缅北禁地

Dr. Viktor Korolchuk earned his PhD in 2000 from the Institute of Biochemistry at the National Academy of Sciences of Ukraine. During his postdoctoral training at the Universities of Bristol and Cambridge, he developed a strong interest in intracellular trafficking and degradation pathways. Since establishing his laboratory at 缅北禁地 in 2011, his research has focused on autophagy and its regulation by mTOR signalling, particularly in the context of cellular and organismal ageing. His work contributed to our understanding of the role of autophagy in maintaining protein, DNA, and organelle homeostasis, as well as its protective function as an oxidative stress response pathway.

Scientific background:

• Professor of Cell Biology, Biosciences Institute, Faculty of Medical Sciences, 缅北禁地, since 2024
• Reader, Biosciences Institute, Faculty of Medical Sciences, 缅北禁地, 2017-2024
• Lecturer, Institute of Ageing and Health, 缅北禁地, 2011- 2017
• Postdoctoral Fellow, University of Cambridge, 2003-2011
• Postdoctoral Fellow, University of Bristol, 2000-2003
• PhD in Biochemistry, Institute of Biochemistry, Kyiv, National Academy of Sciences, Ukraine, 2000

Membership of societies:

• British Society for Research on Ageing (Former Executive board member)

Funding:

• BBSRC, MRC, the Royal Society, Procter & Gamble, Eli Lilly

Keywords

• Intracellular trafficking, autophagy, ubiquitin, protein degradation, nutrient sensing, mTOR, DNA damage, neurodegeneration, ageing. 

Google Scholar:

RESEARCH FOCUS: AUTOPHAGY IN HEALTH AND DISEASE

Autophagy is a mechanism used by cells to survive periods of starvation by degrading cytoplasmic components and releasing much-needed metabolites and energy. Autophagy is a vesicular trafficking pathway in which double-membraned intracellular structures called autophagosomes are formed around portions of cytoplasm containing cellular components destined for degradation. Autophagosomes ultimately fuse with lysosomes, where autophagic substrates are degraded. The process of autophagosome formation and maturation is under tight control and is orchestrated by dedicated machinery.

Both basal and induced autophagy is an important determinants of health and longevity. Indeed, perturbations in the autophagy pathway have been recognised as a causative factor in a number of human pathologies including cancer, heart diseases, diabetes and neurodegeneration. Moreover, the ageing itself, being the most important risk factor in the development of many human diseases, has been associated with insufficient clearance of misfolded, toxic and aggregate-prone proteins via the autophagosome- and lysosome-dependent degradation mechanisms. Most excitingly, many of the treatments prolonging lifespan in model organisms are doing so in an autophagy-dependent manner indicating that efficient cellular quality control via autophagy may be the major determinant of lifespan extension.

CURRENT RESEARCH PROJECTS IN THE LABORATORY

1) Investigation of mechanisms controlling cellular nutrient responses

The majority of treatments prolonging healthy lifespan of laboratory animals suppress nutrient sensing pathways such as mTOR (mammalian Target Of Rapamycin) and stimulate autophagy. The elaborate network of mTOR signalling events integrates upstream signals such as binding of growth factors to plasma membrane receptors, presence of nutrients such as amino acids, glucose and various metabolites in the extracellular medium as well as the intracellular ATP/ADP ratio signifying cellular energy levels (detected by AMP-dependent kinase, AMPK). We have recently described yet another layer of mTOR control which is mediated by nutrient-imposed changes in intracellular pH. This potentially allows regulation of mTOR activity independently of nutrients and, therefore, offers an opportunity to mimic the effect of dietary restriction on lifespan/ageing through pharmaceutical means. Studying processes regulating cellular nutrient responses and extending the knowledge of their fine molecular detail will increase our chances to fight age-related diseases and ultimately to extend human lifespan.

We are currently addressing the following questions:

What receptors/transporters are involved in implementation of nutrient-dependent changes in intracellular pH?

What is the contribution of this regulatory mechanism to the overall control of mTOR by growth factors, amino acids and energy levels?

What is the potential physiological relevance of this mechanism?

2) Physiologic functions of autophagy

The prominent role of autophagy in cellular and organismal health is commonly explained by the homeostatic function. Indeed, having the capacity to dispose of the large intracellular entities, including protein aggregates and entire organelles such as defective mitochondria, autophagy is a major quality control mechanism clearing damaged and dysfunctional cellular components and thus preventing further cellular damage. However, autophagy is also perfectly positioned to serve regulatory roles. Thus, it can be hypothesised that changes in autophagic flux, induced by upstream signalling events, may lead to changes in the activity of downstream pathways by selective degradation of their regulatory components. This selective recruitment of substrates to autophagosomes can be mediated by adapter molecules such as sequestosome-1/p62, which recruits ubiquitylated proteins for selective autophagosomal degradation. We are interested in characterisation of autophagy-dependent regulatory degradative events as this could result in a conceptually novel model of the control over cellular physiology.

Among the questions that we ask here are the following:

What are the endogenous protein substrates of selective autophagy?

How are endogenous autophagy substrates targeted and recruited to autophagosomes?

How do different substrates define physiological roles of autophagy?

3) Role of autophagy in DNA damage response

One potential mechanism by which autophagy can control the rate of aging is by regulating the DNA damage response (DDR) which contributes to the cellular senescence phenotype. This is supported by the evidence that DDR proteins such as p53 and p38MAPK are shown to affect autophagic activity while autophagy may in turn regulate DDR and cellular senescence. Despite the evidence the molecular details that would explain involvement of autophagy in DDR, senescence and ageing are still largely missing.

We are using a systematic approach to study the molecular mechanisms underlying the function of autophagy in DDR and senescence. We use systems-based and experimental approaches to identify molecular links between autophagic and DDR machinery. We are testing if DDR proteins interacting with autophagosomal machinery may be targeted to autophagosome-lysosome pathway for degradation. This is achieved by the analysis of the formation and degradation of relevant DDR complexes induced by stressors such as gamma-irradiation in normal or autophagy-impaired cells. We are aiming to evaluate the relative contribution of both autophagy and the proteasome, two major cellular degradative system, to the regulation of DDR complexes. As DDR and autophagy take place in different cellular compartments (nucleus and cytoplasm, respectively), delivery of DDR machinery to cytoplasm, co-localisation with autophagosomes and subsequent degradation is being investigated by biochemical techniques as well as imaging methods such as high-resolution confocal microscopy of fixed and live specimens and by immuno-electron microscopy. Possible feedback mechanisms, whereby DDR proteins are in turn affecting autophagic activity, are also being investigated.

LABORATORY TECHNIQUES

Biochemistry:               Subcellular fractionation, purification of proteins from complex biological samples; chromatographic and electrophoresis techniques; immunoblotting; metabolomics analyses.

Molecular biology:       Cloning, site-directed mutagenesis, qPCR, production and purification of recombinant proteins using variety of expression systems; genome modification.

Cell biology:                 Fluorescent and confocal microscopy, immunocytochemistry; flow cytometry; electron microscopy.

THE RESEARCH TEAM

Dr. Edward Fiedler, Research Associate

Ms. Gailing Ma, PhD student

Ms. Ashley Davis, PhD student

Mr. Joshua Ratliffe, PhD student

Mr. Niall Wilson, PhD student

Ms. Jiangyu Tang, PhD student

Ms. Lakshana Baheerathan, PhD student

Ms. Stephanie Crabtree, Research Technician

Dr. Max Brown, Visiting Research Fellow

PAST MEMBERS

Dr. Bernadette Carroll (presently a Senior Research Fellow at the University of Bristol)

Dr. Yoana Rabanal (presently an Assistant Professor at the University of Castilla La Mancha)

Dr. Graeme Hewitt (presently a Junior Group Leader at King's College London)

Dr. Diego Manni (presently a Regulatory Affairs Manager at AstraZeneca)

Dr. Gisela Otten (presently a Senior Scientist at Amphista Therapeutics)

Dr. Alison Howard (presently a Senior Tutor at 缅北禁地)

Dr. Lucia Sedlackova (presently a Postdoc at CRG, Barcelona)

Dr. David Shapira (presently a R&D Scientist at Askbio)

Dr. Johan Panek (presently a Staff Scientist at 缅北禁地)

Dr. George Kelly (presently a Research Scientist at UCB)

Dr. Tetsushi Kataura (presently an Assistant Professor at Tsukuba University)

Dr. Takashi Hosaka, (presently an Assistant Professor at Tsukuba University)

OPEN VACANCIES

No postdoctoral vacancies are currently available but we always welcome an interest from enthusiastic students and postdocs who are interested in applying for funding. Applicants should have a strong background in molecular cell biology or genetics and a record of successful research in the areas of molecular biology, cell biology, biochemistry, or genetics.

To discuss available options forward your curriculum vitae, bibliography, and the names and addresses of referees to: Prof. Viktor Korolchuk, Biosciences Institute, Faculty of Medical Sciences, 缅北禁地, Campus for Ageing and Vitality, 缅北禁地 upon Tyne, NE4 5PL or by e-mail addressed to viktor.korolchuk@ncl.ac.uk.

Biology of Ageing, undergraduate course for biomedical students (Module Leader and Lecturer)

Biology of Ageing, MRes module (Lecturer)

Cell Signalling, MRes module (Lecturer)

• Articles

  • Dagbasi A, Holliday A, Carroll B, de Lucia C, Shannon OM, Mathers J, McLaughlin J, French C, Hanyaloglu A, Burden S, Morrison D, Korolchuk V, Frost G. . Nutrition Bulletin 2025, 50(3), 505-513.
  • Takei T, Sasazawa Y, Noshiro D, Kitagawa M, Kataura T, Hirawake-Mogi H, Kawauchi E, Nakano Y, Tashiro E, Saitoh T, Nishiyama S, Ogawa S, Kakuta S, Kazuno S, Miura Y, Taniguchi D, Korolchuk VI, Noda NN, Saiki S, Imoto M, Hattori N. . EMBO Journal 2025, 44, 6527–6555.
  • Panek J, Carriere E, Saleh MB, Sendra K, Kosta G, Korolchuk VI, Hirt RP. . mBio 2025, 16, e01049-25.
  • Chitta P, Barrow TM, Pratumvinit B, Dawangpa A, Kaewboonruang W, Khamrangsee S, Korolchuk VI, Sae-Lee C. . Scientific Reports 2025, 15, 28043.
  • Stefanatos R, Robertson F, Castejon-Vega B, Yu Y, Uribe AH, Myers K, Kataura T, Korolchuk VI, Maddocks ODK, Martins LM, Sanz A. . EMBO Reports 2025, 26, 1957-1983.
  • Kataura T, Sedlackova L, Sun C, Kocak G, Wilson N, Banks P, Hayat F, Trushin S, Trushina E, Maddocks ODK, Oblong JE, Miwa S, Imoto M, Saiki S, Erskine D, Migaud ME, Sarkar S, Korolchuk VI. . Cell Death and Disease 2024, 15(5), 382.
  • Kelly G, Kataura T, Panek J, Gailing M, Salmonowicz H, Davis A, Kendall H, Brookes C, Ayine-Tora DM, Banks P, Nelson G, Dobby L, Pitrez PR, Booth L, Costello L, Richardson GD, Lovat P, Przyborski S, Ferreira L, Greaves L, Szczepanowska K, von Zglinicki T, Miwa S, Brown M, Flagler M, Oblong JE, Bascom CC, Carroll B, Reynisson J, Korolchuk VI. . Developmental Cell 2024, 59(15), 1924-1939.e7.
  • Neves SP, Bomfim LM, Kataura T, Carvalho SG, Nogueira ML, Dias RB, Valverde LDF, Gurgel Rocha CA, Soares MBP, Silva MMD, Batista AA, Korolchuk VI, Bezerra DP. . Biomedicine and Pharmacotherapy 2024, 177, 117059.
  • Tsikandelova R, Galo E, Cerniauskas E, Hallam D, Georgiou M, Cerna-Chavez R, Atkinson R, Palmowski P, Burte F, Davies T, Steel DH, McKibbin M, Bond J, Haggarty J, Whitfield P, Korolchuk V, Armstrong L, Yang C, Dorgau B, Kurzawa-Akanbi M, Lako M. . Stem Cell Reports 2024, 19(8), 1107-1121.
  • Domingues N, Catarino S, Cristovao B, Rodrigues L, Carvalho FA, Sarmento MJ, Zuzarte M, Almeida J, Ribeiro-Rodrigues T, Correia-Rodrigues A, Fernandes F, Rodrigues-Santos P, Aasen T, Santos NC, Korolchuk VI, Goncalves T, Milosevic I, Raimundo N, Girao H. . EMBO Journal 2024, 43(17), 3627-3649.
  • Perri G, French C, Agostinis-Sobrinho C, Anand A, Antarianto RD, Arai Y, Baur JA, Cauli O, Clivaz-Duc M, Colloca G, Demetriades C, de Lucia C, Di Gessa G, Diniz BS, Dotchin CL, Eaglestone G, Elliott BT, Espeland MA, Ferrucci L, Fisher J, Grammatopoulos DK, Hardiany NS, Hassan-Smith Z, Hastings WJ, Jain S, Joshi PK, Katsila T, Kemp GJ, Khaiyat OA, Lamming DW, Lara Gallegos J, Madeo F, Maier AB, Martin-Ruiz C, Martins IJ, Mathers JC, Mattin LR, Merchant RA, Moskalev A, Neytchev O, Ni Lochlainn M, Owen CM, Phillips SM, Pratt J, Prokopidis K, Rattray NJW, Rúa-Alonso M, Schomburg L, Scott D, Shyam S, Sillanpää E, Tan MMC, Teh R, Tobin SW, Vila-Chã CJ, Vorluni L, Weber D, Welch A, Wilson D, Wilson T, Zhao T, Philippou E, Korochuk VI, Shannon OM. . The Journals of Gerontology: Series A 2024, 80(5), glae297.
  • Sun C, Seranova E, Cohen MA, Chipara M, Roberts J, Astuti D, Palhegyi AM, Acharjee A, Sedlackova L, Kataura T, Otten EG, Panda PK, Lara-Reyna S, Korsgen ME, Kauffman KJ, Huerta-Uribe A, Zatyka M, Silva LFSE, Torresi J, Zhang S, Hughes GW, Ward C, Kuechler ER, Cartwright D, Trushin S, Trushina E, Sahay G, Buganim Y, Lavery GG, Gsponer J, Anderson DG, Frickel E-M, Rosenstock TR, Barrett T, Maddocks ODK, Tennant DA, Wang H, Jaenisch R, Korolchuk VI, Sarkar S. . Cell Reports 2023, 42(5), 112372.
  • Sedlackova L, Kataura T, Sarkar S, Korolchuk VI. . Autophagy 2023, 19(8), 2395-2397.
  • Victorelli S, Salmonowicz H, Chapman J, Martini H, Vizioli MG, Riley JS, Cloix C, Hall-Younger E, Machado Espindola-Netto J, Jurk D, Lagnado AB, Sales Gomez L, Farr JN, Saul D, Reed R, Kelly G, Eppard M, Greaves LC, Dou Z, Pirius N, Szczepanowska K, Porritt RA, Huang H, Huang TY, Mann DA, Masuda CA, Khosla S, Dai H, Kaufmann SH, Zacharioudakis E, Gavathiotis E, LeBrasseur NK, Lei X, Sainz AG, Korolchuk VI, Adams PD, Shadel GS, Tait SWG, Passos JF. . Nature 2023, 622, 627-636.
  • Korsgen ME, Sun C, Seranova E, Zatyka M, Astuti D, Kataura T, Barrett T, Korolchuk VI, Sarkar S. . STAR Protocols 2023, 4(3), 102529.
  • Fielder E, Wan T, Alimohammadiha G, Ishaq A, Low E, Weigand BM, Kelly G, Parker C, Griffin B, Jurk D, Korolchuk V, von Zglinicki T, Miwa S. . eLife 2022, 11, e75492.
  • Kurzawa-Akanbi M, Whitfield P, Burte F, Bertelli PM, Pathak V, Doherty M, Hilgen B, Gliaudelyte L, Platt M, Queen R, Coxhead J, Porter A, Oberg M, Fabrikova D, Davey T, Beh CS, Georgiou M, Collin J, Boczonadi V, Hartlova A, Taggart M, Al-Aama J, Korolchuk VI, Morris CM, Guduric-Fuchs J, Steel DH, Medina RJ, Armstrong L, Lako M. . Journal of Extracellular Vesicles 2022, 11(12), 12295.
  • Sasazawa Y, Souma S, Furuya N, Miura Y, Kazuno S, Kakuta S, Suzuki A, Hashimoto R, Hirawake-Mogi H, Date Y, Imoto M, Ueno T, Kataura T, Korolchuk VI, Tsunemi T, Hattori N, Saiki S. . EMBO Journal 2022, 41(22), e111476.
  • Kataura T, Otten EG, Rabanal-Ruiz Y, Adriaenssens E, Urselli F, Scialo F, Fan L, Smith GR, Dawson WM, Chen X, Yue WW, Bronowska AK, Carroll B, Martens S, Lazarou M, Korolchuk VI. . EMBO Journal 2022, 42, 1-16.
  • Sae-Lee C, Barrow TM, Colicino E, Choi SH, Rabanal-Ruiz Y, Green D, Korolchuk VI, Mathers JC, Byun H-M. . Clinical Epigenetics 2022, 14(1), 103.
  • Kataura T, Sedlackova L, Otten EG, Kumari R, Shapira D, Scialo F, Stefanatos R, Ishikawa K-I, Kelly G, Seranova E, Sun C, Maetzel D, Kenneth N, Trushin S, Zhang T, Trushina E, Bascom CC, Tasseff R, Isfort RJ, Oblong JE, Miwa S, Lazarou M, Jaenisch R, Imoto M, Saiki S, Papamichos-Chronakis M, Manjithaya R, Maddocks ODK, Sanz A, Sarkar S, Korolchuk VI. . Developmental Cell 2022, 57(22), 2584-2598.e11.
  • Georgiou M, YAng C, Atkinson R, Pan K, Buskin A, Molina M, Collin C, Alaama J, Goertler F, Ludwig S, Davey T, Luhrmann R, Grellscheid S, Johnson C, Ali R, Armstring L, Korolchuk V, Urlaub H, Mozzafari J, LAko M. . Clinical and Translational Medicine 2022, 12(3), e759.
  • Rabanal-Ruiz Y, Byron A, Wirth A, Madsen R, Sedlackova L, Hewitt G, Nelson G, Stingele J, Wills JC, Zhang T, Zeug A, Fassler R, Vanhaesebroeck B, Maddocks ODK, Ponimaskin E, Carroll B, Korolchuk VI. . Journal of Cell Biology 2021, 220(5), e202004010.
  • Wan T, Weir EJ, Johnson M, Korolchuk VI, Saretzki GC. . Progress in Neurobiology 2021, 199, 101953.
  • Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester A-S, Baumeister R, Brohee L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G, de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K. . Cell 2021, 184(3), 655-674.e27.
  • Garcia-Macia M, Santos-Ledo A, Leslie J, Paish HL, Collins AL, Scott RS, Watson A, Burgoyne RA, White S, French J, Hammond J, Borthwick LA, Mann J, Bolanos JP, Korolchuk VI, Oakley F, Mann DA. . Hepatology 2021, 74(6), 3441-3459.
  • Sedlackova L, Korolchuk VI. . Biogerontology 2020, 21, 381-397.
  • Cerniauskas E, Kurzawa-Akanbi M, Xie L, Hallam D, Moya-Molina M, White K, Steel D, Doherty M, Whitfield P, Al-Aama J, Armstrong L, Kavanagh D, Lambris J, Korolchuk V, Harris C, Lako M. . Stem Cells Translational Medicine 2020, 9(12), 1585-1603.
  • Kucheryavenko O, Nelson G, von Zglinicki T, Korolchuk VI, Carroll B. . Biogerontology 2019, 20, 331–335.
  • CorreiaMelo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk V, Passos JF. . Aging Cell 2019, 18(1), e12882.
  • Hase Y, Chen A, Bates LL, Craggs LJL, Yamamoto Y, Gemmell E, Oakley AE, Korolchuk VI, Kalaria RN. . Brain Pathology 2018, 28(6), 832-843.
  • Carroll B, Otten E, Manni D, Stefanatos R, Menzies F, Smith G, Jurk D, Kenneth N, Wilkinson S, Passos J, Attems J, Veal E, Teyssou E, Seilhean D, Millecamps S, Eskelinen E-L, Bronowska A, Rubinsztein DC, Sanz A, Korolchuk V. . Nature Communications 2018, 9, 256.
  • Carroll B, Korolchuk VI. . FEBS journal 2018, 285(11), 1948-1958.
  • Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI. . Journal of Cell Biology 2017, 216(7), 1949.
  • Korolchuk VI, Miwa S, Carroll B, von Zglinicki T. . EBioMedicine 2017, 21, 7-13.
  • Hallam D, Collin j, Bojic S, Chichagova V, Buskin A, Xu Y, Lafage L, Otten EG, Anyfantis G, Mellough C, Przyboski S, Alhart S, Korolchuk V, Lotery A, Saretzki G, McKibbin M, Armstrong L, Steel D, Kavanagh D, Lako M. . Stem Cells 2017, 35(11), 2305-2320.
  • Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI. . Autophagy 2016, 12(10), 1917-1930.
  • Hewitt G, Korolchuk VI. . Trends in Cell Biology 2016, 27(5), 340-351.
  • Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G. . Scientific Reports 2016, 6, 31750.
  • Santin Y, Sicard P, Vigneron F, Guilbeau-Frugier C, Dutaur M, Lairez O, Couderc B, Manni D, Korolchuk VI, Lezoualc'h F, Parini A, Mialet-Perez J. . Antioxidants & Redox Signaling 2016, 25(1), 10-27.
  • Correia-Melo C, Marques FDM, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SWG, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF. . EMBO Journal 2016, 35(7), 724-742.
  • Klinonsky DJ, et, al. . Autophagy 2016, 12(1), 1-222.
  • Carroll B, Maetzel D, Maddocks ODK, Otten G, Ratcliff M, Smith GR, Dunlop EA, Passos JF, Davies OR, Jaenisch R, Tee AR, Sarkar S, Korolchuk VI. . eLife 2016, 5, e11058.
  • Ward C, Martinez-Lopez N, Otten EG, Carroll B, Maetzel D, Singh R, Sarkar S, Korolchuk VI. . Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2016, 1861(4), 269-284.
  • Vicinanza M, Korolchuk VI, Ashkenazi A, Puri C, Menzies FM, Clarke JH, Rubinsztein DC. . Molecular Cell 2015, 57(2), 219-234.
  • Dalle Pezze P, Nelson G, Otten EG, Korolchuk VI, Kirkwood TBL, von Zglinicki T, Shanley DP. . PLoS Computational Biology 2014, 10(8), e1003728.
  • Lu W, Zhang Y, McDonald DO, Jing HE, Carroll B, Robertson N, Zhang Q, Griffin H, Sanderson S, Lakey JH, Morgan NV, Reynard LN, Zheng L, Murdock HM, Turvey SE, Hackett SJ, Prestidge T, Hall JM, Cant AJ, Matthews HF, Koref MFS, Simon AK, Korolchuk VI, Lenardo MJ, Hambleton S, Su HC. . Cell 2014, 159(7), 1578-1590.
  • Ivanov A, Pawlikowski J, Manoharan I, vanTuyn J, Nelson DM, Rai TS, Shah PP, Hewitt G, Korolchuk VI, Passos JF, Wu H, Berger SL, Adams PD. . Journal of Cell Biology 2013, 202(1), 129-143.
  • Sarkar S, Carroll B, Buganim Y, Maetzel D, Ng AH, Cassady JP, Cohen MA, Chakraborty S, Wang H, Spooner E, Ploegh H, Gsponer J, Korolchuk VI, Jaenisch R. . Cell Reports 2013, 5(5), 1302-1315.
  • Jurk D, Wang C, Miwa S, Maddick M, Korolchuk V, Tsolou A, Gonos ES, Thrasivoulou C, Saffrey JM, Cameron K, von Zglinicki T. . Aging Cell 2012, 11(6), 996-1004.
  • Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC. . Nature Cell Biology 2011, 13(4), 453-460.
  • Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-Arencibia M, Rose C, Luo S, Underwood BR, Kroemer G, O'Kane CJ, Rubinsztein DC. . Molecular Cell 2011, 43(1), 19-32.
  • Rocha JJE, Korolchuk VI, Robinson IM, O'Kane CJ. . PLoS ONE 2011, 6(4), e19087.
  • Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo SQ, Massey DCO, Menzies FM, Moreau K, Narayanan U, Renna M, Siddiqi FH, Underwood BR, Winslow AR, Rubinsztein DC. . Physiological Reviews 2010, 90(4), 1383-1435.
  • Aguado C, Sarkar S, Korolchuk VI, Criado O, Vernia S, Boya P, Sanz P, de Córdoba SR, Knecht E, Rubinsztein DC. . Human Molecular Genetics 2010, 19(14), 2867-2876.
  • Knecht E, Aguado C, Sarkar S, Korolchuk VI, Criado-García O, Vernia S, Boya P, Sanz P, de Córdoba SR, Rubinsztein DC. . Autophagy 2010, 6(7), 991-993.
  • Underwood BR, Imarisio S, Fleming A, Rose C, Krishna G, Heard P, Quick M, Korolchuk VI, Renna M, Sarkar S, García-Arencibia M, O'Kane CJ, Murphy MP, Rubinsztein DC. . Human Molecular Genetics 2010, 19(17), 3413-3429.
  • Sarkar S, Korolchuk V, Renna M, Winslow A, Rubinsztein DC. . Autophagy 2009, 5(3), 307-313.
  • Ravikumar B, Futter M, Jahreiss L, Korolchuk VI, Lichtenberg M, Luo S, Massey DCO, Menzies FM, Narayanan U, Renna M, Jimenez-Sanchez M, Sarkar S, Underwood B, Winslow A, Rubinsztein DC. . Journal of Cell Science 2009, 122(11), 1707-1711.
  • Korolchuk VI, Mansilla A, Menzies FM, Rubinsztein DC. . Molecular Cell 2009, 33(4), 517-527.
  • Rollason R, Korolchuk V, Hamilton C, Jepson M, Banting G. . Journal of Cell Biology 2009, 184(5), 721-736.
  • Koh TW, Korolchuk VI, Wairkar YP, Jiao W, Evergren E, Pan HL, Zhou Y, Venken KJT, Shupliakov O, Robinson IM, O'Kane CJ, Bellen HJ. . Journal of Cell Biology 2007, 178(2), 309-322.
  • Rollason R, Korolchuk V, Hamilton C, Schu P, Banting G. . Journal of Cell Science 2007, 120(21), 3850-3858.
  • Korolchuk VI, Schütz MM, Gómez-Llorente C, Rocha J, Lansu NR, Collins SM, Wairkar YP, Robinson IM, O'Kane CJ. . Journal of Cell Science 2007, 120(24), 4367-4376.
  • Korolchuk VI, Cozier G, Banting G. . Journal of Biological Chemistry 2005, 280(49), 40796-40801.
  • Palmer CL, Lim W, Hastie PGR, Toward M, Korolchuk VI, Burbidge SA, Banting G, Collingridge GL, Isaac JTR, Henley JM. . Neuron 2005, 47(4), 487-494.
  • Kupzig S, Korolchuk V, Rollason R, Sugden A, Wilde A, Banting G. . Traffic 2003, 4(10), 694-709.
  • Korolchuk VI, Banting G. . Traffic 2002, 3(6), 428-439.

• Book Chapters

  • Harris JR, Korolchuk VI. . In: J. Robin Harris and Viktor I. Korolchuk, ed. Biochemistry and Cell Biology of Ageing: Part II Clinical Science. Singapore: Springer, 2018, pp.vii-vii.
  • Pattison CJ, Korolchuk VI. . In: J. Robin Harris and Viktor I. Korolchuk, ed. Biochemistry and Cell Biology of Ageing: Part I Biomedical Science. Singapore: Springer, 2018, pp.25-47.
  • Otten EG, Manni D, Korolchuk VI. . In: Reeve A; Simcox E; Duchen M; Turnbull D, ed. Mitochondrial Dysfunction in Neurodegenerative Disorders: Second Edition. Cham: Springer International Publishing, 2016, pp.255-278.
  • Hewitt G, Carroll B, Korolchuk VI. . In: Hayat, M, ed. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging : Regulation of Autophagy and Selective Autophagy. San Diego: Academic Press, 2015, pp.103-119.

• Editorials

  • Harris JR, Korolchuk VI. . Biochemistry and Cell Biology of Ageing: Part III Biomedical Science 2023, 102, v-v.
  • Harris JR, Korolchuk VI. . Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science 2023, 103, v-v.
  • Korolchuk VI, Goljanek-Whysall K. . Biogerontology 2020, 21, 411-414.
  • Korolchuk VI, Sarkar S, Fanto M. . Journal of Molecular Biology 2020, 432(8), 2445-2448.
  • Harris JR, Korolchuk VI. . Biochemistry and Cell Biology of Ageing: Part II Clinical Science 2019, 91, i-x.
  • Carroll B, Korolchuk VI. . Aging 2017, 9(8), 1851-1852.
  • Sarkar S, Maetzel D, Korolchuk VI, Jaenisch R. . Autophagy 2014, 10(6), 1137-1140.
  • Rubinsztein CD, Cuervo AM, Ravikumar B, Sarkar S, Korolchuk VI, Kaushik S, Klionsky DJ. . Autophagy 2009, 5(5), 585-589.
  • Korolchuk VI, Menzies FM, Rubinsztein DC. . Autophagy 2009, 5(6), 862-863.

• Note

  • Kataura T, Wilson N, Ma G, Korolchuk VI. . Autophagy 2025, 21(1), 249-251.

• Reviews

  • Bury AG, Olejnik A, Tocco C, Saurat N, Stephen E, Hockemeyer D, Schwamborn JC, Studer L, Mastroberardino PG, Bolognin S, Kunath T, Korolchuk VI, Drouin-Ouellet J, Mortiboys H. . npj Parkinson's Disease 2025, 11(1), 289.
  • Kocak G, Dimas MM, Silva LFSE, Silva-Amaral D, Sun C, Cruddas S, Barrett T, Martins-de-Souza D, Cunha-Neto E, Brocardo PS, Kataura T, Korolchuk VI, Sarkar S. . Frontiers in Molecular Biosciences 2025, 12, 1695486.
  • Palmer JE, Wilson N, Son SM, Obrocki P, Wrobel L, Rob M, Takla M, Korolchuk VI, Rubinsztein DC. . Neuron 2024, 113(1), 29-48.
  • Ratliffe J, Kataura T, Otten EG, Korolchuk VI. . BioEssays 2023, 45(11), 2300076.
  • Wilson N, Kataura T, Korsgen ME, Sun C, Sarkar S, Korolchuk VI. . Trends in Cell Biology 2023, 33(9), 788-802.
  • Erskine D, Koss D, Korolchuk VI, Outeiro TF, Attems J, McKeith I. . Acta Neuropathologica 2021, 141, 511-526.
  • Sedlackova L, Kelly G, Korolchuk VI. . Journal of Molecular Biology 2020, 432(8), 2546-2559.
  • Sedlackova L, Korolchuk VI. . Biochimica et Biophysica Acta - Molecular Cell Research 2019, 1866(4), 575-587.
  • Rabanal-Ruiz Y, Korolchuk VI. . International Journal of Molecular Sciences 2018, 19(3), 818.
  • Lane JD, Korolchuk VI, Murray JT. . Essays in Biochemistry 2017, 61(6), 561-563.
  • Rabanal-Ruiz Y, Otten EG, Korolchuk VI. . Essays in Biochemistry 2017, 61(6), 565-584.
  • Carroll B, Korolchuk VI, Sarkar S. . Amino Acids 2015, 47(10), 2065-2088.
  • Carroll B, Hewitt G, Korolchuk VI. . Essays in Biochemistry: Autophagy: Molecules and Mechanisms 2013, 55, 119-131.
  • Klionsky D, Abdalla FC, Abeliovich H, et al. . Autophagy 2012, 8(4), 445-544.
  • Korolchuk VI, Menzies FM, Rubinsztein DC. . FEBS Letters 2010, 584(7), 1393-1398.
  • Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC. . Biochemical Journal 2008, 412, 191-209.