缅北禁地

Gene expression studies during early human development

New technologies are enabling data to be collected on an unprecedented scale and making feasible a renewed focus on gene function, crucial for the large number of genes that play a role in human genetic disorders. One very important aspect of this work is to characterise gene expression patterns. Although animal models provide very powerful ways of studying normal and abnormal development, there are significant differences between humans and animals.

My main research interest is in prenatal human brain development, particularly during the embryonic and early fetal stages. We are analysing gene expression patterns directly during human development both as part of specific projects and also on behalf of registered users of the MRC-Wellcome Trust Human Developmental Biology Resource (HDBR; ). The HDBR is a tissue bank of human embryonic and fetal tissues, for which I am the Director in 缅北禁地 and Prof Andrew Copp is the Director of the London site at the Institute of Child Health, UCL.

The human brain develops initially from a simple tube to a complex, highly organised three-dimensional (3D) structure with unique cognitive functions. In pioneering studies, we have generated 3D models of early human development onto which we are mapping gene expression patterns and defining anatomical features. These form the basis of the HuDSeN (Human Developmental Studies Network) Atlas and human gene expression spatial database (HuDSeN GXD; ), now part of HDBR. HDBR’s HuDSeN GXD developed from the EMAGE database in collaboration with Professor Richard Baldock and his colleagues in the Edinburgh Mouse Atlas Project (). Prof Luis Puelles’ and his colleagues at the University of Murcia () were instrumental in the anatomical delineations of early brain regions in the 3D models.

In collaboration with Dr Gavin Clowry (Institute of Neuroscience, ), we are studying the early development and function of the cortex.

Recently, a collaboration has been established with Prof Muzlifah Hanifa (缅北禁地) and Dr Sarah Teichmann who co-lead the Human Fetal Cell Atlas project (), an exciting new part of the Human Cell Atlas, which aims to generate a single cell atlas of tissues across developmental stages. 

Co-workers

Dr Steven Lisgo, Senior Research Associate

Dr Janet Kerwin,
Senior Research Associate

Dr Yuzhu Cheng, Research Associate

Moira Crosier, Research Associate

Jacqui Dobor, Group Secretary

Lynne Overman, Research Associate

 Project led by Dr Gavin Clowry:

Ayman Alzu’Bi (PhD student)

• Lindsay SJ, Xu YB, Lisgo SN, Harkin LF, Copp AJ, Gerrelli D, Clowry GJ, Talbot A, Keogh MJ, Coxhead J, Santibanez-Koref M, Chinnery PF. . Frontiers in Neuroanatomy 2016, 10, 86.
• Alzubi A, Lindsay S, Kerwin J, Looi SJ, Khalil F, Clowry GJ. . Brain Structure and Function 2017, 222(5), 2309–2328.
• Harkin LF, Lindsay SJ, Xu Y, Alzu'bi A, Ferrera A, Gullon EA, James OG, Clowry GJ. . Cerebral Cortex 2017, 27(1), 216-232.
• Gerrelli D, Lisgo S, Copp AJ, Lindsay S. . Development 2015, 142(18), 3073-3076.
• Al-Jaberi N, Lindsay S, Sarma S, Bayatti N, Clowry GJ. . Cerebral Cortex 2015, 25(3), 631-645.
• Ali H, Forraz N, McGuckin C, Jurga M, Lindsay S, Ip BK, Trevelyan A, Basford C, Habibollah S, Ahmad S, Clowry GJ, Bayatti N. . Stem Cell Reviews and Reports 2012, 8(1), 210-223.
• Cheng YZ, Eley L, Hynes AM, Overman LM, Simms RJ, Barker A, Dawe HR, Lindsay S, Sayer JA. . PloS One 2012, 7(9), e44975.
• Thomas MG, Crosier M, Lindsay S, Kumar A, Thomas S, Araki M, Talbot CJ, McLean RJ, Surendran M, Taylor K, Leroy BP, Moore AT, Hunter DG, Hertle RW, Tarpey P, Langmann A, Lindner S, Brandner M, Gottlob I. . Brain 2011, 134(3), 892-902.
• Ip BK, Bayatti N, Howard NJ, Lindsay S, Clowry GJ. . Cerebral Cortex 2011, 21(6), 1395-1407.
• Kerwin J, Yang YY, Merchan P, Sarma S, Thompson J, Wang XX, Sandoval J, Puelles L, Baldock R, Lindsay S. . Journal of Anatomy 2010, 217(4), 289-299.
• Bayatti N, Moss JA, Sun L, Ambrose P, Ward JFH, Lindsay S, Clowry GJ. . Cerebral Cortex 2008, 18(7), 1536-1548.
• Bayatti N, Sarma S, Shaw C, Eyre JA, Vouyiouklis DA, Lindsay S, Clowry GJ. . European Journal of Neuroscience 2008, 28(8), 1449-1456.
• Lindsay S, Copp AJ. . Trends in Genetics 2005, 21(11), 586-590.
• Lindsay S, Sarma S, Martinez-De-La-Torre M, Kerwin J, Scott M, Luis Ferran J, Baldock R, Puelles L. . Neuroscience 2005, 136(3), 625-632.
• Kerwin JM, Scott MK, Sharpe J, Puelles L, Robson SC, Martínez de la Torre M, Ferran JL, Feng G, Baldock R, Strachan T, Davidson D, Lindsay SJ. . BMC Neuroscience 2004, 5, 27.
• Klauck SM, Lindsay S, Beyer KS, Splitt M, Burn J, Poustka A. . American Journal of Human Genetics 2002, 70(4), 1034-1037.
• Braybrook C, Lisgo S, Doudney K, Henderson D, Marcano ACB, Strachan T, Patton MA, Villard L, Moore GE, Stanier P, Lindsay S. . Human Molecular Genetics 2002, 11(22), 2793-2804.
• Lako M, Lindsay S, Lincoln J, Cairns PM, Armstrong L, Hole N. . Mechanisms of Development 2001, 103(1-2), 49-59.
• Fougerousse F, Bullen P, Herasse M, Lindsay S, Richard I, Wilson D, Suel L, Durand M, Robson S, Abitbol M, Beckmann JS, Strachan T. . Human Molecular Genetics 2000, 9(2), 165-173.
• Clement-Jones M, Schiller S, Rao E, Blaschke RJ, Zuniga A, Zeller R, Robson SC, Binder G, Glass I, Strachan T, Lindsay S, Rappold GA. . Human Molecular Genetics 2000, 9(5), 695-702.
• Strachan T, Lindsay S, Wilson DI. Molecular Genetics of Early Human Development (A Volume in the Human Molecular Genetics Series). Pub Academic Press. ISBN 0-122-20442-5<br>Issn: 0-122-20442-5<br>(Book) 1997.
• Felemban M, Dorgau B, Hunt NC, Hallam D, Zerti D, Bauer R, Ding Y, Collin J, Steel DH, Krasnogor N, Al-Aama J, Lindsay S, Mellough C, Lako M. . Acta Biomaterialia 2018, 74, 207-221.
• Dorgau B, Felemban N, Sharpe A, Bauer R, Hallam D, Steel DH, Lindsay S, Mellough C, Lako M. . Cell Death and Disease 2018, 9(6), 615.
• Keenan ID, Solim ZN, Quigg S, Kerwin J, Lindsay S. . In: Anatomical Society Winter Meeting 2016. 2017, King's College London, UK: Wiley-Blackwell Publishing Ltd.
• Chavali PL, Stojic L, Meredith LW, Joseph N, Nahorski MS, Sanford TJ, Sweeney TR, Krishna BA, Hosmillo M, Firth AE, Bayliss R, Marcelis CL, Lindsay S, Goodfellow I, Woods CG, Gergely F. . Science 2017, 357(6346), 83-88.
• Alzu'bi A, Lindsay SJ, Harkin LF, McIntyre J, Lisgo SN, Clowry GJ. . Cerebral Cortex 2017, 27(10), 4971-4987.