缅北禁地

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Staff Profile

Emeritus Professor Tim Cawston

Strategic Res Advisor (William Leech) and William Leech Professor of Rheumatology

  • Telephone: +44 (0) 191 208 5363
  • Fax: +44 (0) 191 208 5164
  • Personal Website:
  • Address: Faculty of Medical Sciences
    Framlington Place
    缅北禁地 upon Tyne
    NE2 4HH
Research

Research Interests

My laboratory's aim is to discover the mechanisms of collagen cleavage in order to develop new therapies that prevent joint destruction in arthritis. We focus on the collagenases (MMPs-1, -8 and –13), and other enzymes that irreversibly break down fibrillar collagen. I discovered that oncostatin M (OSM) + interleukin 1 (IL-1) dramatically and reproducibly stimulate collagen release from cartilage - a key step in cartilage destruction. MMP-1, -3, -8 and –13 are all upregulated by this cytokine combination along with members of the ADAM (a disintegrin and metalloproteinase) family and can be inhibited by the TIMPs. We showed the importance of collagenase activation in controlling cartilage collagen release and that blocking furin and other serine proteinases prevents such activation.

Gene array analysis of cytokine-treated chondrocytes identified novel genes that highlight potential new mechanisms involved in cartilage breakdown. These include cytokines, proteinases, components of signalling pathways, receptors and cell surface proteins. 

My research currently focuses on mechanisms of collagenolysis and the discovery of new substrates for the collagenases. I aim to study mechanisms of disease in osteoarthritis cartilage and investigate the cellular mechanisms of ageing in relation to extra cellular matrix turnover.  I will collaborate with other members of the MRC/AR-UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA) to investigate these ageing mechanisms in the other tissues of the joint such as tendon, bone and muscle.  Targets identified are investigated in human tissues to relate novel findings to human disease.

 

Keywords

arthritis, collagen, MMP, TIMP, connective tissue

Publications
  • Wang H, Young DA, Cawston TE. . In: World Congress on Osteoarthritis. 2012, Barcelona, Spain: Elsevier Ltd.
  • Hui W, Litherland GJ, Elias MS, Kitson GI, Cawston TE, Rowan AD, Young DA. . Annals of the Rheumatic Diseases 2012, 71(3), 455-462.
  • Lakey RL, Morgan TG, Rowan AD, Isaacs JD, Cawston TE, Hilkens CM. . Rheumatology 2009, 48(5), 502-7.
  • Cawston TE. . Nature Protocols 2009, 4(3), 286-290.
  • Murphy DM, Forrest IA, Corris PA, Johnson GE, Small T, Jones D, Fisher AJ, Egan JJ, Cawston TE, Lordan JL, Ward C. . The Journal of Heart and Lung Transplantation 2008, 27(11), 1210-6.
  • Zhang Q, Hui W, Litherland GJ, Barter MJ, Davidson R, Darrah C, Donell ST, Clark IM, Cawston TE, Robinson JH, Rowan AD, Young DA. . Annals of the Rheumatic Diseases 2008, 67(11), 1633-41.
  • Murphy DM, Forrest IA, Corris PA, Johnson GE, Small T, Jones D, Fisher AJ, Egan JJ, Cawston TE, Ward C, Lordan JL. . American Journal of Physiology: Lung Cellular and Molecular Physiology 2008, 294(3), L592-L599.
  • Litherland GJ, Dixon C, Lakey RL, Robson T, Jones D, Young DA, Cawston TE, Rowan AD. . Journal of Biological Chemistry 2008, 283(21), 14221-14229.
  • Bigg HF, Rowan AD, Barker MD, Cawston TE. . The FEBS Journal 2007, 274(5), 1246-1255.
  • Cawston TE, Morgan TG. . In: Cope, AP, ed. Arthritis Research. US: Humana Press, Inc, 2007, pp.211-226.
  • Young-Min SA, Cawston TE, Marshall N, Coady DA, Christgau S, Saxne T, Robins S, Griffiths I. . Arthritis & Rheumatism 2007, 56(10), 3236-3247.
  • Murphy DM, Forrest IA, Ward C, Corris PA, Johnson GE, Jones D, Fisher AJ, Egan JJ, Cawston TE, Lordan JL. . Thorax 2007, 62(9), 833.
  • Sukkar TZ, Thomason JM, Cawston TE, Lakey RL, Jones D, Catterall JB, Seymour RA. . Journal of Periodontal Research 2007, 42(6), 580-588.
  • Kloppenburg M, Stamm T, Watt I, Kainberger F, Cawston TE, Birrell F, Petersson I, Saxne T, Kvien T, Slatkowsky-Christensen B, Dougados M, Gossec L, Breedveld F, Smolen J. . Annals of the Rheumatic Diseases 2007, 66(9), 1157-1161.
  • Peake NJ, Foster HE, Khawaja K, Cawston TE, Rowan AD. . Annals of the Rheumatic Diseases 2006, 65(4), 501-507.
  • Catterall JB, Rowan AD, Sarsfield S, Saklatvala J, Wait R, Cawston TE. . Rheumatology 2006, 45(9), 1101-1109.
  • Milner JM, Kevorkian L, Young DA, Jones D, Wait R, Donell ST, Barksby HE, Patterson AM, Middleton JM, Cravatt BF, Clark IM, Rowan AD, Cawston TE. . Arthritis Research & Therapy 2006, 8(1), R23.
  • Forrest IA, Ward C, Murphy DM, Johnson GE, Jones D, Lordan JL, Cawston TE, Corris PA. . The Journal of Heart and Lung Transplantation 2006, 25(2), S91.
  • Morgan TG, Rowan AD, Dickinson SC, Jones D, Hollander AP, Deehan D, Cawston TE. . Annals of the Rheumatic Diseases 2006, 65(2), 184-190.
  • Barksby HE, Hui W, Wappler I, Peters HH, Milner JM, Richards CD, Cawston TE, Rowan AD. . Arthritis & Rheumatism 2006, 54(2), 540-550.
  • Barksby HE, Milner JM, Patterson AM, Peake NJ, Hui W, Robson T, Lakey R, Middleton J, Cawston TE, Richards CD, Rowan AD. . Arthritis & Rheumatism 2006, 54(10), 3244-3253.
  • Milner JM, Rowan AD, Cawston TE, Young DA. . Arthritis Research & Therapy 2006, 8(5), R142.
  • Bigg HF, Wait R, Rowan AD, Cawston TE. . Journal of Biological Chemistry 2006, 281(30), 21082-21095.
  • Cawston TE, Wilson AJ. . Best Practice & Research: Clinical Rheumatology 2006, 20(5), 983-1002.
  • Forrest IA, Murphy DM, Lordan JL, Pritchard G, Jones D, Robertson H, Cawston TE, Dark JH, Kirby JA, Ward C, Corris PA. . In: Journal of Heart and Lung Transplantation: 25th Anniversary Meeting of the International Society for Heart and Lung Transplantation. 2005, Philadelphia, Pennsylvania, USA: Elsevier Inc.
  • Young DA, Lakey RL, Pennington CJ, Jones D, Kevorkian L, Edwards DR, Cawston TE, Clark IM. . Arthritis Research & Therapy 2005, 7(3), R503-R512.
  • Peake NJ, Khawaja K, Myers A, Jones D, Cawston TE, Rowan AD, Foster HE. . Rheumatology 2005, 44(11), 1383-1389.
  • Hui W, Barksby HE, Young DA, Cawston TE, McKie N, Rowan AD. . Annals of the Rheumatic Diseases 2005, 64(11), 1624-1632.
  • Young DA, Lakey RL, Pennington CJ, Jones D, Kevorkian L, Edwards DR, Cawston TE, Clark IM. . Arthritis Research & Therapy 2005, 7(3), R503-512.
  • Hui W, Cawston TE, Richards CD, Rowan AD. . Arthritis Research & Therapy 2004, 7(1), R57-R64.
  • Forrest IA, Murphy D, Lordan JL, Pritchard GE, Jones D, Robertson H, Cawston TE, Dark JH, Kirby JA, Corris PA, Ward C. . In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
  • Murphy DM, Forrest IA, Ward C, Pritchard G, Jones D, Egan JJ, Cawston TE, Corris PA, Lordan JL. . In: Winter Meeting of the British Thoracic Society. 2004, London: Thorax: BMJ Publishing Group.
  • Rowan AD, Hui W, Cawston TE, Richards CD. . The American Journal of Pathology 2003, 162(6), 1975-1984.
  • Cawston TE, Milner JM, Catterall JB, Rowan AD. . In: Biochemical Society Symposia: Proteases and the Regulation of Biological Processes. 2003, London, UK: Portland Press.
  • Milner JM, Rowan AD, Elliott SF, Cawston TE. . Arthritis & Rheumatism 2003, 48(4), 1057-1066.
  • Myers A, Lakey R, Cawston TE, Kay LJ, Walker DJ. MMP-1 AND TIMP-1 IN PSORIATIC ARTHRITIS AND SIBLING CONTROLS. In: RHEUMATOLOGY. 2003, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND: OXFORD UNIV PRESS.
  • Young-Min SA, Shakhapur S, Marshall N, Griffiths I, Cawston TE, Grainger AJ. . Journal of Rheumatology 2003, 30(2), 238-240.
  • Hui W, Rowan AD, Richards CD, Cawston TE. . Arthritis & Rheumatism 2003, 48(12), 3404-3418.
  • Cawston T, Wang H, Richards C, Rowan A. . In: Arthritis Research & Therapy: 3rd World Congress of the Global Arthritis Research Network (GARN). 2003, Miyakazi, Japan: BioMed Central Ltd.
  • Hui W, Cawston TE, Rowan AD. . Annals of the Rheumatic Diseases 2003, 62(2), 172-174.
  • Vaidya B, Pearce SHS, Charlton S, Marshall N, Rowan AD, Griffiths ID, Kendall-Taylor P, Cawston TE, Young-Min S. . Rheumatology 2002, 41(2), 180-183.
  • Vaidya B, Pearce SHS, Charlton S, Marshall N, Rowan AD, Griffiths ID, Kendall-Taylor P, Cawston TE, Young Min S. . Rheumatology 2002, 41(2), 180-183.
  • Forrest IA, Ward C, Pritchard G, Rowan AD, Cawston TE, Corris PA. . In: Thorax: Winter Meeting of the British Thoracic Society. 2002, London: BMJ Group.
  • Cawston TE. . Biological Sciences Review 2002, 15, 2-5.
  • Koshy PJ, Henderson N, Logan C, Life PF, Cawston TE, Rowan AD. . Annals of the Rheumatic Diseases 2002, 61(8), 704-713.
  • Cawston TE. . Medicine 2002, 30(8), 27-31.
  • Koshy PJT, Lundy CJ, Rowan AD, Porter S, Edwards DR, Hogan A, Clark IM, Cawston TE. . Arthritis & Rheumatism 2002, 46(4), 961-967.
  • Milner JM, Elliott SF, Cawston TE. . Arthritis & Rheumatism 2001, 44(9), 2084-2096.
  • Cawston TE, Koshy PJT, Rowan AD. . Methods in Molecular Biology 2001, 151, 389-398.
  • Young-Min S, Pearce SHS, Charlton S, Marshall N, Rowan AD, Griffiths ID, Kendall-Taylor P, Cawston TE, Vaidya B. Cytotoxic T lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism in early rheumatoid arthritis. In: RHEUMATOLOGY. 2001, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND: OXFORD UNIV PRESS.
  • Cunnane G, FitzGerald O, Beeton C, Cawston TE, Bresnihan B. . Arthritis & Rheumatism 2001, 44(10), 2263-2274.
  • Milner JM, Elliot SF, Cawston TE. . In: British Society for Rheumatology XVIII Annual General Meeting and the British Health Professionals in Rheumatology Spring Meeting. 2001, Rheumatology: Oxford University Press.
  • Hui W, Rowan AD, Cawston TE. . Annals Rheumatic Diseases 2001, 60(3), 254-261.
  • Cleaver C, Rowan AD, Cawston TE. . Annals Rheumatic Diseases 2001, 60(2), 150-157.
  • Young-Min SA, Cawston TE, Griffiths ID. . Annals of the Rheumatic Diseases 2001, 60(6), 545-549.
  • Cawston TE, Carrere S, Catterall J, Duggleby R, Elliott S, Shingleton WD, Rowan AD. . In: Chadwick, D., Goode, J.A, ed. Chronic Obstructive Pulmonary Disease: Pathogenesis to Treatment. Chichester: Wiley, 2001, pp.205-228.
  • Cawston T, Carrere S, Catterall J, Duggleby R, Elliott S, Shingleton B, Rowan A. . In: Symposium on Chronic Obstructive Pulmonary Disease: Pathogenesis to Treatment. 2001, London, UK: Wiley-Blackwell.
  • Hui W, Rowan AD, Cawston TE. . Cytokine 2001, 16(1), 31-35.
  • Hui W, Rowan AD, Cawston T. . In: British Society for Rheumatology XVIII Annual General Meeting and the British Health Professionals in Rheumatology Spring Meeting. 2001, Rheumatology: Oxford University Press.
  • Harris JB, Cawston TE. . Current Opinion in Pharmacology 2001, 1(3), 279-280.
  • Hui W, Rowan AD, Cawston TE. . Arthritis & Rheumatism 2001, 44(Supplement 9), S62 no. 57.
  • Young-Min SA, Beeton C, Laughton R, Plumpton T, Bartram S, Murphy G, Black C, Cawston TE. . Annals of the Rheumatic Diseases 2001, 60(9), 846-851.
  • Rowan AD, Koshy PJT, Shingleton WD, Degnan BA, Heath JK, Vernallis AB, Spaull JR, Life PF, Hudson K, Cawston TE. . Arthritis & Rheumatism 2001, 44(7), 1620-1632.
  • Catterall JB, Carrere S, Koshy PJT, Degnan BA, Shingleton WD, Brinckerhoff CE, Rutter J, Cawston TE, Rowan AD. . Arthritis & Rheumatism 2001, 44(10), 2296-2310.
  • Richards CD, Catterall JB, Cawston TE, Rowan AD. . Arthritis & Rheumatism 2001, 44(supplement), S112.
  • Elliott SF, Cawston TE. . Drugs & Aging 2001, 18(2), 87-99.
  • Rowan AD, Billington CJ, Knight CG, Cawston TE. . In: Conference on Tissue Inhibitors of Metalloproteinases in Development and Disease. 2000, Banff, Canada: Harwood Academic Publishers, Gmbh.
  • Rowan AD, Billington CJ, Knight CG, Cawston TE. . In: Tissue inhibitors of metalloproteinases in development and diseases: proceedings of the Inhibitors of Metalloproteinases Conference. 2000, Banff, Canada: Harwood Academic.
  • Clark IM, Rowan AD, Cawston TE. Matrix metalloproteinases inhibitors in the treatment of arthritis. Current Opinions in Anti-inflammatory and Immunomodulatory Investigative Drugs 2000, 2, 16-25.
  • Bigg HF, McLeod R, Waters JG, Cawston TE, Clark IM. . FEBS Journal 2000, 267(13), 4150-4156.
  • Clark IM, Bigg HF, Rowan AD, Edwards DR, Mann DA, Bahr MJ, Cawston TE. . In: Tissue Inhibitors of metalloproteinases in development and disease: proceedings of the Inhibitors of Metalloproteinases Conference. 2000, Banff, Canada: Harwood Academic Press.
  • Shingleton WD, Ellis AJ, Rowan AD, Cawston TE. . Journal of Cellular Biochemistry 2000, 79(4), 519-531.
  • Cawston, T.E., Koshy, P.J.T., Rowan, A.D. Assays of MMPs against matrix substrates. Methods in Molecular Biology 1999, Humana Press New Jersey. pp 389-398.
  • Bigg HF, McLeod R, Waters J, Cawston TE, Nolan JF, Clark IM. . Annals of the New York Academy of Sciences: Inhibition of Matrix Metalloproteinases Therapeutic Applications 1999, 878, 506-509.
  • Boyce S, Malhotra R, Worden J, Spaull J, Cawston TE, Sanchez-Ballester J, Stevenage PLPL. . Arthritis and Rheumatism 1999, 42(4), 735-741.
  • Billington CJ, Clark IM, Cawston TE. . Biochemical Journal 1998, 336(1), 207-212.
  • Pountain, G., Hazleman, B. and Cawston, T.E. Circulating levels of IL-1 beta, IL-6 and soluble IL-2 receptor in polymyalgia rheumatics and giant cell arteritis and rheumatoid arthritis. British Journal of Rheumatology 1998, 37, 797-798.
  • Cawson TE. . Molecular Medicine Today 1998, 4(3), 130-137.
  • Cawston TE. . Medicine 1998, 26(5), 4-10.
  • Ridley S.H., Sarsfield S.J., Lee J.C., Bigg H.F., Cawston T.E., Taylor D.J., Dewitt D.L., Saklatvala J. Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase - Regulation of prostglandin H synthase-2, metalloproteinases and IL-6 at different levels. J. Immunol 1997, 158, 3165-3175.
  • Shingleton WD, Mackie EJ, Cawston TE, Jeffcott LB. . Equine Veterinary Journal 1997, 29(5), 360-364.
  • Shingleton WD, Hodges DJ, Brick P, Cawston TE. . Biochemistry and Cell Biology: Biochimie et Biologie Cellulaire 1996, 74(6), 759-775.
  • Bigg, H.F. and Cawston, T.E. Effect of retinoic acid in combination with platelet-derived growth factor-BB or transforming growth factor-beta on tissue inhibitor of metalloproteinases and collagenase secretion from human skin and synovial fibroblasts. Journal of Cellular Physiology 1996, 166, 84-93.
  • Cunnane G, Summers C, Taylor D, Cawston TE, Bresnihan B, FitzGerald O. Elevated serum and synovial fluid levels of collagenase, stromelysin and tissue inhibitor of metalloproteinases (TIMP-1) in early inflammatory arthritis. Arthritis and Rheumatism 1996, 39, 630-630.
  • Jeffcott, L.B., Henson, F.M.D., Voute, L., Vidal, G.H., Shingleton, W.D., Schofield, P.N., Cawston, T.E., Davies, M.E. and Mackie, E. Equine osteochondrosis. Veterinary Record 1996, 138, 480-480.
  • Cawston, T.E. Metalloproteinase inhibitors and the prevention of connective tissue breakdown. Pharmacology & Therapeutics 1996, 70, 163-182.
  • Cawston, T.E. and Billington, C. Metalloproteinases in the rheumatic diseases. Journal of Pathology 1996, 180, 115-117.
  • Riley GP, Harrall RL, Constant CR, Cawston TE, Hazleman BL. . Annals of the Rheumatic Diseases 1996, 55(2), 109-115.
  • Cawston, T.E. and Ellis, A.J. Retinoic acid and interleukin-1 together promote the release of collagen fragments from bovine nasal cartilage in culture. Molecular and Developmental Biology of Cartilage 1996, 785, 219-223.
  • Riley GP, Harrall RL, Cawston TE, Hazleman BL, Mackie EJ. . The American Journal of Pathology 1996, 149(3), 933-943.
  • Cawston TE, Riley GP, Hazleman BL. . Annals of the Rheumatic Diseases 1996, 55(1), 1-3.
  • Riley, G.P., Harrall, R.L., Watson, P.G., Cawston, T.E. and Hazleman, B.L. Collagenase (MMP-1) and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis. Eye 1995, 9, 703-718.
  • Houseman M, Potter C, Marshall N, Lakey R, Cawston T, Griffiths I, Young-Min S, Isaacs JD. . Arthritis Research & Therapy 2012, 14(1), R30.
  • Proctor CJ, Macdonald C, Milner JM, Rowan AD, Cawston TE. . Arthritis & Rheumatology 2014, 66(4), 979-989.
  • Hui W, Young DA, Rowan AD, Cawston TE, Proctor CJ. . In: World Congress of the Osteoarthritis Research Society International (OARSI). 2014, Paris, France: Elsevier Ltd.
  • Cawston TE, Young DA, Rowan DD. . In: Hochberg MC; Silman AJ; Smolen JS; Weinblatt ME; Weisman MH, ed. Rheumatology: Sixth Edition. Philadelphia, PA: Elsevier Inc, 2014, pp.152-159.
  • Proctor CJ, Macdonald C, Milner JM, Rowan AD, Cawston TE. . In: British Society for Matrix Biology Autumn 2013 Meeting. 2013, Cardiff: Wiley-Blackwell.
  • Wang H, Young DA, Cawston TE. . In: Autumn Meeting of the British Society for Matrix Biology (BSMB). 2012, 缅北禁地 upon Tyne, UK: Wiley-Blackwell Publishing Ltd.
  • Radwan MA, Gabrielides C, Rowan AD, Robinson JH, Cawston TE, Young DA. . In: Autumn Meeting of the British Society for Matrix Biology (BSMB). 2012, 缅北禁地 upon Tyne, UK: Wiley-Blackwell Publishing Ltd.
  • Cawston T, Billington C, Cleaver C, Elliott S, Hui W, Koshy P, Shingleton B, Rowan A. . Annals of the New York Academy of Sciences 1999, 878, 120-129.
  • Cawston T, Billington C, Cleaver C, Elliott S, Hui W, Koshy P, Shingleton B, Rowan A. . In: Inhibition of Matrix Metalloproteinases Therapeutic Applications. 1999, Tampa, Florida: Wiley-Blackwell Publishing, Inc.
  • Cawston T, Billington C, Cleaver C, Elliott S, Hui W, Koshy P, Shingleton B, Rowan A. . In: Inhibition of Matrix Metalloproteinases: Therapeutic Applications. 1999, Tampa, Florida, USA: New York Academy of Sciences.