缅北禁地

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Staff Profile

Dr Simon Tual-Chalot

Principal Investigator

  • Personal Website:
  • Address: Biosciences Institute
    Theme Vascular Biology & Medicine
    Faculty of Medical Sciences
    缅北禁地
    Central Parkway
    缅北禁地 upon Tyne
    NE1 3BZ
Background

Graduate student, University of Angers, France, 2008-2011

During my PhD, financed by a prestigious grant awarded by the French Ministry of Research (University of Angers, France, 2008-2011; PI: Dr C Martinez), I revealed for the first time the importance of extracellular vesicles in driving the endothelial dysfunction in diseases associated with hypoxia (Am J Respir Crit Care Med. 2010; Am J Pathol. 2012; Biochim Biophys Acta. 2014).

Marie Curie Fellow, Arthur Lab, 缅北禁地, 2012-2015

I joined 缅北禁地 in 2012, supported by the highly competitive Marie Curie Intra-European Fellowship (host lab: Prof H Arthur; 2012-2015). I first established the mandatory role of Alk1 in the maintenance of vascular integrity (PLoS One. 2014) and then demonstrated the essential cardioprotective role of endoglin after myocardial infarction (Stem Cell Reports. 2017) This work was highlighted in Horizon, the EU Research & Innovation Magazine. Within these studies, I optimised technologies and tools now widely used by the research community to assess in vivo angiogenesis (J Vis Exp. 2013) and vascular remodelling after myocardial infarction by cardiac imaging (Int J Cardiol Heart Vasc. 2016).

Post-doc, Arthur Lab, 缅北禁地, 2015-2018

Thanks to a British Heart Foundation (BHF) Project Grant Application (PI: Helen Arthur; co-I: S TualChalot; 2015-2018) and my Young Investigator Award from Cure HHT (PI: S Tual-Chalot), I demonstrated the importance of endothelial endoglin in the adult vasculature (Circ Res. 2020). In parallel, I contributed through my imaging skills to a highly collaborative work by deciphering the vascular senescence process in age-related cardiovascular diseases (EMBO. 2019; Aging Cell. 2019, 2020).

Post-doc, Stellos Lab, 缅北禁地, October 2018-2023

In the ERC-funded lab of Prof Stellos, I worked on the role of RNA-based mechanisms in vascular endothelial cell homeostasis and disease. (Immunity. 2023). In parallel, I led or contributed with international collaborators to several vascular biology studies and clinical investigations on novel inflammatory markers for cardiovascular disease and ageing (Front Immunol. 2023).

Principal Investigator, 缅北禁地, 2024-present

Supported by the BHF, I am establishing my lab studying one of the most critical processes governing our life: how endothelial cells adapt to ageing in health and diseases.

Research

Cardiovascular disease (CVD) is the leading cause of adult morbidity and mortality globally, and its prevalence grows with age. Ageing is now the main risk factor for CVD development through the deterioration of heart and vessel physiological functions. While CVD has long been a major focus of biomedical research, our understanding of the causes driving cardiovascular ageing is still limited, precluding the design strategies able to contain or delay it. Gaining a better understanding of its mechanisms is of paramount importance for tackling the growing epidemic of age-related diseases. My lab aims at identifying novel mechanism involved in the regulation of vascular ageing and finding new solutions to maintain healthy ageing.

Research Funding:

2024-2025       Royal Society research grant, £69,936

Amyloid-beta and myocardial infarction: unlocking new therapeutic avenues

PI: Dr Simon Tual-Chalot  

2024-2027       BHF project grant, £279,66

Characterising chemotherapy-induced cardiac cell senescence to ascertain its role in chemotherapy- induced heart failure

Co-I: Dr Simon Tual-Chalot (PI: Dr Gavin Richardson)

2024-2027       BHF project grant, £299,998

The role of Amyloid-beta in cardiovascular ageing

PI: Dr Simon Tual-Chalot                   

2022-2025       BHF project grant, £304,017

Senotherapy to improve recovery post-cardiac ischemia reperfusion

Co-I: Dr Simon Tual-Chalot (PI: Dr Gavin Richardson)                  

2022-2024       BHF project grant, £243,111.5

Identifying older donors suitable for transplantation: The use of senescence as a marker of biological

Co-I: Dr Simon Tual-Chalot (PI: Dr Gavin Richardson)                    

2022-2023       Wellcome Trust Institutional Strategic Support Fund, £9,136

The role of Amyloid-beta in cardiovascular ageing

PI: Dr Simon Tual-Chalot; co-I: Dr Gavin Richardson                  

2020-2021       British Society for Research on Ageing consumable grant, £500

The Alzheimer's disease Amyloid-beta hypothesis in vascular ageing

PI: Dr Simon Tual-Chalot                       

2015-2018       BHF project grant, £248,861

Endothelial endoglin is required to maintain normal cardiac function in adult life

Co-I: Dr Simon Tual-Chalot (PI: Prof Helen Arthur)

2015-2016       Young Investigator award from Cure HHT, £19,108

Role of endoglin in HHT and high output heart failure

PI: Dr Simon Tual-Chalot

2013-2015       Marie Curie Intra-European Fellowship, £231,283

Endoglin-mediated vascular regeneration to promote heart repair (VASC-GEN)

Fellow: Dr Simon Tual-Chalot; host lab: Prof. Helen Arthur           


Honours and Awards:

2019: Best oral presentation prize runner up. British Atherosclerosis Society Annual Meeting,    Oxford, UK

2019: Highest Scoring Abstract Basic Science. British Cardiovascular Society and the British     Heart Foundation Annual Meeting, Manchester, UK

2019: Best oral presentation prize runner up. British Cardiovascular Research Society and the   British Atherosclerosis Society Annual Meeting, Manchester, UK

2018: Best poster prize runner up. British Cardiovascular Research Society and the British       Atherosclerosis Society Annual Meeting, Manchester, UK

2015: Young Investigator award from Cure HHT

2013: Marie Curie Intra-European Fellowship. Total Score of 95.2/100

2011: Best poster presentation prize. 27th Annual Meeting of the “Groupe de Réflexion sur la     Recherche Cardiovasculaire”, Lyon, France

2009: Best oral presentation prize. 13th Annual Meeting of French Society of Pharmacology and   Therapeutics, Marseille, France


Committee membership:

2022-present: Board member of the Working group "microcirculation and inflammation" of the European Society of hypertension

2020-present: 缅北禁地 Biosciences Institute Equality, Diversity and Inclusion Steering Committee





Teaching

2021-present    Lecture on vascular endothelial cells for BMS 3017 “Clinical Ageing and Health” and MMB8037 “Cardiovascular Science in Health and Disease” module

2021-present    Member of PhD review panel

2020-present    Teaching Assistant on CMB1004 “Cell Biology” and PSC1002 “Physiology” module

2010-2011       Lecture on Vascular Inflammation (Mres level)

2009-present      Laboratory supervision of 10 MRes students, 14 BSc students and 3 Summer Research Scholarship students





Publications

  • Articles

    • Camacho-Encina M, Booth LK, Redgrave R, Honkanen-Scott MM, Scott III WE, Martin-Ruiz C, MacGowan G, Richardson S, Dark J, Tual-Chalot S, Richardson GD. . Cardiovascular Research 2024, 120(17), 2163-2165.
    • Redgrave RE, Singh E, Tual-Chalot S, Park C, Hall D, Bennaceur K, Smyth DJ, Maizels RM, Spyridopoulos I, Arthur HM. . The American Journal of Pathology 2024, 194(4), 562-573.
    • Delialis D, Georgiopoulos G, Tual-Chalot S, Angelidakis L, Aivalioti E, Mavraganis G, Sopova K, Argyris A, Kostakou P, Konstantaki C, Papaioannou M, Tsilimigras D, Chatoupis K, Zacharoulis AA, Galyfos G, Sigala F, Stellos K, Stamatelopoulos K. . Scientific Reports 2024, 14(1), 14944.
    • Gatsiou A, Tual-Chalot S, Napoli M, Ortega-Gomez A, Regen T, Badolia R, Cesarini V, Garcia-Gonzalez C, Chevre R, Ciliberti G, Silvestre-Roig C, Martini M, Hoffmann J, Hamouche R, Visker JR, Diakos N, Wietelmann A, Silvestris DA, Georgiopoulos G, Moshfegh A, Schneider A, Chen W, Guenther S, Backs J, Kwak S, Selzman CH, Stamatelopoulos K, Rose-John S, Trautwein C, Spyridopoulos I, Braun T, Waisman A, Gallo A, Drakos SG, Dimmeler S, Sperandio M, Soehnlein O, Stellos K. . Immunity 2023, 56(5), 979-997.e11.
    • Redgrave R, Dookun E, Booth LK, Camacho Encina M, Folaranmi O, Tual-Chalot S, Gill JH, Owens WA, Spyridopoulos I, Passos JF, Richardson GD. . npj Aging 2023, 9, 15.
    • Georgiopoulos G, Kraler S, Mueller-Hennessen M, Delialis D, Mavraganis G, Sopova K, Wenzl FA, Raber L, Biener M, Stahli BE, Maneta E, Spray L, Iglesias JF, Coelho-Lima J, Tual-Chalot S, Muller O, Mach F, Frey N, Duerschmied D, Langer HF, Katus H, Roffi M, Camici GG, Mueller C, Giannitsis E, Spyridopoulos I, Luscher TF, Stellos K, Stamatelopoulos K. . JAMA Cardiology 2023, 8(10), 946-956.
    • Kateryna, Tual-Chalot S, Mueller-Hennessen M, Vlachogiannis N, Georgiopoulos G, Biener M, Sachse M, Turchinovich A, Polycarpou-Schwarz M, Spray L, Maneta E, Bennaceur K, Mohammad A, Richardson GD, Gatsiou A, Langer HF, Frey N, Stamatelopoulos K, Heineke J, Duerschmied D, Giannitsis E, Spyridopoulos I, Stellos K. . Frontiers in Immunology 2023, 14, 1177467.
    • Tual-Chalot S, Stellos K. . Cardiovascular Research 2022, 118(8), 1854-1856.
    • Vlachogiannis N, Baker K, Georgiopoulos G, Lazaridis C, Schim van der Loeff I, Hanrath A, Sopova K, Tual-Chalot S, Gatsiou A, Spyridopoulos I, Stamatelopoulos K, Duncan C, Stellos K. . Journal of Cachexia, Sarcopenia and Muscle 2022, 13(3), 1502-1513.
    • Stamatelopoulos K, Mueller-Hennessen M, Georgiopoulos G, Lopez-Ayala P, Sachse M, Vlachogiannis NI, Sopova K, Delialis D, Bonini F, Patras R, Ciliberti G, Vafaie M, Biener M, Boeddinghaus J, Nestelberger T, Koechlin L, Tual-Chalot S, Kanakakis I, Gatsiou A, Katus H, Spyridopoulos I, Mueller C, Giannitsis E, Stellos K. . Journal of the American College of Cardiology 2022, 80(10), 998-1010.
    • Bampatsias D, Mavroeidis I, Tual-Chalot S, Vlachogiannis NL, Bonini F, Sachse M, Mavraganis G, Mareti A, Kritsioti C, Laina A, Delialis D, Ciliberti G, Sopova K, Gatsiou A, Martelli F, Georgiopoulos G, Stellos K, Stamatelopoulos K. . Thrombosis and Haemostasis 2022, 122(11), 1932-1942.
    • Tual-Chalot S, Stellos K. . Cardiovascular research 2021, 117(2), 354-356.
    • Vlachogiannis NI, Tual-Chalot S, Zormpas E, Bonini F, Ntouros PA, Pappa M, Bournia V-K, Tektonidou MG, Souliotis VL, Mavragani CP, Stamatelopoulos K, Gatsiou A, Sfikakis PP, Stellos K. . Journal of Autoimmunity 2021, 125, 102755.
    • Gatsiou A, Georgiopoulos G, Vlachogiannis NI, Pfisterer L, Fischer A, Sachse M, Laina A, Bonini F, Delialis D, Tual-Chalot S, Zormpas E, Achangwa R, Jiang L, Kontogiannis C, Patras R, Hermeking H, Zeiher AM, Stamatelopoulos K, Dimmeler S, Stellos K. . Atherosclerosis 2021, 327, 49-58.
    • Tual-Chalot S, García-Collado M, Redgrave RE, Singh E, Davison B, Park C, Lin H, Luli S, Jin Y, Wang Y, Lawrie A, Jakobsson L, Arthur HM. . Circulation Research 2020, 126(2), 243-257.
    • Dookun E, Walaszczyk A, Redgrave R, Palmowski P, Tual Chalot S, Suwana A, Chapman J, Jirkovsky E, Donastorg Sosa L, Gill E, Yausep O, Santin Y, Mialet Perez J, Owens WA, Grieve D, Spyridopoulos I, Taggart M, Arthur HM, Passos JF, Richardson GD. . Aging Cell 2020, 19(10), e13249.
    • Dorn LE, Tual-Chalot S, Stellos K, Accornero F. . Journal of Molecular and Cellular Cardiology 2019, 129, 272-280.
    • Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot A, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD. . Aging Cell 2019, 18(3), e12945.
    • Anderson R, Lagnado A, Maggiorani D, Walaszczyk A, Dookun E, Chapman J, Birch J, Salmonowicz H, Ogrodnik M, Jurk D, Proctor C, Correia-Melo C, Victorelli S, Fielder E, Berlinguer-Palmini R, Owens WA, Greaves L, Kolsky K, Parini A, Douin-Echinard V, LeBrasseur N, Arthur H, Tual-Chalot S, Schafer M, Roos C, Miller J, Robertson N, Mann J, Adams P, Tchkonia T, Kirkland J, Mialet-Perez J, Richardson GD, Passos J. . The EMBO Journal 2019, 38(5), e100492.
    • Bailey KE, MacGowan GA, Tual-Chalot S, Phillips L, Mohun TJ, Henderson DJ, Arthur HM, Bamforth SD, Phillips HM. . JCI Insight 2019, 4(8), e125172.
    • Gallardo-Vara E, Tual-Chalot S, Botella LM, Arthur HM, Bernabeu C. . Disease Models & Mechanisms 2018, 11(9), dmm034397.
    • Thalgott JH, Dos-Santos-Luis D, Hosman AE, Martin S, Lamande N, Bracquart D, Srun S, Galaris G, de Boer HC, Tual-Chalot S, Kroon S, Arthur HM, Cao Y, Snijder RJ, Disch F, Mager JJ, Rabelink TJ, Mummery CL, Raymond K, Lebrin F. . Circulation 2018, 138(23), 2698-2712.
    • Redgrave RE, Tual-Chalot S, Davison BJ, Singh E, Hall D, Amirrasouli MM, Gilchrist D, Medvinsky A, Arthur HM. . Stem Cell Reports 2017, 8(5), 1287-1298.
    • Redgrave RE, Tual-Chalot S, Davison BJ, Greally E, Santibanez-Koref M, Schneider JE, Blamire AM, Arthur HM. . IJC Heart & Vasculature 2016, 11, 29-34.
    • Tual-Chalot S, Mahmoud M, Allinson KR, Redgrave RE, Zhai ZH, Oh SP, Fruttiger M, Arthur HM. . PLoS One 2014, 9(6), e98646.
    • Tual-Chalot S, Gagnadoux F, Trzepizur W, Priou P, Andriantsitohaina R, Martinez MC. . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2014, 1842(2), 202-207.
    • Tual-Chalot S, Allinson KR, Fruttiger M, Arthur HM. . Journal of Visualized Experiments 2013, 77, 1-5.
    • Jeanneteau J, Hibert P, Martinez MC, Tual-Chalot S, Tamareille S, Furber A, Andriantsitohaina R, Prunier F. . American Journal of Physiology: Heart and Circulatory Physiology 2012, 303(7), H871-H877.
    • López-Andrés N, Tesse A, Regnault V, Louis H, Cattan V, Thornton SN, Labat C, Kakou A, Tual-Chalot S, Faure S, Challande P, Osborne-Pellegrin M, Martínez MC, Lacolley P, Andriantsitohaina R. . PLoS One 2012, 7(7), e39235.
    • Tual-Chalot S, Fatoumata K, Priou P, Trzepizur W, Gaceb A, Contreras C, Prieto D, Martinez MC, Gagnadoux F, Andriantsitohaina R. . American Journal of Pathology 2012, 181(4), 1473-1482.
    • Trzepizur W, Priou P, Paris A, Nardi J, Tual-Chalot S, Meslier N, Urban T, Andriantsitohaina R, Martinez MC, Gagnadoux F. . European Respiratory Journal 2011, 37(5), 1293-1295.
    • Rottner M, Tual-Chalot S, Mostefai HA, Andriantsitohaina R, Freyssinet JM, Martínez MC. . PLoS One 2011, 6(9), e24880.
    • Benameur T, Tual-Chalot S, Andriantsitohaina R, Martínez MC. . PLoS One 2010, 5(8), e12392.
    • Tual-Chalot S, Guibert C, Muller B, Savineau JP, Andriantsitohaina R, Martinez MC. . American Journal of Respiratory and Critical Care Medicine 2010, 182(2), 261-268.

  • Book Chapter

    • Booth k, Redgrave R, Tual-Chalot s, Spyridopoulos I, Phillips HM, Richardson GD. . In: Harris, J.R., Korolchuk, V.I, ed. Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science. Cham, Switzerland: Springer, 2023, pp.45-78.

  • Editorials

    • Amponsah-Offeh M, Tual-Chalot S, Stellos K. . European Heart Journal 2024, 45(18), 1681-1683.
    • Tual-Chalot S, Stellos K. . European Heart Journal 2022, 43(24), 2335-2337.
    • Tual-Chalot S, Stellos K. . Hellenic Journal of Cardiology 2021, 62(2), 149-151.

  • Letter

    • Mareti A, Kritsioti C, Georgiopoulos G, Vlachogiannis NI, Delialis D, Sachse M, Sopova K, Koutsoukis A, Kontogiannis C, Patras R, Tual-Chalot S, Koureas A, Gatsiou A, Stellos K, Stamatelopoulos K. . European Journal of Preventive Cardiology 2019, 27(19), 2288-2291.

  • Note

    • Tual-Chalot S, Stellos K. . Cardiovascular Research 2024, 120(4), E5-E8.

  • Reviews

    • Rios FJ, De Ciuceis C, Georgiopoulos G, Lazaridis A, Nosalski R, Pavlidis G, Tual-Chalot S, Agabiti-Rosei C, Camargo LL, Dabrowska E, Quarti-Trevano F, Hellmann M, Masi S, Lopreiato M, Mavraganis G, Mengozzi A, Montezano AC, Stavropoulos K, Winklewski PJ, Wolf J, Costantino S, Doumas M, Gkaliagkousi E, Grassi G, Guzik TJ, Ikonomidis I, Narkiewicz K, Paneni F, Rizzoni D, Stamatelopoulos K, Stellos K, Taddei S, Touyz RM, Virdis A. . Hypertension 2024, 81(6), 1218-1232.
    • Sachse M, Tual-Chalot S, Ciliberti G, Amponsah-Offeh M, Stamatelopoulos K, Gatsiou A, Stellos K. . Atherosclerosis 2023, 374, 55-73.
    • Jusic A, Thomas PB, Wettinger SB, Dogan S, Farrugia R, Gaetano C, Tuna BG, Pinet F, Robinson EL, Tual-Chalot S, Stellos K, Devaux Y. . Ageing Research Reviews 2022, 77, 101610.
    • Lambrinoudaki I, Delialis D, Georgiopoulos G, Tual-Chalot S, Vlachogiannis NI, Patras R, Aivalioti E, Armeni E, Augoulea A, Tsoltos N, Soureti A, Stellos K, Stamatelopoulos K. . Thrombosis and Haemostasis 2021, 121(05), 650-658.
    • Stakos DA, Stamatelopoulos K, Bampatsias D, Sachse M, Zormpas E, Vlachogiannis NI, Tual-Chalot S, Stellos K. . Journal of the American College of Cardiology 2020, 75(8), 952-967.
    • Tual-Chalot S, Oh SP, Arthur HM. . Frontiers in Genetics 2015, 6, 25.
    • Tual-Chalot S, Leonetti D, Andriantsitohaina R, Martínez MC. . Molecular Interventions 2011, 11(2), 88-94.
    • Martinez MC, Tual-Chalot S, Leonetti D, Andriantsitohaina R. . Trends in Pharmacological Sciences 2011, 32(11), 659-665.