缅北禁地

Introduction

I am a Senior Lecturer and Clinical Exercise Physiologist. I have over 10 years' experience supporting people with long-term health conditions to be physically active, including people with obesity, older adults, and cancer survivors. I now lead an independent programme of research focused on developing and testing physical activity interventions in people at higher risk of, or diagnosed with, cancer.

Roles and responsibilities

Deputy director of research; School of Biomedical, Nutritional and Sport Sciences

Postgraduate research student coordinator; School of Biomedical, Nutritional and Sport Sciences

External activities

Scientific Advisor - Simple App

Editorial Board member - Communications in Kinesiology

Editorial Board member - BMC Sports Science, Medicine and Rehabilitation

Steering Committee Member - UK Therapeutic Cancer Prevention Network Group (UKTCPN)

Qualifications

PhD Clinical Exercise Physiology; University of Hull

MRes Exercise Science; Northumbria University

BSc (Hons) Sport and Exercise Science; York St John University

Higher Education Academy Fellowship

Professional registrations

Clinical Exercise Physiologist - The Academy for Healthcare Science

Previous positions

NIHR-funded postdoctoral researcher; Northumbria University

Lecturer in Exercise Physiology; York St John University

Memberships

British Association of Cancer Research

The Association for the Study of Obesity

Society for Transparency, Openness, and Replication in Kinesiology (STORK) outreach committee

Awards

Open Research Award 2022 (First Prize), 缅北禁地

British Association of Cancer Research Travel Award

Physical activity and cancer

There is good evidence that physical activity after a cancer diagnosis can improve treatment tolerability and improve health-related and clinical outcomes. I am leading trials across diverse cancer types to identify the most effective, acceptable, and scalable ways of supporting health behaviour change in people living with and beyond cancer, with a particular emphasis on becoming more active.

Mechanisms of physical activity and cancer risk

Regular physical activity is associated with a reduced risk of several site-specific cancers, but the underlying mechanisms of action are not fully resolved. I am interested in understanding these mechanisms better to inform the development of more precise, targeted preventive interventions. We have previously shown that exercise causes a protein called interleukin 6 (IL-6) to be released into the bloodstream, which helps repair the DNA of cancer damaged cells. This may be one mechanism underlying the protective effect of exercise against cancer.

Current research projects

: EXpanding into communities to imProve lifestyle sUpport foR womEn after breast cancer (funded by Breast Cancer Now; Lead Investigator)

: Pathophysiology of physical deconditioning in patients treated with chemoradiotherapy for HPV-related oropharyngeal cancer (funded by the Faculty of Medical Sciences, 缅北禁地; Co-investigator)

INTENT: acute exercIse oN colorecTal adENoma growTh (funded by Wellcome Trust Translational Partnership; Lead Investigator)

MOTION: Mechanisms Of acuTe exercIse and cOlorectal caNcer progression (funded by Wellcome Trust Institutional Strategic Support Fund; Lead Investigator)

CASCADE: aCute exercise extrAcellular veSiCle releAse anD contEnt (funded by the Faculty of Medical Sciences, 缅北禁地; Lead Investigator)

Co-creation of an intervention to increase physical activity uptake for dementia risk reduction, among ethnic minority communities in North East England (funded by MRC Attain Healthy Ageing Network; Co-investigator)

Completed research projects

: TELehealth EXercise for patients with primary liver cancer (funded by NIHR 缅北禁地 BRC, Co-investigator)

: Acute Effect of modeRate-intensity aerOBIc exercise on Colon cancer cell growth (funded by the Faculty of Health & Life Sciences, Northumbria University, Lead Investigator)

: PROState cancer patients initiating hormone therapy: effect of exercise on CARDIOvascular health (Co-investigator)

PhD supervision

Impact of lifestyle on liver cancer development and progression (Misti McCain, 缅北禁地)

Exercise as a treatment for chemotherapy induced peripheral neuropathy in women with breast cancer (Rosiered Brownson-Smith, Northumbria University)

Development of an evidence-based diet and exercise app for people living with and beyond colorectal cancer (Anna Fretwell, 缅北禁地)

Impact of thermal strain in people with type 1 and type 2 diabetes (Ollie Page, 缅北禁地)

I am accepting PhD applications in the following areas:

Understanding barriers and facilitators to health behaviours in people living with long-term health conditions

Developing and evaluating physical activity interventions in people at increased risk of, or diagnosed with, cancer

Understanding the biological mechanisms of how physical activity might prevent the progression of certain cancers

Undergraduate teaching

• SES3004 Physical Activity, Exercise and Disease
• SES2000 Principles of Strength and Conditioning
• SES2004 Exercise Physiology
• SES3000 Sport and Exercise Science Research Project

Postgraduate teaching

• SES8001 Exercise Physiology Assessment Skills (module lead)
• SES8099 Exercise Physiology Dissertation
• MMB8044: Exercise in Health and Disease
• SES8000 Applied Exercise Science
• CVR8007 Diagnostic Approaches & Current Treatment of Cardiovascular Disorders

• Articles

  • Brownson-Smith R, Carr J, Orange ST, Cresti N, Saxton JM, Temesi J. . BMC Cancer 2026, Epub ahead of print.
  • Brownson-Smith R, Carr J, Fox KT, Orange ST, Cresti N, Saxton JM, Temesi J. . PLoS ONE 2025, 20(6), e0314437.
  • Orange ST, Dodd E, Nath S, Bowden H, Jordan AR, Tweddle H, Hedley A, Chukwuma I, Hickson I, Sharma Saha S. . International Journal of Cancer 2025, Epub ahead of print.
  • Orange ST, Brown MC, Hallsworth K, Malcomson FC, Corfe B, Tweedie C, Cresti N, Cain H, Court P, Willson C, Ross K, Mathers JC, Saxton JM, Sharp L, Smith SG. . NIHR Open Research 2025, 5(3).
  • Makaracia Y, Nasa K, Gündüzb K, Uysala A, Orange ST, Ruiz-Cárdenase JD. . Measurement in Physical Education and Exercise Science 2024, 28(4), 391-400.
  • Hodgson P, Jordan A, Sinani C, Charura D, Orange ST. . CNS Neuroscience & Therapeutics 2024, 30(2), e14562.
  • Hallsworth K, McCain MV, Fallen-Bailey R, Brown MC, Orange ST, Reeves HL. . BMJ Open 2024, 14(6), e082155.
  • Orange ST, Roebuck J, Marshall P, Madden LA, Vince RV, Bell BT. . British Journal of Health Psychology 2024, 29(4), 943-957.
  • Metcalfe JW, Orange ST, Madden LA, Marshall P, Vince RV. . Supportive Care in Cancer 2024, 32(9), 593.
  • Fretwell A, Dobson C, Orange ST, Corfe B. . Supportive Care in Cancer 2024, 32, 609.
  • Balachandran AT, Orange ST, Yipeng W, Lustin R, Vega A, Quiles N. . Plos One 2024, 19(8), e0308808.
  • Orange ST, Guerin C, Taylor C, Poole L, Sanger K, Clarke S, Goodley L, Bradbury C, Pearmain W. . Communications in Kinesiology 2024, 1, 6.
  • Orange ST. . Best Practice & Research Clinical Gastroenterology 2023, 66, 101841.
  • Orange ST, Leslie J, Ross M, Mann DA, Wackerhage H. . Trends in Endocrinology and Metabolism 2023, 34(11), 749-763.
  • Hicks K, Orange ST, Dulson D, Ansdell P, Todryk S, Gilbert S, Saxton JM. . International Journal of Sports Physiology and Performance 2023, 18(4), 435-439.
  • Scott DJ, Ditroilo M, Orange ST, Marshall P. . International Journal of Sports Physiology and Performance 2023, 18(3), 240–247.
  • Scott DJ, Marshall P, Orange ST, Ditroilo M. . International Journal of Sports Physiology and Performance 2023, 18(3), 231-239.
  • Ross M, Turner JE, Orange ST, Metcalfe R. . Frontiers in Physiology 2023, 14, 1254151.
  • Myslivecek J, Lung C-W, Martins-Marques T, Orange ST, Hiura M, Ding Y. . Frontiers in Physiology 2023, 14, 1267842.
  • Orange ST, Hallsworth K, Brown MC, Reeves HL. . Pilot And Feasibility Studies 2022, 8, 113.
  • Makaraci Y, Nas K, Ruiz-Cárdenas JD, Gündüz K, Aydemir M, Orange ST. . The Journal of Strength and Conditioning Research 2022, 37(12), 2373-2380.
  • Orange ST, Jordan AR, Odell A, Kavanagh O, Hicks KM, Todryk S, Saxton JM. . International Journal of Cancer 2022, 151(9), 1642-1643.
  • Orange ST, Hritz A, Pearson L, Jeffries O, Jones TW, Steele J. . Journal of Sports Sciences 2022, 40(11), 1220-1234.
  • Orange ST, Jordan AR, Odell A, Kavanagh O, Hicks KM, Eaglen T, Todryk S, Saxton JM. . International Journal of Cancer 2022, 151(2), 265-274.
  • Orange ST, Gilbert SE, Brown MC, Saxton JM. . Supportive Care in Cancer 2021, 29, 6369-6378.
  • Orange ST, Hicks KM, Saxton JM. . Cancer Causes & Control 2021, 32, 13-26.
  • Metcalfe R, Kemp R, Heffernan SM, Churm R, Chen Y, Ruffino JS, Conway GE, Tornillo G, Orange ST. . European Journal of Applied Physiology 2021, 121, 2107-2124.
  • Bell BT, Taylor C, Paddock D, Bates A, Orange ST. . Health Psychology Open 2021, 8(1).
  • Orange ST, Metcalfe JW, Liefeith A, Jordan AR. . Gait & Posture 2020, 76, 409-414.
  • Orange ST, Jordan AR, Saxton JM. . Physiological Reports 2020, 8(22), e14635.
  • Orange ST, Metcalfe JW, Marshall P, Vince RV, Madden LA, Liefeith A. . The Journal of Strength & Conditioning Research 2020, 34(3), 728-737.
  • Munson EH, Orange ST, Bray JW, Thurlow S, Marshall P, Vince RV. . Frontiers in Nutrition 2020, 7, 549413.
  • Orange ST, Madden LA, Vince RV. . Journal of Physiotherapy 2020, 66(4), 214-224.
  • Ndjavera W, Orange ST, O'Doherty AF, Leicht AS, Rochester M, Mills R, Saxton JM. . BJU International 2020, 125(1), 28-37.
  • Orange ST, Marshall P, Madden LA, Vince RV. . Translational Sports Medicine 2020, 3(1), 34-45.
  • Orange ST, Metcalfe JW, Liefeith A, Marshall P, Madden LA, Fewster CR, Vince RV. . The Journal of Strength & Conditioning Research 2019, 33(9), 2398-2408.
  • Orange ST, Marshall P, Madden LA, Vince RV. . The Journal of Strength & Conditioning Research 2019, 33(10), 2733-2742.
  • Orange ST, Metcalfe JW, Robinson A, Applegarth MJ, Liefeith A. . International journal of sports physiology and performance 2019, 15(4), 554-561.
  • Orange ST, Marshall P, Madden LA, Vince RV. . Journal of Sports Sciences 2019, 37(11), 1227-1234.
  • Orange ST, Northgraves MJ, Marshall P, Madden LA, Vince RV. . International Journal of Surgery 2018, 56, 328-333.
  • Orange ST, Smith A. . The Health & Fitness Journal of Canada 2016, 9, 21-37.

• Conference Proceedings (inc. Abstracts)

  • Page O, Carruthers M, Taylor GS, Orange ST, Dulson DK, West DJ, Jeffries O. . In: Diabetes UK Professional Conference 2025. 2025, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
  • Hallsworth K, Orange ST, McCain M, Fallen-bailey R, Reeves HL. . In: EASL Congress 2023. 2023, Vienna, Austria: Elsevier BV.
  • Orange ST, Marshall P, Madden L, Vince RV. . In: 5th UK Congress on Obesity. 2018, 缅北禁地, 缅北禁地 upon Tyne, UK: Nature.

• Reviews

  • Brownson-Smith R, Orange ST, Cresti N, Hunt K, Saxton J, Temesi J. . Journal of Cancer Survivorship 2025, 19, 78-96.
  • Alqallaf J, Orange ST, Matu J, Griffiths A, Johnson K, Stavropoulos-Kalinoglou A, Holliday A, Wilson O. . Journal of Nutrition 2024, 154(4), 1087-1100.
  • Fretwell A, Louca P, Cohoon G, Sakellaropoulou A, Henriques Caetano MDP, Koullapis A, Orange ST, Malcomson FC, Dobson C, Corfe BM. . Critical Reviews in Food Science and Nutrition 2024, 65(16), 3173-3185.