缅北禁地

PhD VACANCIES – we are always open to informal enquiries from prospective PhD students, whether Home/EU or non-EU. Please feel free to email me if you are interested (tim.cheek@ncl.ac.uk)

 

Roles and Responsibilities

Dean of Postgraduate Research

 

Qualifications

 

BSc (Hons), Sheffield City Polytechnic (CNAA) 1984

PhD, University of Liverpool 1987

 

Previous Positions

Post-doctoral Researcher, Department of Zoology, University of Cambridge 1987-1998 

(Royal Society University Research Fellow, 1992-96; Official Fellow, Girton College 1996-1998)

缅北禁地 1998-present   

 

Research Interests

The mechanisms and functions of intracellular Ca² signals. Specifically the role of Ca² signals in electrically excitable (neuronal) cell types.

Current work

Ca² signalling in neuronal development

Neurones in the brain are the result of differentiation of neuronal stem cells during development. One of the goals in modern neurobiology is to understand the molecular mechanisms controlling neuronal differentiation, as the ability to produce neurones in vitro will have enormous implications for treatment of neurological disorders and age-related neurodegenerative diseases. Stimulus-induced changes in the concentration of intracellular fee Ca2 underlie many aspects of neuronal cell function, including differentiation, and Ca2 signalling dysfunction has been implicated in a number neurological diseases and disorders.

Our group discovered that the switch from proliferation to differentiation in human neuroblastoma cells is accompanied by a switch in two key Ca² signalling pathways; one pathway (store-operated Ca² entry) becomes down-regulated, while there is a functional upregulation of a non-store-operated pathway.

We are using a combination of molecular, biochemical and cellular techniques to understand the molecular mechanisms that coordinate the switch in Ca² signalling pathways and to unravel the role that the switch plays in driving and maintaining the differentiation response.

Funding

Research in our laboratory is funded by the MRC, the BBSRC and the Wellcome Trust.

Undergraduate

BSc (Hons) - Stage 1, Stage 2, Stage 3

BDS - Stage 1

MBBS - Stage 1, Stage 2

Accelerated MBBS - Stage 1

 

• Hudson L, Begg M, Wright B, Cheek TR, Jahoda CAB, Reynolds NJ. . Journal of Cellular Physiology 2021, 236(12), 8171-8183.
• Whitworth CL, Redfern CPF, Cheek TR. . Molecular Neurobiology 2019, 56(2), 857-872.
• Edwards N, Anderson CMH, Conlon NJ, Watson AK, Hall RJ, Cheek TR, Embley TM, Thwaites DT. . Cellular and Molecular Life Sciences 2018, 75(5), 921-938.
• Bell N, Hann V, Redfern CPF, Cheek TR. . Biochimica et Biophysica Acta: Molecular Cell Research 2013, 1833(3), 643-651.
• Conlon NJ, Edwards N, Anderson CMH, Cheek TR, Thwaites DT. . FASEB Journal 2013, 27, 732-735.
• Heer R, Clarke N, Rigas AC, Cheek TR, Pickard R, Leung HY. . Urology 2010, 76(2), 509.e13-509.e20.
• Sattelle DB, Cordova D, Cheek TR. . Invertebrate Neuroscience 2008, 8(3), 107-119.
• Tottey S, Waldron KJ, Firbank SJ, Reale B, Bessant C, Sato K, Cheek TR, Gray J, Banfield MJ, Dennison C, Robinson NJ. . Nature 2008, 455(7216), 1138-1142.
• Riddoch, F.C., Brown, A.M., Rowbotham, S.E., Redfern, C.P.F., Cheek, T.R. . Cell Calcium 2007, 41(3), 195-206.
• Clarke N, Heer R, Cheek T, Leung T, Pickard R. . European Urology Supplements 2007, 6(2), 138-138.
• Cheek TR, Thorn P. . Cell Calcium 2006, 40(3), 309-318.
• Brown, A.M., Riddoch, F.C, Robson, A., Redfern, C.P.F., Cheek, T.R. . Biochemical Journal 2005, 388(3), 941-948.
• Riddoch, F.C., Rowbotham, S.E., Brown, A.M., Redfern, C.P.F., Cheek, T.R. . Cell Calcium 2005, 38(2), 111-120.
• Brown AM, Riddoch FC, Redfern CPF, Cheek TR. . In: Meeting of the Physiological Society. 2002, University of Leeds, Leeds, England: Journal of Physiology: The Physiological Society.