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Staff Profile

Professor Zofia Chrzanowska-Lightowlers

Professor of Mitochondrial Biology

  • Email: zofia.chrzanowska-lightowlers@ncl.ac.uk
  • Telephone: +44 (0) 191 208 8028
  • Fax: +44 (0) 191 208 8553
  • Personal Website:
  • Address: Wellcome Centre for Mitochondrial Research
    缅北禁地
    The Medical School
    Framlington Place
    缅北禁地 upon Tyne
    NE2 4HH
    England
Background

Introduction

My research focuses on gene expression in the human mitochondrion. The organelle has its own genome and the transcribed RNA is translated in organello. My work aims to identify and understand the molecular mechanisms underlying these processes. We are currently identifying and isolating factors that are important for modulating post-transcriptional regulation in the human mitochondrion. Main questions we are addressing include: What are the rescue mechanisms that act on stalled mitoribosomes? How is mt-RNA targetted for degradation ? What elements affect mitoribosome progression through the transcript ?  Where does translation of each transcript take place at a suborganellar level ?

Roles and Responsibilities

Director of the Institute of Neuroscience (2017 - 2019)
Deputy Director MRes (2003 - current)
Chair Curriculum Committee (MRes) (2003 - current)

Programme lead for MRes Mitochondrial Biology and Medicine

Qualifications

BSc (Hons) Biological Sciences, University of East Anglia
PGCE, University of London
MSc, University of Oregon
PhD, University of 缅北禁地

Research

Research Interests

The mitochondrion is an organelle found in all nucleated cells of higher eukaryotes. It is the site of oxidative phosphorylation and contains its own genome that encodes 13 proteins, which are essential components of these respiratory complexes. In addition to the mRNAs the genome also encodes the 22 tRNAs and 2 rRNAs that are required for this intra-mitochondrial protein synthesis. Our work is focussed on unravelling the nuances of gene expression in mammalian mitochondria.

It is the fate of these mitochondrial mRNA species that we are investigating. Although much is known about the turnover of cytosolic and bacterial transcripts, until very recently almost nothing was clear about the mitochondrial RNA species. Do they behave as their bacterial ancestors or follow the example of the cytosol in which they reside ? What is the normal decay mechanism and what are the enzymes responsible for carrying out these activities ? We have identified that in contrast to yeast, the mammalian mt-transcripts are polyadenylated but the full function of this tail is not yet certain. In addition to completing the stop codon for 7 open reading frames, it affects transcript stability in specific but different ways for the individual mtDNA encoded transcripts. Since the mitochondrial genome cannot yet be manipulated we have used cell lines with identified mutations to try and answer some of these questions. By using a cell line that has a 2 base pair microdeletion the resulting mRNA loses the termination codon, we have identified a ‘non-stop’ decay mechanism and shown that in this situation the inhibition of translation confers stability to the aberrant transcript.

Our work includes investigations into the mitochondrial nucleases and mt-RNA-binding proteins involved in the mechanism described above as well as those involved in the normal deadenylation and decay and characterising their specificity.

We have spent many years investigating the release factors and recycling factors. Although we have learned a great deal the precise function played by mtRF1 and C12orf65 still elude the field, and the role of ICT1 that is not incorporated in the mitoribosome also remains enigmatic. It is however, very likely that these factors are responsible for terminating translation under specific circumstances.

Within our department the link between pure and clinical research is very strong. Many of the neurological conditions that patients present with affect their mitochondrial DNA. In some instances this would be predicted to affect the subsequent transcription and translation. This provides the opportunity to study the differences in the homeostasis of mitochondrial mRNA in controls versus disease.

Postgraduate Supervision

I currently supervise 5 postgraduate PhD students and am tutor to undergraduate and MRes students.

Funding

The Wellcome Trust and the EU currently support the ongoing research in my laboratory

Keywords

RNA metabolism, mitochondrial RNA, degradation, mitochondrial gene expression, polyadenylation, stability

Teaching

Undergraduate Teaching

I have hosted final Honours year undergraduates in my lab for their research project work for over 20 years.


Postgraduate Teaching

I am the Deputy Director for the suite of MRes courses in Medical and Molecular Biosciences.

I am also the Chair of the Curriculum Committee and Director for Admissions and Recruitment.

I am programme director for and teach on the MRes in Mitochondrial Biology and Medicine.


I host Erasmus students from numerous European countries as well as MRes project students in my group.

I am responsible for a number of home, EU and International PhD students that I supervise. 

I have served on the Management Committee for Training for the NIHR funded BRC/BRU programme.

I am involved in the assessment and marking of MBBS, MSci, BSc and MRes student courses.


Publications
  • VanEyck L, Bruni F, Ronan A, Briggs TA, Roscioli T, Rice GI, Vassallo G, Rodero MP, He L, Taylor RW, Livingston JH, Chrzanowska-Lightowlers ZMA, Crow YJ. . Neuropediatrics 2020, 51(03), 178-184.
  • Peretz M, Tworowski D, Kartvelishvili E, Livingston J, Chrzanowska-Lightowlers Z, Safro M. . The FEBS Journal 2020, 287(17), 3814-3826.
  • Bruni F, Proctor-Kent Y, Lightowlers RN, Chrzanowska-Lightowlers ZN. . The FEBS Journal 2021, 288(2), 437-451.
  • Chrzanowska-Lightowlers ZMA, Lightowlers RN. . Molecular Therapy 2020, 28(8), 1749-1751.
  • Ayyub SA, Gao F, Lightowlers RN, Chrzanowska-Lightowlers ZM. . Journal of Cell Science 2020, 133(1), jcs231811.
  • Chrzanowska-Lightowlers ZM, Lightowlers RN. . EMBO Molecular Medicine 2019, 11(1), e9899.
  • Al-Faresi RAZ, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Biochemical Society Transactions 2019, 47(5), 1429-1436.
  • Thompson K, Mai N, Oláhová M, Scialó F, Formosa LE, Stroud DA, Garrett M, Lax NZ, Robertson FM, Jou C, Nascimento A, Ortez C, Jimenez-Mallebrera C, Hardy SA, He L, Brown GK, Marttinen P, McFarland R, Sanz A, Battersby BJ, Bonnen PE, Ryan MT, Chrzanowska-Lightowlers ZMA, Lightowlers RN, Taylor RW. . EMBO Molecular Medicine 2018, 10(9), e9060.
  • Bruni F, Di-Meo I, Bellacchio E, Webb BD, McFarland R, Chrzanowska-Lightowlers ZMA, He L, Skorupa E, Moroni I, Ardissone A, Walczak A, Tyynismaa H, Isohanni P, Mandel H, Prokisch H, Haack T, Bonnen PE, Enrico B, Pronicka E, Ghezzi D, Taylor RW, Diodato D. . Human Mutation 2018, 39(4), 563–578.
  • Bradley P, Waddington CL, Sommerville EW, Hopton S, Pyle A, Champion M, Ohlson M, Siibak T, Chrzanowska-Lightowlers ZMA, Taylor RW, Falkenberg M, Lightowlers RN. . Human Molecular Genetics 2018, 27(10), 1743-1753.
  • Gao F, Wesolowska M, Agami R, Rooijers K, Loayza-Puch F, Lawless C, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Wellcome Open Research 2018, 2, 116.
  • Tai HR, Wang Z, Gong H, Han XJ, Zhou J, Wang XB, Wei XW, Ding Y, Huang N, Qin JQ, Zhang J, Wang S, Gao F, Chrzanowska-Lightowlers ZM, Xiang R, Xiao HY. . Autophagy 2017, 13(1), 99-113.
  • Feichtinger RG, Olahova M, Kishita Y, Garone C, Kremer LS, Yagi M, Uchiumi T, Jourdain AA, Thompson K, D'Souza AR, Kopajtich R, Alston CL, Koch J, Sperl W, Mastantuono E, Strom TM, Wortmann SB, Meitinger T, Pierre G, Chinnery PF, Chrzanowska-Lightowlers ZM, Lightowlers RN, DiMauro S, Calvo SE, Mootha VK, Moggio M, Sciacco M, Comi GP, Ronchi D, Murayama K, Ohtake A, Rebelo-Guiomar P, Kohda M, Kang D, Mayr JA, Taylor RW, Okazaki Y, Minczuk M, Prokisch H. . American Journal of Human Genetics 2017, 101(4), 525-538.
  • Bruni F, Lightowlers RN, Chrzanowska-Lightowlers ZM. . The FEBS Journal 2017, 284(12), 1767-1777.
  • Chrzanowska-Lightowlers Z, Rorbach J, Minczuk M. . RNA Biology 2017, 14(12), 1668-1671.
  • Kartvelishvili E, Tworowski D, Vernon H, Moor N, Wang J, Wong L-J, Chrzanowska-Lightowlers Z, Safro M. . Protein Science 2017, 26(8), 1505-1516.
  • Oláhová M, Thompson K, Hardy SA, Barbosa IA, Besse A, Anagnostou ME, White K, Davey T, Simpson MA, Champion M, Enns G, Schelley S, Lightowlers RN, Chrzanowska-Lightowlers ZMA, McFarland R, Deshpande C, Bonnen PE, Taylor RW. . Journal of Inherited Metabolic Disease 2017, 40(1), 121-130.
  • Maus M, Cuk M, Patel B, Lian J, Ouimet M, Kaufmann U, Yang J, Horvath R, Hornig-Do H-T, Chrzanowska-Lightowlers ZM, Moore KJ, Cuervo AM, Feske S. . Cell Metabolism 2017, 25(3), 698-712.
  • Rozanska A, Richter-Dennerlein R, Rorbach J, Gao F, Lewis RJ, Chrzanowska-Lightowlers ZM, Lightowlers RN. . Biochemical Journal 2017, 474(13), 2145-2158.
  • Zaganelli S, Rebelo-Guiomar P, Maundrell K, Rozanska A, Pierredon S, Powell CA, Jourdain AA, Hulo N, Lightowlers RN, Chrzanowska-Lightowlers ZM, Minczuk M, Martinou J-C. . Journal of Biological Chemistry 2017, 292(11), 4519-4532.
  • Gao F, Wesolowska M, Agami R, Rooijers K, Loayza-Puch F, Lawless C, Lightowlers RN, Chrzanowska-Lightowlers ZM. . Wellcome Open Research 2017, 2, 116.
  • Rorbach J, Gao F, Powell CA, D'Souza A, Lightowlers RN, Minczuk M, Chrzanowska-Lightowlers ZM. . Proceedings of the National Academy of Sciences 2016, 113(43), 12198-12201.
  • Spahr H, Rozanska A, Li XP, Atanassov I, Lightowlers RN, Chrzanowska-Lightowlers ZMA, Rackham O, Larsson NG. . Nucleic Acids Research 2016, 44(14), 6868-6882.
  • Mai N, Chrzanowska-Lightowlers ZMA, Lightowlers RN. . Cell and Tissue Research 2016, 367(1), 5-20.
  • Olahova M, Hardy SA, Hall J, Yarham JW, Haack TB, Wilson WC, Alston CL, He L, Aznauryan E, Brown RM, Brown GK, Morris AAM, Mundy H, Broomfield A, Barbosa IA, Simpson MA, Deshpande C, Moeslinger D, Koch J, Stettner GM, Bonnen PE, Prokisch H, Lightowlers RN, McFarland R, Chrzanowska-Lightowlers ZMA, Taylor RW. . Brain 2015, 138(12), 3503-3519.
  • Olahova M, Haack TB, Alston CL, Houghton JAC, He L, Morris AAM, Brown GK, McFarland R, Chrzanowska-Lightowlers ZMA, Lightowlers RN, Prokisch H, Taylor RW. . European Journal of Human Genetics 2015, 23(7), 935-939.
  • Wesolowska M, Gorman GS, Alston CL, Pajak A, Pyle A, He L, Griffin H, Chinnery PF, Miller JAL, Schaefer AM, Taylor RW, Lightowlers RN, Chrzanowska-Lightowlers ZM. . Journal of Neuromuscular Diseases 2015, 2(4), 409-419.
  • Chrzanowska-Lightowlers ZM, Lightowlers RN. . PLoS Genetics 2015, 11(6), e1005227.
  • Elson JL, Smith PM, Greaves LC, Lightowlers RN, Chrzanowska-Lightowlers ZMA, Taylor RW, Vila-Sanjurjo A. . Mitochondrion 2015, 25, 17-27.
  • Wilson WC, Hornig-Do HT, Bruni F, Chang JC, Jourdain AA, Martinou JC, Falkenberg M, Spåhr H, Larsson NG, Lewis RJ, Hewitt L, Baslé A, Cross HE, Tong L, Lebel RR, Crosby AH, Chrzanowska-Lightowlers ZMA, Lightowlers RN. . Human Molecular Genetics 2014, 23(23), 6345-6355.
  • Hornig-Do H-T, Montanari A, Rozanska A, Tuppen HA, Almalki AA, Abg-Kamaludin DP, Frontali L, Francisci S, Lightowlers RN, Chrzanowska-Lightowlers ZM. . EMBO Molecular Medicine 2014, 6(2), 183-193.
  • Lightowlers RN, Rozanska A, Chrzanowska-Lightowlers ZM. . FEBS Letters 2014, 588(15), 2496-2503.
  • Almalki A, Alston CL, Parker A, Simonic I, Mehta SG, He LP, Reza M, Oliveira JMA, Lightowlers RN, McFarland R, Taylor RW, Chrzanowska-Lightowlers ZMA. . Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease 2014, 1842(1), 56-64.
  • Wesolowska MT, Richter-Dennerlein R, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Frontiers in Microbiology 2014, 5, 374.
  • Lightowlers RN, Chrzanowska-Lightowlers ZMA. . EMBO Molecular Medicine 2014, 6(6), 705-707.
  • Jourdain AA, Koppen M, Wydro M, Rodley CD, Lightowlers RN, Chrzanowska-Lightowlers ZM, Martinou JC. . Cell Metabolism 2013, 17(3), 399-410.
  • Lightowlers RN, Chrzanowska-Lightowlers ZM. . RNA Biology 2013, 10(9), 1433-1438.
  • Dujeancourt L, Richter R, Chrzanowska-Lightowlers ZM, Bonnefoy N, Herbert CJ. . Mitochondrion 2013, 13(6), 871-880.
  • Serre V, Rozanska A, Beinat M, Chretien D, Boddaert N, Munnich A, Rötig A, Chrzanowska-Lightowlers ZM. . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2013, 1832(8), 1304-1312.
  • Bruni F, Gramegna P, Oliveira JM, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . PLoS One 2013, 8(5), e64670.
  • Smith PM, Elson JL, Greaves LC, Wortmann SB, Rodenburg RJT, Lightowlers RN, Chrzanowska-Lightowlers ZMA, Taylor RW, Vila-Sanjurjo A. . Human Molecular Genetics 2013, 23(4), 949-969.
  • Lightowlers RN, Chrzanowska-Lightowlers ZMA. . EMBO Reports 2012, 13(12), 1038-1039.
  • Challen C, Anderson JJ, Chrzanowska-Lightowlers ZMA, Lightowlers R, Lunec J. . International Journal of Oncology 2012, 40(3), 851-859.
  • Boczonadi V, Smith PM, Sitarz K, Chrzanowska-Lightowlers ZMA, Lightowlers RN, Chinnery PF, Horvath R. . In: United Kingdom Neuromuscular Translational Research Conference. 2012, 缅北禁地 upon Tyne, UK: Elsevier Ltd.
  • Bruni F, Gramegna P, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Biochemical Society Transactions 2012, 40(4), 865-869.
  • Kemp JP, Smith PM, Pyle A, Neeve VCM, Tuppen HAL, Schara U, Talim B, Topaloglu H, Holinski-Feder E, Abicht A, Czermin B, Lochmuller H, McFarland R, Chinnery PF, Chrzanowska-Lightowlers ZM, Lightowlers RN, Taylor RW, Horvath R. . Brain 2011, 134(1), 183-195.
  • Chrzanowska-Lightowlers ZMA, Pajak A, Lightowlers RN. . Journal of Biological Chemistry 2011, 286(40), 34479-34485.
  • Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, Huynen MA, Smeitink JA, Lightowlers RN, Chrzanowska-Lightowlers ZM. . EMBO Journal 2010, 29(6), 1116-1125.
  • Crosby AH, Patel H, Chioza BA, Proukakis C, Gurtz K, Patton MA, Sharifi R, Harlalka G, Simpson MA, Dick K, Reed JA, Al-Memar A, Chrzanowska-Lightowlers ZMA, Cross HE, Lightowlers RN. . American Journal of Human Genetics 2010, 87(5), 655-660.
  • Sanaker PS, Toompuu M, Hogan VE, He LP, Tzoulis C, Chrzanowska-Lightowlers ZMA, Taylor RW, Bindoff LA. . Biochimica et Biophysica Acta: Molecular Basis of Disease 2010, 1802(6), 539-544.
  • Dennerlein S, Rozanska A, Wydro M, Chrzanowska-Lightowlers ZMA, Lightowlers RN. . Biochemical Journal (Cell) 2010, 430(3), 551-558.
  • Temperley RJ, Wydro M, Lightowlers RN, Chrzanowska-Lightowlers ZM. . Biochimica et Biophysica Acta (BBA) - Bioenergetics 2010, 1797(6-7), 1081-1085.
  • Temperley R, Richter R, Dennerlein S, Lightowlers RN, Chrzanowska-Lightowlers ZM. . Science 2010, 327(5963), 301-301.
  • Horvath R, Kemp JP, Tuppen HAL, Hudson G, Pyle A, Holinski-Feder E, Abicht A, Czermin B, Walter MC, Gunther-Scholz A, Smith PM, McFarland R, Chrzanowska-Lightowlers ZMA, Lightowlers RN, Lochmuller H, Taylor RW, Chinnery PF. . In: United Kingdom Neuromuscular Translational Research Conference. 2010, Oxford, UK: Neuromuscular Disorders, Elsevier.
  • Richter R, Pajak A, Dennerlein S, Smith PM, Rozanska A, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . In: Biochimica et Biophysica Acta: Bioenergetics. 16th European Bioenergetics Conference. 2010, Warsaw, Poland: Elsevier BV.
  • Antonicka H, Ostergaard E, Sasarman F, Weraarpachai W, Wibrand F, Pedersen AM, Rodenburg RJ, vanderKnaap MS, Smeitink JA, Chrzanowska-Lightowlers ZMA, Shoubridge EA. . American Journal of Human Genetics 2010, 87(1), 115-122.
  • Wydro M, Bobrowicz A, Temperley RJ, Lightowlers RN, Chrzanowska-Lightowlers ZM. . Nucleic Acids Research 2010, 38(11), 3732-3742.
  • Lightowlers RN, Chrzanowska-Lightowlers ZMA. . RNA Biology 2010, 7(3), 282-286.
  • Tuppen HA, Hogan VE, He L, Blakely EL, Worgan L, Al-Dosary M, Saretzki G, Alston CL, Morris AA, Clarke M, Jones S, Devlin AM, Mansour S, Chrzanowska-Lightowlers ZMA, Thorburn DR, McFarland R, Taylor RW. . Brain 2010, 133(10), 2952-2963.
  • Richter R, Pajak A, Dennerlein S, Rozanska A, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Biochemical Society Transactions 2010, 38(6), 1523–1526.
  • Fan KB, Chrzanowska-Lightowlers ZMA, Hesketh JE. . Biochemical and Biophysical Research Communications 2009, 386(1), 82-88.
  • Sanaker PS, Toompuu M, Chrzanowska-Lightowlers Z, He L, Hogan V, Taylor RW, Tzoulis C, Bindoff LA. . In: Neuromuscular Disorders: 14th International Congress of the World Muscle Society. 2009, Geneva, Switzerland: Elsevier Ltd.
  • Horvath R, Kemp JP, Tuppen HAL, Hudson G, Oldfors A, Marie SKN, Moslemi AR, Servidei S, Holme E, Shanske S, Kollberg G, Jayakar P, Pyle A, Marks HM, Holinski-Feder E, Scavina M, Walter MC, Coku J, Gunther-Scholz A, Smith PM, McFarland R, Chrzanowska-Lightowlers ZMA, Lightowlers RN, Hirano M, Lochmuller H, Taylor RW, Chinnery PF, Tulinius M, DiMauro S. . Brain 2009, 132(11), 3165-3174.
  • Boesch P, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Chichester: John Wiley & Sons, Ltd, 2008. Available at: .
  • Rorbach J, Yusoff A, Tuppen H, Abg-Kamaludin D, Chrzanowska-Lightowlers Z, Taylor R, Turnbull D, Mcfarland R, Lightowlers R. . Nucleic Acids Research 2008, 36(9), 3065-3074.
  • Bobrowicz AJ, Lightowlers RN, Chrzanowska-Lightowlers Z. . Biochemical Society Transactions 2008, 36(3), 517-519.
  • Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Biochemical Journal 2008, 416(1), e5-e6.
  • Rorbach J, Richter R, Wessels HJ, Wydro M, Pekalski M, Farhoud M, Kuhl I, Gaisne M, Bonnefoy N, Smeitink JA, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Nucleic Acids Research 2008, 36(18), 5787-5799.
  • Rorbach J, Soleimanpour-Lichaei R, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . In: Biochemical Society Transactions: Focus Topics at Life Sciences. 2007, Glasgow, UK: Portland Press Ltd.
  • Soleimanpour-Lichaei HR, Kuhl I, Gaisne M, Passos JF, Wydro M, Rorbach J, Temperley R, Bonnefoy N, Tate W, Lightowlers R, Chrzanowska-Lightowlers Z. . Molecular Cell 2007, 27(5), 745-757.
  • Mickleburgh I, Chabanon H, Nury D, Fan K, Burtle B, Chrzanowska-Lightowlers Z, Hesketh J. . RNA 2006, 12(7), 1397-1407.
  • Pye D, Kyriakouli DS, Taylor GA, Johnson R, Elstner M, Meunier B, Chrzanowska-Lightowlers ZMA, Taylor RW, Turnbull DM, Lightowlers RN. . Nucleic Acids Research 2006, 34(13), e95.
  • Blakely EL, Rennie KJ, Jones L, Elstner M, Chrzanowska-Lightowlers ZMA, White CB, Shield JPH, Pilz DT, Turnbull DM, Poulton J, Taylor RW. . Pediatric Research 2006, 59(3), 440-444.
  • Mickleburgh I, Burtle B, Hollas H, Campbell G, Chrzanowska-Lightowlers Z, Vedeler A, Hesketh J. . FEBS Journal 2005, 272(2), 413-421.
  • Seal R, Temperley RJ, Wilusz J, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Nucleic Acids Research 2005, 33(1), 376-387.
  • McFarland R, Pye D, Glanville M, Chrzanowska-Lightowlers Z, Turnbull D, Lightowlers R. . In: Biochimica et biophysica acta. Bioenergetics. 2004, Netherlands: Elsevier BV.
  • Maniura-Weber K, Taylor RW, Johnson MA, Chrzanowska-Lightowlers Z, Morris AAM, Charlton CPJ, Turnbull DM, Bindoff LA. . European Journal of Human Genetics 2004, 12(6), 509-512.
  • Chrzanowska-Lightowlers ZMA, Temperley RJ, Smith PM, Seneca SH, Lightowlers RN. . Biochemical Journal 2004, 377(3), 725-731.
  • Chrzanowska-Lightowlers Z, Temperley R, Lightowlers R. . In: Biochimica et Biophysica Acta: Bioenergetics. 6th European Meeting on Mitochondrial Pathology (Euromit 6). 2004, Nijmegen, Netherlands: Elsevier BV.
  • Mickleburgh I, Burtle B, Nury D, Chabanon H, Chrzanowska-Lightowlers ZMA, Hesketh J. . Biochemical Society Transactions 2004, 32(5), 705-7066.
  • Gagliardi D, Stepien PP, Temperley RJ, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Trends in Genetics 2004, 20(6), 260-267.
  • Kolesnikova OA, Entelis NS, Jacquin-Becker C, Goltzene F, Chrzanowska-Lightowlers ZM, Lightowlers RN, Martin RP, Tarassov I. . Human Molecular Genetics 2004, 13(20), 2519-2534.
  • Bidooki S, Jackson MJ, Johnson MA, Chrzanowska-Lightowlers ZMA, Taylor RW, Venables G, Lightowlers RN, Turnbull DM, Bindoff LA. . Neuromuscular Disorders 2004, 14(7), 417-420.
  • Deschauer M, Chrzanowska-Lightowlers ZMA, Biekmann E, Pourfarzam M, Taylor RW, Turnbull DM, Zierz S. . Molecular Genetics and Metabolism 2003, 79(2), 124-128.
  • Kearns P, Chrzanowska-Lightowlers ZMA, Pieters R, Veerman A, Hall AG. . British Journal of Haematology 2003, 120(1), 80-88.
  • Temperley RJ, Seneca SH, Tonska K, Bartnik E, Bindoff LA, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . Human Molecular Genetics 2003, 12(18), 2341-2348.
  • Kearns PR, Chrzanowska-Lightowlers ZMA, Pieters R, Veerman A, Hall AG. . British Journal of Haematology 2003, 120(1), 80-88.
  • Menzies FM, Cookson MR, Taylor RW, Turnbull DM, Chrzanowska-Lightowlers ZMA, Dong L, Figlewicz DA, Shaw PJ. . Brain 2002, 125(7), 1522-1533.
  • Shamloula HK, Mbogho MP, Pimentel AC, Chrzanowska-Lightowlers ZMA, Hyatt V, Okano H, Venkatesh TR. . Genetics 2002, 161(2), 693-710.
  • von Delwig A, Lee JJ, Chrzanowska-Lightowlers ZMA, Robinson JH. . Journal of Leukocyte Biology 2002, 72(1), 163-166.
  • McGregor A, Temperley R, Chrzanowska-Lightowlers Z, Lightowlers NR. . Molecular Genetics and Genomics 2001, 265(4), 721-729.
  • Chrzanowska-Lightowlers ZMA, Lightowlers RN. . RNA 2001, 7(3), 435-444.
  • Lightowlers RN, Selwood SP, Chrzanowska-Lightowlers ZMA. . London, UK: Wiley-Blackwell, 2001. Available at: .
  • Kolesnikova O, Entelis N, Chrzanowska-Lightowlers Z, Lightowlers R, Martin R, Tarassov I. . In: YEAST. 2001.
  • Selwood SP, McGregor A, Lightowlers RN, Chrzanowska-Lightowlers ZMA. . FEBS Letters 2001, 494(3), 186-191.
  • Awad SS, Lightowlers RN, Young C, Chrzanowska-Lightowlers ZMA, Lomo T, Slater CR. . Journal of Neuroscience 2001, 21(21), 8456-8463.
  • Selwood SP, Chrzanowska-Lightowlers ZMA, Lightowlers RN. . In: Colloquium on Organisms, Organs, Cells and Organelles - In Vivo and In Vitro Experimental Systems. 2000, University College Cork, Ireland: Biochemical Society Transactions, Portland Press.
  • Gays F, Unnikrishnan M, Shrestha S, Fraser KP, Brown AR, Tristram CMG, Chrzanowska-Lightowlers ZMA, Brooks CG. . Journal of Immunology 2000, 164(10), 5094-5102.
  • Clark KM, Taylor RW, Johnson MA, Chinnery PF, Chrzanowska-Lightowlers ZMA, Andrews RM, Nelson IP, Wood NW, Lamont PJ, Hanna MG, Lightowlers RN, Turnbull DM. . American Journal of Human Genetics 1999, 64(5), 1330-1339.
  • Clarke K, Taylor R, Johnson MA, Chinnery P, Chrzanowska-Lightowlers ZMA, Andrews R, Nelson I, Wood N, Lamont P, Hanna M, Lightowlers RN, Turnbull DM. . American Journal of Human Genetics 1999, 64(5), 1330-1339.
  • Chrzanowska-Lightowlers ZM, Temperley RJ, McGregor A, Bindoff LA, Lightowlers RN. . Gene 1999, 230(2), 241-247.
  • Toomey JA, Salcedo M, Cotterill LA, Millrain MM, Chrzanowska-Lightowlers Z, Lawry J, Fraser K, Gays F, Robinson JH, Shrestha S, Dyson PJ, Brooks CG. . Journal of Immunology 1999, 163(6), 3176-3184.
  • Szczepanska K, Chrzanowska-Lightowlers Z, Degnan BA, Diamond AG, Robson T, Ryzewska A, Goodacre JA. . Rheumatology 1999, 38(10), 1022-1024.
  • Toomey JA, Shrestha S, de la Rue SA, Gays F, Robinson JH, Chrzanowska-Lightowlers ZMA, Brooks CG. . European Journal of Immunology 1998, 28(1), 47-56.
  • Preiss T, Chrzanowska-Lightowlers ZM, Lightowlers RN. . Trends in Biochemical Sciences 1997, 22(8), 290-290.
  • Bidooki SK, Johnson MA, Chrzanowska-Lightowlers Z, Bindoff LA, Lightowlers RN. . American Journal of Human Genetics 1997, 60(6), 1430-1438.
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