缅北禁地

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Staff Profile

Professor Stephen Bourke

Honorary Prof of Respiratory Medicine

  • Email: stephen.bourke@ncl.ac.uk
  • Telephone: 0191 293 4026
  • Address: Northumbria Healthcare NHS Foundation Trust.
    North Tyneside General Hospital
    Rake Lane
    North Shields
    NE29 8NH
Background

I am a member of the

I have a major interest in COPD, and in motor neuron disease, as outlined in more detail in the adjacent RESEARCH section.

Research

My interests include clinical research in chronic obstructive pulmonary disease (COPD) and respiratory aspects of motor neurone disease.

COPD exacerbation is the 2nd commonest reason for hospitalisation. NICE guidelines endorse hospital at home and early (supported) discharge services in this condition, recommend that selection should be informed by risk of death but acknowledge the (previous) lack of a robust prognostic score. I led development of the DECAF prognostic score to risk stratify such patients, with multicentre validation, in 2,645 patients consecutively admitted to participating sites. DECAF is simple to apply at the bedside, offers excellent discrimination for in-hospital death and outperforms other tools sometimes used in this setting. Routine use to inform care is endorsed by: UK COPD Audit Report and BTS COPD Specialist Advisory Group 2015 and an independent Thorax Editorial 2016. I conceived and supervised a RCT of hospital at home selected by low risk DECAF score (RfPB funded); up to 50% of admitted patients are eligible thus the potential clinical and cost benefits are large. Based on this research, I won a NIHR Clinical Research Impact of the year award 2016.

Following preliminary pilot work, I performed a RCT of NIV in motor neurone disease (MND) / amytrophic lateral sclerosis (Lancet Neurology 2006). NIV was associated with substantial improvements in survival and quality of life. Regarded by NICE, Cochrane and others as the best available evidence, this trial has changed worldwide practice. Surveys conducted in the UK spanning publication of the RCT showed a 3.4 fold increase in the number of patients successfully established on NIV, with similar improvements elsewhere. This programme of research was included by 缅北禁地 in the 2014 Research Excellence Framework submission. I am currently working with NICE Quality Standards Committee and was previously involved in the development of guidelines on NIV in MND. I was a co-applicant and on the steering group for a RCT showing that diaphragmatic pacing reduced survival by eleven months (Lancet Neurology 2015). The device had previously been granted FDA approval on humanitarian grounds and was in clinical use. The results of this trial will prevent further harm to patients and highlights the importance of strict adherence to scientific method.

Recently completed studies:

1. Internal and external validation of the DECAF scoring system; a prognostic tool to predict inpatient mortality in acute exacerbations of COPD (UKCRN 14214). CI.
2. A randomised controlled trial of hospital at home compared to conventional in-patient care in patients presenting with an acute exacerbation of COPD and at low risk of death by the DECAF prognostic score. CI.
3. HOT HMV in COPD: Randomised controlled trial of home mechanical ventilation in hypercapnic COPD patients post acute hypercapnic exacerbation (UKCRN 8059). PI..
4. A randomised controlled trial in patients with respiratory muscle weakness due to motor neurone disease of the NeuRx RA/4 Diaphragmatic Pacing System (DiPALS) (HTA 09/55/33; UKCRN 10660). Co-applicant and steering group.
5. A 52-week treatment, multi-center, randomized, double blind, double dummy, parallel-group, active controlled study to compare the effect of QVA149 (indacaterol maleate / glycopyrronium bromide) with salmeterol/fluticasone on the rate of exacerbations in subjects with moderate to very severe COPD (UKCRN 7132). PI.
6. A Clinical Outcomes Study to compare the effect of Fluticasone Furoate/Vilanterol Inhalation Powder 100/25mcg with placebo on Survival in Subjects with moderate Chronic Obstructive Pulmonary Disease (COPD) and a history of or at increased risk for cardiovascular disease. PI.

COLLABORATORS
External
Dr Nicholas Hart, Lane Fox Respiratory Unit, St Thomas' Hospital and the members of the HOT HMV steering group.
Dr  Christopher McDermott, University of Sheffield, and the members of the DiPALS steering group.
Dr Robert Rutherford, Consultant Respiratory Physician, University Hospital Galway.
Dr Richard Harrison, University Hospital of North Tees.
Dr Meme Wijesinghe, Royal Cornwall Hospitals Trust.

Internal
, Emeritus Professor of Respiratory Medicine, 缅北禁地.
Dr David Cooper, Consultant Respiratory Physician, North Tyneside General Hospital.
Dr Sean Parker, Consultant Respiratory Physician, North Tyneside General Hospital.
Dr Gbenga Afolabi, Consultant Respiratory Physician, North Tyneside General Hospital.
Dr Catherine O’Neill, Consultant in Palliative Care, North Tyneside General Hospital.
Dr Tim Williams, Consultant Neurologist, Royal Victoria Infirmary, 缅北禁地.
Dr Christopher Stenton, Consultant Respiratory Physician, Royal Victoria Infirmary, 缅北禁地. 

Teaching

I regularly teach undergraduate students from the 缅北禁地 undergraduate medical curriculum.

PhD students
Current : Dr Carlos Echevarria
a) Internal and external validation of the Dyspnoea, Eosinopenia, Consolidation, Acidaemia and atrial Fibrillation (DECAF) prognostic score in acute exacerbations of COPD, triaged to hospital admission.
b) Randomised controlled trial of hospital at home compared to conventional in-patient care in patients presenting with an acute exacerbation of COPD and at low risk of death by the DECAF prognostic score.

Publications
  • Anwar GA, McDonnell MJ, Worthy SA, Bourke SC, Afolabi G, Lordan J, Corris PA, De Soyza A, Middleton P, Ward C, Rutherford RM. . Respiratory Medicine 2013, 107(7), 1001-1007.
  • Steer J, Gibson J, Bourke SC. . Thorax 2012, 67(11), 970-976.
  • O'Neill CL, Williams TL, Peel ET, McDermott CJ, Shaw PJ, Gibson GJ, Bourke SC. . Journal of Neurology, Neurosurgery and Psychiatry 2012, 83(4), 371-376.
  • Bourke SC, O'Neill CL, Williams TL, Peel ET, Gibson GJ, McDermott CJ, Shaw PJ. . Journal of Neurology, Neurosurgery and Psychiatry 2012, 83(4), 368-369.
  • Steer J, Norman E, Afolabi OA, Gibson GJ, Bourke SC. . Thorax 2012, 67(2), 117-121.
  • McDermott CJ, Maguire C, Cooper CL, Ackroyd R, Baird WO, Baudouin S, Bentley A, Bianchi S, Bourke SC, Bradburn MJ, Dixon S, Ealing J, Galloway S, Karat D, Maynard N, Morrison K, Mustfa N, Stradling J, Talbot K, Williams T, Shaw P. . BMC Neurology 2012, 12, 74.
  • Steer J, Gibson G, Bourke S. . QJM: An International Journal of Medicine 2010, 103(11), 817-829.
  • Dhar R, Anwar GA, Bourke SC, Doherty L, Middleton P, Ward C, Rutherford RM. . Thorax 2010, 65(6), 553-553.
  • Anwar GA, Bourke SC, Afolabi G, Middleton PG, Ward C, Rutherford RM. . Respiratory Medicine 2008, 102(10), 1494-1496.
  • Servera E, Sancho J, Bourke SC, Tomlinson M, Williams TL, Bullock RE, Shaw PJ, Gibson GJ. . Lancet Neurology 2006, 5(4), 291-292.
  • Bourke SC, Tomlinson M, Williams TL, Bullock RE, Shaw PJ, Gibson GJ. . The Lancet Neurology 2006, 5(2), 140-147.
  • Bourke SC, Gibson GJ. . European Respiratory Journal 2002, 19(6), 1194-1201.
  • Bourke SC, Gibson GJ. . Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2004, 5(2), 67-71.
  • Bourke SC, McColl E, Shaw PJ, Gibson GJ. . Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2004, 5(1), 55-60.
  • Bourke SC, Bullock RE, Williams TL, Shaw PJ, Gibson GJ. . Neurology 2003, 61(2), 171-177.
  • Bourke SC, Nicholson AG, Gibson GJ. . Thorax 2003, 58(11), 1004-1005.
  • Bourke SC, Williams TL, Bullock RE, Gibson GJ, Shaw PJ. . Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders 2002, 3(3), 145-149.
  • Bourke SC, Shaw PJ, Gibson GJ. . Neurology 2001, 57(11), 2040-2044.
  • Bourke SC, Clague H. . Postgraduate Medical Journal 2000, 76(900), 618-624.
  • Bourke SC. . Clinical Medicine 2014, 14(1), 72 -75.
  • Bourke SC, ONeill C. . In: SJ Bourke, ET Peel, ed. Integrated Palliative Care of Respiratory Disease. London, UK: Springer, 2013, pp.171-193.
  • Echevarria C, Bourke SC, Gibson GJ. . Respiratory Medicine Case Reports 2012, 5, 73-75.
  • Bourke SC. Acute Respiratory Failure in ALS: non-invasive ventilation. In: Rassegna di Patologia dell’Apparato Respiratorio. 2008.
  • Echevarria C, Brewin K, Horobin H, Bryant A, Corbett S, Steer J, Bourke SC. . COPD: Journal of Chronic Obstructive Pulmonary Disease 2016, 13(4), 523-533.
  • Echevarria C, Steer J, Heslop-Marshall K, Stenton SC, Hickey PM, Hughes R, Wijesinghe M, Harrison RN, Steen N, Simpson AJ, Gibson GJ, Bourke SC. . Thorax 2016, 71(2), 133-140.
  • McDermott CJ, Bradburn MJ, Maguire C, Cooper CL, Baird WO, Baxter SK, Bourke SC, Imam I, Bentley A, Ealing J, Elliott M, Hanemann CO, Hughes P, Orrell RW, Shaw PJ, Talbot K, Williams T, Ackroyd R, Berrisford R, Galloway S, Karat D, Maynard N, Sarela A, Simonds AK, Taylor L, Leek R, Darlison R, Leigh N, Dewey M, Radunovic A. . Lancet Neurology 2015, 14(9), 883-892.
  • Echevarria C, Steer J, Heslop-Marshall K, Stenton SC, Hickey PM, Hughes R, Wijesinghe M, Harrison RN, Steen N, Simpson AJ, Gibson GJ, Bourke SC. . In: BTS Winter Meeting 2015. 2015, BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND: BMJ Group.
  • Brooks KG, Echevarria C, Cooper D, Bourke SC. . Thorax 2014.
  • Bourke SC, Gibson GJ. . In: Elliott,M; Nava,S; Schonhöfer,B, ed. Non-invasive Ventilation and Weaning: Principles and Practice. London: Hodder Arnold, 2010, pp.351-360.
  • Haq IJ, Althaus M, Gardner AI, Yeoh HY, Joshi U, Saint-Criq V, Verdon B, Townshend J, O'Brien C, Ben-Hamida M, Thomas M, Bourke S, van der Sluijs P, Braakman I, Ward C, Gray MA, Brodlie M. . American Journal of Physiology Lung Cellular and Molecular Physiology 2021, 320(2), L288-L300.
  • Chynkiamis N, Lane ND, Megaritis D, Manifield J, Loizou I, Alexiou C, Riazati S, LoMauro A, Bourke SC, Vogiatzis I. . Journal of Applied Physiology 2021, 131(1), 401-413.
  • Langton DJ, Bourke SC, Lie BA, Reiff G, Natu S, Darlay R, Burn J, Echevarria C. . HLA 2021, 98(1), 14-22.
  • Ward C, Al Momani H, Perry A, Perry JD, Krishnan A, Jones R, Griffin M, Pearson J, Bourke S. . American Journal of Respiratory and Critical Care Medicine 2020, 202(7), 1061-1061.
  • Chynkiamis N, Armstrong M, Hume E, Alexiou C, Snow L, Lane ND, Hartley T, Bourke SC, Vogiatzis I. . Respiratory Physiology and Neurobiology 2020, 277, 103436.
  • Echevarria C, Steer J, Hartley T, Lane N, Bourke SC. . COPD: Journal of Chronic Obstructive Pulmonary Disease 2020, 17(5), 492-498.
  • Echevarria C, Steer J, Bourke SC. . Thorax 2019, 74(10), 941-946.
  • Vogiatzis I, Chynkiamis N, Armstrong M, Lane ND, Hartley TM, Gray WK, Bourke SC. . Journal of Clinical Medicine 2019, 8(1), 94.
  • Tariq MA, Everest FLC, Cowley LA, Wright R, Holt GS, Ingram H, Duignan LAM, Nelson A, Lanyon CV, Perry A, Perry JD, Bourke S, Brockhurst MA, Bridge SH, De Soyza A, Smith DL. . mSystems 2019, 4(4), e00191-18.
  • Bourke SC, Piraino T, Pisani L, Brochard L, Elliott MW. . The Lancet Respiratory Medicine 2018, 6(12), 935-947.
  • Echevarria C, Gray J, Hartley T, Steer J, Miller J, Simpson AJ, Gibson GJ, Bourke SC. . Thorax 2018, 73(8), 713-722.
  • Al Momani H, Perry A, Jones R, McDonnell M, Krishnan A, Robertson A, Griffin M, Rutherford R, Brodlie M, Pearson J, Bourke S, Ward C. . European Respiratory Journal 2018, 52(4), 1801492.
  • Lane ND, Brewin K, Hartley TM, Gray WK, Burgess M, Steer J, Bourke SC. . BMJ Open Respiratory Research 2018, 5(1), e000334.
  • Murphy PB, Rehal S, Arbane G, Bourke S, Calverley PMA, Crook AM, Dowson L, Duffy N, Gibson GJ, Hughes PD, Hurst JR, Lewis KE, Mukherjee R, Nickol A, Oscroft N, Patout M, Pepperell J, Smith I, Stradling JR, Wedzicha JA, Polkey MI, Elliott MW, Hart N. . JAMA 2017, 317(21), 2177-2186.
  • Al-momani H, Perry A, Jones R, Bourke S, Doe S, Perry J, Anderson A, Forrest T, Forrest I, Griffin M, Brodlie M, Pearson J, Ward C. . Scientific Reports 2017, 7, 46546.
  • Echevarria C, Steer J, Heslop-Marshall K, Stenton SC, Hickey PM, Hughes R, Wijesinghe M, Harrison RN, Steen N, Simpson AJ, Gibson GJ, Bourke SC. . Thorax 2017, 72(8), 686-693.
  • McDermott CJ, Bradburn MJ, Maguire C, Cooper CL, Baird WO, Baxter SK, Cohen J, Cantrill H, Dixon S, Ackroyd R, Baudouin S, Bentley A, Berrisford R, Bianchi S, Bourke SC, Darlison R, Ealing J, Elliott M, Fitzgerald P, Galloway S, Hamdalla H, Hanemann CO, Hughes P, Imam I, Karat D, Leek R, Maynard N, Orrell RW, Sarela A, Stradling J, Talbot K, Taylor L, Turner M, Simonds AK, Williams T, Wedzicha W, Young C, Shaw PJ. . Health Technology Assessment 2016, 20(45), 1-185.
  • Bryant JM, Grogono DM, Rodriguez-Rincon D, Everall I, Brown KP, Moreno P, Verma D, Hill E, Drijkoningen J, Gilligan P, Esther CR, Noone PG, Giddings O, Bell SC, Thomson R, Wainwright CE, Coulter C, Pandey S, Wood ME, Stockwell RE, Ramsay KA, Sherrard LJ, Kidd TJ, Jabbour N, Johnson GR, Knibbs LD, Morawska L, Sly PD, Jones A, Bilton D, Laurenson I, Ruddy M, Bourke S, Bowler ICJW, Chapman SJ, Clayton A, Cullen M, Dempsey O, Denton M, Desai M, Drew RJ, Edenborough F, Evans J, Folb J, Daniels T, Humphrey H, Isalska B, Jensen-Fangel S, Jonsson B, Jones AM, Katzenstein TL, Lillebaek T, MacGregor G, Mayell S, Millar M, Modha D, Nash EF, O'Brien C, O'Brien D, Ohri C, Pao CS, Peckham D, Perrin F, Perry A, Pressler T, Prtak L, Qvist T, Robb A, Rodgers H, Schaffer K, Shafi N, Van Ingen J, Walshaw M, Watson D, West N, Whitehouse J, Haworth CS, Harris SR, Ordway D, Parkhill J, Andres Floto R. . Science 2016, 354(6313), 751-757.
  • Echevarria C, Hartley T, Gray J, Muirhead C, Van-Wersch A, Miller J, Steer J, Simpson AJ, Gibson GJ, Bourke SC. . In: British Thoracic Society Winter Meeting 2016. 2016, London: BMJ Group.
  • Murphy PB, Arbane G, Bourke S, Calverley P, Crooks A, Dowson L, Duffy N, Gibson GJ, Hughes P, Hurst JR, Lewis K, Mukherjee R, Nickol A, Oscroft N, Pepperell J, Rehal S, Smith I, Stradling J, Wedizcha W, Polkey MI, Elliott M, Hart N. . In: British Thoracic Society Winter Meeting 2016. 2016, London: BMJ Group.
  • Al-Momani H, Perry A, Stewart CJ, Jones R, Krishnan A, Robertson AG, Bourke S, Doe S, Cummings SP, Anderson A, Forrest T, Griffin SM, Brodlie M, Pearson J, Ward C. . Scientific Reports 2016, 6, 26985.
  • Dismore L, Echevarria C, Van-Wersch A, Simpson AJ, Gibson GJ, Bourke SC. . In: British Thoracic Society Winter Meeting 2016. 2016, London: BMJ Group.
  • Steer J, Gibson GJ, Bourke SC. . BMJ Open Respiratory Research 2015, 2(1), 1-8.
  • Echevarria C, Steer J, Gibson GJ, Bourke SC. . In: British Thoracic Society Winter Meeting 2014. 2014, London: BMJ Publishing Group.
  • Echevarria C, Steer J, Gibson GJ, Bourke SC. . In: British Thoracic Society Winter Meeting 2014. 2014, London: BMJ Publishing Group.
  • Gascoigne AD, Bourke SJ. . In: Integrated Palliative Care of Respiratory Disease. Springer-Verlag London Ltd, 2013, pp.195-205.