chinnery PF, Lightowlers RN, Schaefer AM, Turnbull DM. . Journal of Medical Genetics 2004, 41(2), e19.
    • Gagliardi D, Stepien PP, Temperley RJ, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Trends in Genetics 2004, 20(6), 260-267.
    • Pye D, Watt DJ, Walker C, Lightowlers RN, Turnbull DM. . Neuromuscular Disorders 2004, 14(5), 329-336.
    • Chrzanowska-Lightowlers ZMA, Temperley RJ, Smith PM, Seneca SH, Lightowlers RN. . Biochemical Journal 2004, 377(3), 725-731.
    • Mason PA, Lightowlers RN. . FEBS Letters 2003, 554(1-2), 6-9.
    • Ross GF, Smith PM, McGregor A, Turnbull DM, Lightowlers RN. . Bioconjugate Chemistry 2003, 14(5), 962-966.
    • James AM, Blaikie FH, Smith RAJ, Lightowlers RN, Smith PM, Murphy MP. . European Journal of Biochemistry 2003, 270(13), 2827-2836.
    • Mason PA, Matheson EC, Hall AG, Lightowlers RN. . Nucleic Acids Research 2003, 31(3), 1052-1058.
    • Leontiou C, Lightowlers R, Lakey JH, Austin CA. . FEBS Letters 2003, 554(1-2), 206-210.
    • Temperley RJ, Seneca SH, Tonska K, Bartnik E, Bindoff LA, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Human Molecular Genetics 2003, 12(18), 2341-2348.
    • McGregor A, Smith PM, Ross GF, Taylor RW, Turnbull DM, Lightowlers RN. . Biochimica et Biophysica Acta - Gene Structure and Expression 2003, 1629(1-3), 73-83.
    • Taylor RW, Giordano C, Davidson MM, D'Amati G, Bain H, Hayes CM, Leonard H, Barron MJ, Casali C, Santorelli FM, Hirano M, Lightowlers RN, DiMauro S, Turnbull DM. . Journal of the American College of Cardiology 2003, 41(10), 1786-1796.
    • McFarland R, Clark KM, Morris AAM, Taylor RW, Macphail S, Lightowlers RN, Turnbull DM. . Nature Genetics 2002, 30(2), 145-146.
    • Herrnstadt C, Preston G, Andrews R, Chinnery P, Lightowlers RN, Turnbull DM, Kubacka I, Howell N. . Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2002, 501(1-2), 19-28.
    • Herrnstadt C, Preston G, Andrews R, Chinnery P, Lightowlers RN, Turnbull DM, Kubacka I, Howell N. . Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 2002, 501(1-2), 19-28.
    • Muratovska A, Lightowlers RN, Taylor RW, Turnbull DM, Smith RAJ, Wilce JA, Martin SW, Murphy MP. . Nucleic Acids Research 2001, 29(9), 1852-1863.
    • Awad SS, Lightowlers RN, Young C, Chrzanowska-Lightowlers ZMA, Lomo T, Slater CR. . Journal of Neuroscience 2001, 21(21), 8456-8463.
    • Taylor RW, Wardell TM, Lightowlers RN, Turnbull DM. . Neurological Science 2001, 21(3), 909-912.
    • Taylor RW, Wardell TM, Connolly BA, Turnbull DM, Lightowlers RN. . Nucleic Acids Research 2001, 29(16), 3404-3412.
    • Selwood SP, McGregor A, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . FEBS Letters 2001, 494(3), 186-191.
    • Lightowlers RN, Lill R. . EMBO Reports 2001, 2(12), 1074-1077.
    • Chrzanowska-Lightowlers ZMA, Lightowlers RN. . RNA 2001, 7(3), 435-444.
    • Turnbull DM, Lightowlers RN, Taylor RW. . Functional Neurology 2001, 16(4), 89-96.
    • Elson JL, Andrews RM, Chinnery PF, Lightowlers RN, Turnbull DM, Howell N. . American Journal of Human Genetics 2001, 68(1), 145-153.
    • McGregor A, Temperley R, Chrzanowska-Lightowlers Z, Lightowlers NR. . Molecular Genetics and Genomics 2001, 265(4), 721-729.
    • Chinnery PF, Thorburn DR, Samuels DC, White SL, Dahl H-HM, Turnbull DM, Lightowlers RN, Howell N. . Trends in Genetics 2000, 16(11), 500-505.
    • Taylor RW, Wardell TM, Lightowlers RN, Turnbull DM. . Neurological Sciences 2000, 21(9), S909-S912.
    • Taylor RW, Chinnery PF, Turnbull DM, Lightowlers RN. . Human Reproduction 2000, 15(2), 79-85.
    • Nagy E, Henics T, Eckert M, Miseta A, Lightowlers RN, Kellermayer M. . Biochemical and Biophysical Research Communications 2000, 275(2), 253-260.
    • Nagy E, Henics T, Eckert M, Miseta A, Lightowlers RN, Kellermayer M. . Biochemical and Biophysical Research Communications 2000, 275(2), 253-260.
    • Awad SS, Stocksley MA, Young C, Lightowlers RN, Slater CR. . European Journal of Neuroscience 2000, 12(supplement), 278-278.
    • Chinnery PF, Taylor RW, Diekert K, Lill R, Turnbull DM, Lightowlers RN. . Gene Therapy 1999, 6(12), 1919-1928.
    • Chinnery PF, Taylor RW, Diekert K, Lill R, Turnbull DM, Lightowlers RN. . Gene Therapy 1999, 6(12), 1919-1928.
    • Chinnery PF, Zwijnenburg PJG, Walker M, Howell N, Taylor RW, Lightowlers RN, Bindoff L, Turnbull DM. . American Journal of Medical Genetics. Part A 1999, 85(5), 498-501.
    • Chinnery PF, Zwijnenburg PJG, Walker M, Howell N, Taylor RW, Lightowlers RN, Bindoff L, Turnbull DM. . American Journal of Medical Genetics 1999, 85(5), 498-501.
    • Chrzanowska-Lightowlers ZM, Temperley RJ, McGregor A, Bindoff LA, Lightowlers RN. . Gene 1999, 230(2), 241-247.
    • Clarke K, Taylor R, Johnson MA, Chinnery P, Chrzanowska-Lightowlers ZMA, Andrews R, Nelson I, Wood N, Lamont P, Hanna M, Lightowlers RN, Turnbull DM. . American Journal of Human Genetics 1999, 64(5), 1330-1339.
    • Clark KM, Taylor RW, Johnson MA, Chinnery PF, Chrzanowska-Lightowlers ZMA, Andrews RM, Nelson IP, Wood NW, Lamont PJ, Hanna MG, Lightowlers RN, Turnbull DM. . American Journal of Human Genetics 1999, 64(5), 1330-1339.
    • K. M. Clark,D. J. Watt,R. N. Lightowlers,M. A. Johnson,J. B. Relvas,J. W. Taanman,D. M. Turnbull. SCID mice containing muscle with human mitochondrial DNA mutations. An animal model for mitochondrial DNA defects. J Clin Invest 1998, 102(12), 2090-5.
    • K. M. Clark, D. J. Watt, R. N. Lightowlers, M. A. Johnson, J. B. Relvas, J. W. Taanman and D. M. Turnbull. SCID mice containing muscle with human mitochondrial DNA mutations - An animal model for mitochondrial DNA defects. Journal of Clinical Investigation 1998, 102, 2090-2095.
    • E. J. Brierley, M. A. Johnson, R. N. Lightowlers, O. F. W. James and D. M. Turnbull. Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle. Annals of Neurology 1998, 43, 217-223.
    • E. J. Brierley,M. A. Johnson,R. N. Lightowlers,O. F. James,D. M. Turnbull. Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle. Ann Neurol 1998, 43(2), 217-23.
    • Chinnery PF, Howell N, Lightowlers RN, Turnbull DM. . Brain 1998, 121(10), 1889-1894.
    • P. F. Chinnery, N. Howell, R. N. Lightowlers and D. M. Turnbull. Genetic counselling and prenatal diagnosis for mtDNA disease. American Journal of Human Genetics 1998, 63, 1908-1910.
    • D. M. Turnbull,R. N. Lightowlers. An essential guide to mtDNA maintenance. Nat Genet 1998, 18(3), 199-200.
    • D. M. Turnbull and R. N. Lightowlers. An essential guide to mtDNA maintenance. Nature Genetics 1998, 18, 199-200.
    • Taylor R.W., Chinnery P.F., Clarke K., Turnbull D.M., Lightowlers R.N. Treatment of mitochondrial disease. Journal of Bioenergetics and Biomembranes 1997, 29, 195-204.
    • Taylor R.W., Chinnery P.F., Clark K.M., Lightowlers R.N., Turnbull D.M. Selective inhibition of mutant mitochondrial DNA replication. Emerging Therapeutic Targets 1997, 1, 249-252.
    • R. W. Taylor, P. F. Chinnery, D. M. Turnbull and R. N. Lightowlers. Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids. Nature Genetics 1997, 15, 212-215.
    • K. M. Clark,L. A. Bindoff,R. N. Lightowlers,R. M. Andrews,P. G. Griffiths,M. A. Johnson,E. J. Brierley,D. M. Turnbull. Reversal of a mitochondrial DNA defect in human skeletal muscle. Nat Genet 1997, 16(3), 222-4.
    • K. M. Clark, L. A. Bindoff, R. N. Lightowlers, R. M. Andrew, P. G. Griffiths, M. A. Johnson, E. J. Brierley and D. M. Turnbull. Reversal of a mitochondrial DNA defect in human skeletal muscle. Nature Genetics 1997, 16, 222-224.
    • Chinnery PF, Howell N, Lightowlers RN, Turnbull DM. . Brain 1997, 120(10), 1713-1721.
    • P. L. Adams,R. N. Lightowlers,D. M. Turnbull. Molecular analysis of cytochrome c oxidase deficiency in Leigh's syndrome. Ann Neurol 1997, 41(2), 268-70.
    • P. L. Adams, R. N. Lightowlers and D. M. Turnbull. Molecular analysis of cytochrome c oxidase deficiency in Leigh's syndrome. Annals of Neurology 1997, 41, 268-270.
    • Bidooki SK, Johnson MA, Chrzanowska-Lightowlers Z, Bindoff LA, Lightowlers RN. . American Journal of Human Genetics 1997, 60(6), 1430-1438.
    • P. F. Chinnery, N. Howell, R. N. Lightowlers and D. M. Turnbull. Genetic counselling for patients with mitochondrial DNA defects - Predicting the outcome of pregnancy based on maternal mutant load. Neurology 1997, 48, 49002-49002.
    • R. F. Taylor, P. F. Chinnery, R. N. Lightowlers and D. M. Turnbull. Gene therapy for mitochondrial DNA diseases. Neurology 1997, 48, 4085-4085.
    • Clark K.M., Bindoff L.A., Lightowlers R.N., Andrews R.M., Griffiths P.G., Johnson M.A., and Turnbull D.M. Correction of a mitochondrial DNA defect in human skeletal muscle. Nature Genet 1997, 15.
    • P. F. Chinnery, M. A. Johnson, R. W. Taylor, R. N. Lightowlers and D. M. Turnbull. A novel mitochondrial tRNA phenylalanine mutation presenting with acute rhabdomyolysis. Annals of Neurology 1997, 41, 408-410.
    • M. A. Dunn,K. Brown,R. Lightowlers,M. A. Hughes. A low-temperature-responsive gene from barley encodes a protein with single-stranded nucleic acid-binding activity which is phosphorylated in vitro. Plant Mol Biol 1996, 30(5), 947-59.
    • Preiss T, Sang AE, Chrzanowska-Lightowlers ZMA, Lightowlers RN. . FEBS Letters 1995, 367(3), 291-296.
    • A. A. Morris,R. W. Taylor,R. N. Lightowlers,A. Aynsley-Green,K. Bartlett,D. M. Turnbull. Medium chain acyl-CoA dehydrogenase deficiency caused by a deletion of exons 11 and 12. Hum Mol Genet 1995, 4(4), 747-9.
    • T. Preiss,S. A. Lowerson,K. Weber,R. N. Lightowlers. Human mitochondria: distinct organelles or dynamic network?. Trends Genet 1995, 11(6), 211-2.
    • Preiss T, Chrzanowska-Lightowlers ZM, Lightowlers RN. . Biochimica et Biophysica Acta 1994, 1221(3), 286-289.
    • Chrzanowska-Lightowlers ZMA, Preiss T, Lightowlers RN. . Journal of Biological Chemistry 1994, 269(44), 27322-27328.
    • R. Schillace,T. Preiss,R. N. Lightowlers,R. A. Capaldi. Developmental regulation of tissue-specific isoforms of subunit VIa of beef cytochrome c oxidase. Biochim Biophys Acta 1994, 1188(3), 391-7.
    • T. Preiss,R. N. Lightowlers. Post-transcriptional regulation of tissue-specific isoforms. A bovine cytosolic RNA-binding protein, COLBP, associates with messenger RNA encoding the liver-form isopeptides of cytochrome c oxidase. J Biol Chem 1993, 268(14), 10659-67.
    • R. N. Lightowlers. Neurologic complications of inherited mitochondrial abnormality, and neurologic consequences of inborn errors of metabolism. Curr Opin Neurol Neurosurg 1993, 6(3), 429-36.
    • J. E. Sadlock,R. N. Lightowlers,R. A. Capaldi,E. A. Schon. Isolation of a cDNA specifying subunit VIIb of human cytochrome c oxidase. Biochim Biophys Acta 1993, 1172(1-2), 223-5.
    • Chrzanowska-Lightowlers ZMA, Turnbull DM, Bindoff LA, Lightowlers RN. . Biochemical and Biophysical Research Communications 1993, 196(1), 328-335.
    • L. A. Bindoff,N. Howell,J. Poulton,D. A. McCullough,K. J. Morten,R. N. Lightowlers,D. M. Turnbull,K. Weber. Abnormal RNA processing associated with a novel tRNA mutation in mitochondrial DNA. A potential disease mechanism. J Biol Chem 1993, 268(26), 19559-64.
    • Chrzanowska-Lightowlers ZMA, Turnbull DM, Lightowlers RN. . Analytical Biochemistry 1993, 214, 45-49.
    • R. N. Lightowlers. Hereditary disorders including mitochondrial diseases. Curr Opin Neurol Neurosurg 1992, 5(3), 368-74.
    • Lightowlers RN, Chrzanowska-Lightowlers ZMA, Marusich M, Capaldi RA. . Journal of Biological Chemistry 1991, 266(12), 7688-7693.
    • R. D. Carrero-Valenzuela,F. Quan,R. Lightowlers,N. G. Kennaway,M. Litt,M. Forte. Human cytochrome c oxidase subunit VIb: characterization and mapping of a multigene family. Gene 1991, 102(2), 229-36.
    • G. Ewart,R. Lightowlers,Y. Z. Zhang,V. J. Balan,N. Kennaway,R. A. Capaldi. Tissue specificity and defects in human cytochrome c oxidase. Biochim Biophys Acta 1990, 1018(2-3), 223-4.
    • B. H. Robinson,D. M. Glerum,W. Chow,R. Petrova-Benedict,R. Lightowlers,R. Capaldi. The use of skin fibroblast cultures in the detection of respiratory chain defects in patients with lacticacidemia. Pediatr Res 1990, 28(5), 549-55.
    • S. M. Howitt,R. N. Lightowlers,F. Gibson,G. B. Cox. Mutational analysis of the function of the a-subunit of the F0F1-APPase of Escherichia coli. Biochim Biophys Acta 1990, 1015(2), 264-8.
    • R. Lightowlers,G. Ewart,R. Aggeler,Y. Z. Zhang,L. Calavetta,R. A. Capaldi. Isolation and characterization of the cDNAs encoding two isoforms of subunit CIX of bovine cytochrome c oxidase. J Biol Chem 1990, 265(5), 2677-81.
    • N. G. Kennaway,R. D. Carrero-Valenzuela,G. Ewart,V. K. Balan,R. Lightowlers,Y. Z. Zhang,B. R. Powell,R. A. Capaldi,N. R. Buist. Isoforms of mammalian cytochrome c oxidase: correlation with human cytochrome c oxidase deficiency. Pediatr Res 1990, 28(5), 529-35.
    • R. N. Lightowlers,R. A. Capaldi. Nucleotide sequence of the cDNA encoding subunit AED (VIB) of beef heart cytochrome c oxidase. Nucleic Acids Res 1989, 17(14), 5845.
    • R. Lightowlers,S. Takamiya,R. Wessling,M. Lindorfer,R. A. Capaldi. Cloning and sequencing of the cDNA for a 13th different subunit (IHQ) of beef heart cytochrome c oxidase. J Biol Chem 1989, 264(28), 16858-61.
    • R. N. Lightowlers,S. M. Howitt,L. Hatch,F. Gibson,G. Cox. The proton pore in the Escherichia coli F0F1-ATPase: substitution of glutamate by glutamine at position 219 of the alpha-subunit prevents F0-mediated proton permeability. Biochim Biophys Acta 1988, 933(2), 241-8.
    • R. N. Lightowlers,S. M. Howitt,L. Hatch,F. Gibson,G. B. Cox. The proton pore in the Escherichia coli F0F1-ATPase: a requirement for arginine at position 210 of the a-subunit. Biochim Biophys Acta 1987, 894(3), 399-406.
    • G. B. Cox,D. Webb,L. Hatch,R. Lightowlers,A. Munn,F. Gibson. Altered translation of the uncC gene coding for the epsilon subunit of the F1F0-ATPase of Escherichia coli. J Bacteriol 1987, 169(7), 2945-9.

  • Book Chapters

    • Chrzanowska-Lightowlers ZM, Lightowlers RN. . In: Antoni Barrientos and Flavia Fontanesi, ed. The Mitoribosome: Methods and Protocols. 53-72: Humana Press, 2023, pp.53-72.
    • Albus CA, Berlinguer-Palmini R, Chrzanowska-Lightowlers ZM, Lightowlers RN. . In: Antoni Barrientos, Flavia Fontanesi, ed. The Mitoribosome. Methods and Protocols. Humana New York, NY: Springer, 2023, pp.303-316.
    • Zorkau M, Proctor-Kent Y, Berlinguer-Palmini R, Hamilton A, Chrzanowska-Lightowlers ZM, Lightowlers RN. . In: Methods in Molecular Biology. Humana Press Inc, 2021, pp.159-181.
    • Bigger B, Taylor RW, Turnbull DM, Lightowlers RN. . In: Holt, I.J, ed. Genetics of Mitochondrial Diseases. Oxford, UK: Oxford University Press, 2003, pp.327-344.
    • Blakely EL, Elson JL, Cottrell DA, Brierley EJ, Turnbull DM. Mitochondrial Involvement in Ageing. In: MS, Ebadi; Marwah, J; Chopra, RJ, ed. Mitochondrial Ubiquinone (Coenzyme Q10): biochemical, functional, medical and therapeutic aspects in human health and disease. Arizona: Prominent Press, 2001.
    • Taylor RW, McGregor A, Lightowlers RN, Turnbull DM. Gene therapy for mitochondrial DNA defects. In: Ebadi, MS, ed. Mitochondrial Ubiquinone (Coenzyme Q10): biochemical, functional, medical and therapeutic aspects in human health and diseases. Prominent Press, Arizona, 2000.

  • Conference Proceedings (inc. Abstracts)

    • Boczonadi V, Smith PM, Sitarz K, Chrzanowska-Lightowlers ZMA, Lightowlers RN, Chinnery PF, Horvath R. . In: United Kingdom Neuromuscular Translational Research Conference. 2012, 缅北禁地 upon Tyne, UK: Elsevier Ltd.
    • Mileshina D, Ibrahim N, Boesch P, Lightowlers RN, Dietrich A, Weber-Lotfi F. . In: Mechanisms of Ageing and Development: 3rd International Genome Dynamics in Neuroscience Conference on DNA Repair and Neurological Disease. 2011, Brighton, UK: Elsevier Ireland Ltd.
    • Rorbach J, Soleimanpour-Lichaei R, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . In: Biochemical Society Transactions: Focus Topics at Life Sciences. 2007, Glasgow, UK: Portland Press Ltd.
    • Turnbull DM, Brown DT, Lightowlers RN. . In: Neuromuscular Disorders: 7th International Congress of the World Muscle Society. 2002, Rotterdam, Netherlands: Elsevier Ltd.
    • McFarland R, Taylor RW, Chinnery PF, Lightowlers RN, Turnball DM. . In: Journal of Neurology, Neurosurgery and Psychiatry: Proceedings of the Association of British Neurologists. 2002, Oxford: BMJ Group.
    • Kolesnikova O, Entelis N, Chrzanowska-Lightowlers Z, Lightowlers R, Martin R, Tarassov I. . In: YEAST. 2001.
    • Selwood SP, Chrzanowska-Lightowlers ZMA, Lightowlers RN. . In: Colloquium on Organisms, Organs, Cells and Organelles - In Vivo and In Vitro Experimental Systems. 2000, University College Cork, Ireland: Biochemical Society Transactions, Portland Press.
    • Awad S, Buckel A, Lightowlers RN, Slater CR. . In: British Neuroscience Assosciation Abstracts: 15th National Meeting. 1999, Liverpool, UK: British Neuroscience Association.
    • Bidooki SK, Bindoff LA, Johnson MA, Lightowlers RN. . In: FASEB Journal. 1999, Federation of American Societies for Experimental Biology.
    • Lightowlers RN, Sang AE, Preiss T, Chrzanowska-Lightowlers ZMA. . In: 657th Meeting of the Biochemical Society. 1996, University of Aberdeen, Scotland: Biochemical Society Transactions, Portland Press.

  • Editorials

    • Russell OM, Lightowlers RN, Turnbull DM. . Molecular Cell 2016, 62(1), 5-6.
    • Chrzanowska-Lightowlers ZM, Lightowlers RN. . PLoS Genetics 2015, 11(6), e1005227.
    • Lightowlers RN, Chrzanowska-Lightowlers ZMA. . EMBO Reports 2012, 13(12), 1038-1039.
    • Lightowlers RN. . EMBO Reports 2011, 12(6), 480-481.
    • Bruni F, Lightowlers RN. . Molecular Therapy 2011, 19(8), 1404-1405.

  • Letters

    • McFarland R, Taylor RW, Elson JL, Lightowlers RN, Turnbull DM, Howell N, Scaglia F, Vogel H, Hawkins EP, Vladutiu GD, Guan M-X, Liu L-L, Wong L-JC. . American Journal of Medical Genetics 2004, 131(1), 107-110.
    • Morris AAM, Lightowlers RN. . Lancet 2000, 356(9233), 941.
    • Andrews RM, Kubacka I, Chinnery PF, Lightowlers RN, Turnbull DM, Howell N. . Nature Genetics 1999, 23(2), 147-.
    • Preiss T, Chrzanowska-Lightowlers ZM, Lightowlers RN. . Trends in Biochemical Sciences 1997, 22(8), 290-290.

  • Notes

    • Lightowlers RN, Chrzanowska-Lightowlers ZMA, Russell OM. . EMBO Reports 2020, 21(9), e50964.
    • Krishnan KJ, Reeve AK, Samuels DC, Chinnery PF, Blackwood JK, Taylor RW, Wanrooij S, Spelbrink JN, Lightowlers RN, Turnbull DM. . Nature Genetics 2008, 40(3), 275-279.
    • Turnbull DM, Lightowlers RN. . Nature Genetics 2002, 30(4), 345-346.
    • Turnbull DM, Lightowlers RN. . Nature Medicine 2001, 7(8), 895-896.
    • Chinnery PF, Taylor RW, Diekert K, Lill R, Turnbull DM, Lightowlers RN. . Gene Therapy 2000, 7(9), 813-813.
    • Chinnery PF, Taylor RW, Diekert K, Lill R, Turnbull DM, Lightowlers RN. . Gene Therapy 2000, 7(9), 813.
    • Morris AAM, Lightowlers RN. . Lancet 2000, 355(9212), 1290-1291.
    • Preiss T, Hall AG, Lightowlers RN. . Journal of Biological Chemistry 1993, 268(33), 24523-24526.

  • Online Publication

    • Lightowlers RN, Selwood SP, Chrzanowska-Lightowlers ZMA. . London, UK: Wiley-Blackwell, 2001. Available at: .

  • Reviews

    • Ayyub SA, Gao F, Lightowlers RN, Chrzanowska-Lightowlers ZM. . Journal of Cell Science 2020, 133(1), jcs231811.
    • Russell OM, Gorman GS, Lightowlers RN, Turnbull DM. . Cell 2020, 181(1), 168-188.
    • Hoogewijs K, James AM, Murphy MP, Lightowlers RN. . Small Methods 2018, 2(3), 1700297.
    • Rai PK, Craven L, Hoogewijs K, Russell OM, Lightowlers RN. . Essays in Biochemistry 2018, 62(3), 455-465.
    • Bruni F, Lightowlers RN, Chrzanowska-Lightowlers ZM. . The FEBS Journal 2017, 284(12), 1767-1777.
    • Mai N, Chrzanowska-Lightowlers ZMA, Lightowlers RN. . Cell and Tissue Research 2016, 367(1), 5-20.
    • Lightowlers RN, Taylor RW, Turnbull DM. . Science 2015, 349(6255), 1494-1499.
    • Meagher M, Lightowlers RN. . Biochimie 2014, 100, 121-124.
    • Lightowlers RN, Rozanska A, Chrzanowska-Lightowlers ZM. . FEBS Letters 2014, 588(15), 2496-2503.
    • Lightowlers RN, Chrzanowska-Lightowlers ZM. . RNA Biology 2013, 10(9), 1433-1438.
    • Chrzanowska-Lightowlers ZMA, Pajak A, Lightowlers RN. . Journal of Biological Chemistry 2011, 286(40), 34479-34485.
    • Kyriakouli D, Boesch P, Taylor R, Lightowlers R. . Gene Therapy 2008, 15(14), 1017-1023.
    • Muratovska A, Lightowlers RN, Taylor RW, Wilce JA, Murphy MP. . Advanced Drug Delivery Reviews 2001, 49(1-2), 189-198.
    • Taylor RW, Wardell TM, Smith PM, Muratovska A, Murphy MP, Turnbull DM, Lightowlers RN. . Advanced Drug Delivery Reviews 2001, 49(1-2), 121-125.
    • Lightowlers RN, Jacobs HT, Kajander OA. . Trends in Genetics 1999, 15(3), 91-93.
    • Lightowlers RN, Chinnery PF, Turnbull DM, Howell N, Turnbull DM. . Trends in Genetics 1997, 13(11), 450-455.
    • Chrzanowska-Lightowlers ZMA, Lightowlers RN, Turnbull DM. . Gene Therapy 1995, 2(5), 311-316.